A new study shows that even triple negative breast cancers with low androgen receptor expression can benefit from anti-androgen receptor therapy. The treatment, which targets the androgen receptor, was found to increase programmed cell death, inhibit growth, and increase necrosis in animal models.
A University of Colorado Denver study found that increased bicycle use leads to reduced collisions between cyclists and motorists, attributed to the 'safety in numbers effect'. The study focused on Boulder, Colorado, where high bicycling rates resulted in lower crash rates.
Researchers at the University of Colorado School of Medicine have solved a biochemical mystery surrounding viral RNA molecules. The study reveals how these molecules mimic cellular RNAs as part of their strategy to infect cells and multiply, offering insights into potential treatments or vaccines against infectious diseases.
A CU Denver study reveals that major roads built through lower-income neighborhoods often neglect public health issues, including air pollution and crime. The study's author emphasizes the importance of incorporating public health into transportation planning to minimize hazards and create healthier environments.
Researchers have identified two distinct pathways that influence the aggressiveness of pediatric brain tumors, suggesting different treatment approaches. The study found that point mutations in the BRAF gene lead to a more aggressive form of the disease than K:B fusion.
The DREAM project has successfully mined genomic data to predict breast cancer cell line responses to drugs, achieving 78% accuracy in identifying sensitive versus resistant cell lines. The study also identified molecular markers that can be tested against large collections of human samples.
The challenges in cancer molecular testing require effective communication between oncologists and pathologists. Close communication, systems approaches, and new institutional protocols can help ensure efficient testing and optimal patient outcomes.
A University of Colorado Cancer Center study found NTRK1 mutations in over 1% of non-small cell lung cancer patients. The study also developed a test for rapid detection of NTRK1 oncogenes, marking a new frontier in lung cancer treatment.
A non-invasive breath test has been developed to detect lung cancer by analyzing volatile organic compounds in exhaled breath. The device can distinguish between patients with lung cancer and chronic obstructive pulmonary disease (COPD), as well as define the stage of any present cancer.
OMP-54F28, a Wnt inhibitor targeting cancer stem cells, has shown promising results in a Phase I clinical trial. The drug was generally well-tolerated and resulted in stable disease for over six months in several patients with advanced solid tumors.
Researchers have found that crizotinib produces significant responses in patients with intermediate and high MET amplification, resulting in a 60-67% overall objective response rate. The drug showed early activity against MET-dependent cells in preclinical laboratory studies.
The investigational agent DMOT4039A, a combination of chemotherapeutic agent and antibody, showed initial evidence of anti-cancer activity in a phase I clinical trial for pancreatic and ovarian cancers. The drug targets mesothelin-rich cancer cells, reducing the risk of off-target effects.
Researchers found that discontinuing statins in patients with advanced illnesses resulted in improved overall quality of life and lower costs without increased deaths. Patients who stopped taking statins appeared to live slightly longer, with median survival times of 229 days compared to 190 days for those continuing the drug.
Scientists used a new technology called GRO-Seq to map the genes directly regulated by p53, a tumor suppressor gene that helps prevent cancer. The study identified dozens of new genes that are activated by p53, which could lead to new strategies for fighting cancers.
A team of researchers created a database called K-Map that allows scientists to reposition existing drugs to treat various types of cancer. The database enables the evaluation of rational drugs and drug combinations, leading to new potential treatments such as bosutinib for non-small cell lung cancer.
School-based flu vaccine programs face financial challenges due to low reimbursement rates from third-party payers. Despite parental support for the program, billing and reimbursement issues pose significant problems for administrators.
Researchers found a significant increase in marijuana-positive drivers involved in fatal motor vehicle crashes in Colorado after medical marijuana commercialization in 2009. The proportion of such drivers increased from 4.5% to 10% between 1994 and 2011, outpacing the 34 non-medical marijuana states.
A new study found that individuals recently released from prison or on parole have a significantly increased risk of visiting hospitals and emergency departments. The study suggests potential cost savings if preventive care can be provided through timely access to health insurance coverage.
A patient diagnosed with advanced, incurable lung cancer was found to have early stage, curable lung cancer after stopping a rare antibiotic that caused liver and lung damage. The team's findings suggest that toxicity due to the antibiotic may be mistaken for cancer spread.
Researchers found that pravastatin significantly slowed the growth of kidney cysts in children and young adults with ADPKD, reducing progression of kidney disease. The study's results suggest early intervention may be key to preventing long-term complications of ADPKD.
A study published in JAMA found that corticosteroids do not improve bile flow in infants with biliary atresia six months after surgery. Infants who received steroids experienced more surgical complications and infections than those receiving a placebo.
The Kempe Center presents its first National Kempe Scientific Impact Award to Dr. David Finkelhor for his sustained scientific contributions to the field of child abuse and neglect. Finkelhor's extensive research has informed policy and practice to benefit children and families.
Research shows that high school friends are the most likely to be unfriended on Facebook, often due to polarizing comments or frequent uninteresting posts. The studies also found that being close friends at one point in time can intensify emotional responses to unfriending.
Researchers at the University of Colorado School of Medicine have identified a target for treating Dengue fever and other flavivirus diseases. The team discovered that the virus produces a unique RNA molecule with an unprecedented 'knot-like' structure, making it resistant to an enzyme that normally destroys RNA.
A new study reveals that rapid development of new towns in Asia, Africa, and Latin America exposes low-income workers to natural disasters, diseases, and health risks. The research highlights the need for urban planners to consider the needs of poor communities when designing these cities.
