A recent CU Anschutz study reveals that people with Type 2 diabetes perceive exercise as more difficult due to metabolic and cardiovascular challenges. The researchers found elevated lactate levels and increased rating of perceived exertion among individuals with the disease.
A University of Colorado Cancer Center study found TAK-733 to be highly active against colorectal cancer cells and tumors, with 42 of 54 cell lines sensitive to the drug. However, inconsistent absorption and bioavailability were observed, raising concerns about safety and tolerability.
A new study suggests that chronic dehydration caused by global climate change may be responsible for the Mesoamerican Nephropathy epidemic, which has killed over 20,000 people. The disease is most prevalent among manual laborers on sugar cane plantations in Central America.
Researchers at CU Anschutz Medical Campus discovered that increasing Adiponectin during pregnancy can reduce the chances that the baby will become obese as well. This breakthrough could potentially break the cycle of obesity that has approached epidemic proportions in society.
Homo naledi, discovered in South Africa, has a unique combination of derived cranial vault and hand morphology. Its age is unknown, but it may represent an intermediate between Australopithecus and Homo erectus.
A University of Colorado Cancer Center study found that 41% of open lung cancer clinical trials excluded patients with previously treated CNS disease, while 26% allowed those with untreated CNS involvement. The study suggests that current practice may be based on habit rather than scientific rationale.
Researchers discovered a way to create cell immunity to the E. histolytica parasite by silencing specific genes involved in potassium transport. This approach could lead to the development of new drugs targeting the parasite and preventing deadly diseases.
A University of Colorado Cancer Center study identified a specific ratio of MET to centromere 7 that defines patients with MET-driven lung cancer susceptible to crizotinib treatment. This threshold has been associated with responses approaching 70 percent in clinical trials.
A new study by CU Denver reveals that smaller cities in the developing world are often unprepared for disasters, lacking basic infrastructure and redundant systems. Climate change is expected to exacerbate these threats, particularly in mountainous regions such as India's Darjeeling District.
A study found that leaner children consume more polyunsaturated fatty acids, leading to improved body composition. The research suggests a link between PUFA consumption and reduced body fat and abdominal adiposity in diverse groups of children.
CU researchers call for improved firearm safety counseling by physicians, emphasizing respectful dialogue and cultural competence. They argue that physicians should reconsider their approach to discussing firearm safety with patients, acknowledging the diverse perspectives of gun owners.
A new tool called the Kinase Addiction Ranker (KAR) improves the ability to match drugs to disease by predicting what genetics are truly driving a patient's cancer. The tool clarifies the best drug or combination of drugs that targets specific genetic abnormalities, leading to more effective treatment options.
A Phase 1 trial of LOXO-101 demonstrated a rapid and significant response in the first patient with a TRK fusion cancer. The patient's tumors substantially regressed after four months of treatment, meeting partial response criteria.
A new model suggests that evolutionary pressures from healthy tissue keep cells with cancerous mutations in check. The study proposes that the ecosystem of a healthy tissue landscape allows healthy cells to outcompete those with cancerous mutations, but when this balance changes due to aging or stressors, cancer cells can thrive.
A 30-year study of 4,941 thyroid cancer patients found that moderate TSH suppression can bring benefits comparable to more extreme approaches, with potentially fewer side effects. The research supports a shift towards more tailored hormone suppression strategies for high-risk patients.
Researchers at the University of Colorado School of Medicine have developed a safe and lower-cost way to diagnose and treat digestive tract problems in children, using unsedated transnasal endoscopy. The procedure has been shown to be effective in evaluating pediatric patients with potentially chronic problems in their esophagus, reduc...
Researchers found a direct link between education levels and death, with higher education predicting longevity due to factors like income, behaviors, and social well-being. The study suggests that improving educational attainment could substantially improve survival in the US population, especially among those with low education.
A new study from CU Denver found a developing consensus among researchers that children of same-sex couples experience no negative impact on social and behavioral outcomes. The study analyzed thousands of peer-reviewed articles and discovered an overwhelming scientific consensus in support of this conclusion.
A phase III clinical trial shows necitumumab significantly improves median overall survival in stage IV squamous non-small cell lung cancer patients. The drug's 'fully human' EGFR antibody approach demonstrates potential as a novel immunotherapy strategy.
A new study from the University of Colorado Anschutz Medical Campus found that a low-cost, non-profit weight loss program offers clinically significant and long-term weight loss results. The TOPS program, which costs just $92 a year, was shown to be effective in maintaining weight loss for over seven years.
Clinical trials demonstrate improved survival rates for patients with metastatic melanoma using immune therapies nivolumab and pembrolizumab. These treatments target the 'don't attack' protein PDL1 on tumors, allowing the immune system to prime against tumor tissue.
Women treated for gynecologic cancers experience decreased sexual activity, with younger and premenopausal women at higher risk. Counseling during treatment may help alleviate long-term effects on sexual health.
A University of Colorado Cancer Center study found significant genetic differences between colorectal cancer tumors in young and old patients. The study identified altered gene signaling pathways, including PPAR and IGF1R, which may be involved in the development of younger CRC tumors.
ONT-380 demonstrates activity in stage IV HER2+ breast cancer patients, with one patient experiencing complete regression of brain metastases and improved overall survival. The drug's ability to target the HER2 growth factor receptor makes it a potential treatment for brain metastases.
Researchers at CU Anschutz Medical Campus have discovered a crucial molecular pathway involved in the renewal of taste buds. This finding may help improve the quality of life for cancer patients suffering from chemotherapy-induced taste dysfunction.
