Researchers identified microRNA-22 as a key player in Ewing's Sarcoma, regulating KDM3A gene expression. Targeting KDM3A with small-molecule inhibitors may provide new therapeutic options for the disease.
A phase II clinical trial of Avastin (Bevacizumab) with cisplatin and pelvic radiation for locally advanced cervical cancer showed promising results. The study found improved overall survival rates of 89.8% at 2 years and 80.2% at 3 years compared to historical controls.
A new study, funded by the NIH, will investigate whether reducing uric acid levels can slow down kidney function decline in people with type 1 diabetes. The research aims to find an additional safe and inexpensive way to prevent or delay kidney failure.
A new study suggests that autophagy plays a key role in determining the fate of cancer cells when treated with anti-cancer drugs. Cells with high levels of autophagy were more susceptible to death from certain drugs, while those with low levels of autophagy were more resistant.
A recent study published in the Journal of General Internal Medicine found that Medicaid beneficiaries are more likely to seek emergency care due to access issues rather than the severity of their illness. The study suggests that policy makers should focus on increasing timely access to primary care, especially for Medicaid beneficiaries.
A study published in Stem Cells reveals that bladder cancer originates from distinct stem cells for muscle-invasive and non-muscle invasive types. Genetic profiling identified specific gene signatures associated with each cell population, which predicted tumor stage and patient survival.
A University of Colorado Cancer Center study found that ALK and ROS1 gene rearrangements, known to drive subsets of lung cancer, are also present in some colorectal cancers. This implies that drugs used to target ALK and ROS1 in lung cancer may have applications in treating a subset of colorectal cancer patients.
A new disease related to NKH has been discovered through genetic research led by University of Colorado professor Johan Van Hove. The variant, also known as non-ketotic hyperglycinaemia, shares similar symptoms with NKH and was found in eight patients from around the world.
A new study reveals that high school athletes playing at higher elevations suffer fewer concussions than those closer to sea-level. The researchers analyzed concussion statistics from athletes playing multiple sports in 497 high schools and found a significant decrease in concussion rates among all sports played above 600 feet.
A recent study has identified MUC5B as a key protein involved in various lung-related ailments, including MRSA infections and cystic fibrosis. The protein helps control certain infections by coating airway surfaces in the nose and lungs.
Meniere's disease affects 3-5 million people in the US, causing dizziness, ringing, and hearing loss. Researchers suggest a new theory linking the disorder to low blood flow in the brain and inner ear, offering a potential treatment avenue by addressing vascular risk factors.
A University of Colorado Cancer Center study validates the CARING criteria, a prognostic tool determining risk of death within a year of hospital admission. The tool uses five criteria: cancer diagnosis, chronic illness admissions, nursing home residency, ICU admission with multi-organ failure, and hospice guidelines.
A partial skeleton of Paranthropus boisei, a human ancestor characterized by its 'robust' jaw and skull bones, has been found in Tanzania. The find suggests that the species was more ruggedly built than previously thought and had strong forearms and powerful upper body.
Researchers at the University of Colorado have synthesized the most active component of grape seed extract, B2G2, which induces apoptosis in prostate cancer cells while leaving healthy cells unharmed. The findings suggest that B2G2 is a promising lead compound for future clinical trials and preclinical studies.
Researchers found that Neanderthals divided their shelters into different areas for various activities, including a hunting stand, base camp, and residential area. This discovery highlights the sophistication of Neanderthal spatial organization, challenging previous assumptions about their behavior and cognitive abilities.
The Burmese python genome study found large numbers of rapidly evolved genes linked to extreme characteristics such as rapid increases in metabolism and organ growth after feeding. The researchers discovered that snakes have undergone incredible changes at all levels of their biology, including physiological and molecular changes.
A University of Colorado Cancer Center study found that crizotinib treatment reduces kidney function in ALK positive non-small cell lung cancer patients. Kidney function recovered after treatment, but additional tests are recommended if concerns arise.
A new study from the University of Colorado Denver estimates that wind turbines killed over 600,000 bats in 2012, a significant blow to pollination and insect control. The study found that areas near the Appalachian Mountains had the highest bat fatality rates, with some species experiencing fatalities of up to 40%.
A study found that top dermatology journals have strong social media followings, but lesser-known journals lag behind professional organizations and patient advocacy groups in disseminating information. The study suggests that leveraging social media can be an effective way for journals to educate the public.
A study published in Physics in Medicine and Biology found that endorectal balloon placement errors can reduce radiation dose coverage, leading to uneven targeting of cancerous areas. Image guidance is crucial to ensure accurate prostate positioning.
Two studies surveyed parents and adolescents at school-based health centers (SBHCs) and found highly positive views, with 83% trusting the providers to take good care of their children. SBHCs serve as the main source of medical care for many students, offering vaccinations, check-ups, and mental health counseling.
Researchers found that tumors may switch dependence from VEGF-A to related growth factors like VEGF-C, VEGF-D, and placental growth factor when targeted by bevacizumab. This change allows colorectal cancer to continue growing despite the blockage of VEGF-A.
A study led by a CU School of Medicine researcher has confirmed the Gene Expression Classifier (GEC) test can accurately identify benign thyroid nodules, significantly reducing the need for unnecessary surgeries. The test was found to have a very high negative predictive value, with only one nodule out of 71 identified as cancerous.
Researchers found that metformin works differently in high- versus low-glucose conditions. High glucose levels reduce metformin's effectiveness, making it necessary to use a higher dose or explore glucose control measures.
The University of Colorado Anschutz Medical Campus received a $48.4 million grant to expand clinical and translational research, increase workforce capacity, and promote community engagement. The grant will support the development of new infrastructure, informatics capabilities, and innovative research strategies.
