Researchers at Scripps Research Institute have identified a mechanism controlling tumor aggressiveness and developed a simple treatment that inhibits cancer progression. In mice, the treatment prolongs life when tested with drugs already used for other conditions.
A new compound developed by scientists at Scripps Research Institute protects heart cells from damage caused by heart attacks. The compound inhibits a specific enzyme, reducing tissue death by up to 34% and mitochondrial dysfunction.
Researchers have discovered that TRF2 suppresses DNA damage response by blocking signaling pathways, preventing chromosomes from sticking together. This finding has implications for understanding cancer and the aging process, as telomere shortening can lead to chromosomal instability.
Researchers have identified plasmacytoid dendritic cells (pDCs) as a key producer of type I interferons in lupus, which can be targeted to prevent autoimmunity. Blocking this pathway may offer a potent weapon against the disease.
A new study by Scripps Research Institute scientists confirms a critical role for microRNA-182 in the development of emotional memory in the amygdala. MicroRNA-182 was found to promote local protein synthesis and support synapse-specificity of memories.
A new study from the Scripps Research Institute found that a complex set of overlapping neuronal circuits in fruit flies drives temperature preferences. The research used imaging techniques to visualize neuron activity and showed that dopaminergic neurons process multiple inputs to generate outputs, influencing behavior.
Scientists will use high-throughput screening to identify novel inhibitors of ASK1, a promising therapeutic target for diseases like rheumatoid arthritis. The grant aims to develop new treatments using compounds from the Scripps compound collection.
Researchers at TSRI have determined the structure of Ltn1, a 'quality-control' protein that ensures protein-making machinery works smoothly. The study suggests Ltn1 may be relevant to human neurodegenerative diseases such as ALS.
Researchers found blocking JNK interaction with Sab can protect against neuronal damage, suggesting a potential new target for drug development. The study also showed that inhibiting JNK signaling leaves other cell signaling intact, which could mean fewer side effects in future therapies.
Researchers at Scripps Research Institute have devised an inexpensive and sensitive method to mark and select cells. The technique utilizes the tight binding of two proteins that are cheaply obtainable but not found in human or other mammalian cells, enabling efficient cell sorting with minimal unwanted side effects.
Researchers solved the structure of α-catenin, a protein crucial for cell binding and tissue formation. The discovery reveals how α-catenin interacts with the cytoskeleton and cadherins to stabilize adhesion complexes.
Researchers achieved a feat in synthetic chemistry by inventing a method to synthesize polyhydroxylated steroids, used in heart-failure medications and other drugs. The new strategy enables rapid modifications of hydroxylated steroids, which could help pharmaceutical chemists tweak natural toxins like ouabain.
Researchers at The Scripps Research Institute have solved the high-resolution structure of halofuginone, a compound derived from Chang Shan, shedding light on its biological process. This discovery could lead to the development of new drugs targeting aminoacylation, a crucial step in protein synthesis.
Researchers at Scripps Florida have developed a new method to alter RNA function in living cells by designing molecules that recognize and disable disease-associated RNAs. This approach has the potential to treat genetic disorders such as myotonic dystrophy, which can cause muscle wasting and other symptoms.
Scientists from Scripps Research Institute have developed a synthetic compound that reverses the effects of fatty liver disease by suppressing lipid production in the liver. The compound, SR9238, also significantly lowered total cholesterol levels and reduced markers for liver damage.
Researchers at Scripps Research Institute discover TMHS protein, a key component of mechanotransduction channels in the ear. The finding suggests a promising new approach to gene therapy for certain types of deafness, as it restores sound perception in newborn deaf mice.
Researchers will use Drosophila melanogaster to define how the brain organizes different types of memories among its neurons and understand Pavlovian conditioning.
The William R. Kenan, Jr. Charitable Trust has awarded Scripps Florida a $1 million grant to expand its education outreach programs in Palm Beach County.
Researchers at Scripps Research Institute determine the structure of two proteins that form specialized subunits within cells, crucial for maintaining cell health. This discovery has implications for developing new cancer therapies by inhibiting autophagosome formation.
A set of chemical tools simplifies the creation of potential new drug compounds, enabling previously time- and cost-prohibitive chemical modifications. The toolkit works in a variety of conditions, including water and biological media.
Researchers identified a group of microRNAs that work together to suppress the spread of cancer by repressing epithelial-to-mesenchymal transition. This discovery offers potential therapeutic targets and diagnostic tools for predicting and inhibiting cancer metastasis.
Researchers at Scripps Research Institute discover a novel cell signaling process that improves immune cell function, potentially leading to new treatments for cancer and infectious diseases. The study identifies a key regulator of immune function and suggests the development of drugs that enhance Natural Killer cell activity.
Researchers at Scripps Research Institute describe the structure and function of influenza's ribonucleoprotein (RNP) complex, which is essential for viral replication. The study provides new insights into the flu virus's vulnerabilities, including a shape-change during gene transcription and key interactions between proteins.
A Scripps Research Institute team has identified a key factor controlling damage to brain cells in a mouse model of Parkinson's disease. The discovery, led by scientist Bruno Conti, points to the IL-13 receptor as a potential target for new treatment options.
Researchers show tRNA synthetases, essential in protein production, can also regulate transcription through a single chemical alteration, with implications for immune response and cancer. This transformation may lead to new treatments for allergies and cancer.
Researchers at The Scripps Research Institute identify a new pathway regulated by HDAC4 that plays a major role in information processing. This discovery offers insight into how imbalances in this pathway contribute to cognitive abnormalities in humans.
