Researchers have found that commonly used algorithms for identifying patients with recurrent cancer are flawed and often mislead researchers. These algorithms rely on billing codes or secondary tumors to identify patients, but this approach can be inaccurate, as it may not distinguish between new cancers and recurrences.
Researchers have discovered a way to manipulate the hepatitis C RNA to block its hijacking of cell machinery, potentially leading to new treatments.
Researchers found that microRNA-26a suppresses melanoma cell growth while leaving healthy cells unharmed. Reintroducing microRNA-26a to melanoma cell lines led to a marked decrease in cancer cell survival, suggesting it as a potential therapeutic target for melanoma treatment.
A study by the University of Colorado Anschutz Medical Campus suggests that a healthy lifestyle during menopause, including diet and exercise, can lower breast cancer risk. In obese postmenopausal women, excess calories fuel tumor growth, but in lean counterparts, they are stored in healthy tissues.
A new five-year grant will support research on the benefits of pre-pregnancy maternal nutrition for baby health. The project aims to compare daily supplements given at three months or 12 weeks gestation, as well as a control group with home visits and education.
Researchers discovered purines, specifically adenosine, can generate outside cells to protect organs from anesthesia-induced damage. Activating adenosine receptors in critical organs like lungs and heart also provides protection.
Researchers found that microRNA-218 is low in medulloblastoma patients and its addition stops disease occurrence. The microRNA also affects genes involved in tumor growth and migration, offering potential targets for therapy.
Recent advancements in lung cancer treatment focus on targeting specific genetic mutations, resulting in improved patient response rates (70-80%) compared to traditional chemotherapies. However, challenges remain in securing funding for clinical trials and staying ahead of the disease's rapid mutation rate.
A University of Colorado Cancer Center review suggests rice bran offers anti-cancer properties due to its synergistic bioactive compounds. The clinical trial tests rice bran's effectiveness in preventing colon cancer recurrence, with researchers exploring the optimal composition and daily intake for chemoprevention.
The growing US population and increased life expectancy necessitate new approaches to prostate cancer treatment. Researchers are exploring targeted therapies, immunotherapy, and precision radiation targeting to improve treatment outcomes for older patients.
Researchers have found that targeting resistant lung cancer 'pockets' with focused radiation can prolong disease control in patients who initially respond to crizotinib or erlotinib. This approach showed significant benefits in patients whose cancers progressed in the brain, where the drugs are less effective.
Reintroducing miR-200c to aggressive triple-negative breast cancer cells restores sensitivity to anoikis, causing the cells to self-destruct. This approach shows promise as a less toxic alternative to chemotherapy.
Researchers found a direct relationship between neighborhood income and racial composition and the probability of receiving bystander-initiated CPR. The study suggests that targeted, low-cost CPR training efforts are needed to address disparities in life-saving interventions.
A new study by University of Colorado Denver reveals that today's adolescents are abusing prescription pain medications at a rate 40 percent higher than previous generations. The prevalence of prescription pain medication abuse among the current generation of youth is higher than any generation ever measured, driven by factors such as ...
Researchers discover cancerous mRNA's poly(A) tails can evade the body's safeguards, allowing it to escape regulatory mechanisms. This discovery opens up a new avenue for understanding how genes are activated or inactivated without mutations.
A 2-year-old hominin child's skull fragment unearthed in Tanzania shows signs of anemia-induced porotic hyperostosis due to a diet lacking in meat. The discovery suggests that meat consumption became essential for proper functioning, leading to brain development and evolution.
The CU Cancer Center is conducting a Phase I clinical trial of OMP-54F28, a drug that targets cancer stem cells and the Wnt signaling pathway. The trial aims to assess the safety and efficacy of the agent in patients with advanced solid tumor cancers.
Researchers found that DNp63a employs epigenetics to silence anti-proliferative genes, keeping cancer cells alive independently of p53. This discovery opens up new possibilities for targeting the protein's partner enzymes to break its cancer-causing mechanism.
A University of Colorado study shows that bladder cancer patients with high CD24 expression have worse prognoses and may benefit from anti-androgen therapies. CD24 expression depends on androgens, and blocking these hormones may diminish the proliferative and metastatic power of bladder cancer cells.
A low-cost sun protection intervention, including mailed kits with resources and educational activities, led to higher frequency of sun-protective behaviors among children. The study found significant gains in sun-protective behavior and awareness across all measures.
Research reveals that tumor hypoxia drives aggressive behavior and poorer prognosis in various cancers. CD24 overexpression is linked to tumor growth and metastasis, making it a potential therapeutic target.
A University of Colorado Cancer Center study found that parents' concern about skin cancer does not affect their children's outdoor play time or obesity rates. The research suggests that children can get plenty of physical activity and prevent skin cancer by using sun protection measures.
Researchers explored the effectiveness of resveratrol in preventing head and neck cancer in Fanconi anemia patients, a rare genetic disorder affecting DNA repair. The study found that resveratrol may eliminate cancer cells in these patients by making them sensitive to certain drugs.
A study published in the Journal of Thoracic Oncology found that patients with low thymidylate synthase (TS) levels and high fibroblast growth factor stimulator (FPGS) levels respond better to pemetrexed treatment. This combination predicts longer survival durations.
A recent University of Colorado Cancer Center case study found a patient with ALK+ lung cancer who tested negative for the EML4-ALK fusion gene using the FDA-approved FISH assay, yet showed dramatic response to crizotinib. Next-gen sequencing revealed genetic shards that may have avoided detection by the test.
