A study published in American Journal of Roentgenology found that routine screening mammography benefits women between 40-49 years by detecting smaller tumors and high-risk lesions at earlier stages. This practice can lead to improved survival rates and reduced need for chemotherapy or extensive surgery.
Researchers at University Hospitals Cleveland Medical Center found cochlear implantation provides robust and long-term hearing restoration for patients with advanced otosclerosis. The study used newer surgical techniques to minimize complications, demonstrating an effective treatment option for this challenging group of patients.
Researchers have identified protein biomarkers that can help determine which GBM patients may benefit from standard treatment, enabling personalized medicine. A 'systems' approach also found networks of genes that characterize short-term survivors from long-term GBM survivors.
A new non-invasive technology, stool DNA (sDNA) testing, is being studied in a five-year clinical trial to detect colon cancer in its earliest stages. The test aims to improve colon cancer screening rates and decrease mortality from the deadly disease by complementing colonoscopy.
A new international multi-site randomized study found that a catheter procedure to close a hole in patients' hearts was not more effective than medical therapy in preventing recurrent strokes. The study, led by Anthony Furlan, M.D., of University Hospitals Case Medical Center, enrolled 909 patients and showed no statistically significa...
Researchers found gene mutations in DNMT3A and NPM1, as well as translocations, associated with improved patient outcomes when treated with higher doses of daunorubicin chemotherapy. This discovery could help physicians tailor treatment plans for individual patients.
The Elisabeth Severance Prentiss Foundation has donated $5 million to the University Hospitals Eye Institute to support various programs, including the Center for Retina and Macular Disease. The gift will help launch a new phase of expansion and enhancement of facilities and equipment across the UH system.
Researchers at UH Case Medical Center have discovered a novel treatment approach for cutaneous T-Cell lymphoma, which is a chronic and progressive disease affecting the skin. The new study finds that adding O6-benzylguanine to carmustine enhances topical chemotherapy efficacy, reducing toxicity and improving treatment outcomes.
Researchers from UH Seidman Cancer Center presented groundbreaking research on autophagy and its potential as a novel therapeutic target for lymphoma and other lymphoid neoplasia. The study showed that targeting autophagy may enhance glucocorticoids' effectiveness in killing cancer cells, offering new hope for cancer treatment.
Researchers found adult stem cells from bone marrow have potential to improve heart function after a heart attack. However, the original two-week timeframe was not favorable, but the concept still shows promise for recovering lost or damaged heart tissue.
Researchers are investigating a novel gene therapy approach using LG631 to improve tolerance and effectiveness of chemotherapy for glioblastoma, a devastating brain cancer. The study aims to prevent damage to bone marrow, enabling patients to receive higher doses with fewer side effects.
Researchers at UH Rainbow Babies & Children's Hospital are conducting two studies to investigate the role of vitamin D in preventing heart disease and inflammation in HIV-positive individuals. The studies will explore the effects of vitamin D deficiency on immune system function, bone density, and cardiovascular health.
University Hospitals neurosurgeons champion brain bypass in select patients with complex brain aneurysms or cerebrovascular disorders. The procedure can reduce stroke risk and improve symptoms in young patients with moyamoya syndrome.
A pivotal Phase 3 clinical trial found that ivacaftor provides sustained improvement in lung function, growth, and other signs and symptoms for cystic fibrosis patients. The therapy targets the underlying cause of CF, restoring balance on airway surfaces.
Studies highlight obstacles to increasing breastfeeding rates among low-income mothers, including lack of support and knowledge. Community health workers emphasize the need for additional education and resources to promote breastfeeding.
Advanced PET scans can identify aggressive tumors and predict patient prognosis, potentially intensifying treatment for patients with locally advanced lung cancer. The study found a strong correlation between radiation dose intensity and local control of the cancer.
The FDA has approved a diaphragm pacing system to help ALS patients breathe longer without the aid of a ventilator. The system, called NeuRx Diaphragm Pacing System, provides electrical stimulation to the diaphragm muscles and conditions them to delay respiratory failure.
The Division of Pain Medicine at University Hospitals Cleveland Medical Center received a 2011 Medical & Academic Partnerships Fellowship Award from Pfizer Inc. The Epilepsy Center also received an award for its nationally competitive research. The fellowships support patient-oriented research to improve healthcare outcomes.
A large clinical trial found that intensive medical treatment reduced strokes and deaths by 50% compared to brain stenting in high-risk patients. The study, SAMMPRIS, showed that aggressive management of risk factors and lifestyle changes can significantly impact stroke prevention.
The Ohio Third Frontier Commission has awarded $2.5 million to advance two significant imaging research projects at the Philips Healthcare Global Advanced Imaging Innovation Center, a collaboration among University Hospitals Case Medical Center and Case Western Reserve University.
Researchers at Cleveland institutions collaborate on a ground-breaking study testing the feasibility and safety of using mesenchymal stem cells to treat multiple sclerosis. The Phase 1 trial aims to decrease disease activity and promote repair in patients with MS.
A new urine-based test has been found to be more accurate than traditional prostate cancer screening methods, detecting the disease in 100% of cases while minimizing false positives. The PSA/SIA assay works by analyzing changes in PSA protein structure associated with cancer.
A Phase 1 clinical trial is underway to test the safety and efficacy of TMC207, an experimental anti-tuberculosis drug with activity against both susceptible and resistant TB. The study will be led by Dr. Robert Salata and involves 32 healthy participants.
The hospital is participating in two new studies: one examining new treatments for wheezing in young children with colds and another investigating whether Vitamin D can help adolescents and adults control their asthma. The goal of these trials is to find better treatments for this common and often poorly managed condition.
