A recent study published in JAMA Internal Medicine found that a collaborative care intervention significantly improved depression and fatigue in patients with chronic heart failure. While it did not affect their overall health status, the treatment offered benefits to these patients' quality of life.
Researchers at CU Anschutz have discovered a new approach to reprogramming adult skin cells into induced pluripotent stem cells (iPSCs) with unprecedented efficiency. This breakthrough has significant implications for the development of new corrective stem cell-based therapies for currently incurable diseases like Epidermolysis Bullosa.
In three clinical trials, larotrectinib demonstrated a 75% overall response rate in patients with TRK fusion genes, with 86% continuing treatment or undergoing curative surgery. This study marks a new paradigm in cancer drug development, defining cancers by molecular changes rather than site of occurrence.
A study found that patients with advanced cancer were less capable of making treatment decisions than healthy adults, but doctors often overestimated their competence. The research suggests a shift in patient-doctor relationships, emphasizing the importance of respecting patient autonomy while ensuring decision-making capacity.
Researchers discovered that a common blood pressure medication, methyldopa, can prevent the onset of type 1 diabetes in up to 60% of those at risk by blocking a specific molecule. The study used a supercomputer and found that methyldopa not only blocks the DQ8 molecule but also doesn't harm other immune cells.
A new study published in the Journal of Occupational and Environmental Medicine found that women with depression, anxiety, and fatigue are more likely to be injured at work. The study, which analyzed claims data from over 17,000 employees, suggests that behavioral health factors significantly affect women's risk of injury but not men's.
CU researchers found that givinostat improved the heart's ability to relax, holding promise for treating patients with diastolic dysfunction and heart failure with preserved ejection fraction. Fibrosis is not the sole cause of diastolic dysfunction; a defect in muscle cell relaxation contributes.
Researchers from ColoradoSPH identified new risk factors for a mysterious kidney illness affecting farm workers worldwide. The study found that access to water, rest, and shade reduces the rates of kidney disease onset and injury severity.
The new guidelines update the 2013 recommendations to include genetic alterations driving lung cancer and new drugs to target these alterations. Testing for ROS1 in all cases of lung adenocarcinoma is now recommended, as well as using circulating tumor DNA and cytology specimens when tissue is unavailable.
Researchers have found that PD-1 inhibitors can be effective in treating supratentorial pediatric ependymoma, a type of brain cancer with poor prognosis. The study identified RELA-fusion as a genetic cause and showed that these tumors express high levels of PD-L1, which can be targeted by PD-1 inhibitors.
A study by University of Colorado researchers found that changes to the nursing home quality ratings system led consumers to choose better providers. The simplified five-star system used on Nursing Home Compare motivated consumers to select higher-rated nursing homes, while low-rated facilities with limited options struggled.
A study found that pediatric cancer patients' microbiome diversity can predict the risk of developing blood infections, suggesting a link between gut health and bloodstream infections. The researchers argue that prevention and treatment strategies may depend on the source of infection, rather than relying solely on central line hygiene.
Researchers found PQQ can prevent fatty liver disease progression in young mice fed a high-fat diet by protecting their microbiome. The study suggests that maternal diet affects offspring's gut health, leading to an increased risk of developing the disease.
The Colorado Consortium for Prescription Drug Abuse Prevention at CU Anschutz Medical Campus receives a $1.5 million grant from the Colorado Health Foundation to advance its mission to reduce misuse and abuse of prescription drugs in Colorado.
A University of Colorado Cancer Center study found low post-treatment mortality rates for both surgery and targeted radiation in early-stage lung cancer patients. Patients over 80 years old showed significantly higher mortality rates with surgery compared to targeted radiation.
A recent review by CU researcher Vesna Jevtovic-Todorovic examines the effects of general anesthesia on developing brains, revealing that multiple, shorter-lasting exposures during vulnerable periods cause significant impairments. The study's findings have important implications for pediatric surgery and anesthesia practices.
The ACA Medicaid expansion was positively associated with improved hospital performance and a reduced likelihood of hospital closure, particularly in rural markets. This is due to increased access to healthcare for previously uninsured adults, resulting in better health outcomes and less need for emergency care from hospitals.
The new guidelines provide strategies for including patients with brain metastases in clinical trials, addressing the lack of data on drug effects in the brain. The approach includes three specific strategies based on initial understanding of a drug's possible activity in the brain.
Researchers found that exercise increases DJ-1 protective gene expression, preventing abnormal protein accumulation in the brain. This may help slow Parkinson's disease progression.
An international study discovered five new regions of the genome associated with increased asthma risk, characterized by epigenetic marks on gene enhancers. The genetic variants also show associations with auto-immune diseases and inflammatory component diseases, highlighting the importance of pleiotropy in multifactorial diseases.
Researchers in Colorado study 200 people affected by AFFF contamination, collecting data on biological markers and health indicators to assess biopersistence and potential health impacts of PFASs. The study aims to provide a better understanding of the effects of long-term exposure to these chemicals.
Researchers have discovered that radiosurgery can be an effective treatment option for patients with four or more brain lesions, even when the number of deposits exceeds the traditional three-lesion threshold. The study found no significant difference in survival rates between patients treated with radiosurgery for 4-10 metastases and ...
Scientists discovered a complex color vision circuit in mice involving the M5 cell, which may process color information and lead to new treatments for humans. This finding expands our understanding of color vision and its relationship with other types of vision.
Smokers with targetable genetic alterations in their lung cancer benefit equally from targeted therapies as non-smokers. Targeted treatments improve survival by 1.5 years, regardless of smoking status.
