The Harrington Discovery Institute has awarded over $700,000 to 10 US scientists for their innovative medical research. These scholars will support the commercialization of their work and have access to expertise and oversight in all aspects of drug development.
The Harrington Discovery Institute has announced three new scholars in collaboration with FFB and ADDF, selected through a competitive review process for their research on therapies for retinal degenerative diseases and Alzheimer's disease. The institute provides financial support and drug development assistance to accelerate these pro...
A new study from University Hospitals Connor Integrative Health Network reveals that improvisational music therapy can effectively manage acute pain and improve mood in adult patients with sickle cell disease. Music therapy, when actively engaged with a therapist, has a stronger impact on pain management than passive listening to music.
African American preterm infants experienced a significant decrease in recurrent wheezing with sustained vitamin D supplementation, according to a new study published in JAMA. The daily dose of vitamin D through six months of age decreased recurrent wheezing by more than 10%.
Dr. Helen Hobbs has made a groundbreaking discovery linking a gene mutation (PCSK9) to lower levels of LDL, or 'bad cholesterol', improving treatment of high cholesterol. Her research led to the development of an FDA-approved therapy within 10 years.
A recent study published at the American College of Cardiology meeting found a significant link between Inflammatory Bowel Disease (IBD) and an increased risk of heart attacks. The research revealed that IBD is associated with higher odds of having a heart attack, especially in younger patients.
The Harrington Discovery Institute awards support groundbreaking research in cancer, diabetes, osteoporosis, and addiction. Physician-scientists receive financial backing and critical resources to advance their work from the clinical realm.
Glioblastoma (GBM) is driven by two distinct subsets of cancer stem cells, each with its own transcriptional program and morphological characteristics. Targeting these cell populations using combined BMI1 and EZH2 inhibition achieves modest efficacy in solo treatments but synergistic results when used together.
Researchers call for consistent, robust standards for developing meta-analyses due to the dramatic increase in published studies. The American Heart Association recommends improving quality through technical guidelines and emphasizing the need for statistical expertise and clear justifications.
A high-dose influenza vaccine significantly reduced the risk of respiratory and all-cause hospitalization among Medicare residents at nursing homes, with a 12.7% relative reduction in respiratory illness hospitalizations and an 8.5% reduction in all-cause hospitalizations.
The DAWN trial shows that mechanical thrombectomy with medical therapy improves functional independence and decreases post-stroke disability in selected patients. Patients treated with the retrieval system had a 35% better outcome at 90 days compared to those who received medication alone.
Daniel J. Drucker, Joel F. Habener, and Jens J. Holst were awarded the Harrington Prize in Medicine for their discovery of incretin hormones and translation into treatments for major metabolic diseases like diabetes. Their work has resulted in breakthrough therapies such as GLP-2 for intestinal disorders.
Two renowned medical researchers, Sanford Markowitz and Mukesh K. Jain, receive $6.7 million awards from the National Institutes of Health (NIH) to advance studies on colon cancer and age-related cardiovascular risks.
The Harrington Discovery Institute has announced grant funding for 11 physician-scientists from premiere universities. The recipients will receive up to $700,000 in capital to support the transition of their work into the private sector.
The Harrington Discovery Institute has selected three 2016 partnership scholars to support groundbreaking research in Alzheimer's disease and blindness. The scholars will receive funding and expert pharmaceutical guidance to advance their discoveries into new medicines.
A researcher at UH Seidman Cancer Center is presenting a phase II clinical trial testing the effectiveness of combining chemotherapy with an immunotherapeutic agent, pembrolizumab, for patients with metastatic triple-negative breast cancer. The trial aims to improve survival rates and reduce disease recurrence.
Researchers from UH Seidman Cancer Center and Case Comprehensive Cancer Center present new findings on treating multiple myeloma, lymphoma, and other hematologic disorders. The studies show significant therapeutic benefits for patients who participate in phase I trials.
