A new study from the University of Colorado School of Medicine found that elderly drivers are often more open to discussing their driving status than clinicians initially thought. The research suggests that health care providers should start conversations with elderly drivers earlier, perhaps at age 65 when Medicare benefits kick in.
Researchers have discovered a new oncogene, RET rearrangement, which is present in 15.7% of lung adenocarcinoma patients and may be targeted with existing tyrosine-kinase inhibitors. This finding presents a promising treatment option for patients with this specific mutation.
A new study by the University of Colorado Anschutz Medical Campus found a significant increase in unintentional ingestions of marijuana by children since Colorado's drug laws modification in 2009. The number of children treated for exposure to marijuana increased from zero before 2009 to 588 after October 1, 2009.
A recent study published in Cell Reports reveals how certain genes control the ratio of proteins p21 and PUMA, which determines whether tumors adapt or die when faced with p53-activating drugs. The researchers found a handful of genes that fine-tune this balance.
Researchers found a genetic risk factor for pulmonary fibrosis in people with the MUC5B gene variant, associated with increased lung inflammation and scarring. The study suggests that pulmonary fibrosis may be part of a larger syndrome, potentially leading to early detection and treatment.
A study published in JAMA found that a specific genetic variation is associated with improved survival in some cases of pulmonary fibrosis. The researchers identified the MUC5B promoter polymorphism as a key factor, which may lead to the development of new treatments for this deadly lung disease.
A recent study published in JAMA found that dual-chamber implantable cardioverter-defibrillators (ICDs) are associated with more complications than single-chamber devices. The research, led by Pamela Peterson, MD, suggests that the added complexity of dual-chamber ICDs may outweigh any potential benefits.
Researchers found that pro-factor D, a protein secreted by fat cells in the knee joint, is linked to rheumatoid arthritis. The discovery could lead to new gene therapies to eliminate the protein and prevent disease progression.
Researchers discovered that combining a few microRNAs enhances anti-breast cancer activity without the unwanted side effects of amplifying a single microRNA. This technique targets tumor-specific genes while sparing healthy tissue.
The study found that couples with larger age gaps have lower earnings, less education, and reduced cognitive abilities. Physical attractiveness was also negatively affected in these relationships. The researchers suggest that social networks play a key role in shaping marriage choices and earning potential.
A new study published in JAMA found that 129 out of 6,920 injured children suffered gunshot wounds, with 14% accessing unlocked, loaded guns. The study highlights the importance of storing firearms safely to prevent child deaths and injuries.
A recent study by the Colorado School of Public Health found that health impact assessments can identify potential health risks associated with natural gas development. The assessment identified health effects such as headaches and respiratory issues in a western Colorado town, highlighting the importance of considering public health i...
A new study found that criminal background checks and pre-admission screening questions are ineffective in predicting students who will commit crimes on college campuses. Only a small fraction of students with prior criminal records were identified as likely to engage in misconduct during college.
A multicenter study found that 84% of lung cancer patients taking crizotinib have low testosterone levels, with 80% experiencing symptoms such as sexual dysfunction or depression. The study suggests that hormone replacement therapies may alleviate these symptoms and provide a new treatment option for affected patients.
Researchers discovered that high cholesterol levels can cause defective cell division, leading to Alzheimer's disease and atherosclerosis. Cholesterol disrupts the process of cell division, resulting in cells with incorrect numbers of chromosomes and genes.
Pulmonary fibrosis is a condition where lung tissue becomes thickened and scarred, with no approved drugs for its most common form. A new study found that genetic variation accounts for approximately one-third of the risk, identifying seven novel genetic risk loci involved in host defense, cell-cell adhesion, and DNA repair.
Breast cancers with high androgen receptor (AR) levels are more likely to relapse after estrogen-targeting therapies. Anti-androgen therapy shows promising responses in cell lines and preclinical models, offering a new potential target for breast cancer treatment.
Research at the University of Colorado Anschutz Medical Campus reveals that hsa-miR-146a is overexpressed in most metastatic bladder cancer tumors. This tiny miRNA molecule plays a crucial role in making bladder cancer more aggressive.
Researchers have identified a set of misregulated genes common to tobacco-related cancers, which are associated with poor patient outcomes in lung and bladder cancers. These genes relate to the regulation of the cell cycle and could serve as a new prognostic tool to predict survival rates for patients with tobacco-related cancers.
A phase 1 clinical trial of Rigosertib, a dual kinase inhibitor, demonstrated the drug's effectiveness in patients with head and neck cancer who have failed platinum-based therapies. The results led to an 80-patient multi-institutional Phase II trial to explore biomarkers for accurate patient matching.
Research reveals Six2 homeoprotein promotes detachment of breast cancer cells from tissues, enabling their survival through the bloodstream and colonization at distant sites. Higher Six2 expression in human breast cancer tissues is associated with aggressive metastasis.
Researchers found that Mer receptor overexpression correlates with melanoma progression and aggressiveness, driving disease severity. Investigational drug UNC1062 blocks Mer survival signaling, killing melanoma cells in dishes and mouse models.
A novel protein governing metastasis and chemoresistance in pediatric osteosarcoma has been discovered using K9 osteosarcoma samples. The IGF2BP1 protein's overexpression is linked to aggressive disease progression, offering a potential target for treatment.
Research shows that inhibiting autophagy in breast cancers dependent on it may be enough alone to kill the disease. Chloroquine, an anti-malaria drug, has been found to inhibit autophagy and is being tested as a potential treatment for certain breast cancer subtypes.
The novel inhibitor XL-184 (Cabozantinib) showed significant tumor growth decrease in 12 colorectal cancer explants, with 8 exhibiting stable disease. The drug targets both VEGFR2 signaling pathway and c-MET for survival of tumor cells.
