A study found that almost all pediatricians encounter requests to spread out vaccines, with increasing numbers agreeing to do so despite risks. Most physicians feel tension between building trust and prioritizing child safety.
Pediatric cancer patients who receive antibiotics within 60 minutes of reporting fever and neutropenia have decreased intensive care consultation rates and lower mortality. The study shows that timely antibiotic delivery can lead to significant reductions in hospitalization and fatalities among pediatric cancer patients.
A new study published in Molecular Cancer Therapeutics shows that a low percentage of androgen-receptor-positive cells in triple-negative breast cancer cells can benefit from anti-androgen therapies. This finding may lead to a larger pool of patients eligible for targeted cancer therapy.
A new study found that a centralized notification system improved immunization rates by reaching 87% of eligible children and increasing documentation rates. The system was more cost-effective than practice-based approaches, with substantial cost savings expected from a societal perspective.
Researchers found the varicella zoster virus in 74% of biopsies with giant cell arteritis but only 8% of normal skin biopsies. The study suggests a new treatment approach for giant cell arteritis, combining steroids with antiviral medication.
Researchers have identified over 30 genes with a strong impact on Immunoglobulin E, allergies, and asthma. These genes offer potential novel drug targets for treating these conditions, which affect 30% of the population.
Researchers at CU School of Medicine have identified Muc5ac, a protein involved in airway hyperreactivity, as a potential target for reducing obstruction in asthma. The study found that genetic removal of Muc5ac eliminated airway hyperreactivity, offering new hope for treating this chronic respiratory disease.
Research found a link between altered gut bacteria and liver disease in adolescents with cystic fibrosis. The study suggests that targeting the gut microbiome may help prevent advanced liver disease.
A study found that TERT mRNA levels are highly predictive of aggressive bladder cancers, allowing doctors to recommend targeted treatments and improve patient outcomes. The study also suggests that telomerase reactivation is crucial for the progression of bladder cancers, highlighting a potential target for disease intervention.
Researchers at the University of Colorado School of Medicine have discovered an RNA structure-based signal that bridges evolutionary divergence between bacteria and eukaryotes, enabling protein synthesis. This finding challenges long-held assumptions about the molecular signals initiating protein synthesis in these distinct life forms.
A study found that young adult survivors (18-39) report higher distress levels than older survivors, despite similar time since treatment completion. Fear of cancer recurrence and financial burden were key predictors of elevated distress in these young adults.
A University of Colorado study finds alterations in expression of PIK3R3 and PTEN genes in young-adult Ewing Sarcoma, commonly observed in adult tumors. These findings could lead to adapted therapeutic strategies for adult cancers to treat Ewing Sarcoma.
Health economics calculations for targeted anti-cancer therapies are often based on assumptions that can change when re-examined. Adjusting these assumptions can significantly alter the cost-effectiveness ratio, making treatments seem more or less viable.
A study published in PLOS ONE found that exposure to certain chemicals used in cosmetics, plastics, and household cleaners can trigger early menopause in women. Women exposed to these chemicals were up to six times more likely to be menopausal than non-exposed women, with a potential increase in infertility and health risks.
The CUDC-101 clinical trial, conducted at the University of Colorado Cancer Center, demonstrated activity against key drivers of head and neck cancer. In the study, patients with medium- to high-risk head and neck cancer showed significant results after treatment with CUDC-101 combined with radiation and chemotherapy.
A new study from the University of Colorado Denver Business School suggests that greater transparency is needed to help investors evaluate the quality of audits performed by multiple firms. The research found that when investors learn about audits being done by other firms, they react negatively and stock prices fall.
A CU Denver study reveals that cities investing in compact street networks and multi-modal infrastructure are better equipped to withstand sudden changes in gas prices. The research found that 69.4% of households would struggle to afford commuting costs if gas prices tripled, highlighting the need for expanded transportation choices.
A CU Denver study reveals that experiencing racial discrimination during pregnancy can significantly impact a woman's physical health and pass these effects on to her infant. The research found an association between maternal ethnic discrimination and increased levels of stress hormones in pregnant women and their infants.
A study published in British Medical Journal: Tobacco Control found that 11 top universities allow tobacco sales on 'campus cash' debit cards, which are often prepaid by parents. The research highlights the risk of students buying cigarettes with their parents' money, raising concerns about campus health policies.
Psoriasis affects 3.2% of the US population, with annual costs ranging from $51.7 billion to $135 billion, including direct healthcare costs, absenteeism, and intangible effects on mental health.
A University of Colorado Cancer Center study reveals that reprogramming damaged stem cells can prevent cancer after full-body radiation. The research suggests that genetic inhibition of the C/EBPA gene allows healthy stem cells to dominate the blood cell production system, reducing the risk of leukemia.
A recent article describes clinical trials targeting TRK fusions in various cancer types, including lung, breast, and melanoma. The TRK family of genes can cause cancer when improperly fused with other nearby genes.
Research reveals that blocking androgen receptors can reduce the growth of estrogen-positive breast cancers and kill triple-negative breast cancer cells. Combining these drugs with HER2 or mTOR-targeting therapies shows promise for increased effectiveness in treating breast cancer.
A University of Colorado Cancer Center study reveals that triple-negative breast cancer cells process tryptophan to promote survival while detached, allowing them to metastasize. The kynurenine pathway, specifically the enzyme TDO2, plays a key role in degrading tryptophan and evading anoikis.