Researchers from UH Rainbow presented data on improving clinical outcomes for pediatric hematologic disorders, including findings on acquired aplastic anemia treatment algorithms and red blood cell transfusions in critically ill children. The studies aimed to improve long-term outcomes and transplant options for these rare diseases.
A new study characterizes pediatric injuries onboard commercial airline flights, finding that lap infants are at greater risk for injury due to scalding burns from hot beverages or soups. Falls from the seat also contribute to in-flight injuries among this age group.
A study published in Neurosurgical Focus reports the use of a minimally invasive laser procedure to treat large, 'inoperable' brain tumors, including glioblastomas. The procedure combines laser interstitial thermotherapy with a small craniotomy to remove cooked tumors and prevent swelling.
Researchers discovered 15 gene mutations that contribute to more aggressive colon cancer in African-Americans, resulting in higher recurrence and metastasis rates. These findings explain the disparity in colorectal cancer rates and death rates between African-Americans and other groups.
A new study found that young children with mild, persistent asthma can tolerate acetaminophen without worsening their symptoms. The study, funded by the National Heart, Lung, and Blood Institute, compared acetaminophen to ibuprofen in 300 children aged 1-5 years old.
Researchers at University Hospitals Seidman Cancer Center have identified a rare gene variant associated with familial Barrett esophagus (FBE) and esophageal cancer. The study found that this mutation disrupts normal esophageal lining maturation, increasing disease risk.
Researchers at University Hospitals Case Medical Center are conducting a clinical trial using Philips fMRI Scanner to detect brain activation in patients with early and middle stages of Alzheimer's. The study aims to develop faster and more precise real-time methods for fMRI experimentation, which may help improve diagnosis accuracy.
Researchers from UH Seidman Cancer Center will present data on a new online tool for estimating individualized survival probabilities in patients with newly diagnosed glioblastoma. The studies also explore promising new treatments, including pembrolizumab for head and neck squamous cell carcinoma, and improve patient participation in c...
Researchers are exploring whether deep brain stimulation (DBS) can provide relief for patients with bipolar disorder who do not respond to medications. The study aims to identify structural targets in the brain that may be involved in the disorder and potentially treat it through DBS.
Jeffrey M. Friedman was honored for his discovery of leptin and the neural pathway that regulates feeding behavior, providing a foundation for understanding obesity and related pathologies. The award recognizes his translational research that has impacted our understanding of human biology and disease treatment.
A Phase 2 study found that patients treated with MultiStem therapy experienced a complete or near full recovery from their stroke after one year, with 23.1% achieving this outcome compared to 8.2% of placebo patients. The therapy appears to reduce local inflammatory response and protect neurons in the brain.
A new study from University Hospitals Case Medical Center found that making colonoscopy available at no cost to eligible Medicare beneficiaries did not increase the number of people who regularly undergo the procedure. In contrast, routine mammography screenings significantly increased following the Affordable Care Act's mandate for lo...
Researchers at Case Western Reserve University School of Medicine received NIH grants to study Parkinson's disease, investigating gliptins for effective treatment. They also explored regenerating stem cells to heal the brain after a stroke and targeting brain tumor stem cells to develop new therapy strategies.
A new mobile biochip device, the HemeChip, can rapidly screen for sickle cell disease with just a few drops of blood, providing an easy-to-use and cost-effective tool for equitable diagnosis. This technology has the potential to make a huge difference in developing nations worldwide by enabling early treatment.
The study found that intensive management of high blood pressure, below the commonly recommended target, significantly reduces rates of cardiovascular disease and lowers risk of death. The results also showed a 38% reduction in heart failure and a 43% reduction in death from heart-related events.
A study analyzed 15,613 pediatric ED visits due to legal interventions between 2008 and 2010. Most injuries resulted from blows or manhandling, affecting mostly males and teenagers. The issue comes with significant financial costs, including $16.3 million in total ED charges.
A new study found that high-dose flu shots significantly reduced hospitalizations among older nursing home residents during the influenza season. The study showed a 1.2% difference in admission rates between those who received high-dose vaccine and standard dose vaccine, resulting in thousands fewer hospitalizations.