A two-year study found that female breast cancer survivors lost an average of 6% of their body weight through lifestyle changes, which may lower the risk of cancer recurrence. The study's results suggest that modest weight loss could become a routine part of oncology care to improve patient outcomes.
A phase I/II clinical trial found that brigatinib responded to treatment in 58 of 78 ALK+ patients, with a 13.4-month progression-free survival rate for those previously treated with crizotinib. Brigatinib also showed promise in treating brain metastases, with a 30% decrease in tumor size and controlled disease for 15.6 months.
A clinical trial at University of Colorado Anschutz Medical Campus demonstrates an intervention that successfully reduces caregiver stress in cancer patients treated with stem cell transplantation. The study shows significant lower stress levels and improved quality of life for caregivers.
A University of Colorado Cancer Center study found smokers are 60% less likely to vote than non-smokers in a recent election. The data comes from the Colorado Tobacco Attitudes and Behaviors Study, which reached 11,626 people through random digit dialing.
More than half of Medicaid enrollees opt for hospital emergency departments due to convenience and access to technology, rather than primary care clinics. This finding exposes a gap in healthcare services, as patients may avoid costs associated with travel and time away from work but neglect preventive care and chronic disease management.
Researchers have developed a miniature fiber-optic microscope that can penetrate deeply into the brain of a living mouse. This breakthrough technology allows scientists to study brain function in unprecedented detail and has potential human applications in understanding brain disease and developing new treatments.
The CU Anschutz College of Nursing has received $14,997 in funding from the Patient-Centered Outcomes Research Institute to develop a program reducing veteran suicides. The program will engage with veterans and caregivers through monthly meetings to identify protective factors for suicide prevention.
A phase 1/2 trial of rociletinib in EGFR-mutant non-small cell lung cancer showed a 59% response rate and 13.1 month progression-free survival, offering hope for patients with previously treated disease.
A new model, XactMice, allows researchers to test anti-cancer therapies in an environment similar to real patients. Human blood stem cells are used to grow a human-like immune system before tumor transplantation.
A new library of authenticated canine cancer cell lines, FACC-29, has been established to aid in research and drug development. The panel includes 29 cell lines from various cancers, allowing researchers to test new treatments and predict responses.
A study found a significant increase in diabetic ketoacidosis rates among Colorado youth with type 1 diabetes, from 39% in 1998 to 46% in 2012. The incidence of this life-threatening complication rose sharply after 2007, coinciding with an increase in child poverty prevalence.
Researchers found that children given daily doses of oral insulin developed a protective immune response to the disease, which could lead to the development of a vaccine against type 1 diabetes. The study showed increased immunity with higher doses of oral insulin, suggesting a potential treatment strategy.
Researchers found that silibinin from milk thistle significantly slowed the growth of colorectal cancer stem cells in mice, reducing tumor size and metabolism. Re-injecting these cancer stem cells into new mice showed a loss of their potential to form aggressive tumors even without silibinin exposure.
Research by University of Colorado Cancer Center investigator Tim Byers found that taking more dietary supplements than needed can lead to a higher risk of developing cancer. The study, which involved thousands of patients and ten years of research, showed that some supplements may even increase cancer risk by 20%.
A collaborative study by the University of Colorado Cancer Center and National Cancer Institute reports TERT gene promoter alterations in 69% of bladder cancers. The study suggests these alterations may be an early precursor to the disease and could lead to genetic testing for screening.
Research reveals FGFR1 amplification in 22.7% of small cell lung cancer tumors, implying applicability to non-small cell lung cancer treatments
Research shows obesity is a key shared risk factor for cancer, diabetes, and cardiovascular disease, contributing to 20% of cancers and 58% of type 2 diabetes. Collaboration between researchers from different disciplines could lead to better understanding of how these factors drive diseases.
A gene expression model called COXEN predicts canine osteosarcoma response to doxorubicin, potentially allowing veterinary oncologists to choose the most effective drug. The approach validates human models used to predict drug response in clinical trials.
A University of Colorado Cancer Center opinion argues that announcing the causality could save lives. The link between UV tanning and skin cancer is supported by eight out of nine criteria used to determine a causal relationship in disease, including strength of association, consistency of association, and temporality.
Researchers say there is enough evidence to declare indoor UV radiation tanning causes skin cancer. The authors urge the US Surgeon General to make a stronger statement regarding UV tanning devices, citing eight out of nine Bradford Hill criteria as satisfied.
A study by CU researchers found that brain activity affects the development of insulating sheaths on axons, promoting neural connections. The findings have implications for understanding psychiatric disease and tie into current conversations about the adolescent and teenage brain.
A University of Colorado Cancer Center study found a heritable genetic cause of acute lymphoblastic leukemia (ALL), similar to the BRCA mutation that affects breast and ovarian cancer risk. The ETV6 gene mutation is present at birth and increases the development of ALL, with the potential for future strategies to prevent the disease.
A study by University of Colorado Anschutz Medical Campus highlights the need for better communication between hospital clinicians and primary-care physicians to prevent missed test results and hospital readmissions. The researchers found that establishing accountability for pending tests and home health care via formal service agreeme...
A new study suggests discontinuing statins in patients with life-limiting illness can improve quality of life without adverse health effects. The study found no significant differences in mortality between those who continued and discontinued statin therapy.
A recent study defines a distinct subtype of aggressive prostate cancer marked by MAP3K7 and CHD1 gene loss, accounting for 10% of all cases and 25% of fatal outcomes. Researchers used stem-cell models to show that these genetic changes disrupt healthy tissue formation, leading to hybrid cells with aggressive characteristics.