Researchers have discovered a combination of two drugs that target both the MAPK and PI3K signaling pathways, resulting in more effective killing of colorectal cancer cells. The dual approach overcomes the limitations of individual drug treatments, showing promise for treating laboratory models of colorectal cancer.
The investigational drug AG-120 has demonstrated 'extremely promising' early phase 1 clinical trial results for patients with acute myeloid leukemia (AML) harboring IDH1 mutations. This finding builds on previous phase 1 results of a related drug, AG-221, and offers hope for the treatment of this high-risk population.
A University of Colorado Cancer Center study found that TAK-733, a next-gen melanoma drug, exhibited anti-cancer activity in 10 out of 11 patient tumor samples grown in mice. The drug showed significant shrinkage in tumors up to 100%, regardless of BRAF mutation status.
The study reveals IL-37's role in regulating the adaptive immune system by inhibiting antigen recognition. This allows for potential manipulation of IL-37 levels to sensitize or desensitize the immune system in various diseases.
A recent study published in Psycho-Oncology highlights the need for well-designed trials to determine the effectiveness of phone counseling interventions for cancer survivors. The research found that while some studies showed significant improvement, the results were not robust across multiple end points or studies.
A CU Denver study reveals that upgrading bridges, roads and infrastructure can help mitigate flood damage. The researchers suggest using scour control methods and improving construction materials to increase resilience against future flooding.
A University of Colorado Cancer Center study found that vitamin D upregulates GDF-15, a gene suppressing inflammation in prostate tissue. This suggests vitamin D could be used to target NFkB, promoting tumor suppression.
The study found that measles death rates were 197 times greater in developing countries than in developed countries, while syphilis death rates were 33-45 times higher. Ebola mortality rates were also significantly higher in developing countries, with 4,447 deaths compared to just two in developed nations.
A team of researchers from around the world will collaborate on a clinical research project focused on eosinophilic gastrointestinal diseases. The Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) will investigate eosinophilic and allergic disorders, with the goal of improving patient care and outcomes.
A phase 1 clinical trial of crizotinib against ROS1-positive lung cancer showed a 72% response rate and 19.2 months progression-free survival, suggesting potential for durable action against this subtype of lung cancer.
Researchers found alterations in genes BAP1, KDM6A, and others contributing to bladder cancer development. These findings suggest potential therapeutic targets for specific subtypes of the disease.
Researchers developed a novel approach to target the activation of Ral proteins, which drive tumor growth in several human cancers. A compound called BQU57 proved most successful in slowing cancer cell growth and activation.
A CU Denver study reveals that vaccine refusal is more common among children from higher-income families with educated mothers. These parents often rely on alternative practices like breastfeeding and social monitoring to prevent disease, rather than vaccinations. In contrast, lower-income families face barriers to accessing healthcare...
A new study by CU Denver researcher Zaneta Thayer found that poor women experience higher cortisol levels during pregnancy, giving birth to infants with elevated cortisol responses to stress. These early life disparities can lead to serious disease later in life and highlight the need for stress reduction and social support.
A CU Denver study found that government regulations are causing an inequitable distribution of marijuana dispensaries in disadvantaged areas. The majority of allowable land for marijuana businesses is located in the city's poorest and most ethnically and racially diverse neighborhoods.
A CU Denver study found that compact city designs with many intersections are healthier, promoting more walking and biking. The research discovered a correlation between wider streets and increased obesity and diabetes rates.
Researchers have created a comprehensive database to study microRNA regulation of genes and their targets. The multiMiR database combines 50 million records from existing repositories, enabling efficient analysis and identification of new treatment options.
A new study reveals that Denver's sports stadiums have excessive parking spaces, leading to heat islands and missed economic opportunities. The research suggests transforming inefficient parking into better investments to incentivize carpooling and other modes of transportation, improving the spectator experience and downtown businesses.
A CU Denver study explores the connection between preferred ethnic labels and cultural heritage among Latin American descent individuals. The research found that Hispanic students identified with traditional US values, while Chicana/o students were more likely to identify with their cultural heritage.
A new test developed at CU School of Pharmacy helps monitor the effectiveness of HIV prevention drug Truvada, taken once daily to prevent HIV infection. The test measures tenofovir levels in red blood cells, showing a continuous gradient of increasing efficacy with consistent dosing.
Researchers found that engaging stakeholders early, being pragmatic rather than perfect, using existing research networks and delegating tasks can help streamline healthcare research. These streamlined mechanics allowed the project to complete data collection in under 18 months.
Researchers at the University of Colorado Anschutz Medical Campus found that YouTube is a promising platform for disseminating research in dermatology. The study analyzed 100 videos with over 47 million views, driving 6,325 subscriptions to distinct user pages.
A University of Colorado study found that home visits from nurses significantly reduced preventable child deaths and maternal mortality among low-income families. The Nurse-Family Partnership program improved pregnancy outcomes, childhood health, and women's economic self-sufficiency.
A recent study found that over 60 percent of Navajo children have untreated oral health issues, including 69.5 percent of children having untreated tooth decay. The Navajo Nation faces significant barriers to accessing dental care, with a low dentist-to-patient ratio and limited access to healthcare services.
Researchers have identified genetic markers that can predict the development of celiac disease in infants. The study found a significantly higher risk for celiac disease among Swedish children compared to their European counterparts.
Research highlights significant barriers to driving evaluations for older adults, including high insurance costs and low awareness among healthcare providers. The study suggests improved referral systems and third-party reimbursement could increase participation.