Researchers at Scripps Research Institute have discovered a mechanism enabling cancer cells to sustain abnormal growth by nullifying natural defense against uncontrolled division. Cks proteins overexpression causes incipient cancer cells to ignore braking signals, leading to unchecked cell division.
Researchers discovered that all GARS mutations causing CMT type 2D lead to a structural opening in the protein, creating space for other proteins to bind and cause havoc. This finding may lead to the development of drugs targeting this region, offering new therapeutic avenues for the disease.
Researchers will use induced pluripotent stem cells and genome editing technology to recreate participants' own heart artery-lining cells in a dish. The goal is to understand how the 9p21 'gene desert' region contributes to heart disease.
Researchers have discovered a surprising molecular pathway in skin cells that produces nitric oxide, a versatile signaling molecule involved in wound-healing and temperature-sensation. This alternative process could lead to better drugs for treating wounds.
The Scripps Research Institute scientists have discovered a new model of blood clot formation, which could lead to better drugs for preventing heart attacks and other clot-related conditions. The findings highlight the role of P2X7 receptor in activating tissue factor, a key player in the clotting process.
The Scripps Research Institute has received a $2.2 million grant to develop novel therapeutics for treating substance abuse. The researchers aim to disrupt the addictive cycle by targeting the kappa opioid receptor, which plays a critical role in drug addiction.
A Scripps Research scientist has won a grant to study the malaria parasite in the liver, aiming to develop better drugs to combat the disease. The research will focus on understanding pathways essential to parasite development in both blood and liver stages.
Researchers at Scripps Research Institute found a way to disrupt a critical enzyme interaction that prevents cell death, potentially leading to new treatments for heart attack and stroke. The discovery could provide a new therapeutic target against conditions including neurodegenerative diseases like Parkinson's.
A team of Scripps Research scientists found a key biological mechanism underpinning the transition to alcohol dependence. They discovered that neuropeptide Y, a naturally occurring anti-stress agent, plays a crucial role in mediating the transition to alcohol dependence by modulating GABA release in the amygdala.
Researchers at Scripps Research Institute successfully synthesized a rare natural product, conolidine, which shows potent analgesic properties comparable to morphine. The compound has remarkably few side effects, but its mechanism of action remains unknown.
Researchers from Scripps Research Institute identify a class of compounds that powerfully block serine hydrolase activity without affecting other enzymes. The discovery opens up new avenues for studying these enzymes and developing treatments for various diseases.
A Scripps Research Institute scientist has identified a new role for a biological pathway that affects lifespan in Caenorhabditis elegans. The study reveals that N-acylethanolamine signaling molecules play a key role in mediating the effect of diet on lifespan.
Scientists have identified a molecular sensor of temperature within immune cells, which primes the immune response to temperature shifts. This discovery could provide new insights into the mechanisms underlying fever and its effects on the immune system.
Scripps Research Institute investigators Joel Gottesfeld and Kristin Baldwin receive grants to explore stem cells' potential in biology and medicine. The funding supports studies on induced pluripotent stem cells, including methods to identify cancer-causing mutations and their impact on genetic diseases.
Researchers have developed a genetic model of premature aging disorders in zebrafish, which can be used to screen and develop compounds to treat these conditions. The model reveals that a specific gene mutation leads to accelerated aging in the fish, providing new insights into age-related diseases.
Scripps Research and Moffitt Cancer Center collaborate on a $2.1 million grant to understand the origins of prostate cancer and develop novel treatments. The study aims to define how B cells control the spread of hormone-refractory cancer, potentially leading to effective treatments.
A newly developed compound, SR1001, has been shown to effectively suppress the severity of multiple sclerosis in animal models with minimal side effects. The discovery holds promise for treating other autoimmune diseases and targets a specific cell type involved in autoimmunity.
Researchers at Scripps Research Institute and Lawrence Berkeley National Laboratory have discovered a key enzyme in DNA replication that may be exploited to develop an effective anti-cancer therapy. The enzyme FEN1 works in a way opposite to accepted dogma, providing a sophisticated machine for cutting DNA.
Researchers at Scripps Research Institute identified a change in calcium influx into specific brain neurons that is fundamental to long-term memory. This increase, known as a memory trace, is observed in normal fruit flies but absent in mutants with impaired long-term memory.
DNA can alter protein structure and function, leading to targeted therapies for diseases like osteoporosis and cancer. The study used HDX mass spectrometry to detect these long-range structural effects, revealing a complex biochemical dialogue between receptor, ligand, coregulatory proteins, and DNA.
Researchers identify protein TLE3 as a key regulator of fat cell development, which can be targeted to improve adipose tissue function and alleviate symptoms of diabetes. By understanding how fat cells form, scientists aim to develop better treatments for obesity and related disorders.
Researchers at Scripps Research Institute found that an E. coli enzyme must move to function properly, and blocking these movements renders it defective. The study may lead to the development of more specific and effective drugs targeting enzymes.
Researchers found that Hsp90, a common 'chaperone' protein, helps loose p53, contradicting its previous role in folding other proteins. This discovery adds to the growing knowledge of proteins' adaptability and activity in unfolded states.
Researchers used a new virus-based technique to map individual nerve pathways in mice and found significant diversity in how the olfactory system is wired. This suggests that each person's unique wiring may contribute to their distinct olfactory experiences, raising questions about how humans perceive smells.
Researchers at Scripps Research Institute have made a groundbreaking discovery about the structure of the MRN DNA repair complex, revealing its powerful molecular motor workings. The finding has implications for designing non-toxic drugs to treat disorders such as cancer and cystic fibrosis.
