A Colorado School of Public Health researcher found that a new federal disclosure law has little effect on the prescribing of certain medications, including statins and SSRIs. The study suggests that transparency is important but may not be enough to deter physicians from accepting payments from pharmaceutical companies.
A study published in Cancer Research found that RalA and RalB proteins are associated with aggressive cancer characteristics in human tumors. The signature of genes changed by these proteins predicts poor outcomes. Removing these proteins from cancer cells may stop the genetic changes that cause aggressive cancer.
High doses of beta-carotene, selenium, and folic acid have been shown to increase cancer risk in a recent study. The University of Colorado Anschutz Medical Campus has warned that these supplements should not be taken beyond their recommended daily allowance.
A study by Guido Frank and colleagues found that anorexic women's brains are overactive in response to food cues, while obese women's brains are underactive. This suggests a link between brain function and eating behavior in these conditions.
A study published in Pediatrics shows that school-based health centers are effective in delivering vaccines to adolescents, particularly when students receive timely reminders. The research found that 77% of females and 66% of males received at least one vaccine after receiving reminders.
A study published in Nature Genetics found a correlation between eye color and the risk of developing certain serious skin conditions. People with blue eyes were less likely to have vitiligo, while those with brown eyes may be at lower risk for melanoma.
Researchers discovered that strong light can activate a protein called Period 2, which regulates heart metabolism and minimizes damage from heart attacks. This finding suggests that daylight exposure could reduce the risk of having a heart attack or suffering damage from one.
A team of scientists at CU Denver has developed a novel energy system that increases the amount of energy harvested from microbial fuel cells by more than 70 times. This breakthrough improves energy efficiency and enables active extractions of electrons from bacteria.
Researchers at the University of Colorado Anschutz Medical Campus found that a lack of a specific gene interrupts neural tube closure, a condition that can lead to serious birth defects. The study reveals new insights into neural tube development and opens up a new pathway for understanding how neural tube defects occur.
A recent report highlights the dangers faced by US youth in the workplace, with dozens dying and thousands injured annually due to poorly regulated environments. The Colorado School of Public Health is advocating for stronger federal oversight and research into preventing workplace injuries among young people.
A University of Colorado Cancer Center study found that men taking crizotinib for lung cancer experience a significant drop in testosterone levels, which can lead to fatigue, low bone density, and decreased sex drive. Regular monitoring and treatment of testosterone deficiency can improve patients' overall quality of life.
A recent study published in the Journal of the American Academy of Dermatology found that UV photographs can predict melanoma risk factors in 12-year-olds. The study's results suggest that primary care physicians can use UV photography to provide better sun protection counseling, potentially preventing melanoma cases.
A new study found that air emissions from hydraulic fracturing (fracking) near natural gas drilling sites can cause non-cancer health impacts, such as eye irritation, headaches, and respiratory problems. The study also calculated higher cancer risks for residents living closer to wells.
A recent study found that the protein Mer resides in the nucleus of leukemia cells, suggesting it may influence gene expression and contribute to cancer development. This discovery opens up new avenues for targeted treatments and potentially more accurate diagnoses.
A major study published in the Journal of Clinical Investigation has identified a method to stop bladder cancer from metastasizing to the lungs. The study found that adding the protein RhoGDI2 to tumors reduces versican production, blocking the ability of cancer cells to grow in the lungs.
The largest-ever study of childhood Acute Lymphoblastic Leukemia (ALL) reveals a remarkable improvement in the five-year survival rate, increasing from 83.7% in 1990-1994 to 90.4% in 2000-2005. This significant advancement is attributed to better treatment and drug optimization, not the introduction of new drugs.
Researchers identified ways to reduce costs of molecular profiling and targeted therapies, enabling more patients to benefit from personalized treatments. The methods include recommending testing only for high-risk patients and merging tests to lower combined prices.
A University of Colorado Cancer Center investigator has received a prestigious grant to develop targeted treatments for squamous cell lung cancer. The project aims to identify prognostic signatures and molecular targets for early-stage patients, paving the way for personalized cancer care.
A phase I clinical trial of patients with advanced pancreatic cancer showed promise with rigosertib, achieving stable disease in 11 of 19 patients for a median duration of 113 days. The drug targets PLK1 and PI3K signals that allow cancer cells to divide rapidly.
A CU Denver study reveals a positive correlation between Green School practices and student achievement in science, with the Midwest region showing the highest average survey score. The research highlights the importance of green schools in promoting environmental literacy and sustainability.
The new drug Vemurafenib doubles the median survival time of metastatic melanoma patients with a specific genetic mutation, from 6 months to 15.9 months. In responding patients, the drug stops cancer progression for an additional 6.7 months.
Researchers found two forms of an enzyme in fructose metabolism, one causing fatty liver and obesity, the other protecting against these conditions. The study provides new insights into the cause of metabolic syndrome, a condition affecting over 25% of adults in the US.
Researchers found that breast cancers can hijack an embryonic program to promote tumor growth and survival. A new study details how this 'on-off' switch is flipped by a protein called SIX1, which allows doctors to delete the pathway when it promotes tumors.
Four new drugs offer innovative methods of action against prostate cancer, including bone protective agents, hormone treatments and immunotherapy. These advancements could extend survival prognosis and potentially turn prostate cancer into a chronic disease.
Research from the Colorado School of Public Health shows that breastfeeding can lower body mass index for children of diabetic pregnancies, reducing their risk of childhood obesity. Children who were breast-fed had a slower BMI growth as they grew older compared to those who nursed less than six months.
