A CU Anschutz study discovered a genetic component that breaks down contraceptive hormones in some women, potentially leading to pregnancy. The research may lead to the development of more precise medical tools to tailor treatment to individual patients.
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) is a distinct form of cancer linked to textured breast implants. Clear guidelines formalize treatment strategy, recommending surgical techniques like stepwise en bloc resection for complete oncologic resection and removal of involved lymph nodes.
A team of researchers led by James DeGregori will identify lung tissue characteristics that enable cancer cell growth, aiming to predict cancer risk and develop interventions. The study aims to modulate the lung environment to reduce cancer risk, rather than targeting cancer cells alone.
Researchers found that estrogen affects astrocytes, which produce growth factors promoting brain metastasis. Anti-estrogen therapy may prevent brain metastasis in women with triple-negative breast cancer.
A new study by Colorado researchers finds that group dynamics-based exercise class increases quality of life beyond personal training for breast cancer survivors. Both groups showed similar physical gains, but the women in the group-dynamics class outpaced those in personal training.
A study of 872 young adults found that 14.4% borrowed over $10,000 due to illness or treatment, while 54% experienced mental task impairment. Cancer treatment with chemotherapy increased the risk of these issues significantly.
A survey of Colorado home health care clinicians found that 60% lacked adequate information from hospitals to guide patient treatment. The study highlights major gaps in communication between hospital and home health staff, which can result in medication errors and other serious consequences.
Researchers identified a genetic mutation in the PKD1L1 gene linked to Biliary atresia, a devastating condition that affects many children. The study found five patients with two copies of mutations and three additional patients with one mutation, providing new insights into the cause of the disease.
A new study has identified areas of chromosomes associated with higher rates of asthma in those of African ancestry. The research used advanced technology to identify loci on chromosome 17q12-21, which may contribute to the increased risk of asthma in this population.
A recent study by CU Anschutz researchers has implicated a complex unexamined gene family in autism severity, suggesting that this underexplored area of the human genome may hold key insights into the disorder and potentially lead to new clinical therapies.
A new study published in Environmental Research found that people living in drafty homes in low-income, urban communities are at a higher risk of respiratory health issues such as asthma. The study revealed that residents in homes with the highest air-exchange rates were more likely to report chronic cough and asthma-like symptoms.
A University of Colorado study shows that low-molecular weight PAHs, commonly found in secondhand smoke and environmental exposures, can cause cancer-promoting changes in lung cells within 30 minutes.
A study found that breast cancers diagnosed in young women within 10 years of giving birth are more likely to metastasize than those diagnosed less recently or not at all. The risk is highest among women up to 10 years postpartum and is most pronounced in stage I or II breast cancer.
Children with solid organ transplants are hospitalized due to vaccine-preventable infections at significantly higher rates than the general population. According to a new study, hospitalization among transplant recipients was up to 87 times higher than in the general population.
Scientists have identified natural antibodies within protein corona that trigger immune system response to nanoparticles. Depleting these antibodies reduces complement system activation, enabling safe delivery of cancer-fighting drugs and imaging agents.
A new study found that patients with stage IV ALK-positive lung cancer have a median overall survival of 6.8 years, significantly higher than the 2 percent five-year survival rate for all NSCLC patients. This optimistic outlook is attributed to targeted therapies and careful surveillance.
A study by the University of Colorado Anschutz Medical Campus found that Facebook advertising can effectively reach rural communities with information and reminders about cancer screening. The EndCancer initiative resulted in a high engagement rate, with 96% of participants staying enrolled.
Researchers identify strong genetic risk factor for IPF, linking mucociliary dysfunction to lung scarring. The study provides a breakthrough in understanding the cause of IPF and potentially its treatment.
The University of Colorado Anschutz Medical Campus will partner with the Allen Institute for Immunology to understand the human immune system and find novel mechanisms to halt or reverse rheumatoid arthritis. The research program aims to identify biomarkers for early detection and develop new treatments for this debilitating disease.
A pilot study found that residents living in areas with high oil and gas activity showed higher blood pressure, stiffer blood vessels, and inflammation markers. The study suggests a possible connection between oil and gas development and cardiovascular disease.
Researchers found that Catholic health care facilities often limit common women's health services like contraception and sterilization, and may only offer pills as a contraceptive method. The study highlights the need for further exploration of how institutional restrictions impact patient outcomes.
A study published in Clinical Endocrinology found that DHEA therapy increased bone mineral density in older women, particularly in the lumbar spine, total hip, and trochanter. However, the increases were not as large as seen with other treatments like bisphosphonates.
A CU Anschutz study found that female academic hospitalists face inadequate paid parental leave, difficulty with breastfeeding support and diminished career opportunities. The study calls for more generous paid leave policies to attract and retain women in the profession.
A study published in Supportive Care in Cancer examines the experiences of providers offering concurrent cancer therapy and hospice care to veterans. The findings highlight the importance of preserving hope while transitioning into end-of-life care, as well as the need for dedicated liaisons between VA and hospice systems.
A new combination treatment of venetoclax and azacitidine has shown a 91 percent response rate in older adults with newly diagnosed acute myeloid leukemia (AML). The treatment has been associated with no more side effects than the use of azacitidine alone, and patients with IDH mutations have experienced long-lasting responses.
Researchers have identified a genetic change common to 80% of human melanomas and developed a molecule that targets this change. The molecule binds to melanocortin-1 receptor (MC1R) on the surface of melanoma cells, allowing for imaging and potential therapy delivery.