A breakthrough in drug development has led to the creation of a vaccine against methamphetamine, which could potentially treat meth addiction. The vaccine, called MH6, was tested on rats and found to be highly effective at blocking the typical effects of meth intoxication.
Researchers at Scripps Research Institute have discovered new selective inhibitors of diacylglycerol lipases (DAGL), enzymes involved in making 2-AG, a key cannabinoid. Early tests suggest these compounds may also reduce pro-inflammatory molecules linked to rheumatoid arthritis, potentially leading to new therapeutic approaches.
A recent genomics study reveals that comparing diseased patients' genomes with those of people from similar ancestries can dramatically simplify searches for harmful mutations, potentially leading to more effective treatments. The study's tool, the Scripps Genome Adviser, uses a reference panel of less than 20 genomes to identify ances...
Scientists at Scripps Research Institute found that drastically reducing VEGF activity in the retina can cause severe vision loss. Deleting the VEGF gene from adult mice revealed its crucial function in maintaining retinal health. Further studies are necessary to determine the effects of anti-VEGF drugs on patients.
Researchers will use x-ray crystallography and NMR to understand the structural rules governing nuclear receptors' activity. The goal is to fill gaps in knowledge about these proteins' role in metabolism, cancer, inflammation, and bone health.
Researchers at Scripps Research Institute have discovered a genetic sequence that can alter its host gene's activity in response to cellular energy levels, a finding that could have broad implications for biology and medicine. The energy-sensing switch, known as a riboswitch, detects the molecule ATP and controls global metabolic regul...
A study found that rats who had intermittent access to alcohol exhibited cognitive impairment similar to established alcoholism after just a few months. The researchers linked this impairment to the activation of a small group of neurons that inhibit executive control functions in the prefrontal cortex.
A scientist from Scripps Research Institute has received a grant to develop new chemical reactions for the laboratory preparation of rare natural products, including anticancer and antifungal agents. The project aims to establish a firm scientific foundation for driving medicinal pursuits with improved efficiency.
Researchers have identified genetic variations in genes associated with bipolar disorder I and II, providing new insights into the complex biochemical pathway involved. The study found associations between variants in PDE10A, DISC1, and GNAS genes and an increased risk of developing the mental illness.
Researchers at Scripps Research Institute have developed a screening method to identify RNA targets and potential drug compounds. The new technology probes millions of RNA-ligand combinations, enabling the definition of RNA motifs and small molecules that bind to RNA.
A team of scientists at Scripps Research Institute has been awarded $2.1 million to study compounds that may improve the quality of life for ALS patients by inhibiting the JNK enzyme. The study aims to develop a neuroprotective drug to prevent motor neuron death and lengthen patients' lifespan.
A team led by biologists at The Scripps Research Institute has solved the long-standing mystery of how mice know to nurse. The trigger turns out to be a signature mix of unique odors that the offspring learn.
Researchers at Scripps Research Institute have developed a new technology that can identify potential biomarkers for ulcerative colitis in animal models. The study focuses on protein arginine deiminases (PAD) and their role in diseases such as cancer, multiple sclerosis, and rheumatoid arthritis.
Scientists at Scripps Research Institute developed a new technique to synthesize complex terpenes, a crucial step towards cheaper and fully synthetic cancer drugs like Taxol. The breakthrough mimics a natural biochemical phenomenon that allows cells to make these compounds, overcoming significant challenges in organic chemistry.
The Scripps Research Institute has received a $20 million grant to research HIV drug resistance and develop new anti-HIV treatments. The HIVE Center will investigate the structure and function of HIV, including how it responds to drugs used in AIDS therapy.
Researchers will investigate sulfenylation, a process that can lead to cellular stress and damage, to find new treatments for lung and breast cancers. The study aims to modify the process with potential drug compounds to diagnose and monitor diseases.
Researchers at Scripps Research Institute and Sea Lane Biotechnologies discovered an unusual antibody, C05, that can neutralize various flu viruses by targeting the receptor binding site. The unique antibody uses only a single loop to grab this site, making it potentially useful for developing universal flu vaccines and therapies.
Researchers at Scripps Research Institute found a connection between the ghrelin peptide and brain cells involved in alcoholism. The study suggests that blocking ghrelin's activity could help dampen or turn off cravings in alcoholics, offering new possibilities for treating addiction.
Scientists at Scripps Research Institute have determined the structure of a critical protein from the Marburg virus, which blocks the human immune system. The breakthrough provides a major step forward in understanding how the deadly virus works and may be useful in developing potential treatments for those infected.
Scripps Research scientists have devised a powerful new technique to discover and expand the power of large numbers of antibodies, immune system proteins that detect and destroy invaders. The method rapidly identifies antibodies with useful biological activity, enabling the creation of unusual antibodies with desired effects.
A massive online metabolite database, METLIN, has been developed to provide comprehensive biochemical information about cellular metabolism. The database includes over 60,000 compounds with detailed tandem mass spectrometry information on more than 10,000 metabolites.
Researchers have designed a compound that shows promise as a potential therapy for fragile X syndrome, a genetic condition causing mental retardation, infertility, and memory impairment. The molecule improves RNA splicing process and minimizes repeat-associated defects in cells.
A team led by Richard Ulevitch has received a five-year project renewal from the National Institutes of Health to investigate the workings of the immune system. The grant aims to improve human diseases such as viral and bacterial infections, and inherited immune disorders.
Researchers discovered a key interaction between skin cells and gamma delta T cells, revealing a molecular trigger for wound healing. The CD100 receptor plays a crucial role in signaling the activation of these immune cells, which then stimulate new epithelial cell production to repair damaged tissues.