Researchers identified mechanisms that allow TRK-fusion lung cancer cells to evade targeted therapies. Specific genetic changes, including amino acid positions in TRK fusion genes, confer resistance to LOXO-101. This study's findings may have implications for other kinase-driven cancers treated with tyrosine kinase inhibitors.
Researchers developed a method to isolate circulating tumor cells from blood samples using gas microbubbles. The technique successfully isolated up to 80% of cancer cells in some cases, offering a rapid and inexpensive way to analyze these rare and fragile cells.
A national survey of IVF cycles found that elective single-embryo transfer results in fewer adverse outcomes and ideal pregnancy outcomes, including single, full-term babies of normal birth weight. The study also shows that insurance coverage for infertility treatment is associated with increased use of elective single-embryo transfer.
A University of Colorado Cancer Center study identifies epiregulin as a potential biomarker for lung cancer, with mice lacking the growth factor developing fewer tumors and reduced inflammation. The findings suggest epiregulin increases cell proliferation, promoting tumor growth.
A new study confirms the success of Boot Camp Translation, a patient-engagement method that translates complex medical guidelines into locally relevant language. The process has improved cancer testing, asthma management and hypertension control in various communities across the US.
A CU Denver study reveals that many communities fail to incorporate historic preservation into their disaster management plans, putting cultural resources at risk. The study identified numerous historic sites in hazardous areas, including those in Florida's National Register of Historic Places in a 100-year floodplain.
A new tool, IMPACT, interprets whole-exome sequencing data to identify candidate genes linked to cancer and recommends FDA-approved targeted treatments. The tool has been validated in patients with EGFR-mutated non-small cell lung cancer and melanoma, showing its potential to accelerate precision medicine.
The University of Colorado Anschutz Medical Campus has established a $10 million National Behavioral Health Innovation Center with a five-year commitment from The Anschutz Foundation. The center aims to improve mental and behavioral health through innovative approaches, collaboration, and community engagement.
African American patients are less likely to receive a common genomic test that predicts the seriousness of early-stage breast cancer. The study found higher scores among African Americans, indicating an increased likelihood of aggressive tumor biology benefiting from chemotherapy.
A recent study found that only about half of suicidal patients are questioned about their access to firearms or lethal means by emergency department doctors, leaving a significant opportunity for intervention. Easy access to guns is particularly concerning, with 25% of patients keeping loaded and unlocked guns at home.
Researchers are developing personalized assessment tools to predict and prevent radiation-induced cancers in astronauts and on Earth. High-energy ions, like those used in cancer treatments, pose a risk of new tumors and more aggressive cancer types.
Researchers at CU Anschutz Medical Campus are conducting a study to detect prenatal marijuana use and its association with adverse outcomes, such as fetal growth restriction and hypertension. The study aims to develop a survey tool for new mothers to provide accurate information on marijuana use during pregnancy.
A key brain receptor has been found to both strengthen and weaken synapses, offering new insights into mechanisms driving depression, drug addiction, and Alzheimer
A University of Colorado study reveals a weak link between MN1 and aggressive AML, suggesting EPZ-5676 as a potential tool to break this link. The drug inhibits chromatin regulators Mll1 and Dot1l, which are essential for MN1's leukemia-causing effects.
Researchers at the Colorado School of Public Health have published a comprehensive review of ways to monitor physical activity and tools for occupational exposure scientists. The study highlights complex relationships between physical activity and common chronic diseases, such as heart disease and arthritis.
A recent study found that over half of elderly colorectal cancer patients receive ineffective treatments, leading to significant financial burdens. The study examined data from over 20,000 Medicare patients between 2000 and 2009, revealing a 32% increase in treatment costs and only a one-month increase in median survival.
Researchers have identified the EZH2 gene as a driver of aggressive pediatric leukemia subtype ETP-ALL, characterized by stem-like cells and increased growth signaling. The study provides potential therapeutic targets, including the existing drug ruxolitinib, for this previously challenging disease.
A large-scale analysis of patient records found that chemotherapy before radiation therapy did not improve overall survival rates for head and neck cancer patients. Patients who received concurrent chemotherapy and radiation had slightly longer median overall survival times compared to those receiving chemotherapy alone.
A study published in Cancer found that combining chemotherapy with radiation therapy improves survival rates among a subset of elderly head and neck cancer patients, specifically those aged 71 to 79. This improvement was not previously shown in patients older than 70 years.
The 'NewSTEPs 360' program aims to improve timeliness measures in newborn screening, resulting in more infants receiving early treatment for rare but serious conditions. The initiative provides quality improvement training and technical assistance to selected states, aiming to reduce delays in diagnosis and save lives.
Researchers found that pay-for-performance measures disproportionately penalize hospitals caring for poor, minority, or publicly insured patients. Adjusting for social determinants of health reduced penalties for these hospitals.
Researchers have identified antigens that activate autoreactive T cells in autoimmune diabetes, a potential trigger for the disease. The discovery provides insight into how the immune system is tricked into destroying the body's own beta cells.
Researchers have successfully flipped macrophages from a pro-cancer, wound-repair promoting phenotype (M2) to an anti-tumor, kill-type (M1) phenotype. This breakthrough could lead to improved cancer immunotherapies by enhancing the body's natural killer cells' ability to target tumor tissue.
A national survey reveals that high school wrestlers are prone to skin infections, with the head and neck being the most frequent site. Most skin infections can be treated within three to six days, but some may have more serious eye and neurological involvement.
A study found that HER2-positive lung cancer is caused by either gene amplification or mutation, rather than both. This distinction implies the need for different treatment options, including targeted therapies approved for breast cancer.
