Researchers at CU Anschutz Medical Campus found a correlation between hospital handoffs and increased mortality rates. The study analyzed data from 2008 to 2014 and found an absolute increase of 1.5-1.9% in hospital mortality rates among patients exposed to end-of-rotation transitions in care.
A study comparing four tests for PD-L1 expression has found that three tests cluster together, but the results vary with different scales. The goal of the ongoing study is to determine which test predicts treatment response most accurately.
A study by CU Anschutz found that high doses of vitamin D reduce acute respiratory illness (ARI) in older nursing home residents. The findings suggest a 40% reduction in ARI among those taking higher doses of vitamin D.
Kathryn Colborn's project aims to develop an automated early warning system for malaria transmission in Mozambique. The system will use novel statistical models and online tools to predict future monthly case rates, helping the Ministry of Health with prevention planning.
A team of researchers has developed a new prediction model that uses crowdsourced data from 550 international researchers to provide more accurate prognosis for patients with metastatic castration-resistant prostate cancer. The model, called ePCR, was developed through a collaboration between 16 institutions and used a computational le...
Researchers at the University of Colorado Anschutz Medical Campus found a strong association between a genetic mutation and left ventricular noncompaction, a rare form of heart muscle disease. The study sequenced nearly 5,000 genes in 335 patients with a family history of the disease to identify common genetic variants.
Scientists have found that the Zika virus uses a complex molecular process to produce disease-causing small RNAs. The researchers used x-ray crystallography to understand the structure of these RNA segments, which interact with and block cellular enzymes.
A study of over 1,200 patients found that mild postoperative pulmonary complications are associated with increased intensive care unit admission and early mortality. The researchers call for more interventions to curb these risks and improve patient outcomes.
Researchers found altered brain pathways in individuals with anorexia and bulimia nervosa, overriding the hypothalamus' drive to eat. This reversal allows their brains to fend off hunger signals, making it harder for them to consume food.
A study published in Gynecologic Oncology found that less than half of cervical cancer patients receive standard-of-care treatment, highlighting the need for improved access. Patients who received brachytherapy had better overall survival rates compared to those receiving only two components of SOC.
Researchers found thousands of genetic translocations in both healthy and cancerous mouse cells, highlighting the importance of considering individual genetic backgrounds. By using 'de novo assembly', scientists can compare a patient's cancer cells to their own healthy cells, reducing errors in translocation discovery.
Researchers from Colorado State University discovered that a cancer cell's shape may offer similar clues to predict how dangerous it is and guide treatment strategies. By analyzing cell shape using Zernike moments, the team was able to identify patterns that distinguish invasive osteosarcoma cell lines.
Researchers found that combining FLT3 inhibition with drugs inducing oxidative stress improves efficacy against acute myeloid leukemia (AML). This approach, which targets genes involved in antioxidant response, shows promise for combination therapy.
Scientists have created a genetic catalog of the African diaspora in the Americas, revealing why certain diseases hit those with African ancestry harder. The study found changes in DNA that put Africans at higher risk for diseases, and highlights the importance of understanding population histories to tailor clinical care.
Researchers identified 23 locations on the human genome linked to vitiligo susceptibility. The study provides a framework for understanding the genetic architecture and biological mechanisms of vitiligo, highlighting relationships with other autoimmune diseases.
A study published in Redox Biology found that a decreased cysteine/cystine ratio in plasma may predict the progression of epilepsy. The study used a rat model and found significant changes in the biomarker after seizures were induced, suggesting its potential as a redox biomarker for epilepsy.
Researchers discovered that the experimental drug AMPI-109 works by flipping a molecular switch on PRL-3 enzyme, which initially puts cancer cells to 'sleep' and then leads to their death. This mechanism could sensitize triple-negative breast cancers to immunotherapy, offering new treatment options.
A recent study published in PLOS Genetics identified two genes associated with human facial size and found additional candidates for genes affecting facial shape. The research used a genome-wide association study on an African population, providing new insights into the genetic basis of normal human facial variation.
A new study suggests that cancer in sub-Saharan Africa is linked to malaria and Epstein-Barr virus, particularly in children born to mothers with malaria during pregnancy. This increased risk of infection may lead to early exposure and a weakened immune system, making it harder for the body to manage the virus.
Researchers at University of Colorado Anschutz developed a technique to estimate patient adherence to antiretroviral drugs. The test measures traces of PrEP medicine in dried blood samples, providing an objective way to determine consistent use.
Cancer cells counteract telomere breakdown by building them up with the enzyme telomerase. A new study using CRISPR gene editing technology reveals telomerase's mechanism, allowing scientists to identify potential targets for anti-cancer drugs.
A team of neuroscientists and engineers will use a special microscope to reconnect neural communication between brain parts severed by injury or disease. If successful, this could improve conditions for those with Parkinson's, stroke, or neurological problems.
Researchers at the University of Colorado Anschutz Medical Campus found that sleep apnea worsens non-alcoholic fatty liver disease in obese adolescents. The study, published in the Journal of Hepatology, suggests that obstructive sleep apnea and low nighttime oxygen levels can promote the progression of the disease.
A survey of over 1,300 physicians found that 96.7% recognized shaken baby syndrome and abusive head trauma as valid diagnoses, supported by scientific literature and clinical experience. The study aims to dispel controversy surrounding these conditions, emphasizing the importance of accurate diagnosis for child care.
A University of Colorado Cancer Center study found that only 4.6% of cases had discrepancies between initial and final evaluations, with most being due to process errors or interpretation errors. The study aimed to reduce discrepancy rates by identifying trends and implementing changes.