Research suggests that GLBT smokers face unique challenges in quitting, with a quarter uncomfortable approaching doctors for help. More than 70% of surveyed GLBT smokers have no plans to quit smoking.
Researchers recommend a stop-and-go approach to balance oxaliplatin dose with neurological side effects, maximizing effectiveness while minimizing harm. Supplements such as calcium and magnesium may mitigate drug damage, improving patient outcomes.
Different subgroups of non-small cell lung cancer exhibit distinct patterns of spread in the body, suggesting fundamentally different diseases. Targeted therapies have shown dramatic clinical responses in patients with ALK positive NSCLC, offering new hope for treatment.
A study of 64,659 women found that only 173 received recommended breast screening MRI despite being at high enough risk. The researchers aim to understand the disconnect and assess the value, feasibility, and implementation of breast MRI screening.
Researchers found grape seed extract to be effective in killing head and neck squamous cell carcinoma cells without harming healthy cells. The extract damages cancer cells' DNA and prevents repair pathways from functioning.
Researchers found artists average 3.95-6.16 years on album charts, 34% debut once, 50% on singles chart; second phase examines music trends and artist longevity
Pregnant women exposed to armed conflict have a higher risk of giving birth to underweight babies due to psychological stress. The study, conducted in the Israeli-occupied territories during the Second Intifada, found a positive association between conflict-related fatalities and low-birth weight children.
A study published in Leukemia identifies a molecular braking process that acute myeloid leukemia (AML) cells use to evade chemotherapy, allowing them to survive treatment. When this brake is removed, AML cells die, providing hope for improved survival rates for patients with the disease.
Scientists have documented how ALK positive advanced non-small cell lung cancer becomes resistant to crizotinib, a previously effective treatment. Researchers now aim to develop combination therapies to tackle this resistance and improve patient outcomes.
Researchers have discovered a key to stopping brain cancer cell growth and migration by inhibiting a specific signaling pathway. The study, published in Nature: Oncogene, shows that targeting the Mer pathway can make brain cancer cells more sensitive to chemotherapy and prevent them from escaping to other areas of the brain.
Researchers have discovered a way to selectively target the glutathione pathway in brain cancer cells, making them more susceptible to chemotherapy. The breakthrough could potentially improve treatment outcomes for the nearly 45,000 people diagnosed with brain cancer each year.
A new downloadable tool from the University of Colorado Cancer Center guides cancer survivors through a personalized exercise plan, helping them set goals and track progress. The program aims to overcome common challenges faced by cancer patients, including fatigue and self-doubt.
A study by the University of Colorado School of Medicine found that crowded emergency departments lead to delayed and less effective pain management for children with acute long bone fractures. Patients were 4-47% less likely to receive timely care and 3-17% less likely to receive effective care when crowding was high.
A recent study published in Clinical Cancer Research found that arginine supplementation can reactivate cancer-fighting T-cells in patients with glioblastoma. This is achieved by replenishing the amino acid arginine, which is depleted due to persistent neutrophil activity. The result is an improved immune response against cancer cells.
A new device developed at the University of Colorado Cancer Center uses gold nanoparticles to detect lung cancer in exhaled breath, distinguishing between small-cell and non-small-cell lung cancer. The device has shown promising results in preliminary studies, with the potential to revolutionize lung cancer screening and diagnosis.
Researchers found that silibinin from milk thistle prevents lung cancer growth by inhibiting COX2 and iNOS production. This natural compound may be as effective as current treatments for lung cancer, targeting promising therapeutic targets STAT1 and STAT3.
Researchers found that elderly individuals over 60 experience reduced specificity in olfactory sensory neurons, making it harder to differentiate between smells. This can lead to malnutrition and increased risk of poisoning due to impaired ability to detect spoiled food and toxic vapors.
Researchers found that inhibiting Notch signalling converts triple-negative breast cancer cells into hormone-receptor positive cells, making them dependent on estrogen. This technique has potential for combination therapy, where a Notch inhibitor is used to make all cancer cells hormone-sensitive.
Researchers discover a compound that prevents Type 1 diabetes in mice and has similar effects on human cells from diabetic patients. The finding signals a new direction in fighting the disease and other autoimmune disorders.
Fecal immunochemical testing (FIT) is an accurate predictor of colorectal cancer, but it remains inferior to colonoscopy for prevention. Yearly FIT screenings may allow treatment to follow closely on the heels of discovery, but practices with repeat testing over time perform poorly.
Researchers will explore molecular changes in prostate cancer progression to therapy resistance using cutting-edge technologies like molecular imaging and ultra-high throughput DNA sequencing.
The University of Colorado Denver has been awarded a $750,000 grant by the National Science Foundation to investigate sustainable cities. The four-year project will bring together researchers from 20 US universities and international partners to reduce energy use, carbon emissions, and mitigate climate risks in urban areas.
A study published in JAMA found that hospitals' compliance with the Children's Asthma Care measures had no impact on patient outcomes, including return to the hospital for another asthma attack. The researchers concluded that these measures may not be suitable for public reporting, accreditation, or pay-for-performance policies.
High levels of fibroblast growth factor-23, a hormone regulating phosphorous levels, can predict premature death in kidney patients. The discovery allows for earlier interventions with drugs to lower phosphorous and reduce hormone levels.
A new study found that simpler defibrillators with fewer risks of surgical problems and death are equivalent in benefits to complex devices. The study analyzed over 100,000 records and suggests re-evaluation of routine use of dual-chamber defibrillators.