A large international clinical study found that patients with large strokes had significantly better recovery after endovascular thrombectomy plus medical management. The SELECT2 study showed almost 20% of patients who received thrombectomy regained functional independence, compared to 7% on medical treatment only.
A new study found that massage therapy significantly reduces pain, stress, and anxiety in children, adolescents, and young adults with cancer or sickle cell disease. The study published in Pediatric Blood & Cancer reports clinically significant benefits from massage therapy, highlighting its potential as a non-pharmacologic treatment o...
Researchers demonstrate a model for developing probiotic therapies to modulate the microbiome by targeting intestinal biofilms and identifying beneficial microbial strains. The study showed positive effects in reducing GI symptoms and improving overall well-being in healthy individuals.
A new study by University Hospitals Seidman Cancer Center demonstrates that social determinants of health, not just race, significantly influence prostate cancer outcomes. The research, published in JAMA Network Open, found that accounting for social determinants reduced racial disparities in mortality rates.
A new study found that music therapy resulted in clinically significant reductions in pain and anxiety for patients with cancer and sickle cell disease. Patients with SCD who received music therapy also reported significantly higher pain and anxiety at baseline compared to those without SCD.
A recent study found that adults who receive chiropractic spinal manipulation for low back pain are less likely to undergo discectomy over two years. The study, published in BMJ Open, used real-world data and controlled for variables such as age and smoking.
Researchers at University Hospitals and Case Western Reserve University have discovered a small-molecule oral drug that reduces PCSK9 levels and lowers cholesterol by 70% in animal models. This breakthrough could also improve the efficacy of cancer immunotherapies.
A new study published in Journal of the American College of Cardiology found that drug-coated balloons outperformed bare metal stents in treating femoropopliteal lesions. The research showed improved 12-month patency and freedom from clinically driven reintervention and major adverse events with drug-coated balloons.
Cleveland researchers reveal a new strategy to prevent blood clots by targeting overactive neutrophils, reducing clotting risk while minimizing bleeding risk. The findings may be especially impactful for cancer patients who experience blood clot complications.
A new study identifies nitric oxide as a key molecule in the β2-adrenergic receptor feedback loop, mediating airway relaxation. The research team discovered that preventing nitric oxide's feedback mechanism leads to a powerful airway relaxant. Mice with a specific mutation in the β2 AR gene are resistant to bronchoconstriction and asthma.
Researchers from University Hospitals developed a transfusion appropriateness algorithm to analyze blood transfusions for adult patients. The algorithm led to a decrease in transfusions and an increase in appropriate use, resulting in cost savings of $2.5 million over 12 months.
A new study reveals that areas once 'redlined' in the 1930s continue to suffer from higher rates of cardiometabolic health risk factors, including obesity, diabetes, and high blood pressure. Neighborhoods with lower grades on historical redlining maps had better access to healthcare and lower rates of disease.
A drug targeting IDH1 mutations in select cancers also inhibits wild-type form under certain conditions, making it a promising therapeutic option. Laboratory experiments and mouse models demonstrate the efficacy of Ivosidenib against various cancer types, including pancreatic, colorectal, ovarian, and lung cancer.
Research suggests that PSA screening can prevent a significant number of prostate cancer deaths, with lower numbers than previously estimated. The study's findings support the benefits of PSA screening, especially for young healthy men and Black men, who have historically been underrepresented in clinical trials.
Researchers at University Hospitals and Case Western Reserve University have discovered a new receptor, Ptprd, that controls appetite and body weight. The receptor trap drug suppresses appetite, body weight, and blood glucose levels in obese mice.
A new study published in Mayo Clinic Proceedings found a significant link between socioeconomic deprivation and premature cardiovascular mortality in the US. Counties with high social deprivation had the highest rates of premature cardiovascular deaths, highlighting the need for targeted interventions to address health disparities.