A new approach using metabolic imaging could help determine a patient's response to targeted therapies much earlier and with greater precision than traditional tumor shrinkage. This method recognizes a drug's ability to stop cancer cells' energy overuse, allowing for more accurate assessments of treatment success.
A new tool, HiPub, helps researchers visualize connections between genes, proteins, drugs, and diseases in the vast biomedical literature. It extracts relevant information from text and visualizes it in a network, streamlining knowledge discovery.
The CU Training Program in Cancer Biology has earned a prestigious National Cancer Institute T32 grant, funding PhD-level and postdoctoral training positions. This award recognizes the program's excellence in interdisciplinary education of next-generation cancer scientists.
A University of Colorado Cancer Center study found cord blood transplants had a lower incidence of severe chronic graft-versus-host disease and allowed patients to discontinue immunosuppression sooner. The results suggest cord blood may be equal to or better than matched, unrelated donor transplants.
A national survey of 3,914 adults found that two-thirds are open to healthcare providers discussing firearms at home, while 66% support talking about seatbelts. Women were more likely than men to support gun discussions, and gun owners with children or suicide risk factors also endorsed the idea.
Researchers discovered leukemia stem cells in fatty tissue of obese patients were more resistant to chemotherapy, using fatty acids as their energy source and actively signaling fat for lipolysis. This adaptation could help explain poorer outcomes in obese patients, potentially shedding light on new strategies to target cancer stem cells.
Researchers developed a novel method to identify likely cancer drivers among hundreds of genomic alterations. The technique uses tumor gene alterations to report on cancer progression, pinpointing GON4L as a potential driver and therapeutic target.
A new study at CU Anschutz Medical Campus shows a program pairing junior faculty with seasoned mentors can significantly increase grants won. The Clinical Faculty Scholars Program helped participants win about four times as many grants as those who didn't take the course, with mean annual dollars increasing from $27,343 to $83,427.
West Nile virus causes memory loss and mood disorders by sparking inflammation that prunes synapses, the connections between nerve cells. Researchers have identified potential new treatments for the mosquito-borne illness.
Researchers identified TIP60 as an enzyme required for HIF1A activity in human colorectal cancer cells, showing its potential as a target for cancer treatment. The study also revealed the molecular mechanisms by which TIP60 promotes HIF1A activity and highlights the importance of basic research in cancer discovery.
A University of Colorado Cancer Center study used whole-exome sequencing to characterize genetic alterations in 25 commonly used bladder cancer cell lines. The researchers found 76 altered genes, many involving oncogenes like TERT and TP53, which can predict patient response to cisplatin treatment
A University of Colorado study found that Hispanic white and non-Hispanic black young adults are more likely to die from cancer than their white counterparts, with mortality risks ranging from 1.36 to 1.77 times higher.
A study found that while overall colorectal cancer rates are decreasing, the incidence of late-stage cancer in young patients is increasing. The study, which analyzed data from Colorado patients, reveals a significant rise in late-stage CRC diagnoses among those under 50.
A study found that genes involved in the Wnt signaling pathway are more frequently altered in younger patients with colorectal cancer. This pathway drives the growth and proliferation of cancer stem cells. The research suggests targeting this pathway may be a promising strategy for treating aggressive CRC in young patients
Millions of Americans take long-term opioid medications to manage chronic pain, but transitioning away can be complex and anxiety-provoking. However, study participants reported improved quality of life after the transition, highlighting the importance of intensive support from family and healthcare providers.
Adults under 40 are not being sufficiently screened for lipid abnormalities while taking antipsychotics, which increases cardiovascular risk. Improved screening of this age group is crucial for early detection and intervention.
Physicians use more hospice care, spend more time in Intensive Care Units (ICUs) and just as much time in hospitals compared to the rest of the population. Doctors used an average of 2.4 days longer in hospice care at the end of life.
Researchers found that obese women and those with anorexia nervosa struggle to distinguish between flavors, which could impact food intake. The study suggests that altering the taste intensity of food may be a potential treatment for eating disorders.
A study from the University of Colorado Anschutz Medical Campus found that long-term participation in a national weight-loss program led to significant weight loss and improved health outcomes. The researchers followed over 65,000 participants who joined the Take Off Pounds Sensibly (TOPS) program between 2005 to 2010.
A CU Anschutz study finds that breast milk hormones impact the development of healthy bacteria in infants' guts, potentially protecting them from intestinal inflammation, obesity, and diseases. Researchers found a positive association between insulin, leptin, and microbial diversity in the infant's stool.
A study found that chronic exposure to interleukin-1 causes overproduction of immune cells, resulting in an imbalanced blood system. This imbalance can lead to inefficient oxygen delivery, immunodeficiency, and increased cancer risk. Researchers suggest that therapies may be able to reverse the effects of chronic inflammation on blood ...
Researchers found that mice flown aboard the space shuttle developed early signs of liver disease, including increased fat storage and changes to genes responsible for breaking down fats. This study has implications for future missions to Mars, highlighting the need for further research on the impact of spaceflight on human physiology.
Researchers discovered YEATS domain proteins as the first reader of histone lysine crotonylation, a critical epigenetic mark. This discovery has implications for human disease, particularly in cancers such as leukemia and glioblastoma.
Researchers found that breast cancer stem cells secrete molecules that allow neighboring cells to detach and metastasize. The hedgehog signaling pathway plays a crucial role in this process, suggesting that targeting it could reduce metastatic potential.
The phase 1b clinical trial of atezolizumab has reported promising results in 23 patients with metastatic colorectal cancer. Fifty-two percent responded to treatment, and median progression-free survival was 14.1 months. Another patient, Rodney Bearfoot, has remained on the study for over three years despite a stage 4 diagnosis.