Researchers at the University of Illinois Chicago are developing a community-based weight loss program for African American breast cancer survivors. The program aims to improve diet and physical activity habits, as well as reduce body mass index and weight-related health risks.
A study found that anti-tobacco television advertising helps reduce adult smoking rates, with state-sponsored campaigns being the most effective. The researchers analyzed exposure to ads from various sponsors and found a significant association between higher ad exposure and lower smoking rates.
A study published in Molecular Cell found that more than 30% of PDZ domains interact with various membrane lipids, controlling their cellular location and interaction with other protein partners.
Freezing eggs or ovarian tissue for delayed childbearing proves costly for society, with an additional $130,000 required per live birth. The study suggests doing nothing is the most cost-effective option, while freezing eggs is less expensive than ovarian tissue.
The discovery of a previously unknown root extension in hair cells suggests the brain regulates sound sensitivity and head position. This finding challenges current understanding of how hair cells work, with the striated organelle connecting the rootlets to the cell membrane enabling feedback from the cell to the detectors.
Researchers found that a protein called FOXM1 protects cancer cells from chemotherapy and radiation-induced cell death. Combining standard drugs with proteasome inhibitors may improve treatment effectiveness.
Researchers found that naked mole-rats retain a tolerance for oxygen deprivation into adulthood, similar to infant humans. This discovery could lead to better brain cell protection during heart attacks or strokes.
Researchers at the University of Illinois College of Medicine have identified a molecule embedded in liver cells that enables hepatitis C virus entry. Ezetimibe, an FDA-approved cholesterol drug, has been shown to inhibit HCV infection and may provide a new treatment option for patients.
UIC researchers found a molecular mechanism that allows immune cells to reduce tissue damage from inflammation in lung injury. TRPM2 channel modulates the production of reactive oxygen species, helping to protect against inflammation and tissue injury.
A study by University of Illinois at Chicago demographer S. Jay Olshansky found that most US presidents live longer than expected for men of their same age and era. On average, a president's lifespan was 79.8 years during the first eight presidencies
Researchers have identified a key target of DNA damage checkpoint enzymes that must be modified to enable stable telomere maintenance. This finding may hold crucial implications for preventing cancer and understanding human aging.
Researchers have created a highly sensitive surface that enables multivalent binding, allowing for the efficient capture of circulating tumor cells from the blood. The combination of nanotechnology and biomimicry demonstrates great potential for detecting rare tumor cells.
Researchers suggest that the placenta's invasiveness into the uterine wall may lead to increased blood loss at delivery. Biomarkers produced by trophoblasts could potentially predict risk, allowing women to make informed decisions about their birthing site and medical care.
Researchers found that tomosyn regulates synaptic signaling and plays a crucial role in controlling whether synapses get stronger or weaker, affecting memory formation. Knocking out tomosyn impaired fruit flies' ability to retain memories.
A University of Illinois study found that boating, kayaking, and fishing on the Chicago River pose a risk of gastrointestinal illness comparable to swimming at other local waters. The study, which enrolled over 11,000 participants, revealed higher rates of eye symptoms among river users.
Two UIC studies will investigate how mass media and tax/price affect tobacco use. One study measures exposure, search, and sharing of pro-anti-tobacco info to understand smoking behaviors. The other assesses policies impacting retail tobacco prices over a decade.
Researchers at the University of Illinois at Chicago have created a biosensor to measure membrane lipid levels, which can act as switches turning on or off protein-protein interactions. This technique allows for real-time quantification and monitoring of lipid molecules, potentially leading to new pathways for disease treatment.
Researchers discovered that PTK6 protein, which regulates cell growth in normal tissue, activates proliferation of damaged cells in cancerous breast tissue. Mice lacking PTK6 gene were highly resistant to carcinogen-induced colon tumors.
A new study examining direct-to-consumer drug ads on TV aims to determine whether these ads educate patients and improve health or drive up sales. The researchers will analyze data from millions of patients using Nielsen Media Research and healthcare utilization data.
The study aims to investigate the pathobiology of acute lung injury (ALI) and develop novel therapeutic approaches. Researchers will focus on the role of sphingosine-1-phosphate (S1P) in lung cell signaling and inflammation.
African-Americans and Latinos with uncontrolled type 2 diabetes often struggle to meet their therapeutic goals due to economic, social, and cultural factors. Researchers are exploring an intervention combining clinic-based pharmacists and community-based health promoters to improve lifestyle behaviors and medication compliance.
Researchers have identified two gene classes associated with new prion formation in yeast, which may provide a genetic key to understanding neurodegenerative disorders like Creutzfeldt-Jakob and Huntington's disease. The study found that genes important for prion generation also increased toxicity in the presence of certain proteins.
Researchers have identified an enzyme that drives the production of estradiol, a potent form of estrogen, in human breast cancer tissue. The enzyme creates a positive cycle where estradiol sustains its own production, leading to aggressive and potentially deadly cancer types.
A randomized trial found that older workers who received personalized coaching alongside a web-based risk assessment reported improved physical activity and reduced dietary fat intake. In contrast, those in a control group experienced a decline in waist circumference at six months that was maintained at 12 months.
Researchers have found evidence suggesting humans settled in North America around 15,500 years ago, earlier than previously estimated. The discovery was made using optical dating technique at the Buttermilk Creek complex in central Texas.
Victims of severe elder abuse show higher rates of physical harm, mental illness, and substance abuse compared to non-abused individuals. The study found that 29% of abuse victims tested positive for alcohol, highlighting the importance of addressing this issue.
