Researchers shed light on how vertebrates developed closed circulation systems, essential for carrying blood to organs and tissues. A specific domain in tRNA synthetase plays a crucial role in proper embryonic development, influencing key regulator of new blood vessel growth.
Researchers have identified a family of proteins called piezo proteins that detect painful touch. The discovery provides evidence for the mechanotransduction pathway and potential new treatments for diseases related to sensory nerve dysfunction.
Researchers have created a high-resolution virtual image of S1P1 receptors, critical in controlling MS and other diseases. The molecular map points toward promising new drug discovery paths.
Scientists at Scripps Research Institute have identified a single prion protein that causes neuronal death similar to 'mad cow' disease, with toxic effects up to 10 times more potent than larger prion species. The study opens new avenues for exploring neurodegenerative disorders like Alzheimer's and Parkinson's diseases.
Researchers reveal detailed structure and function of UVR8 protein, a key player in plant protection against UV radiation. The molecule's unique light-sensing ability allows it to orchestrate gene activity and switch on protective responses in plants.
Researchers have created a biological computer that uses biomolecules to decipher images encrypted on DNA chips, showcasing the potential for a new type of computing system. The device, based on Alan Turing's design, can process vast amounts of information in parallel, making it faster than traditional electronic computers.
Researchers developed a highly sensitive blood test for detecting and analyzing circulating tumor cells (CTCs) in cancer patients. The 'biopsy in a blood test' provides information comparable to surgical biopsies, enabling better monitoring, prediction, and understanding of cancer progression.
Graham Johnson's entry, a collaboration with colleagues, won first place in the video category for its visualization of complex 3D data sets. The winning tool enables scientists to compare parameters of complicated structures at a glance.
The Scripps Research Institute has proven the plausibility of a new pathway to life's essential sugars called the glyoxylate scenario, potentially pushing past the formose reaction hurdle. This alternative pathway, led by Ramanarayanan Krishnamurthy, reveals efficient conversion of DHF and glyoxylate to ketoses.
Researchers at Scripps Research Institute found that a cell surface protein called CDCP1 protects tumor cells from apoptosis and promotes metastasis. The team identified plasmin as the key enzyme responsible for cleaving CDCP1, which triggers a signaling cascade blocking apoptosis and enabling cancer cells to colonize distant organs.
Scientists from Scripps Research Institute have discovered dimethylsphingosine (DMS), a molecule produced at abnormally high levels in the spinal cords of rats with neuropathic pain, which appears to cause pain when injected. Inhibiting DMS production may be a fruitful target for drug development.
Researchers at Scripps Research have identified a compound that can repair specific defects in RNA, a key step in developing treatments for incurable diseases like Huntington's. The new technology targets toxic RNA defects associated with Spinocerebellar ataxia and Kennedy disease.
Researchers have discovered that proteins and ligands engage in a complex dance-like interaction, influencing the binding modes of ligands and receptor dynamics. This finding has implications for designing future diabetes treatments.
Sathyanaryanan Puthanveettil, a Scripps Research scientist, has been awarded two notable grants to study the critical component of long-term memory formation. He will investigate the role of kinesin in this process using the marine snail Aplysia.
Researchers found that DNA stays too tightly wound in certain brain cells of schizophrenic subjects, pointing to new therapies. The study suggests treatment might be most effective early on for minimizing or reversing symptoms.
Scientists have elevated little-studied cellular mechanism sulfenylation to potential drug target by showing its importance in cell signaling and cancer. A new chemical probe allowed detection of minute differences in sulfenylation rates, revealing a key role for hydrogen peroxide in activating epidermal growth factor receptor.
A Scripps Research Institute study found that an anti-stress peptide can prevent and reverse some cellular effects of acute alcohol and alcohol dependence in animal models. The researchers suggest that drugs derived from this peptide could play a role in treating complex disease.
A Scripps Florida scientist has received a $3.4 million grant to study a new compound that blocks HIV replication by targeting the viral protein Tat. The goal is to evaluate its therapeutic potential in animal models and optimize it for human clinical trials, potentially leading to a novel class of anti-viral drugs.
Scripps Research scientists have identified a key gene that plays a crucial role in maintaining metabolic balance. The study found that the melanocortin-3 receptor (MC3R) expressed outside the brain is equally important as its central nervous system counterpart.
Researchers have identified an antibody that neutralizes Sudan virus, one of the most deadly human pathogens caused by ebolavirus. The new findings suggest a key spot for neutralizing ebolaviruses, which could lead to the development of effective vaccines and antibody-based therapies.
Scientists at Scripps Research Institute have created a new class of small molecules with the potential to serve as a rich foundation for drug discovery. The approach combines synthetic chemistry and advanced screening technologies, overcoming molecular limitations associated with current methods.
A team of scientists from Scripps Research Institute has identified a family of chemical compounds that could lead to the development of novel drugs capable of not only alleviating symptoms but also preventing the deadly disease. The new class of compounds is highly effective against malaria parasites in both the blood and liver stages.
Researchers at Scripps Research Institute have determined the atomic structure of a protein used by the Lassa fever virus to replicate within infected cells. The study reveals an unexpected molecular crevice where the viral protein grips viral genes, making it a target for potential antiviral drugs.
A Scripps Research Institute scientist has been awarded a $1 million grant to study adropin, a peptide hormone that may improve insulin sensitivity and treat type 2 diabetes. The research aims to explore adropin's potential role in glucose homeostasis and its application as a protein-based therapy.
A Scripps Research Institute scientist has successfully produced a simpler relative of Taxol called eudesmane and created a retrosynthesis pyramid to produce target compound. The researchers hope that the innovation will lead to understanding of nature's processes and develop more widely applicable techniques.