Scientists at Scripps Research Institute and University of Pennsylvania discovered over 400 receptors in warm sensitive neurons, which regulate body temperature. The new method, sequencing single neurons, identified these receptors, revealing their role in diseases like schizophrenia and Parkinson
Researchers from Scripps Research Institute determine a new structure of the human A2A adenosine receptor, bound to a full agonist, revealing a super stabilizing agonist. This finding has important implications for drug design, particularly for treating diseases such as Parkinson's and COPD.
Researchers from Scripps Research and MIT have discovered a class of extremely potent anti-cancer and anti-neurodegenerative disorder compounds. These compounds, including ABL127, were found using high-throughput screening and innovative testing techniques, and show promise for treating cancer and Alzheimer's disease.
A new diagnostic test called PluriTest enables researchers to determine the quality of pluripotent stem cell lines with remarkable sensitivity and specificity. The test uses a detailed molecular model of normal pluripotent cells to identify genomic aberrations, alerting scientists to perform additional analysis.
Researchers at Scripps Institute develop a novel technology that synthesizes complex cellular structures from simple starting materials, creating uniform cell-like compartments. The new process is highly efficient and customizable, revolutionizing the field of synthetic biology.
The study found three genes that protect mice from brain amyloid accumulation, with lower expression in the liver protecting the mouse brain. One gene encodes Presenilin, a protein contributing to human Alzheimer's, which is expressed in the liver but not the brain.
Scientists from Scripps Research Institute have discovered a new type of RNA molecule, called riboswitches, that can turn genes on or off in response to cellular energy needs. These findings may have implications for designing new antibiotics against harmful bacteria.
A new compound has shown significant effectiveness in protecting brain cells directly affected by Parkinson's disease, a progressive and fatal neurodegenerative disorder. The compound, SR-3306, aims to inhibit JNK enzymes that play a key role in neuron survival.
A Scripps Research study reveals a new mechanism controlling brain formation, where reelin regulates glial-independent migration of nerve cells. The findings have significant implications for understanding diseases such as schizophrenia and autism.
Researchers have created a novel technique to detect transiently folded protein structures in intrinsically disordered proteins, such as α-synuclein. This method enables scientists to study the mechanism of plaque formation in neurodegenerative disorders and potentially develop new ways to regulate these complex proteins.
Researchers at Scripps Research Institute discover a way to stabilize proteins by attaching specific oligomeric arrays of sugars, potentially increasing the stability and reducing the cost of protein-based drugs. The new methodology has broad implications for the drug industry, particularly for glycoprotein-based drugs.
A Scripps Research scientist has identified a natural molecule that inhibits the activation of thrombin-activatable fibrinolysis inhibitor (TAFI), preventing stable clot formation. This discovery could lead to novel and cost-effective treatments for blood clotting diseases like Hemophilia A.
Researchers at Scripps Research Institute successfully converted adult skin cells into beating heart cells through a direct reprogramming strategy, bypassing the need for embryonic-like stem cells. This breakthrough discovery has the potential to lead to new treatments for diseases such as heart disease, Parkinson's, and Alzheimer's.
Researchers found a discrete brain pathway that regulates vulnerability to nicotine addiction and identified the nicotinic receptor subunit α5 as a potential target for anti-smoking therapies. The study suggests boosting this subunit's expression may help individuals resist nicotine's addictive properties.
A new Scripps Research study has mapped the dynamic changes in brain connectivity during development, revealing that connections are constantly forming and dissolving. The research highlights the importance of understanding these mechanisms to better comprehend conditions such as autism and schizophrenia.
Researchers at Scripps Research Institute found that enzyme ADAR1 slows down measles virus replication and protects cells against other respiratory viruses. The discovery provides a significant improvement in understanding measles infections, which kill around 150,000 children and adults worldwide.
Researchers at Scripps Research and UVa determine the structure of HIV's protein package, also known as the capsid. The detailed description provides a roadmap for developing drugs that can disrupt its formation and prevent infection. The study uses X-ray crystallography to reveal the flexibility and mobility of the capsid's components.
The Scripps Research Institute team created a library of 50 synthetic compounds from natural Japanese-plant compounds, including one that shows great promise in inhibiting HIV replication and fighting inflammation. The compound has been identified as a promising lead for potential use as an HIV-fighting drug.
The Scripps Research Institute has been awarded $3.17 million over four years to develop compounds that counteract disruptions of the human biological clock, associated with sleep disorders and bipolar disease. The grant supports research on nuclear receptors, a promising drug target for various diseases.
Researchers at Scripps Research and the University of Pennsylvania have received an $8.2 million grant to develop novel compounds that could become drug candidates for treating tobacco addiction. The project focuses on enhancing nicotinic receptors in the brain to reduce nicotine's positive impact on reward centers.
Researchers identify potential antibody biomarkers for Alzheimer's, Parkinson's and multiple sclerosis using synthetic compounds. Synthetic peptoids capture immunoglobulin antibodies from blood samples with high accuracy.
A Scripps Research chemist devised a new method to quantify changes in proteins resulting from stress, which could provide insights into disease progression and treatment. The technique focuses on cysteine S-hydroxylation, allowing researchers to monitor protein modifications at the individual cysteine site.
Researchers have developed a long-lasting anti-cocaine immunity in mice using a unique vaccine that combines bits of the common cold virus with a particle that mimics cocaine. The approach may offer a simple way to break and reverse cocaine addiction, potentially useful for treating other addictions as well.
Researchers found that the core protein interacts with non-structural helicase protein, playing a critical role in viral replication. This new understanding supports a potential new therapeutic target for hepatitis C drug development and may prevent production of infectious viral particles.
A Scripps Research Institute scientist has discovered a molecular switch controlling protein synthesis in ribosomes, which could lead to potential treatments for cancer and other diseases. The study suggests that regulating this process may help prevent disease states such as Alzheimer's and diabetes.