The University of Colorado Anschutz Medical Campus has received a grant to advance implementation science and cancer control efforts. The Center will develop resources and education to enhance cancer prevention and control in Colorado and nationally.
Researchers from University of Colorado Cancer Center Department of Radiation Oncology won the IAEA safety competition by recognizing the importance of a positive attitude towards radiation safety and developing department-wide processes for communicating safety standards. The team used Safety Month as an opportunity to broadcast and t...
Researchers at CU School of Medicine have developed a new imaging method called 'fast MRI' that can effectively identify traumatic brain injuries in children without exposing them to ionizing radiation or anesthesia. The study found that fast MRI was completed successfully in nearly all cases, with accuracy similar to CT scans.
A research team at the University of Colorado School of Medicine has identified BRD4 as a central regulator of cardiac fibroblast activation. Chemical inhibitors of BRD4 potently block cardiac fibroblast activation, providing a potential therapeutic target for heart failure treatment.
A study from the University of Colorado School of Medicine found that physicians' delivery and communication practices must improve to boost HPV vaccine completion rates. Pediatricians who strongly recommend the vaccine have higher acceptance rates, and optimizing HPV delivery through standing orders and alert systems can also help.
The team aims to understand how genetics contributes to driving aggressive pathology in prostate cancer by combining pathology, computational modeling, and genomics. They plan to identify therapeutic options by testing combinations of genes in mouse models of the disease.
Researchers have identified a new way to target the third most common oncogene, TERT. The study reveals that TERT messenger RNA is held up in the nucleus, and keeping it trapped could be an effective strategy for treating cancer. This discovery offers a promising new approach in the fight against TERT over-activation.
A study led by CU School of Medicine researcher Rui Zhao sheds light on the mechanism of pre-mRNA splicing, a complex process that converts precursor mRNA into mature mRNA for protein production. The research proposes a unified model explaining three fundamental phenomena in pre-mRNA splicing without requiring different spliceosomes.
Researchers have mapped a previously uncharted region of the human genome that gives rise to various diseases. Using advanced imaging techniques, they discovered extreme variability in DNA sequences between individuals and populations, which may lead to genetic testing for parents before having children.
Chronic kidney disease, linked to heat exposure and dehydration, is expected to surge globally as temperatures rise. Climate change also threatens to increase cardiovascular disease, Lyme disease, and other illnesses in vulnerable communities.
Researchers have discovered that natural killer cells interact with HLA class 2 proteins, which can activate them to attack cancer cells. This breakthrough may lead to new ways to harness the immune system to fight cancer and avoid attacking healthy tissues.
Researchers discovered that intense light amplifies the PER2 gene, which bolsters blood vessels and offers protection against heart attacks. The study found that mice exposed to intense light had reduced cardiac tissue damage after a heart attack, suggesting a potential therapeutic strategy for humans.
A study of over 1.4 million military veterans found that those with moderate or severe traumatic brain injury (TBI) are more likely to die by suicide, with a significant increase in firearm use as a means of suicide. The researchers emphasize the importance of screening for lifetime history of TBI to prevent future deaths by suicide.
A recent study found that higher maternal Choline levels during pregnancy can prevent fetal brain developmental problems caused by marijuana use. Infants exposed to prenatal marijuana had decreased cerebral nervous system inhibition and lower 'regulation' scores, leading to attention and social function problems later in life.
New studies by CU researchers reveal that both genetic and environmental factors play significant roles in the onset of vitiligo. The findings suggest that unidentified factors contribute to the disease's complex etiology, complicating personalized medicine approaches.
A recent study found that US physicians prescribe opioids more frequently to patients during hospitalization and at discharge compared to peers in other countries. The study adjusted for pain severity and patient illness, but still observed a significant difference.
A new study found mothers living near intense oil and gas development have a 40-70% higher chance of having children with congenital heart defects. The study analyzed 3,324 infants born in Colorado from 2005-2011, estimating monthly intensity of well activity to confirm positive associations between maternal exposure and CHDs.
Researchers found that patients undergoing combined breast and gynecologic surgeries had significantly longer hospital stays and higher complication rates compared to those with single-site surgery. The study highlights the importance of separating these procedures for better patient outcomes.
The University of Colorado Cancer Center is enrolling patients in a Phase II clinical trial evaluating the effectiveness of Rucaparib, a PARP inhibitor, as maintenance therapy for endometrial cancer. The trial aims to determine the drug's ability to prevent cancer cell growth and death in patients with metastatic or recurrent disease.
Ashkenazi Jewish women with known BRCA status have a 98% 5-year survival rate compared to 74% for those without knowledge, requiring less chemotherapy and extensive surgery. Early testing could prevent breast cancer or start high-risk screening at an earlier age.
Researchers sequenced canine cancer cell lines to identify human-like genetic changes driving canine cancers. The study found 61 genetic variants that match known drivers of human cancer, and showed sensitivity to human medicines.
A University of Colorado Cancer Center study reveals that combining immunotherapy with histone deacetylase (HDAC) inhibition sensitizes cancers to anti-PD1 therapy. HDAC inhibitors upregulate major histocompatibility complex (MHC) proteins, presenting antigens to T cells and making them effective against cancer cells.
A new study finds that cancer incidence increases uniformly with age, contradicting the traditional model of oncogenesis. The research suggests that selection pressure acting on healthy cells and cancer cells determines who gets cancer, with a shift in favor of cancer-causing mutations in older age.
New research highlights the importance of diverse genetic data in understanding complex traits and diseases. By studying a large number of groups together, scientists have discovered dozens of discoveries that would not have been possible in single-population studies.