Postmenopausal women with vulvar and vaginal atrophy often suffer from dyspareunia despite recognizing its physical, emotional, and psychological consequences. Women are not educated about treatment options or the underlying clinical cause of VVA.
Active surveillance can reduce overtreatment by almost 50 percent at 15 years, according to a new review article. The approach involves monitoring and testing patients with regular intervals, rather than immediate treatment. The authors found that this strategy can balance the risk of overdiagnosis and overtreatment in prostate cancer.
A new NIH-funded study launched at UH Seidman Cancer Center aims to investigate the effects of physical activity on functional status, body composition, and biomarkers associated with breast cancer prognosis in older breast cancer survivors. The five-year clinical trial will focus on African American and low socioeconomic status women.
The Harrington Discovery Institute has selected scholars to collaborate with R&D partners, including University of Oxford, Alzheimer's Drug Discovery Foundation and Foundation Fighting Blindness. The program aims to bridge the 'Valley of Death' gap in bringing new medications from lab to market.
A new study published in the Journal of Clinical Oncology found that music therapy significantly lowered anxiety levels for patients undergoing surgical breast biopsies. The study involved 207 patients who received either live or recorded music before surgery, with results showing a 43% reduction in anxiety compared to usual care.
A new study published in Journal of Immunotherapy demonstrates that T cells derived from lymph nodes can be expanded and activated to attack melanoma. This innovative approach, called adoptive immunotherapy, is being tested in a human clinical trial at UH Seidman Cancer Center.
A new classification system has been developed to improve the diagnosis and treatment of low- and intermediate-grade gliomas (LGGs), reducing the reliance on subjective tumor appearance. The system uses molecular and genetic analysis to identify three distinct groups of LGGs with varying prognoses, offering a more objective approach.
University Hospitals Case Medical Center researchers will present data from several new studies evaluating a potential novel combination treatment for cancer patients with advanced solid tumors. Additionally, experts will analyze gene mutations in small cell lung cancer, revealing significant clinical correlation to overall survival an...
Researchers at University Hospitals Cleveland Medical Center found a new non-invasive stool DNA testing method comparable to colonoscopy for detecting large polyps in African Americans. The study suggests this technology may improve colon cancer screening rates and decrease mortality.
Randomized clinical trials demonstrate endovascular therapy is highly beneficial in treating acute ischemic strokes. The new studies, published simultaneously in NEJM, attribute the improved results to superior surgical technology and improved neuroimaging criteria.
A study by University Hospitals Cleveland Medical Center found that laparoscopic colectomy procedures resulted in $6,689 lower costs compared to open surgery, with patients experiencing fewer days of health care utilization. The study also showed a significant difference in healthcare expenditures and patient workdays after the procedure.
A recent study from UH Case Medical Center examines the effects of social media on mental health care and treatment. Doctors and patients often blur the lines of their relationships, with social media research helping to prevent injury in some cases.
A survey shows that postmenopausal women with VVA report improved satisfaction with VagiCap, a vaginal estrogen treatment. The study found that 63% of women on TX-004HR VagiCap reported an improved quality of life after just two weeks of therapy.
Douglas R. Lowy, MD, has been awarded the 2015 Harrington Prize for Innovation in Medicine for his key discoveries leading to the development of the human papillomavirus (HPV) vaccine. The vaccine has been shown to offer close to 100% protection against HPV-caused cancers.
A novel biochip has been developed to evaluate red blood cell properties in sickle cell patients, providing a potential tool for monitoring and managing the disease. The research aims to identify and predict flare-ups, allowing for earlier treatment and prevention of complications.
A study published in International Scholarly Research Notices (ISRN) Stroke found that overall knowledge about stroke in Uganda is poor. Researchers surveyed 1,600 residents and discovered three-quarters were unaware of stroke risk factors and warning signs, or recognized the brain as the affected organ.