Researchers at CU Anschutz Medical Campus discover that infant gut microbes altered by maternal obesity increase the risk of obesity and non-alcoholic fatty liver disease later in life. The study suggests that altering the microbiome through probiotics or supplements may help reduce this risk.
A recent study found that cancer stem cells rely on amino acids for energy, rather than glucose, and this difference makes them susceptible to targeting without harming healthy cells. Researchers have already shown promise with this approach in clinical trials against acute myeloid leukemia, with potential applications to other cancers.
A study by CU Anschutz found a significant association between prescribed access to psychotropic drugs and their use in attempted suicides. The researchers investigated 27,876 people who attempted suicide at least once and found that 70% of those using psychotropic drugs had prescribed access.
Researchers have developed a new strategy against HER2-driven lung cancers using tarloxotinib, a potent HER2/EGFR inhibitor that is more active in low-oxygen conditions than existing therapies. This innovative approach has shown significant promise in treating patients with HER2 lung cancer.
A large international clinical trial found that alirocumab, a PCSK9 antibody, reduced the chance of additional heart problems or stroke in heart attack survivors. LDL cholesterol levels decreased by 50% with alirocumab treatment, leading to a 15% reduction in risk of death from coronary heart disease, another heart attack, or stroke.
A new article published by CU researchers provides an overview of biological and chemical agents that might be used in potential terror attacks. The authors describe how to recognize, diagnose, treat, and report exposures to various agents, aiming to better prepare healthcare providers for such emergencies.
A study by University of Colorado researchers found genetic variants in the FUT2 gene increase the risk of recurrent or chronic middle ear infections in children. The variants affect the microbiome of the middle ear, making it more susceptible to specific bacteria.
Researchers developed a new combination treatment that flips the switch on melanoma cells by targeting Bcl-2, MCL-1, and DRP-1 proteins. The approach killed melanoma cells and cancer stem cells in laboratory tests, offering an alternative option for patients who don't respond to current treatments.
A new study published in the Journal of Bone and Joint Surgery found that home care with physical therapy significantly improves recovery rates for knee replacement surgery patients. The study analyzed Medicare claims data and found that patients receiving six to nine home-care visits by a physical therapist had better outcomes.
A team of CU researchers has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. The study found that patients with RA are at risk of developing progressive pulmonary fibrosis, enabling potential interventions to prevent this condition.
A study found that cancer stem cells with MHC Class I molecules upregulate and retain CDK1 protein, allowing them to initiate tumor growth. Sox2 transcription factor plays a key role in maintaining their stemness.
Researchers from the University of Colorado School of Medicine have identified previously unknown genetic causes of mitochondrial diseases, including cardiomyopathy and excess acid in blood. The study found that mutations in specific genes caused lethal conditions, and increasing a nutritional compound improved cell function.
Leukemia undercuts normal cells' ability to consume glucose, leading to a diabetic-like condition that favors cancer growth. Researchers have identified key strategies, including manipulating insulin production and gut bacteria, which can be targeted with low-tech therapies like serotonin supplementation.
The ALTA-1 trial found brigatinib to be a first-line treatment option for advanced ALK-positive non-small cell lung cancer, with a 51% reduction in progression or death risk compared to crizotinib. Patients treated with brigatinib also showed improved response rates and longer progression-free survival.
Phase 1 and phase 2 clinical trials of entrectinib in ROS1-positive non-small cell lung cancer demonstrated a response rate of 77.4 percent and median duration of response of 24.6 months. Entrectinib also showed competitive results in patients with brain metastases and poor prognosis
A study published in Cell Reports has identified Np63a as a driver of squamous cell carcinoma growth and found that activating tumor suppressor genes TGFB2 and RHOA can halt this process. This discovery provides a promising pathway for developing new cancer treatments.
Researchers have discovered a new combination treatment targeting pre-leukemia stem cells by inhibiting protein synthesis and oxidative phosphorylation pathways. The treatment, involving FDA-approved drugs omacetaxine and venetoclax, has shown promising results in killing cancerous cells while leaving healthy stem cells unharmed.
Researchers at the University of Colorado Anschutz Medical Campus have discovered that T cells elicited from subunit vaccines can reproduce without glucose, supporting their expansion and potentially defeating cancerous tumors. This finding has major implications for the development of immunotherapies for cancer patients.
Researchers found that judicial bypass processes function as a form of punishment for adolescents, causing emotional harm through unpredictability and shame. Adolescents in Texas reported difficulties with transportation, intimidating court environments, and biased GALs who imposed unwanted adoption offers.
A research team at the University of Colorado School of Medicine has identified a potential target for treating pain during surgery, aiming to reduce the use of narcotics. By understanding how nociceptors work, researchers hope to develop new therapies and decrease post-surgical pain duration and intensity.
Scientists have created a more complete humanized mouse model by combining human hematopoietic stem and progenitor cells with mesenchymal stem cells. This allows for more realistic testing of immunotherapies, leading to improved cancer treatment predictions. The new model enables researchers to compare the interaction of the immune sys...
A Colorado study found that more than half of sampled stores sold cigarettes to minors, despite a third being detected after multiple visits. The study suggests that testing each store more than once and verifying age from ID would improve enforcement.
A University of Colorado Cancer Center study reveals that inhibiting the action of lysosomes can efficiently kill metastatic cancer cells. Researchers found that the level of a protein called ID4 predicts which cancer patients will benefit most from treatment with chloroquine.
A study by University of Colorado Anschutz Medical Campus found that doctors with personal cancer experience are 17% more likely to recommend ovarian cancer screening to low-risk women, despite guidelines against it. This bias may be due to overestimating a patient's risk and prioritizing their experience over evidence-based guidelines.