Researchers found that cancer patients across all stages exhibit a high burden of somatic symptoms, including fatigue, pain, and insomnia. These symptoms significantly impair daily functioning and overall well-being, highlighting the need for comprehensive symptom management strategies.
Researchers at Indiana University School of Medicine found gray matter changes in breast cancer patients' brains during and after chemotherapy treatment. Memory and executive functions were most affected, with some women experiencing subtle and others severe cognitive impairments.
Toxoplasma gondii parasite triggers stress response mechanism to survive outside host cells, enabling it to find new hosts and infect them. Researchers identify critical pathway that helps the parasite overcome environmental stresses, offering potential new treatments for toxoplasmosis infection.
According to a study published in JADA, asthma and cavities are both prevalent childhood diseases in the US. However, researchers found little evidence suggesting that asthma causes tooth decay, with some studies showing children with asthma having fewer cavities.
The survey found that interest in receiving the HPV vaccine increased if it was available free of charge, but decreased as out-of-pocket costs rose. Convenience also played a role, with many women preferring to receive the vaccine at a doctor's office rather than a local pharmacy.
A new antiviral drug has shown significant promise in treating hepatitis C, particularly in patients with genotype 1, the most difficult to treat. Adding the drug nearly doubled the treatment's effectiveness when given for 48 weeks.
The School of Science at IUPUI is launching a program to encourage science majors to become teachers, addressing the shortage in science educators. Through the Noyce Summer Internship program, freshmen and sophomores share their enthusiasm for science with middle school and high school students.
A new study has found that centralized telephone-based care management can significantly reduce pain and depression in cancer patients. The INCPAD study combined automated calls with follow-up calls from nurse care managers, and the results showed improved outcomes for patients with all types of cancers.
A six-year study found that anticholinergic medications increase the risk of mild cognitive impairment and memory loss in older adults, especially those from African-American communities. The researchers suggest that these drugs may worsen cognitive function, but not necessarily lead to Alzheimer's disease.
Researchers at Indiana University School of Medicine successfully treated acute kidney injury in laboratory experiments using genetically reprogrammed cells producing a protein that aids kidney development. The treatment, administered intravenously, showed significant improvements in kidney function and reduced physical damage.
A new study of child homicides found that fatalities are evenly distributed across all months, contradicting widespread notions of increased risk during winter holidays. Experts emphasize that prevention efforts should be a year-round priority, as common stressors on caregivers like tantrums and accidents occur throughout the year.
Indiana University School of Medicine and Regenstrief Institute collaborate to develop specialized graduate programs in health IT. The programs will provide training, distance learning opportunities, and on-the-job experience for healthcare professionals.
A phase I clinical trial of the combination of decitabine and carboplatin has shown promising results in treating late-stage ovarian cancer, with four patients experiencing no disease progression after six months. The treatment regimen has been found to be well-tolerated, with mild adverse reactions.
Researchers identify two promising proteins, eIF5A and DHS, as potential targets for preventing diabetes. Blocking their actions significantly reduced the development of diabetes in mice, offering a new route for drug therapies.
A study published in PLoS One investigates the reliability of peer review and its influence on journal editors' decisions to publish or reject research. The results suggest that reviewers agree on manuscript disposition rates barely exceeding chance, while editor decisions are significantly influenced by reviewer recommendations.
A new study from Indiana University School of Medicine offers a blueprint for hospital systems, physicians, and caregivers to implement evidence-based research in patient care. The study highlights the need for healthcare providers to overcome end-zone hurdles and provides a framework for success.
A new research facility at Riley Hospital for Children will improve the process of turning laboratory research into new treatments for sick children. The IU School of Medicine will conduct comprehensive phenotyping studies and test the safety and effectiveness of potential new treatments.
A study found that male viewers were influenced by visual aspects of a female character when making moral decisions, while women's responses were less affected. Researchers suggest this could impact future systems, such as medical decision-making and crime reenactments.
A new study from the Regenstrief Institute provides a framework for evaluating the costs, effort, and value of health information exchange services. The framework will help track the development and utilization of these services, crucial for understanding their impact on quality of care and patient safety.
Leading physician policy experts propose several policy solutions to help the US prepare for an aging adult population. The proposed solutions include increasing funding for geriatrics in medical schools, leveraging Medicare's educational subsidy, and requiring practicing physicians to complete geriatric continuing education credits.
Researchers present novel approaches to identify and treat congenital cardiovascular defects, which can lead to heart failure. Studies focus on molecular mechanisms and imaging techniques to diagnose and follow patients.
A national survey found that nearly four in 10 Americans who want to repeal the law also support its core provisions, including insurance mandates. The public option was surprisingly popular, with 59% of respondents supporting it when framed as a choice between government and private health insurance.
According to a new national survey by Indiana University's Center for Health Policy and Professionalism Research, 58% of Americans support health care reform, despite some wanting the law repealed. Younger individuals were most supportive of repeal, but many also want Congress to continue working on health care system reforms.
A new graphical tool called RXplore allows physicians to instantly track down the cause of drug side effects by retrieving adverse reaction data for multiple medications simultaneously. The study found that physicians can retrieve accurate information 65% faster using Rxplore than traditional resources.
The Regenstrief Institute is leveraging its Indiana Network for Patient Care to automate the disability case determinations process, reducing time and increasing completeness of medical data. This will facilitate faster decision-making and decrease the burden on healthcare providers.
