Researchers at Indiana University identified a unique gene signature in pancreatic cancer patients who can benefit from targeted therapies cutting off the growth pathways fed by abnormal blood vessels. This finding suggests that these patients may benefit from precision medicine approaches.
Geographically isolated wetlands provide significant benefits to water quality, including sediment retention and nutrient transformation. The loss of these wetlands would likely cause serious harm to North American waters.
A study found that taking a pre-exercise supplement of omega-3 PCSO-524, derived from the New Zealand green-lipped mussel, has significant positive effects on post-exercise muscle damage. The subjects experienced less muscle soreness, pain, strength loss, fatigue, and inflammatory proteins in their bloodstreams.
The editorial highlights the need for bold action to improve end-of-life care in nursing homes, focusing on symptom control, advance care planning, and high-quality palliative care. Nursing home providers are urged to prioritize training staff in these areas to ensure better support for patients and their families near the end of life.
The Strategic Pharma-Academic Research Consortium (SPARC) has awarded over $1.9 million to advance research on autoimmune diseases such as multiple sclerosis, lupus, and Crohn's disease. The funded projects will focus on understanding the root causes of these conditions and developing new treatments.
A new study by Regenstrief Institute and Indiana University finds that obese black and white women have distinct attitudes towards weight, with black women being more accepting of obesity. Despite differing views, neither group expressed a desire to lose weight or increase physical activity.
Researchers at Indiana University School of Medicine identified a novel pathway that enables solid tumor cancer cells to grow. The protein Mdm2 plays an active role in making p53 ineffective, providing a new target for therapeutic approaches.
A team of Indiana University researchers has been awarded a major grant to develop and use chemical tagging methods to understand how bacterial cells build their cell walls, a key target for new antibiotics. The team plans to create new probes to track peptidoglycan synthesis in bacteria such as E. coli, B. subtilis, and S. pneumoniae.
Researchers at Indiana University have discovered a way to use nitrogen gas as a nitrogen source for bioethanol-producing bacteria, increasing ethanol yield and reducing costs. This breakthrough could make cellulosic ethanol more competitive with corn ethanol and gasoline, benefiting the industry and environment.
The book, 'Unfinished Work: The Struggle to Build an Aging American Workforce,' explores how businesses, governments, and individuals deal with the issue. Coleman traveled extensively, including Japan, France, and Sweden, to research how companies are adapting to an aging workforce.
Researchers from Indiana University and Regenstrief Institute call for further research to determine if medications' adverse cognitive effects can be reversed. They also highlight the need for safer alternatives to prevent Alzheimer's disease and other dementing disorders.
A new report by an independent panel found that evidence-based approaches to treating chronic pain are lacking, with no existing algorithm for determining the best treatment approach. The panel recommends multidisciplinary care incorporating patients' perspectives and emphasizes the need for more research on opioids and other treatments.
The OPTIMISTIC program uses specially trained RNs to review hospital transfers and identify areas for quality improvement, aiming to reduce preventable hospitalizations by up to 50% in nursing home residents.
A new study from Indiana University finds that a patient self-reporting version of the Healthy Aging Brain Care Monitor is reliable and valid. The tool measures 27 items on a four-point scale to assess cognitive, functional and psychological symptoms, providing valuable information for busy physicians.
In a six-month trial, 49% of patients withheld clinically sensitive information from their healthcare providers. Patients sought control over who accessed their records, but doctors had mixed reactions. The study aimed to balance individual privacy with healthcare providers' needs for relevant data.
Researchers Susan Alt and Timothy R. Pauketat have been awarded $640,000 in grants to continue their study of Cahokia Mounds, uncovering new insights into the history of civilizations. The projects focus on the role of religion in organizing complex societies, with a emphasis on archaeology, anthropology and cultural innovation.
The IU and Regenstrief GRACE study is a pioneering program that provides comprehensive care management for older adults in their homes. It has been shown to improve quality of life, reduce hospital admissions, and decrease healthcare costs, making it a model for geriatric medicine.
Scientists at Indiana University and colleagues have demonstrated a technique for correcting genetic mutations in sperm-producing adult stem cells, a breakthrough that could prevent inherited defects in future generations. The method uses homologous recombination to repair flawed segments of DNA with correct ones.
Research by Indiana University scientists reveals that soil mineral surfaces determine nitrous acid release into the atmosphere, playing a pivotal role in smog formation and greenhouse gas lifetime. This finding could contribute to improved models for understanding and controlling air pollution, a significant public health concern.
Researchers found that nursing home hospice patients have longer stays, are more likely to be women and have dementia, and often receive higher Medicare spending compared to those living in the community. The study also identified a 'crossover' group with significantly longer hospice stays.
Research by Indiana University geographer Scott M. Robeson and colleagues finds that temperature anomalies are warming at a faster rate than the overall average temperature, particularly in extreme heat and cold events. These trends have significant impacts on water supplies, agricultural productivity, and human health.
A new peptide developed by IU researchers has effectively cured lab animals of obesity, diabetes, and associated lipid abnormalities. The peptide combines the properties of three gastrointestinal hormones, GLP-1, GIP, and glucagon, and has shown unprecedented efficacy in reducing body weight and controlling metabolism.
Indiana University researchers are developing a computational model to predict acetaminophen-induced liver failure, using advanced microscopic and computational technologies. The model aims to reduce the use of animals in toxicity studies while enabling realistic scientific predictions for environmental and human health problems.
The Wake Up and Breathe program significantly reduced delirium in critically ill patients, while also decreasing sedation levels and coma prevalence. However, the study found a trend towards increased duration of mechanical ventilation.