The University of Illinois Chicago has received a $950,000 USDA grant to integrate obesity-prevention strategies into programs for low-income families. The program, Hip-Hop to Health, was previously found effective in reducing body mass index in minority children and will now be tested with an additional population.
Researchers at the University of Illinois Chicago discovered a strong correlation between victimization experiences and substance abuse. Lesbians and bisexual women are more likely to report any victimization over their lifetime, with higher rates of childhood sexual abuse and partner violence.
Researchers at the University of Illinois Chicago have discovered a signaling mechanism in the bacterial ribosome that detects proteins activating genes for antibiotic resistance. This mechanism may lead to the development of more effective antibiotics by understanding how signals are generated and transmitted within the ribosome.
Damage to a specific area of the brain and decreased noradrenaline levels are linked to multiple sclerosis progression. The study found that noradrenaline plays a crucial role in preventing inflammation and preserving blood-brain barrier integrity.
A study by University of Illinois Chicago researchers found that certain strains of Listeria monocytogenes can invade the heart, leading to serious and difficult-to-treat cardiac infections. The bacteria display modified proteins that enable easier entry into cardiac cells, making them a new target for treatment.
Researchers at the University of Illinois Chicago have discovered a family of small molecules that bind to the Ebola virus's outer protein coat and inhibit its entry into human cells. The findings demonstrate a potential breakthrough in preventing Ebola infection, with further studies planned to confirm efficacy.
Researchers focus on disrupting FLVCR protein in mosquitoes to block Plasmodium transmission, a crucial step in preventing malaria spread. By targeting this protein, they hope to develop a vaccine to stimulate an immune response and prevent the disease.
Researchers found that nearly one-third of LGBT youth have attempted suicide in their lifetime, but about 70% did not meet criteria for any mental disorders. The study also revealed that bisexual youth tend to have lower rates of mental health problems compared to gay and lesbian youth.
A University of Illinois Chicago study found that black raspberries can prevent colorectal tumors in two mouse models, reducing tumor incidence by up to 60 percent. The findings suggest that black raspberries' ability to inhibit tumor development may be linked to their suppression of a protein called beta-catenin.
Researchers at UIC are investigating both acquired and familial causes of heart failure with a focus on identifying markers for diagnosis and targets for cures. The five-year funding supports an ongoing program-project grant led by R. John Solaro, which looks at the underlying maladaptive changes that lead to heart failure.
A team of researchers led by Boris Igiâ31 and Emma Goldberg found that long-term evolutionary survival favors plants that avoid self-fertilization. This leads to greater genetic diversity among nightshade species. By avoiding self-fertilization, plants can more easily keep beneficial mutations and protect against harmful ones.
A disease mechanism linking hereditary amyotrophic lateral sclerosis (ALS) to the more common sporadic form has been discovered. The findings point to the P38 enzyme as a key factor in disrupting axonal transport, a disruption that results in loss of connectivity and symptoms of ALS long before the neurons actually die.
Researchers identified distinct brain network abnormalities in children with pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD), with the ADHD group showing more severe dysfunction in working memory circuits. The study suggests that better differentiation between the two disorders could lead to more ac...
Scientists at the University of Illinois Chicago have found a gene expression mechanism that contributes to drug resistance in aggressive ER-positive breast tumors. The study reveals how estrogen and inflammatory proteins work together to drive cancer progression.
Researchers at UIC's Brodie Laboratory have successfully developed a technique to reattach teeth using stem cells, which could lead to a major advance in the battle against gum disease. The new strategy involves using periodontal ligament stem cells to form new fibrous attachments between the tooth and bone.
The University of Illinois Chicago has received a $12.4 million grant to study the predictors of smoking patterns from adolescence through young adulthood. Researchers will track approximately 1,200 youth to explore social and emotional contexts that influence smoking behavior.
Researchers found that medical students who attended workshops on contextual clues during patient examinations showed significant improvement in treating patients with unique contexts. The study suggests that individualized care is something that can be taught and should be part of medical training.
A study by University of Illinois Chicago biologist Jennifer Schmidt found that a female whale shark produced 304 embryos with the same father, suggesting she stores sperm after a single mating event. This finding could indicate that mating occurs as an isolated event rather than in breeding grounds.
Most hospitals surveyed have adopted hand-hygiene practices to prevent MRSA spread. The study found that nearly all hospitals review antimicrobial prescription orders to reduce bacterial resistance.
A new tagging technique developed by researchers at the University of Illinois Chicago provides a clearer and more dynamic view of protein-protein interactions in living mammalian cells. The technique uses luminescence resonance energy transfer to label proteins with differently colored, luminescent molecules, allowing for faster data ...
Babies born between 34 and 37 weeks gestation are more likely to experience respiratory issues, with risks decreasing as gestational age approaches full term. Respiratory distress syndrome was found in 11% of 34-week deliveries and transient tachypnea in 6.4% of the same group.
A new study published in the International Journal of Cancer has identified microRNA-138 as a gene that regulates cancer cell migration and may hold the key to reducing the spread of oral cancers. The research found that a reduced level of microRNA-138 is associated with enhanced ability of tongue squamous cell carcinoma cells to spread.
A new study reveals that physicians often fail to take into account individual patients' circumstances when providing care. The research used actors to simulate real patients in clinic visits, finding that only 22% of physicians provided error-free care during contextually complicated encounters. The study suggests that physician train...
A researcher at the University of Illinois Chicago is using computer modeling to improve the durability of mud bricks and rammed earth structures. The project aims to provide insights into their structural behavior and design safer buildings.