Researchers identified a new drug, AMPI-109, effective against triple-negative breast cancer by targeting the PTP4A3 oncogene. The study also provided molecular insights into the disease's biology.
Scientists at the University of Colorado School of Medicine have identified solitary chemosensory cells as potential causes of non-allergic rhinitis. These cells detect irritants and trigger an inflammatory response, leading to symptoms such as a runny nose and difficulty breathing.
A phase II trial of efatutazone with erlotinib failed to improve efficacy in patients with refractory non-small cell lung cancer, but researchers hope to refine future treatments by identifying the right biomarker for individual patients. The study found that fluid retention was a key factor contributing to the lack of success.
Researchers develop a new strategy to kill bladder cancer cells by attaching gold nanorods to EGFR proteins, which are overexpressed on these cells. The application of low-intensity laser heat the nanorods, killing the cancer cells without harming healthy tissue.
Silibinin from milk thistle extract reduces self-renewal of colorectal cancer stem cells, affecting cell signaling associated with inflammation. The compound also decreases levels of CSC self-renewal-promoting mRNAs.
Researchers develop a technique to trick prostate cancer cells into using more glucose for imaging via PET scans, reducing the need for repeated biopsies. This method has potential therapeutic applications by cutting off cancer cells' energy supply from lipids.
A University of Colorado study shows that cancer cells can outlive chemotherapies by using autophagy, a process where cells recycle damaged parts. This finding has implications for developing drugs that inhibit autophagy to sensitize cancer cells to chemotherapy.
A University of Colorado Cancer Center study identifies AGL as a key driver of bladder cancer growth, linked to hereditary liver disease glycogen storage disease 3. Low AGL levels correlate with poorer prognosis and increased tumor proliferation.
A recent study found that DKA rates among US youth with type 1 diabetes remained unchanged over the last 8 years, affecting nearly a third of all youth with the condition. The study also showed disproportionate rates among younger children, non-White racial/ethnic groups, and those without private health insurance.
A study published in PLOS Genetics found that the DUF1220 gene family is linked to the severity of autism symptoms. The research suggests that increasing copies of this gene segment may be associated with more severe symptoms, particularly social deficits, communicative impairments, and repetitive behaviors.
Researchers found that parents serve their children similar portions to those they serve themselves, which can lead to unhealthy eating habits. To promote healthy eating, experts recommend paying attention to portion sizes and encouraging children to eat according to their hunger cues.
The University of Colorado will receive a $2.1 million grant to help adolescents with Type 1 diabetes manage their disease and improve health outcomes through the Flexible Lifestyle 3mpowering Change (FL3X) study. The study aims to teach teens how to manage insulin, blood sugar, and daily tasks, with positive outcomes from a pilot study.
Researchers at CU Denver Anschutz Medical Campus will receive $3 million as part of a national effort to study pediatric stroke. The focus is on understanding mechanisms of injury, protection, and repair of the brain following stroke in children, with the goal of training a new generation of pediatric stroke physicians.
A new study investigating racial disparities in birth outcomes reveals that environmental factors are more likely to contribute to differences in preterm birth and low birth weight between African-Americans and whites. The findings suggest that addressing socioeconomic inequality and discrimination may be key to reducing these disparit...
Researchers found that mothers of children with acute lymphoblastic leukemia (ALL) experience significant lifestyle changes, including difficulty sleeping and managing anxiety, even after treatment has ended. Depression symptoms were also common, affecting 26% of mothers.
A University of Colorado study used a COXEN model to match tumors with optimal drugs, significantly extending patient survival. The model analyzed genetic data from thousands of tumor samples to identify response patterns.
A University of Colorado study shows that teens who watched a video about the cosmetic effects of UV exposure were more likely to use sunscreen than those who watched a health-based video. This finding suggests that addressing appearance-related concerns can be an effective way to modify sun-protective behaviors in teenagers.
The study highlights the effectiveness of traditional institutions like Fa'aSamoa and The Samoan Way in responding to natural disasters. These community-based approaches have strong social capital and can be leveraged in disaster management policies and programs, providing a 'win-win' scenario.
A recent study published in Gerontology highlights the long-term effects of childhood obesity on late-life health, finding that obese children may be more predisposed to complications independent of adult obesity. Early exposure to obesity can alter metabolism during a critical developmental time frame, leading to increased risk of met...
A recent study published in Biology of Blood and Marrow Transplantation found that parents of children undergoing stem cell transplant experience increased distress during the procedure but recover to normal levels of adjustment. Parents demonstrate remarkable recovery despite facing significant life challenges.
A new study found that 3D mapping biopsies detect nearly three times as many cancerous zones in prostate cancer patients compared to ultrasound-guided biopsies. The study suggests that 3D mapping biopsies can accurately assess the location, stage, and risk of prostate cancer, leading to more targeted treatment options.
A study by the University of Colorado School of Medicine found that only 62-65% of adults aged 65+ received pneumococcal or influenza vaccines, highlighting a growing public health concern. The study suggests using Immunization Information Systems to improve vaccination rates and address financial barriers.
Researchers at the University of Colorado Cancer Center have identified shared genetic signatures between lung and bladder cancers, which may refine patient prognoses and treatment choices.
A study found that patients with ALK+ non-small cell lung cancer can continue treating with crizotinib after receiving targeted radiation therapy to eliminate resistant disease pockets. This approach improves 2-year survival rates compared to those who discontinued the drug earlier.
A study published in the New England Journal of Medicine found a wide range of dangers associated with synthetic marijuana use. The substance has been linked to altered mental status, irregular heartbeat, seizures, and breathing difficulties, resulting in over 263 emergency room visits in Colorado alone.