Researchers found that Paragazole increases the sensitivity of triple-negative breast cancer cells to chemotherapy by inducing expression of estrogen receptors. The drug outperforms chemotherapy alone in a range of breast cancer cell lines, offering new hope for treatment options.
A CU Cancer Center study reveals that the transcription factor SPDEF regulates E-Cadherin production, inhibiting prostate cancer metastasis. The researchers found that increasing or decreasing SPDEF levels directly affects E-Cadherin expression, making it a crucial factor in preventing cancer spread.
Researchers at the University of Colorado Cancer Center have developed a new technology that uses cholesterol rafts to deliver genetic payloads into cancer cells. This innovative approach overcomes the long-standing challenge of delivering nucleic acids across cell membranes.
A study found that less than half of emergency room medical providers believe most or all suicides are preventable and rarely ask about firearm availability. This can lead to missed opportunities to save lives, as many providers think it's the responsibility of psychiatrists or social workers to address firearms.
Youth with type 1 diabetes face increased risk of heart attacks, strokes, blindness, and kidney failure after transitioning to adult care without adequate support. The study found that nearly 80% of individuals had left pediatric care by age 21, highlighting the importance of effective transition planning.
Researchers found that bitter melon juice restricts glucose metabolism and kills pancreatic cancer cells, cutting their energy source. The study used mouse models and showed a 60% reduction in disease development compared to controls.
A new protein Smad7 has been found to protect against and heal mouth sores commonly associated with cancer treatment. The protein was administered genetically or topically to mouse models, resulting in dramatic resistance to oral mucositis development.
Researchers have found that inhibiting the Mer receptor increases sensitivity to chemotherapy in leukemia cells, reducing toxic side effects while maintaining effectiveness.
A recent study discovered a gene responsible for obesity in mice, and deleting it eliminated obesity even on high-fat diets. The researchers believe this may be replicated in humans using existing technology targeting the specific gene.
Women with Lynch Syndrome have a 50-60% lifetime risk of developing colorectal cancer, but an 11% risk of breast cancer, 11% risk of kidney cancer, and 9% risk of bladder cancer. This study expands the spectrum of cancers associated with Lynch Syndrome.
A University of Colorado Cancer Center review found that resistant starch kills pre-cancerous cells and reduces inflammation, promoting the growth of good bugs in the bowel. Consuming resistant starch, found in legumes, green bananas, and starchy products, may also have implications for breast cancer prevention.
A study published in Journal of Pediatric Oncology Nursing found that discomfort with tube feeding is the main reason families prefer IV nutrition. Tube feeding is associated with better gut function and lower infection rates, but perceived discomfort leads to a preference for IV feeding.
A multi-site clinical trial shows that Bright IDEAS problem-solving skills training reduces mothers' levels of anxiety and symptoms of posttraumatic stress after a child's cancer diagnosis. The training also improves overall coping with a child's illness, making things seem manageable for parents.
Researchers warn that molecularly targeted therapies may stunt growth, delay puberty, or increase the risk of diabetes in children. The lack of long-term data on these treatments raises concerns about their use in pediatric patients. Experts recommend using these drugs only in clinical trials to monitor side effects.
A study by University of Colorado Anschutz Medical Campus researcher Christopher Sibona found that 40% of people would avoid someone who unfriended them in real life. The factors predicting avoidance include the person's emotional response, geographical distance, and the strength of the relationship before the unfriending.
Silibinin kills UVA-damaged cells, protecting against DNA damage. It also protects human skin cells from UVB radiation by increasing expression of interleukin-12, promoting cell repair.
A University of Colorado study reveals that lung and GI cancer patients are more prone to E. coli and Klebsiella pneumoniae infections, particularly after aminopenicillin treatment. This knowledge can inform targeted antibiotic therapy before complications arise.
A University of Colorado Cancer Center study found that SPARC acts as an anti-inflammatory drug, reducing tumor growth and metastasis in bladder cancer. The protein is produced by healthy tissue to mute tumors, but aggressive cancers suppress its production, leading to faster disease progression.
Researchers discovered that grape seed extract selectively targets advanced colorectal cancer cells with fewer genetic mutations, leading to increased effectiveness in treatment. The compound induces oxidative stress and programmed cell death, reversing its effects when antioxidants are present.
Researchers found that choline supplementation during pregnancy and early infancy inhibited the response to repeated sounds, a trait commonly seen in schizophrenia patients. The study suggests choline may be a new approach to schizophrenia prevention.
Researchers found three distinct subtypes of non-Hodgkin's lymphoma, each more aggressive than the next, with varying levels of abnormal DNA methylation. This study suggests that epigenomic abnormalities play a significant role in cancer development and progression.
A high-fiber diet, rich in inositol hexaphosphate (IP6), can control prostate cancer progression by inhibiting tumor growth and slowing glucose metabolism. Researchers found that IP6 reduced tumor volumes and slowed glucose metabolism in prostate cancer models.
A new study proposes a possible pathway to benefit from drugs for lung cancer prevention by identifying microRNA-34c as a surrogate endpoint. Changes in its expression six months after treatment correlate with benefit from the drug, potentially speeding up the pace of discovery and bringing new agents to market.
A study published in the American Journal of Public Health found that timely reminders from state or local health departments are more effective at increasing immunization rates among preschool children than those from primary care practices. The study suggests that partnerships between public health departments and primary care provid...
A new study by University of Colorado researchers found significant differences in eligibility criteria for Part C early intervention services among US states. The study highlights the need for more uniform criteria to ensure that all eligible children receive necessary services.