Researchers from Indiana University School of Medicine found a genetic link between neurofibromatosis type 1 disease and cardiovascular disease in children. The study suggests that treatments targeting inflammation may be effective in preventing sudden death from cardiovascular disease.
Researchers found that physicians prioritize what's best for the patient overall, followed by the patient's preferences and pain management. However, ageist assumptions may influence decision-making, with a decreased reliance on patient preferences among older adults.
A large eight-year study found that Medicare patients are 5.5 times more likely to undergo routine cataract surgery than those receiving care from the Department of Veterans Affairs. The disparity may be attributed to financial incentives, physician-driven decisions, or a lack of ophthalmologists within the VA system.
A study found that sexually experienced girls resume sexual activity after periods of abstinence, with short-term factors including good relationships, personal interest, and mood influencing the decision. Long-term predictors include relationship quality and personal interest.
Researchers have discovered a gene linked to a newly recognized multisystem autoimmune disorder affecting Amish children, characterized by chronic diarrhea, enlarged organs, and developmental delays. The ITCH gene plays a crucial role in regulating the immune system, and identifying it may lead to effective treatment for these children.
A new study found that nearly a third of patients age 65 and older referred to a specialist do not receive treatment due to failed referrals. The study revealed that only 50% of those referred had the opportunity to receive treatment, highlighting the need for improved health information technology to address this issue.
A seven-year study found that Medicare reimbursement led to higher nursing home admissions and shorter hospital stays compared to VA facilities. However, death rates were similar for veterans with hip fractures treated under either system.
A new study by Indiana University School of Medicine researchers found that deaf children's word-learning skills are strongly affected by their early auditory experience, whether through normal means or with a cochlear implant. Children who received the implant at a young age performed similarly to their normal-hearing counterparts.
Developing local human capacity is key to implementing e-health tools in low-income countries, but a chicken-and-egg problem exists. Dr. Tierney's East African Center of Excellence in Health Informatics has built upon decades-long collaborations to train individuals and implement health information technology tools.
Indiana University researchers have identified a mechanism used by the tuberculosis bacterium to evade the body's immune system and discovered a compound that can block its survival. The IU team synthesized the compound I-A09, which successfully blocked the TB bacterium's activity in laboratory tests.
A new study has found that acyclovir, a common medication used to treat herpes symptoms, does not reduce the transmission of HIV. The research, conducted in seven sub-Saharan countries, suggests that frequent genital herpes recurrences can increase HIV levels in the blood and genital tract.
A recent study found that teenage minority boys who experience discrimination are more likely to smoke, while their female counterparts show no such association. Researchers investigated 2,561 adolescents and discovered that perceived discrimination had a positive impact on smoking rates among boys, but not girls.
Researchers found that custom videogames improved hand function and forearm bone health in teens with hemiplegic cerebral palsy. The games were designed to be used remotely, reducing costs and increasing accessibility to rehabilitation therapy.
A team of researchers from Indiana University and Stanford University has determined how a 'chemical chaperone' activates the ALDH2 enzyme, which plays a crucial role in metabolizing toxins after a heart attack. The discovery could lead to new treatments by restoring enzyme function, reducing muscle damage caused by heart attacks.
A long-term study by Indiana University School of Medicine found that frequent testing and treatment does not reduce the prevalence of chlamydia in urban teenage girls. Despite regular screenings, 84% of repeated infections were reinfections.
According to a new study, half of urban teenage girls may acquire at least one common sexually transmitted infection (STI) within two years of becoming sexually active. The researchers found that repeated infections with chlamydia, gonorrhea, and trichomoniasis were very common among the participants.
Researchers investigated over 300 proteins in axolotl limbs, discovering key proteins involved in cell reprogramming and avoiding cell death. These findings may contribute to a better understanding of limb regeneration and potentially lead to new treatments for human amputations.
Researchers identified a critical pathway that stimulates Mdm2 production, binding to and extinguishing tumor suppressors like p53. Preventing Mdm2's destruction is crucial to preventing cancer from spreading within the body.
A new Indiana University School of Medicine study found that involving family members in medical rounds improves care and communication. Families reported increased feelings of inclusion, respect, and a better understanding of their child's care. Participation is voluntary, and family members can ask questions and offer input.
The new center will connect IU's expertise with Moi University and hospital to increase electronic health record capacity in one of the world's poorest regions. Trained locals will use electronic tools to solve healthcare problems, enhancing outcomes and public health.
Emergency medical services providers can now securely access patients' pre-existing health information, enabling informed treatment decisions and efficient care delivery. The Indiana Network for Patient Care (INPC) link allows paramedics and EMTs to access patient records in real-time, improving care quality and safety.
Palliative care is crucial for dementia patients as they often suffer from untreated pain and symptoms due to their inability to report their condition. The need for improved symptom management, emotional support, and family support has been emphasized by experts.
Researchers identified a genetic defect that selectively affects white blood cell production, potentially predisposing individuals to inflammatory bowel disease. The study's findings may provide insight into why IBD develops and help inform future treatment strategies.
The new center will leverage expertise from diverse groups to develop innovative public health information tools, improving patient care and expanding data exchange between physicians and public health agencies. Initial work focuses on newborn screening, immunization data, and public health alert delivery.
A new study found that depressive symptoms are associated with increased levels of interleukin-6, an inflammatory protein predicting cardiovascular events. In contrast, levels of interleukin-6 were not related to later increases in depressive symptoms among healthy adults.