Remote monitoring of patients with continuous pulse oximetry and heart rate devices was associated with reduced death rates. This technology advance improved patient safety, lowered mortality, and increased accuracy in care.
A new study found that music therapy sessions improved patients' ability to manage chronic pain and enhance their quality of life. The intervention, which included music-based breathing exercises and progressive muscle relaxation, was feasible, acceptable, and beneficial among adults with Sickle Cell Disease.
A team led by Reshmi Parameswaran at University Hospitals Seidman Cancer Center has developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers, which triples the targeted antigens on cancer cells. The new BAFF CART product is effective in killing multiple B-cell cancers with minimal side effects.
A meta-analysis published in The Lancet Oncology reveals that men with intermediate- and high-risk prostate cancer experience improved overall survival with the addition of hormone therapy to radiotherapy. The study found prolonged adjuvant hormone therapy benefits men, while neoadjuvant hormone therapy did not.
Pollution has been linked to nine million deaths worldwide in 2019, with five million due to cardiovascular disease. The researchers emphasize the need for individual physicians to consider pollution as a risk factor when treating patients, and advocate for government-supported interventions to reduce exposure.
Defects in surgical care cost the American health care system over $12 billion annually. A holistic approach through Centers of Excellence can address these defects, increasing quality, patient experience, and reducing costs.
Researchers from University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine found that combining long-term injectable medications with psychosocial intervention improves adherence and symptoms in patients with bipolar disorder. The study enrolled 30 people with bipolar disorder who had adherenc...
A recent study suggests that the gut microbiome plays a significant role in mental health, with disruptions in beneficial microorganisms linked to depressive disorders. The researchers propose a multifaceted approach to manage depression through rebalancing and maintaining the gut microbiome using diet, probiotics, and lifestyle changes.
The SPRINT study found that lowering systolic blood pressure to less than 120 mm Hg significantly reduces the risk of heart attack, stroke, and death from cardiovascular disease. The study also showed a 25% decrease in all-cause mortality.
A new study found a substantial decrease in minimally invasive surgery use for cervical cancer after the publication of a major study in 2018. The study assessed 2,437 patients and showed that surgeons changed their methods, but still saw room for improvement at non-academic medical centers.
A new study reveals a potential mechanism linking traumatic brain injury (TBI) and Alzheimer's disease (AD), as well as a method for preventing nerve cell degeneration after injury. Researchers discovered a blood biomarker of neurodegeneration that could stage severity and progression of TBI-induced nerve cell deterioration.
Dr. Jaeger's designation recognizes her high degree of experience with GreenLight Laser Therapy, providing effective relief from BPH symptoms like frequent urination and weak urine flow. The procedure is a minimally invasive outpatient solution with no incisions or impact on sexual function.
Researchers at UH Rainbow Babies & Children's Hospital studied the impact of face masks on heart rate and oxygen levels. The study found that wearing a cloth or surgical mask did not impair oxygenation in healthy adults, either at rest or during physical activity.
Skeletal muscle plays a key role in regulating body glucose levels and affects fat storage and metabolism. A new study found that Kruppel-like factor 15 (KLF15) is crucial for skeletal muscle fat uptake and utilization, leading to obesity and metabolic disease.
Researchers found that intensive blood pressure lowering is effective in reducing cardiovascular risk, especially in patients exposed to high levels of fine particulate matter. The study suggests that ambient air pollution may influence the benefit of intensive BP lowering.
Researchers developed GeoMEDD, a near-real-time spatial assessment of COVID-19 cases to help hospitals and health departments respond to clusters of outbreaks. The methodology enhances traditional mapping by analyzing data streams from various sources to identify emergent patterns.
Researchers estimate sub-optimal behaviors cost the US healthcare system over $1.3 trillion annually, with a focus on eliminating 'defects' in value. The study proposes a framework to reduce costs and improve care value proposition through targeted interventions.
A new paper calls for psychiatrists to adopt skills and a mindset shift to help eliminate defects in healthcare organizations. The authors propose that psychiatrists become 'systems engineers' to identify and address systemic issues contributing to suboptimal care.