Researchers have identified melanoma stem cells marked by the enzyme ALDH, which exhibit high tumorigenicity and resistance to chemotherapy. Targeting these cells with a new therapy could boost the effectiveness of existing drugs.
Pediatric cancer patients who underwent total body irradiation (TBI) before age 3 are at risk of developing endocrine, metabolic, and other complications. The study found that 90% showed abnormally low levels of growth hormone and 71% were under height.
The human brain's unique cognitive capacity is attributed to a specific protein domain, DUF1220, which has more copies in humans than other species. The protein's dosage is linked to brain size, with higher numbers associated with macrocephaly and lower numbers with microcephaly.
A phase III clinical trial shows Enzalutamide extends life by five months, with significant survival benefits and reduced side effects compared to traditional chemotherapy. The study also reveals improved measures including PSA blood levels and progression-free survival.
A systematic approach to improve screening rates for colorectal cancer resulted in a fourfold increase in screening among low-risk individuals. The protocol, which included introductory phone calls and mailed testing kits, saw CRC screening rates jump from 47 to 72 percent in three years.
Researchers uncover chromosomal translocations that cause cancer, potentially leading to targeted therapies and personalized treatment. The study's findings may enable doctors to offer more accurate prognoses and inform treatment decisions.
A study published in Oncogene found that progestins regulate miRNA-29, a molecule that helps breast cancer cells revert to a stem-like state marked by proteins CD44 and CK5. This phenomenon makes breast cancers more resistant to treatments targeting hormone dependence.
A recent study by University of Colorado researchers found that 73.8% of adolescents in substance abuse treatment used medical marijuana recommended to someone else. Regular use of medical marijuana began at a younger age among these patients, and they had more severe symptoms of marijuana abuse and conduct disorder.
New human-derived breast cancer models retain heterogeneity, allowing researchers to test drugs more accurately. These models can help identify unique features in individual tumors, enabling targeted treatment.
A University of Colorado study found that roofers who work with hot asphalt have higher levels of DNA damage and potentially higher cancer risk due to polycyclic aromatic hydrocarbon (PAH) exposure. The study suggests that PAH absorption through skin plays a role in this increased risk.
Chronic obstructive pulmonary disease (COPD) increases lung cancer risk through a novel mechanism involving long-term oxygen depletion and HIF-2a tumor growth signaling. COPD-induced signals may be susceptible to prevention or treatment with VEGFR-2 and EGFR inhibitors.
A meta-analysis of 10 studies found that cognitive behavioral therapy and pharmacologic interventions decrease depressive symptoms in cancer patients. The study also identified effective interventions for different stages of cancer and cultural subpopulations.
Researchers suggest using multicellular tumor spheroid (MCTS) models to improve cancer drug discovery, as they more accurately mimic human tumors. MCTS models can help identify specific genetic mutations targeted by drugs and interact with the surrounding environment.
Researchers have discovered a drug that boosts memory function in individuals with Down syndrome, improving verbal episodic memory and showing significant improvement in cognitive abilities. The study suggests potential implications for slowing down or halting the development of Alzheimer's disease in adults with Down syndrome.
A study published in Leukemia & Lymphoma reveals that IDH mutations drive the production of 2-hydroxyglutarate, leading to abnormal gene regulation and increased risk of relapse. Researchers believe targeting IDH mutations may hold promise for treating AML.
A study published in Journal of Biological Chemistry found that prostate cancer cells lacking the protein SPDEF are unable to establish colonies at possible sites of metastasis, highlighting a potential biomarker for untreated cancers. Researchers hope to regulate SPDEF expression to prevent cancer cell metastasis.
A study by University of Colorado School of Medicine researchers found that foster children who receive mentoring and skills training have improved placement outcomes, with 44% fewer changes in care and 82% lower risk of residential treatment. They are also twice as likely to reunify with their biological families.
Researchers argue that a new focus on controlling energy balance and preventing weight gain is needed to combat the growing epidemic of obesity. By matching food intake to a higher level of physical activity, individuals can achieve 'energy balance' and maintain a healthy body weight.
Researchers argue that changing tissue landscape promotes higher cancer rates in the elderly, rather than accumulating oncogenic mutations. Healthy cells in young bodies outcompete cells with cancerous mutations when conditions change.
Researchers have discovered that high levels of protein EYA3 are associated with a poor response to chemotherapy in Ewing's sarcoma patients. Lowering EYA3 levels may help increase the effectiveness of existing therapies and improve outcomes.
Researchers discovered that combining EGFR inhibitors with Wnt pathway inhibition can improve the durability of lung cancer remission. The Wnt pathway allows lung cancer cells to escape from EGFR-targeted therapy, but disrupting this pathway could lengthen the usefulness of existing treatments.
A recent study published in Gynecologic Oncology reveals that widely available cell lines are often misidentified or contaminated, leading to faulty cancer science. Researchers suggest verifying cell lines as a prerequisite for publishing, and the team is working to build a database to help identify mismatched cell lines.
Postmenopausal women who have had a hysterectomy may experience stiffer arteries, increasing the risk of cardiovascular disease. Hormonal changes and decreased estrogen levels after menopause may contribute to this effect.
Researchers found that normalizing blood glucose levels in pre-diabetes patients can significantly reduce the risk of developing Type 2 diabetes. A study published in The Lancet revealed a 56% reduction in progression to diabetes among participants who achieved normal glucose regulation, regardless of its duration.
Researchers have identified androgen receptors as a key target for treating breast cancer, leading to the development of enzalutamide as a potential new therapy. The study suggests that blocking these receptors can inhibit cancer growth, offering new hope for patients with hormone-dependent breast cancers.