A University of Michigan AI solution, INDIGO, can predict how current drugs can be combined to create more effective tuberculosis treatments. The tool identified several strong combinations, including those with antipsychotics and antimalarials.
Engineers at University of Michigan have developed a 3D transistor array design that integrates high-voltage devices with low-voltage silicon chips, enabling more compact and functional chips. This breakthrough paves the way for individual transistors to handle both digital and analog signals, overcoming current limitations.
Researchers used fluorescent gel to test vaccine effectiveness in wild vampire bats, showing a 2.6-fold increase in population-level immunity compared to conventional non-spreadable vaccines. The study suggests a strategic switch from poisoning to vaccination could lead to a dramatic reduction in rabies across Latin America.
Researchers found that siloxanes increase biogas reactivity, leading to faster ignition and energy release. Harnessing siloxanes could bolster energy production from biogas, reducing costs and making it a more economically attractive option for landfill operators.
Let's Encrypt, a nonprofit certificate authority co-founded by J. Alex Halderman, has revolutionized the implementation of HTTPS on websites worldwide. By offering free certificates and an automated process, it has driven a significant increase in secure websites, with the internet now boasting an 80% adoption rate.
A recent study published in Proceedings of the National Academy of Sciences reveals how the human immunodeficiency virus (HIV) evades detection by the zinc-finger antiviral protein ZAP. Researchers found that HIV's RNA has evolved to mimic a specific sequence, allowing it to dodge ZAP's binding ability.
A new study by University of Michigan researchers found that men who receive caregiving from their spouses are more prone to feeling guilty and depressed due to negative spousal exchanges. In contrast, wives in caregiving relationships show less susceptibility to these effects, suggesting a difference in gender dynamics.
A new study by researchers at the University of Michigan and University of Pennsylvania indicates that individuals disproportionately find polls more credible when their preferred candidate is leading. The study suggests that emphasizing polls' methodological quality can lessen voters' biases, potentially benefiting democracy.
The current US reduction strategy for the Detroit River doesn't address Lake Huron, a major source of phosphorus. The new study suggests that reducing phosphorus loads from the remainder of the watershed by 72% is unrealistic without adjustments to the strategy.
A study found that Hurricane Maria's damage to Puerto Rican coffee farms was not linked to the amount of shade on the farm. However, farmers' socioeconomic context and ability to fertilize their plants were key factors in determining resilience. Weeds played a significant role in the recovery process.
A new U-M study found that various forms of discrimination are associated with increased rates of depression and suicidal thoughts among African American men. The researchers suggest that expanding current mental health interventions to include culturally relevant suicide prevention resources may be a viable option.
A new study from the University of Michigan and Dartmouth University found that US-born residents are significantly more likely to use prescription opioids than new immigrants. The study analyzed data from the national Medical Expenditure Panel Survey and found that US-born residents were more than five times as likely to use opioids a...
Researchers developed implantable scaffolds that attract and analyze cancer cells, providing unique information on disease progression. The technology has potential to improve early detection and monitoring of cancer treatments.
A University of Michigan researcher found that breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those not exposed to the storm. The study suggests disaster-related healthcare disruptions and highlights the need for improved access to healthcare during disasters.
A team at the University of Michigan developed a new catalyst that selectively produces the correct version of twisted molecules, which are essential for medicines. The catalyst is made from mineral nanoparticles and can work in water, reducing costs and environmental impact.
A team of researchers has revealed how nacre, the rainbow-sheened material lining mussel shells, achieves its remarkable hardness and resilience. By studying the nano-engineering process, they found that combining microscopic 'bricks' of aragonite with organic mortar enables strength without losing resilience, setting it apart from hum...
A University of Michigan study found that 15% of older adults readmitted to hospitals within a month after discharge, with many returning for preexisting infections. Patients discharged home or to home care were more likely to return with linked infections than those discharged to skilled nursing homes, contradicting conventional wisdom.
A University of Michigan study found that minority groups perceive negative news as a call to action, increasing collective effort and long-term change. Negative media depictions can inspire positive behaviors among group members.
A team of researchers has revealed the structure of P-Rex1 bound to Gbg, providing a detailed understanding of how this protein complex promotes cell movement and metastasis. The findings offer important insights into cancer cell migration and regulation, paving the way for potential therapeutic targets.
Biologists have documented the widespread presence of the notorious chytrid fungus in 80 species of frogs from lowland rainforest sites in the Peruvian Amazon. The study found that even lowland frogs with high levels of fungal infection showed no external signs of disease, suggesting they could serve as a large disease reservoir.
Researchers at the University of Michigan have discovered that unstable metal organic frameworks can be used to deliver insoluble drugs in an amorphous state, increasing bioavailability. The MOF delivery system allows for rapid release of drugs, with controlled dosage and minimal toxicity.
A new study from the University of Michigan suggests that an opt-out organ donation policy could alleviate some of the burden on US waiting lists, but its impact would be marginal. The researchers found that such a policy could potentially translate to large gains in life years for thousands of patients awaiting organ transplantation.
Researchers at University of Michigan discovered a new way to calculate interaction between metals and alloying materials, enabling faster search for materials with high hardness and resistance to cracking. This breakthrough could accelerate development of better alloys for turbine engines and nuclear reactors.
A new 3D structure made from protein fibers allows for the reliable growth of patient cancer cells, enabling doctors to test medications on model tumors grown from a patient's own cells. This breakthrough could lead to more effective treatments and better understanding of cancer biology.