A study by Indiana University researchers has found that subtle variations in movement patterns among individuals with autism spectrum disorder are indicators of the disorder's severity. The study also identified a pattern of random minute speed fluctuations in some parents of children with autism, suggesting a genetic role in movement...
A new randomized controlled study, SPADE symptom pentad, investigates sleep problems, pain, anxiety, depression, and energy/fatigue in primary-care patients. The study aims to improve patient care by exploring how symptom scores can benefit physicians' treatment.
A recent study by Indiana University researcher Jonathon Beckmeyer found that adolescents' alcohol use is influenced by their close friends' use, regardless of peer consumption perceptions. Parents can encourage teens to make friendships with non-alcohol-using friends to help prevent teen alcohol use.
A study by Indiana University researchers found nearly 60% of Latino adolescents experienced depression, with those having moderate acculturative stress being 10 times more likely to have depression. A yearlong program boosting self-mastery and resiliency is being developed to address this issue.
A study by Indiana University researcher Uzay Kirbiyik found that younger and male drivers in larger vehicles are more likely to survive head-on collisions. The study also revealed that vehicle inequities, such as weight and rigidity, contribute significantly to driver fatalities.
A study by Indiana University found that setting specific family rules about healthy eating and sedentary behavior leads to healthier practices in children. Children from households with set guidelines were more likely to eat fruits and vegetables, limit screen time, and make healthier choices overall.
Researchers identify genes and networks that enable tiny Atlantic killifish to alter their body form in response to environmental changes, providing insight into phenotypic plasticity. The study's findings have substantial implications for understanding molecular evolution and its applications in climate change, medicine, and regenerat...
Researchers at Indiana University identified two proteins, FAK and PAK1, as crucial for the development of acute myeloid leukemia. They also found that targeting these proteins can block the disease's progression.
Researchers at IU School of Medicine are evaluating the advantages of physical exercise, cognitive exercise, or a combination of both on the aging brain. The five-year project aims to enhance cognitive abilities in older adults with mild memory loss and may lead to a delay in dementia onset.
A genetic variant associated with better memory performance was found in a large analysis of genomic data and memory test results from over 14,000 older adults. The researchers discovered that the gene FASTKD2 has not been linked to cognition before, but the G nucleotide variant showed a correlation with improved episodic memory.
A new oral interferon-free therapy has produced significantly fewer side effects and is prescribed for 24 weeks. Cirrhosis caused by hepatitis C is the leading reason for liver transplantation in the U.S., with patients having lower survival rates than those transplanted for other causes of cirrhosis.
A new climate model simulates global carbon cycle interactions between plants and microbes, revealing a loss of soil carbon stocks in temperate regions due to increased microbial activity. The CORPSE model predicts gains in soil carbon capture in boreal regions and tropical South America.
A study of the volunteer advocate program found that it provided comprehensive care to incapacitated patients, including end-of-life decisions and Medicaid applications. The program's success demonstrates a viable alternative to overwhelmed state agencies and provides hope for vulnerable individuals without surrogates.
Researchers at Indiana University School of Medicine have identified Sestrin 3 as a critical regulator of glucose homeostasis and insulin sensitivity in the liver. Mice with the protein showed improved glucose tolerance, while those without it exhibited impaired glucose metabolism.
Researchers at Indiana University have found that a panel of microRNAs in plasma can accurately diagnose pancreatic ductal adenocarcinoma, the most common type of pancreatic malignancy. The discovery could lead to a blood test for early detection and potentially improve treatment outcomes.
A new study by researchers at The Kinsey Institute and the Fred Hutchinson Cancer Research Center has found that having young children in the house can help women experience fewer hot flashes and night sweats during menopause. This unexpected benefit may be linked to increased oxytocin levels, associated with nurturing care.
A recent study by Indiana University School of Medicine found that nearly 21% of youths screened positive for mental health issues requiring follow-up. Female detainees were more likely to screen positive than male detainees, with significant disparities in service utilization based on race/ethnicity. The findings underscore the need f...
A new study from Indiana University recommends that primary-care doctors use a patient's medical history to diagnose common symptoms, often resolving issues without further tests. The study also highlights the importance of communication and symptom-specific treatments for effective management.
A team led by Indiana University's Jay Lennon is exploring the role of dormancy in microbial diversity and its impact on ecosystem processes. The five-year project aims to understand how dormant microbes contribute to geographic patterns of diversity.
Newly created endothelial colony-forming cells can proliferate into human blood vessels, restoring blood flow in mice with damaged tissues. The discovery opens the door for potential treatments for diseases like amputation and blindness.
The IU-Regenstrief CHICA system significantly increased the number of children screened for developmental delay at ages 9, 18, and 30 months. The system also improved developmental delay surveillance by eliciting concerns from parents during visits.
A new Kinsey Institute study found that single parents of children under 5 date and are sexually active as often as singles without children, with no gender differences. The study also revealed that these individuals may be seeking adult company to help with childcare.
A new study by Indiana University researchers found that combining an epilepsy medication with morphine can effectively treat neuropathic pain. The combination of the two drugs resulted in improved pain management and reduced need for opioids, offering a potential solution to the difficult-to-treat condition.
Researchers found that teenage girls who skipped school or failed tests were more likely to engage in vaginal sex and less likely to use condoms. The study also showed a link between academic events and emotional experiences in romantic relationships.
A new study found that taking short walking breaks during prolonged sitting can significantly improve endothelial function and reduce cardiovascular risks. The research involved 11 healthy men who sat for three hours with or without regular breaks, showing that breaks can prevent decline in arterial function.
A commentary calls for physicians to carefully review older patients' medication lists and consider their anticipated life expectancy, goals of care, and treatment targets. This approach can help reduce the number of unnecessary prescriptions and minimize harm from medications in older adults.