The study found that indoor tanning is often free at secondary facilities, especially apartments, and offers discounted rates at primary tanning salons. Marketing strategies like unlimited tanning packages and time-limited price reductions appeal to young adults.
A study found that 54% of FDA dermatology advisors received at least one payment from pharmaceutical companies following drug approvals. The majority of these payments came from competitors rather than manufacturers, sparking concerns about potential biases in advisory decisions.
Researchers developed COXEN, a predictive tool that analyzes gene expression to predict response to chemotherapy in bladder cancer patients. The trial showed COXEN's ability to predict response using Gemcitabine-Cisplatin (GC) biomarker.
A new study presented at ASCO 2019 shows that brigatinib is effective in patients who have received another next-generation ALK inhibitor. The 40-50 percent response rate suggests that brigatinib may be a useful treatment option for these patients. Detailed molecular analyses will help determine the characteristics of patients sensitiv...
A recent study found that older adults are using cannabis for various reasons, including pain management and depression. Despite the benefits, many report barriers to accessing medical marijuana, such as a lack of provider education and stigma. The study suggests that healthcare providers need to be more open to discussing cannabis use...
A survey of 48 oncologists and healthcare providers found that most believe medical marijuana has benefits for cancer patients, but are uncomfortable prescribing it. The main concerns include uncertain dosing, limited knowledge of available products, and potential interactions with other medications.
A virtual clinical trial using real-world data found entrectinib to be more effective than crizotinib in treating ROS1+ lung cancer. Patients on entrectinib stayed on treatment longer and had a 44% increased chance of cancer recurrence compared to those on crizotinib.
A University of Colorado study found that young-onset patients with colorectal cancer often experience prolonged rectal bleeding before diagnosis, leading to advanced stage cancer at the time of diagnosis. The average delay between symptom onset and diagnosis was 294 days.
A recent study published in Journal of Thoracic Oncology found that about 3% of brigatinib patients experience shortness of breath within hours of starting the drug. However, with appropriate supportive care, most patients can rapidly build tolerance and continue on the drug without incident.
A study published in the New England Journal of Medicine suggests that climate change may be contributing to a mysterious epidemic of chronic kidney disease among agricultural workers. The researchers found that heat exposure and heavy labor are common factors in the disease, which is also linked to toxins such as glyphosate and lead.
Scientists at CU Anschutz Medical Campus identified a rare genetic mutation causing an immune dysregulation syndrome, characterized by recurrent infections and autoimmune complications. The discovery provides unique insights into cell biology and suggests the possibility of treating the disease with gene therapy.
A study found that younger, more active older adult women prefer wearable sensors for personal activity data collection, while their parents prefer smart home sensors. The technology's acceptability is crucial for promoting adoption into daily life.
A CU School of Medicine postdoctoral fellow created an international database of women scientists to address concerns that women's scientific expertise is often excluded in the public realm. The database has grown to list over 7,500 women and features a study published in PLOS Biology.
Research reveals that T-regulatory cells, which suppress the immune response, are driving tumor resistance to radiotherapy. Inhibiting EphB4-ephrinB2 interaction reduces T-reg cell activity, allowing immune cells to target cancer effectively.
A study by CU Anschutz researchers found that men who have sex with men have unique gut microbiomes that drive immune activation and may increase their risk of HIV infection. The study suggests a direct link between microbiome composition and immune activation in HIV-negative and HIV-positive MSM.
A group of medical students from the University of Colorado Anschutz Medical Campus improved Wikipedia articles on skin-related diseases, increasing their visibility by millions of views. They added evidence-based information from Cochrane Reviews to make the articles more complete and accurate.
A University of Colorado Cancer Center study identifies a possible way to predict which melanomas are hot and cold for immunotherapy. Tumors with specific genetic changes in the NF-kB signaling pathway are more likely to respond to anti-PD1 immunotherapies, suggesting a potential biomarker for treatment prediction.
A study published in Fertility and Sterility found that female reproductive endocrinology and infertility subspecialists make $67,000 less than their male counterparts annually. Researchers attribute the pay gap to factors such as salary compression and women's reluctance to negotiate over salary.
A University of Colorado Cancer Center study identifies a compound that inhibits the action of the SIX1/EYA transcriptional complex, which is involved in cancer metastasis. The compound dramatically suppresses breast cancer-associated metastasis in mouse models.
Researchers found tarloxotinib effective against various cancer types, including ovarian and breast cancers with NRG1 gene fusions. The drug targets low-oxygen conditions, making it potentially more tolerable than existing therapies.
Researchers found that combining adavosertib with irinotecan, navitoclax or capecitabine increased its effectiveness against pancreatic cancer. The study aimed to identify new combinations of drugs to enhance adavosertib's effect.
A University of Colorado Cancer Center study found that tobacco use creates a field of precancerous cells that fertilize nearby cancer cells, enabling them to grow and resist therapy. The research suggests that these precancerous cells provide fuel through EGFR ligands, allowing cancer cells to bypass PI3K inhibition.
A new CU Anschutz study found that physical activity is essential for maintaining substantial weight loss, rather than diet. Successful weight-loss maintainers engage in high levels of physical activity to prevent weight regain.
A study found that mild sleep apnea in pregnant women was associated with higher blood sugar levels and an increased risk of childhood obesity. The researchers suggest that addressing sleep apnea may help improve maternal and infant outcomes.
A study by CU Anschutz researchers found that 79% of Catholic hospitals reported their affiliation, but only 28% explained the impact on patient care. Greater transparency would allow for informed patient choices.
A study led by the University of Colorado found that choline supplements can prevent fetal brain developmental problems when a mother has the flu during pregnancy. Higher levels of choline in mothers also improved their children's ability to pay attention and regulate their behavior.