A study of extremely low-birth-weight (ELBW) children found that chronic health conditions and asthma rates remained stable between ages 8-14. However, the obesity rate increased among ELBW children, mirroring the current obesity epidemic.
A new meta-analysis study found that three-lead cardiac pacemakers implanted in those with heart failure fail to help up to 40 percent of patients. Patients with less severe electrical disturbance in their hearts did not receive any benefit from these devices.
Researchers found that the HSPPC-96 vaccine for recurrent glioblastoma (GBM) extended median survival to 11 months, compared to the current three to five month survival rate. The vaccine showed a favorable safety profile and evoked a significant innate immune response in patients.
A new study published in the New England Journal of Medicine found that treating girls with Turner syndrome with low doses of estrogen and growth hormone significantly increased their adult height. The treatment also showed modest synergy between growth hormone and low-dose estrogen in promoting growth.
A novel clinical trial is exploring a new method to potentially prevent recurrence of early stage, aggressive breast cancer. The study is recruiting patients with HER-2 neu+ breast cancer and aims to identify high-risk patients who may benefit from an additional cancer-targeting drug.
Researchers are conducting a pilot study to test image-guided neurothermal ablation, a new procedure using local radiofrequency energy to treat premature ejaculation. The treatment aims to provide an outpatient option for symptom control with limited side effects.
The University Hospitals system has implemented a successful approach to stroke care, increasing the use of tPA therapy for ischemic stroke patients by 13.5 times. The System Stroke Program (SSP) educated community hospital staff and ensured timely treatment, resulting in better patient outcomes.
A significant study found that inadequate sleep is associated with an almost 50% increase in the risk of colorectal adenomas compared to those sleeping at least seven hours per night. The researchers suggest that effective intervention to improve sleep duration and quality could be a new avenue for preventing colon cancer.
A study published in Plastic and Reconstructive Surgery found that nearly 90% of patients experienced at least partial relief from migraine headaches after five years. The surgery targets 'trigger sites' in the muscles or nerves producing pain, with significant improvements in quality of life.
African American women have lower incidence rates yet poorer survival rates for ovarian cancer compared to women of other races. The study aims to determine how risk factors differ between African American and white women, with the goal of preventing this deadly disease.
Researchers are exploring the potential link between vitamin D intake and a protein that may help prevent Barrett's esophagus from turning into cancer. Patients with Barrett's esophagus will take vitamin D weekly for four months to measure its effects on esophageal cancer risk.
A new study finds that self-hypnosis taught with videotape training significantly reduced tic control in children and adolescents with Tourette Syndrome. After just a few sessions, almost all participants experienced a dramatic increase in tic control.
A study published in The Lancet found that intensive blood glucose control showed microvascular benefits, such as reduced albuminuria and cataract extractions, but no significant reduction in cardiovascular disease. Intensive therapy was also associated with increased weight gain and high risk of severe low blood sugar.
Cardiologists at University Hospitals Case Medical Center have discovered a significant association between angiotensin-receptor blockers (ARBs) and an increased risk of new cancers. The meta-analysis found that patients taking ARBs had a 8-11% higher risk of developing new cancer compared to those taking control medications.
Researchers from University Hospitals Case Medical Center will present new clinical research findings on biomarker-driven treatment in stage II colon cancer and the utility of the Vulnerable Elders Survey for predicting sixth-month functional decline among older patients with newly diagnosed breast cancer. Additionally, a study found t...
Triapine regimen provides significant reduction in cancer disease and cancer control, shows great promise for patients at high risk of relapse and death. The study's complete response rate was observed and no disease progression documented through 18 months of median follow-up.
Researchers are conducting a Phase 2 clinical trial to evaluate the safety and effectiveness of CERE-110, a viral-based gene transfer system delivering nerve growth factor to slow Alzheimer's disease progression. The study aims to delay AD symptoms and progression in patients with mild to moderate Alzheimer's.
Researchers at University Hospitals Case Medical Center report promising results from a study treating glioblastoma multiforme with Gamma Knife radiosurgery, increasing patient survival rates by almost four months compared to traditional radiotherapy alone.
Researchers followed 79 patients with migraine headaches for five years after surgery, finding promising outcomes for treating trigger sites. The study found that 88% of remaining patients maintained initial positive response to surgery, with 29% experiencing complete elimination of migraines.
Researchers at University Hospitals Case Medical Center found that African Americans with non-small cell lung cancer have a lower frequency of drug-sensitizing genetic mutations, which may impact response to EGFR inhibitor drugs. The study highlights the need for personalized treatment approaches based on ethnicity and genetic variation.
The University Hospitals Case Medical Center has been awarded the 2009 Quality Leadership Award from the University HealthSystem Consortium, recognizing its excellence in delivering high-quality care. The award is given to teaching hospitals that demonstrate exceptional performance using six domains of care.
The GAP study investigates the safety and effectiveness of IGIV in patients with mild to moderate AD, aiming to slow disease progression. Initial research suggests that IGIV may neutralize toxic forms of beta amyloid, promoting its elimination.
A new study identifies a group of individuals born with genetic mutations that increase their risk of developing colon cancer. The study found that these mutations affect the glycosylation process, leading to alterations in mucus production and tumor development.
Researchers at Case Western Reserve University and University Hospitals Cleveland Medical Center found that two simple clinical measurements failed to identify TB patients who could benefit from a shorter treatment course. The study involved over 1,000 TB patients in Africa, Brazil, and Asia, but ultimately showed that these measures w...