A recent study published in the journal Obesity found that home-schooled children were less likely to be obese and had lower calorie intakes than traditionally schooled kids. The study's lead author noted that differences may reflect the unique environment of home-school families, but further research is needed.
Researchers at CU University of Colorado discovered that maximum heart rate drops with age because the sinoatrial node's natural pacemaker cells beat more slowly in older individuals. This decrease limits athletic performance and is a leading cause for nursing home admissions among otherwise healthy seniors.
A new study explores why low-income parents, particularly those from minority groups, may not be getting the human papillomavirus (HPV) vaccine. English-speaking parents expressed concerns about the vaccine's need and safety, while Spanish-speaking parents feared the vaccine would encourage sexual activity due to lack of provider expla...
A study by CU researchers has identified a soy derivative as the likely cause of liver damage in patients receiving intravenous nutrition. The finding may lead to better treatments for patients with intestinal problems or pancreatitis who rely on intravenous feeding.
A $5.9 million Department of Defense grant enables the development of drugs that target androgen receptors as a driver of breast cancer. The treatment shows promising results in preclinical work and may offer new options for patients with previously limited therapy.
A CU Cancer Center study found that young patients with metastatic colorectal cancer have a higher risk of treatment failure and worse survival rates compared to middle-aged patients. The study analyzed data from over 20,000 patients and showed a significant increase in disease progression and death among those under 40.
A study published in JAMA Dermatology found over 200 mobile apps related to dermatology, but most are free with no guarantees of accuracy. Doctors advise users to use common sense and cross-reference apps with other sources before relying on them.
A recent study published in Nature Communications suggests that the body's production of fructose from non-fructose containing carbohydrates may be a key factor in obesity and insulin resistance. Researchers found that mice converted glucose to fructose in the liver, leading to the development of fatty liver and insulin resistance.
A University of Colorado Cancer Center study found that current ALK-positive lung cancer criteria may miss patients who could benefit from crizotinib. The researchers suggest that doctors should re-evaluate borderline or atypical cases, potentially expanding treatment eligibility.
Researchers identify a rare genetic disorder, cblX, linked to Vitamin B12 metabolism, which can cause severe health problems. The discovery was made possible by studying a Colorado boy named Max Watson and his family, who participated in the study.
A study found wait times for colorectal cancer operations at VA hospitals rose to 32 days, but researchers believe longer waits may be due to improved care and outcomes. The study suggests that more careful care is worth the wait, even if it means delayed treatment.
Research found that teens with anorexia nervosa had larger insula and orbitofrontal cortex brain areas, which may contribute to their ability to starve themselves. These brain regions process taste and body perception, potentially leading to a distorted sense of hunger and fullness.
A recent study found that children with amplified chromosome 21 are at higher risk of treatment failure, but not worse outcomes, than those without the genetic abnormality. Recognizing this amplification could lead to improved cure rates in low-risk patients treated aggressively.
A new study reveals that young female cancer survivors experience significant impairment in quality of life due to fertility concerns. The study found that women's perception of their own fertility status was the most influential factor in determining overall quality of life.
A targeted cancer drug has shown dramatic responses in patients with specific gene mutations, raising questions about the need for expensive Phase III trials. The author argues that a lower bar for approval could streamline the process and bring effective treatments to patients sooner.
A recent study found that in K9 osteosarcoma samples, NOTCH signaling was elevated overall but aspects of Notch signaling were noticeably deactivated in the worst cancers. The researchers also discovered that HES1 protein expression was lower in aggressive tumors, contradicting previous expectations.
Researchers have discovered that cancer cells can fuse with blood cells, enabling them to travel through the body and seed new tumors. This breakthrough has major implications for treating metastatic cancers.
A University of Colorado study shows that luteolin, a common autism supplement, blocks progesterone's action but promotes estrogen-stimulated breast cancer growth. The findings highlight the need for caution when consuming flavonoid supplements, as their effects on the endocrine system are not yet fully understood.
A study found that angiography and percutaneous coronary interventions were lower among Medicare Advantage beneficiaries compared to those covered by Medicare fee-for-service. There was also significant geographic variation in procedure rates between payment types.
Researchers found that introducing solid foods before 4 months increases Type 1 diabetes risk, while breast-feeding reduces it. The study suggests parents wait until after 4 months and introduce solid foods by 6 months or soon after with breastfeeding to lower the risk.
A cancer doctor turned to immunotherapy after his Great Dane's lung cancer diagnosis. The treatment, using an engineered vaccine, significantly prolonged the dog's life and has sparked interest in testing on human brain cancer patients.
Researchers discovered that low-molecular-weight PAHs, such as 1-MeA, can promote cancer growth by disrupting cell communication and upregulating inflammatory genes. These findings suggest that even less toxic PAHs can contribute to cancer development when exposed to secondhand smoke.
A protein complex called Mediator, specifically enzyme CDK8, plays a crucial role in tumor cell survival under hypoxic conditions. Inhibiting CDK8 could provide a potential target for cancer-fighting drugs, particularly those targeting HIF1A transcription factor.
A recent study revealed a new mutation in atypical chronic neutrophilic leukemia (CNL) patients, allowing doctors to prescribe targeted treatment ruxolitinib. The treatment brought significant improvements to the patient's health, including reduced white blood cell counts and normalized other blood counts.
Researchers have discovered a new oncogene, NTRK1, that drives a subset of lung cancers. A novel targeted treatment approach has been proposed, with preclinical studies showing effective silencing of mutated NTRK1 genes using specific compounds.