A Scripps Research scientist has been awarded a $500,000 grant to study the genetic mutations associated with Parkinson's disease. The researcher will investigate two genes, LRRK2 and SGK1, which have shown a link between their mutations and reduced risk of Parkinson's disease.
Scripps Research scientists identify a new metabolic pathway for controlling brain inflammation, suggesting anti-inflammatory drugs with tissue-specific effects. Blocking enzyme MAGL reduces brain inflammation in mice, providing protection against conditions like Alzheimer's and Parkinson's.
Researchers have discovered a highly effective antibody that can neutralize approximately 70% of globally circulating HIV strains by targeting the virus's envelope protein. The new findings suggest a promising target for AIDS vaccine development, with potential implications for broadening the protection against the fast-mutating virus.
A Scripps Florida scientist has been awarded a $2.2 million grant to explore the role of host cell signaling pathways in HCV-induced liver cancer. The research aims to identify new therapeutic targets for treating chronic HCV infections.
Researchers found almost no DNA structural mutations in induced pluripotent stem cells reprogrammed using a standard four-gene method. The study used advanced chromosomal error-mapping methods and detected only one mutation per line, which likely originated from the reprogramming process.
Native American communities have the highest alcohol-related death rates, but how and why this is prevalent remains unclear. The new five-year MERIT award will investigate early underage drinking's impact on risk for alcoholism and develop culturally relevant treatment programs.
Two Scripps Research scientists, Michael Petrascheck and Brian Paegel, have won the NIH Director's New Innovator Award. Petrascheck will conduct research on aging in C. elegans using $1.5 million in funding, while Paegel will evolve new molecular tools for protein sequencing.
Researchers identified a specific receptor-based mechanism that triggers cytokine storms, leading to severe lung damage and organ failure. The discovery opens new possibilities for treating this condition with targeted therapies.
A Scripps Research team has overcome a major purification problem for stem cells, enabling more reliable and safe treatments. The new method uses lectin arrays to separate stem cells from other cell types, promising significant cost savings and reliability improvements.
Researchers found that high levels of lysophosphatidic acid (LPA) can lead to congenital hydrocephalus in mice by disrupting brain development and causing excess cerebrospinal fluid buildup. Blocking LPA's action prevents the effect, offering a potential new treatment for the condition.
Scripps Research scientists have identified a specific region of the β2-adrenergic receptor where changes in structure lead to altered signaling function. The study's findings could lead to the development of highly selective therapeutic drugs targeting this receptor.
Researchers at Scripps Research Institute have successfully produced stem cells from two endangered species, a drill and the northern white rhinoceros. These cells could enable lifesaving medical therapies or offer the potential to preserve or expand genetic diversity by offering new reproduction possibilities.
Researchers have discovered a new class of anti-diabetic compounds that target a unique molecular switch, potentially offering fewer side effects than existing drugs. The new compound, SR1664, blocks Cdk5's action on PPARG and shows improved blood sugar levels without weight gain or fluid retention.
Researchers at Scripps Research Institute discovered that fetal brain damage from oxygen deprivation is linked to the action of a fatty molecule called LPA, which can be targeted with drugs. This finding provides a new strategy to limit or prevent serious developmental brain diseases.
Researchers find that a specific white blood cell type, neutrophils, promote tumor growth and spread by inducing new blood vessel formation. This discovery opens the door to developing novel drugs targeting early-stage cancers.
Researchers at Scripps Research Institute have identified chemical compounds that prevent the abnormal aggregation of the TTR protein, holding it together in its functional form. The compounds have the potential to help hundreds of thousands of people affected by TTR-related amyloid diseases or at risk for them.
Researchers at Scripps Research Institute successfully designed a new antibiotic that can target and kill the most resistant bacterial infections. The compound, an analogue of vancomycin, overcomes the resistance mechanism by altering the key atom in the peptidoglycan structure.
Researchers have defined a specific protein complex that allows cells to remove damaged mitochondria via autophagy, a process crucial for maintaining cellular integrity. This discovery highlights the interaction between Hsp90-Cdc37 and Ulk1, which is essential for efficient mitochondrial clearance.
Researchers pinpointed a novel mechanism involving β-arrestin-1, β2-adrenoreceptors, and catecholamines in chronic stress-induced DNA damage, which can lead to various disorders including cancer, aging, and neuropsychiatric conditions.
Researchers have devised a new technique that simplifies the improvement of drugs and other products by adding a CF3 molecule. This method reduces the need for high-heat equipment and metal catalysts, making it safer and more accessible to chemists.
Scientists from Scripps Research Institute have defined the structure of one of the cell's most basic engines required for cell growth. The study reveals a series of redundant mechanisms that assure production of critical cellular building blocks while avoiding missteps, which could lead to disease.
A Scripps Research scientist has identified the critical role of a night blindness gene in facilitating rapid signal transmission in the eye's initial response to light. This discovery sheds light on the molecular mechanisms underlying low-light vision, highlighting the importance of nyctalopin in coordinating the assembly and precise ...
Researchers at Scripps Research Institute develop a highly successful vaccine against heroin high, producing antibodies that stop the effects of heroin and its metabolites. The vaccine shows promise for those trying to break their heroin addiction, with only three out of seven rats self-administering heroin after booster shots.
Kristopher Nazor, a Scripps Research Institute scientist, has been awarded a pre-doctoral fellowship from Autism Speaks Foundation to investigate the genetic form of autism known as Fragile X Syndrome. He will use pluripotent stem cell technology to understand how neural development is affected in this disorder.
Researchers at Scripps Research and Crucell have discovered an antibody that can neutralize a range of human-affecting flu viruses in lab-dish tests and in mice, including H3 and H7 subtypes. The new antibody has the potential to protect people against most influenza viruses, and could lead to a universal flu vaccine.