A University of Colorado study found distinct genetic drivers in colorectal cancer among young and old patients, with potential implications for targeted therapies.
A recent study published in JAMDA found that nearly half of hospital readmissions from post-acute care facilities occur within 14 days, and patients who experience readmission have a higher mortality rate. The researchers also identified the need for invasive devices and advanced care as contributing factors to readmissions.
A new study proposes that genetic drift contributes to the development of leukemia in young children. The researchers used a computational model describing blood stem cell population dynamics and found that drift plays a significant role in early-life leukemia formation. In contrast, selection drives leukemia development in older adults.
A new study reveals that docetaxel retains effectiveness in patients with castration-resistant metastatic prostate cancer (mCRPC) treated with abiraterone. Following abiraterone, 40% of patients experienced a 50% reduction in prostate-specific antigen (PSA), demonstrating the activity of this drug sequencing.
A new clinical trial is evaluating a method to pinpoint and spare healthy lung tissue during lung cancer radiotherapy using advanced image analysis techniques on 4D CT scans. The researchers aim to improve quality of life for patients by sparing functional portions of the lung.
Even before the Affordable Care Act (ACA), cancer survivors in non-expansion states had limited access to healthcare. The study analyzed data from the 2012 and 2013 Behavioral Risk Factor Surveillance System and found that these survivors were less likely to have a personal doctor, receive an annual checkup, or see a doctor due to cost.
A study by the Colorado School of Public Health found cheerleading to be relatively safe compared to other high school sports, with an injury rate ranking 18th out of 22. However, severe injuries were more common than expected, highlighting the need for prevention efforts and standardized safety measures.
Results of a phase 1b clinical trial show ONT-380 achieves at least stable disease in 58% of patients with metastatic HER2+ breast cancer, including 11 partial responses and one complete response in patients with brain metastases.
A phase IIR/III clinical trial investigates whether surgery or stereotactic body radiation can control metastasis while continuing breast cancer therapy. Researchers aim to define parameters for determining which patients benefit from this 'weeding the garden' approach.
A phase 1 clinical trial found that enzalutamide is active and well-tolerated alone and with fulvestrant in patients with advanced breast cancer. The study supports a larger trial of the combination, building on promising preclinical data and targeting androgen receptors in breast cancer.
A new study published in Annals of Oncology shows that abiraterone acetate is effective in treating aggressive prostate cancers, even those with high Gleason scores. The treatment extended progression-free survival by up to 16.5 months in patients previously treated with docetaxel.
New study from CU Denver finds that even low levels of natural gas leakage can make it as damaging as coal for climate change. The research shows a leakage rate of 3.9% over 20 years and 9.1% over 100 years makes natural gas equivalent to coal in terms of greenhouse gas emissions.
Researchers found that therapeutic hypothermia significantly reduces damage to the brain after cardiac arrest, with patients who received treatment experiencing better neurological outcomes and higher survival rates. The therapy has been shown effective on both shockable and non-shockable heart rhythms.
Researchers have found that bone marrow stem cells can produce fat cells that contribute to chronic illnesses like diabetes and cardiovascular disease. The discovery highlights the possibility of genetically modifying fat-storing cells to prevent or reverse fat-related diseases.
A CU research study found that Latino patients on dialysis prefer aggressive care and earlier discussions about end-of-life decisions. The study highlights the importance of delivering palliative care in a culturally sensitive way to meet the needs of this growing segment of the US population.
A University of Colorado Cancer Center study shows that breast cancer patients without prescription drug coverage are less likely to start and continue hormonal therapy due to high costs. Women from lower-income households were particularly affected, highlighting the need for affordable prescription coverage.
Researchers at CU Anschutz Medical Campus discovered that patients given opioid pain medication on discharge had a 25% higher risk of becoming chronic users. The study found that medical patients were more likely to progress to chronic use compared to surgical patients.
Research suggests that healthy cells are optimized for a healthy ecosystem; changes in this ecosystem allow cancer-causing mutations to outcompete healthy rivals, leading to an increase in cancerous cells. Inflammation is a critical factor in this process, hurting the growth and maintenance of healthy B-cell progenitor cells.
A lack of sufficient sleep reduces the body's sensitivity to insulin, impairing blood sugar regulation and increasing diabetes risk. The study found that insufficient sleep impairs insulin sensitivity, leading to a reduced ability to regulate blood sugar levels.
A recent study published in International Journal of Gynecological Cancer found that protein CK5 marks ovarian cancers likely to be resistant to cisplatin. This marker could help predict and analyze platinum resistance, potentially improving treatment outcomes.
Researchers found that nanoparticles can evade the human immune system by changing their sugar coating, making them more visible during MRI imaging. This breakthrough could lead to the development of new medicines to target tumors.
Research by University of Colorado School of Medicine faculty found that one in five pediatricians dismiss families who refuse vaccines. The study suggests that states with philosophical exemption laws and easier exemption processes have lower vaccination rates and higher rates of vaccine-preventable diseases.
A large study published in The Lancet found that limited exposure to general anesthesia in infancy does not increase the risk of developmental issues. The study involved over 700 infants and compared the outcomes of children who received general anesthesia with those who received spinal anesthesia.
A study published in the Journal of the American College of Radiology describes a successful intervention to decrease anxiety related to mammography, increasing breast cancer screening rates. The study found that information about the logistics and outcomes of mammography reduced anxiety and improved understanding among participants.
Researchers found no significant difference in new polyp formation between patients with vitamin D and/or calcium supplements and those without. The study's results contradict previous findings in models and smaller human trials, highlighting the need for further research on promising cancer prevention strategies.