Researchers have developed a novel nano-carrier to deliver the Chinese medicine compound gambogic acid, enhancing its anti-cancer effect and reducing off-target toxicity. The treatment shows promise in treating triple-negative breast cancer with improved efficacy and reduced damage to organs.
Researchers have found that hyocholic acids, a component of bile acids, are a strong risk indicator of type 2 diabetes. The study suggests that HCAs can regulate blood glucose levels and protect against diabetes, opening up opportunities for HCA-based predictive markers and anti-diabetic drugs.
A study by HKBU scientists reveals symbiotic relationship between clams and bacteria, enabling them to adapt to deep-sea conditions. The research found 28 genes transferred from ancestral chemoautotrophic bacteria to the clam, facilitating chemosynthesis and energy production.
Researchers at Hong Kong Baptist University develop a peptide-linked drug targeting two viral proteins produced by Epstein-Barr virus, reducing cancer cell damage and increasing drug uptake rates. The novel drug has shown efficacy in animal models and is being further developed for clinical trials.
The new risk score, developed by HKBU and CUHK researchers, uses urine spermine levels to estimate a patient's risk of developing prostate cancer. The test has been shown to accurately identify high-risk patients and help reduce unnecessary biopsies.
A study by Hong Kong Baptist University found that slow-moving tropical cyclones bring about 20% more rainfall, resulting in increased flood risks in the region. The research also identified a correlation between slower moving speeds and higher rainfall volumes.
Scientists from HKBU developed a novel approach to manipulating molecular chirality using helical metal nanostructures. This method eliminates potential side effects associated with drugs containing molecules in incorrect chiral arrangements, enabling the mass production of purer and cheaper drugs.
A HKBU-led research team developed a novel antiviral drug that selectively disrupts EBV protein, leading to tumour shrinkage and improved survival rates in animal models. The drug has shown promising results in targeting latent EBV infection, providing new treatment options for nasopharyngeal carcinoma.
A new research model developed by HKBU scientists characterizes disease transmission patterns among different age groups and populations. The model enables policymakers to design work resumption plans that balance containment of disease transmission risk with gradual economic reopening.
Researchers discovered highly sensitive snails can digest cellulose, form hard eggshells and pack neurotoxins in eggs. Genome sequencing revealed key adaptations enabling the invasion of freshwater wetlands.
Researchers at HKBU found that Nerve Growth Factor (NGF) promotes intestinal stem cell growth, leading to high serotonin levels and IBS-like symptoms. The study links early life stress to lifelong health consequences, providing new insights into gastrointestinal disease treatment.
Researchers from Hong Kong Baptist University have invented a new method that can detect target molecules in pharmaceuticals and pesticides in just five minutes. This breakthrough could lead to the production of higher quality medicinal drugs with no side effects.
A new series of tangram games has been developed to train and assess children's reading, writing, and word identification skills at an early age. The games, led by Dr Simpson Wong, aim to identify children with early visual processing difficulties and provide suitable support.
African lake sedimentary cores revealed a continuous record of climate change extending back one million years, linking aridification to technological and evolutionary changes in early humans. The research suggests that climate variability drove human migration and the development of new tools, providing a selective pressure for survival.
Researchers at Hong Kong Baptist University have developed a metal compound that inhibits the enzyme lysine-specific demethylase 5A (KDM5A) in TNBC tumours with less toxicity in mice. This discovery holds great promise for the development of targeted drugs for TNBC therapy, offering a new approach to treating this difficult form of bre...
Researchers at Hong Kong Baptist University have designed and synthesized a smart globular macromolecular machine vehicle for actively controlled cancer drug delivery, enhancing the efficacy of targeted therapy drugs. The breakthrough offers insights into targeted therapies such as Chlorambucil in leukemia treatment.
A Hong Kong Baptist University study found that skin squames from humans contribute to odors in air-conditioning systems by providing a food source for bacteria. The researchers recommend installing filters to capture skin squames, which can help mitigate odor problems.
A research team from HKBU has developed a new technology to accurately establish a gene regulatory route for analyzing genetic function and understanding complex biological events. The 'LogicTRN' algorithm can help locate key regulatory routes for complicated diseases, facilitating targeted therapy drug development.
Research found that human-perceived temperature (AP) increased 0.04oC per decade faster than actual air temperature (AT), with projected increases of up to 0.17oC per decade in low-latitude areas. AP is expected to continue rising, posing bigger threats to cities and communities, especially in tropical and sub-tropical regions.
Researchers at Hong Kong Baptist University have invented multifunctional cyanine compounds that can be used for detection, imaging and treatment of Alzheimer's disease. The discovery has been granted US patents and a Chinese patent.
Researchers at Hong Kong Baptist University developed a new generation of smart anti-cancer drug molecules by connecting a tumor-targeting aptamer with a plant-derived cytotoxic drug. The resulting aptamer-drug conjugate shows excellent antitumor activity and decreased toxicity in experiments using a mouse model.
Researchers at Hong Kong Baptist University have developed a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma. The aptamer-functionalised lipopolymer delivery system successfully delivered CRISPR/Cas9 to tumor cells, inhibiting malignancy and angiogenesis.
A research team has assembled the first complete genome of a deep-sea mussel, providing new insights into its molecular mechanisms of adaptation. The study found that modern deep-sea mussels evolved from shallow-water mussels approximately 110 million years ago.