A new phase 2 trial found that high-intensity exercise can safely reduce worsening of motor symptoms in early-stage Parkinson's disease. Participants who exercised three times a week showed minimal decline in symptoms, while those who didn't exercise experienced significant worseness.
A new study published in Archives of Toxicology shows that common combinations of low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs) can help spark the development of cancer, even if each chemical is not known to cause cancer alone.
Researchers studied African populations, finding a high degree of variability in skin pigmentation that cannot be explained by just a few genes. The study suggests that multiple genes contribute to the process, with variations increasing near the equator.
Researchers discover that CDK8 plays a critical role in allowing cancer cells to use glucose for energy. Blocking CDK8 activity combined with glycolysis inhibitors slows cancer cell growth more effectively than either approach alone.
Current RECIST guidelines face challenges in measuring cancer response with emerging targeted therapies. Researchers propose a new baseline approach to track stability and separate tumor burden from treated areas.
The alisertib and TAK-228 combination shows promise in treating solid tumors, particularly triple-negative breast cancer. In a phase 1 clinical trial, the treatment was generally well-tolerated, with patients experiencing fatigue and decreased neutrophil count as common side effects.
Researchers have developed a new medicine, tarloxitinib, that brings high doses of anti-EGFR drugs to tumors while keeping toxic levels in healthy tissues. The prodrug-based approach has shown promising results in tests against lung cancer cells with EGFR exon 20 insertions.
A study found that adequate vitamin D levels during infancy and childhood are associated with a reduced risk of islet autoimmunity, a precursor to type 1 diabetes. Vitamin D status varies by latitude, and higher childhood levels are significantly linked to decreased risk of IA.
Scientists have developed a new theory of molecular evolution that explains how genes function and why proteins evolve. The theory applies statistical mechanics to understand protein evolution at a basic level, revealing the importance of amino acid interactions and sequence entropy of folding.
A University of Colorado Cancer Center study finds a genetic change called ALK-fusion in a patient sample of a melanoma subtype called mucosal melanoma. Treated with FDA-approved drugs, the tumor responded dramatically. The study suggests that these non-sun-exposed melanomas may be more susceptible to targeted treatments.
A study published in ACS Nano describes the real-time visualization of liposomes escaping from blood vessels into surrounding skin cells in living mice. Researchers found that liposomes can invade skin cells within five minutes of injection and remain there for up to seven days.
A recent CU Anschutz study found that climate change can spur outbreaks of infectious diseases like Zika, malaria, and dengue fever. The researchers discovered a 12-fold increase in Zika cases in Ecuador after an earthquake struck the region during an exceptionally strong El Niño event.
A study published in Genome Research investigated the role of p53 in tumor suppression and found that no single gene serves as a backup 'second in command' to activate its functions. Instead, p53 relies on a multifunctional team of genes contributing to tumor suppression.
CU Anschutz and CU Boulder scientists have won a $2 million grant from the National Institutes of Health to refine their unique 2P-FCM microscope, which allows deeper brain imaging and dynamic focus capability. The researchers will deploy the microscope to laboratories across the country to study neural activity in various species.
A community-based program, Bridges to Care, reduced ED visits and hospital admissions while increasing primary care use among Medicaid-eligible high ED users. The program provided intensive medical, behavioral health, and social care coordination services.
A new study from the University of Colorado Anschutz Medical Campus found that law enforcement agencies and gun retailers are willing to offer voluntary, temporary storage of guns to prevent suicide. Most people, including health providers, may not know what safe outside-the-home storage is available and what their options are.
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes. Patients experienced a lower rate of confirmed severe hypoglycemia than observed in patients on placebo and also had weight loss.
A University of Colorado study found that blood tumor markers can predict lung cancer progression, allowing for earlier adjustments to treatment plans. Markers were associated with a 10% or greater rise in 53% of patients experiencing cancer progression, but not limited brain progression cases.
Researchers engineered antibodies to target EGFR on bladder tumors and used gold nanoparticles to deliver heat via plasmon resonance. This technique successfully slowed and reversed tumor growth in mice, with minimal side effects.
Researchers developed a new assay to detect gene fusions in dozens of genes simultaneously, identifying a rare MET fusion in a late-stage lung cancer patient. The patient showed an almost complete response to targeted therapy crizotinib after over 8 months of treatment.
A University of Colorado Cancer Center paper describes a mechanism linking viral infection and cancer caused by APOBEC3 enzymes, which are part of the immune system's response to viruses. The research suggests that targeting these enzymes could prevent or treat certain types of cancer.
Researchers from CU Anschutz and UC San Diego found that creosote bush compounds exhibit potent anti-parasitic activity against Giardia and Naegleria fowleri, two deadly parasites responsible for giardiasis and primary amoebic meningoencephalitis. The discovery could lead to a more effective treatment option for these infections.
Researchers found that patients with deeper tumor shrinkage due to targeted treatment had better progression-free survival and overall survival rates. The study suggests that initial response could be an early indicator of a drug's effectiveness, influencing both clinical trials and treatment goals.
A study by Cathy Bradley found that small cash incentives and interactions with health program coordinators can increase primary care visits among low-income individuals, reducing emergency department use and improving patient care. The study showed a significant reduction in costs overall.
A study published in Hormones & Cancer found that obese rats with sensitive androgen receptors had more aggressive tumors, even after anti-estrogen treatment. Researchers identified inflammation and cytokine interleukin 6 as key factors contributing to this sensitivity, highlighting the potential for personalized therapeutic strategies.
International researchers developed a mathematical model predicting docetaxel discontinuation due to adverse events, incorporating five clinical factors. The combined model stratified patients into low and high risk groups, with the high group having more than double the likelihood of discontinuation.