The study aims to enroll non-pregnant adults older than 18 and will investigate the safety, immune response, and efficacy of the vaccine. UH Cleveland Medical Center is part of the NIAID-supported COVID-19 Prevention Network (CoVPN) and has extensive knowledge in vaccine research.
Researchers will investigate acupuncture's effectiveness in managing pain in emergency departments across the US, with a goal of reducing opioid prescriptions. The three-year study involves 150 participants and aims to provide evidence for non-pharmacologic pain management methods.
Researchers have discovered a neuroprotective treatment that can reverse cognitive impairment caused by chronic traumatic brain injury. The brief pharmacologic treatment, known as P7C3-A20, restored normal cognitive function in mice and stopped chronic neurodegeneration.
A new US study found that socioeconomic factors are linked to heart failure mortality rates in the United States. The study analyzed over 1.2 million deaths from heart failure across 3,048 counties between 1999 and 2018, revealing significant disparities in mortality rates based on measures of wealth and social deprivation.
Researchers found that air pollution contributed to a pre-diabetic state similar to eating an unhealthy diet, with effects reversible upon cessation. Living in densely polluted environments may be added as a risk factor for cardiometabolic diseases.
A new study published in JAMA found that Fast Breast MRI detected significantly more breast cancers than digital breast tomosynthesis (3-D mammography) in average-risk women with dense breast tissue. The study showed that Fast Breast MRI was almost two and a half times more effective at detecting breast cancers in these women.
University Hospitals has received a $1 million grant from the Ohio Opioid Technology Challenge to further develop its opioid pill tracking technology. The platform, UH Care Continues, helped keep over 12,000 prescription opioid pills out of circulation in just six months by leveraging algorithms to prompt clinicians to evaluate patient...
Physician-scientist leaders propose a plan to revive the number of physicians conducting research, highlighting the importance of innovation in medicine due to an aging population and increasing communicable diseases. A nonprofit foundation is established to support the development of new physician-scientists.
Researchers found that montelukast can disrupt inflammatory signaling in diabetic retinopathy, reducing small blood vessel and nerve damage. The study offers an early approach to treat type 1 diabetes and suggests a potential new treatment for the disease.
Researchers identified a group of people who appeared to have naturally mounted an immune response to TB despite being exposed for over 10 years. The study found that nearly 200 people from 2500 households tested negative on repeated standard TB tests, suggesting either insufficient test sensitivity or a natural defense.
The Phase 1 clinical trial shows median survival of GBM patients was 3.5-fold the expected survival based on published modeling studies, with very few side effects among patients. The gene therapy uses O-benzylguanine and temozolomide with repair enzyme MGMT.
Researchers found that pre-treatment with caffeine prevented PGE1-induced respiratory complications and inflammation in baby rats. Caffeine, commonly used to treat apnea of prematurity, may offer similar benefits for infants with congenital heart disease.
Researchers discovered seven genetic variants linked to type 2 diabetes in young people, with one variant novel to youth. The study used data from a large pediatric cohort and found that obesity-related variants contribute to the risk of developing Type 2 diabetes in younger individuals.
The medical staff of the Neonatal Intensive Care Unit (NICU) at University Hospitals Rainbow Babies & Children's Hospital implemented a model for improvement to decrease hypothermia in very low birth weight (VLBW) babies. As a result, they achieved a 97.5% reduction in temperature less than 36 degrees over four years.
Dr. Carl June receives the 2019 Harrington Prize for his contributions to CAR T therapy, a revolutionary cancer treatment. The prize honors his development of new strategies and culture systems that have enabled CAR T clinical trials.
The University of Oxford and Harrington Discovery Institute have established a global center for rare diseases, combining capabilities to deliver new treatments. The centre aims to address unmet need in rare disease research and will leverage resources to support cutting-edge breakthroughs.