A new study by the University of Michigan found that interprofessional collaboration and on-the-job training significantly improve linkages to HIV testing and primary care. This can help decrease HIV transmission and promote viral suppression among vulnerable populations.
A recent University of Michigan study reveals that people tend to prioritize protecting close relationships over reporting immoral acts, even in cases of theft and sexual harassment. Researchers found that this bias can be attenuated by adopting a psychologically distanced perspective.
Researchers mapped Detroit's unofficial footpaths, revealing a 70% decline on the far east side between 2010 and 2016. The study highlights the importance of informal pathways in urban planning and social justice
Fungi's genes encode enzymes that use simple building blocks to build complex molecules through a decade-long collaborative research effort, revealing a surprising Diels-Alder reaction. This discovery opens paths for improving chemical reactions and harnessing the enzyme to create new compounds with biological activities.
A study by University of Michigan wildlife ecologist Nyeema Harris found that human pressures on mammals in West African protected areas are driven primarily by livestock grazing and forest product gathering, not poaching. The research highlights the need for conservation efforts to incorporate livestock husbandry into management plans.
Researchers at U-M aim to collect individual-level data across all parts of the criminal justice system, linking it with social and economic data to examine previously unanswerable research questions. The project will create a nationally integrated repository for crime data to support research and evidence-based policy.
Researchers at the University of Michigan used a state-of-the-art climate model to simulate the extreme warming of the Early Eocene Period, finding that the rate of warming increased dramatically as carbon dioxide levels rose. The simulations suggest that future warming could accelerate due to an increase in climate sensitivity.
A University of Michigan study found that a high sugar diet depletes key brain metabolites, affecting behavior and potential connections to depression. The researchers compared fasting and fed fruit flies, discovering rapid changes in brain versus body metabolites.
Research suggests that overweight adolescents experience a biological response driving reduced appetite when stressed, eating about 35% fewer calories in the two hours following. This study challenges the common assumption that stress leads to overeating and highlights the importance of understanding individual responses to stress.
Researchers have identified a receptor protein that can detect extreme cold temperatures in creatures. The study found that the glr-3 gene, responsible for making the GLR-3 receptor protein, is required for worms to sense cold temperatures and is evolutionarily conserved across species.
A University of Michigan study found that children with vitamin D deficiency during elementary school were nearly twice as likely to develop externalizing behavior problems as those with higher levels. Low levels of the protein transporting vitamin D were also linked to self-reported aggressive behavior and anxious/depressed symptoms.
A new University of Michigan study found that spanking is harmful for all three racial groups, despite cultural differences. Spanking at age 1 predicts child behavior issues at age 3, leading to more spanking at age 5. The study's findings highlight the need for discipline alternatives to spanking in Native American communities.
A new study by University of Michigan researchers reveals that Asian carp can survive and grow in larger portions of Lake Michigan than previously believed. The findings suggest that the fish can thrive in various diets, including detritus, and have suitable habitat volumes throughout the water column.
The study reveals a high-definition picture of cell-to-cell signaling in the liver, identifying cellular changes that could drive nonalcoholic steatohepatitis progression. Single-cell analysis also uncovers new information about star-shaped cells and their role in liver fibrosis.
A study by D. André Green found that cold temperatures speed up the monarchs' internal timer, allowing them to terminate diapause and prepare for spring migration. The research suggests that cold temperature plays a critical role in regulating the timing of biological processes in monarchs.
A team of researchers has successfully measured the rate of heat transfer through a single molecule, a key step towards building molecular computers. The study found that the heat transfer rate was relatively constant across different chain lengths, with rates of up to 20 picowatts per degree Celsius.
Research by University of Michigan and Michigan State University researchers found that diversity in science teams surprisingly does not lead to positive outcomes for the diverse individuals themselves. Participants with underrepresented demographic characteristics experienced negative team climate and lower satisfaction.
A recent study found that nearly 11% of high school seniors reported misusing prescription drugs in the past year, with 44% relying on multiple sources. This increases the risk of substance use disorders and other issues.
The approach demonstrated in mice enhances healing by reprogramming aggressive immune cells to work for the body, reducing inflammation and promoting regeneration. This technology could lead to new therapeutic strategies for patients with spinal cord injury and inflammatory diseases.
A University of Michigan study finds that poor communication among healthcare workers is a major contributor to catheter-related infections. The researchers suggest that routine patient care like catheter use can have serious consequences if communication breaks down.
A study of over 3,000 US counties found 412 high-risk areas with high opioid overdose mortality and low treatment capacity. Strategies to increase primary care clinician capacity and employment opportunities in these counties are recommended.
A new technology allows clinicians to map patient pain in real-time using augmented reality glasses and brain data. The study tested on 21 volunteer dental patients showed promising results, predicting pain with accuracy of about 70%. The tech has the potential to improve pain measurement for various conditions.
A new study found that patients who meditate or listen to calming music before receiving written health information are more likely to pay attention and retain the details. The researchers recommend using this time wisely by relaxing in the waiting room, such as meditating or listening to calming music.
A global experiment involving 40 countries found that citizens were more likely to report lost wallets with money than without, with a significant increase in returns for larger sums. The study suggests that people prioritize honesty over personal gain, even when no one is watching.
A University of Michigan study challenges the notion that growing life expectancy inequality is driven by opioid use. The research suggests that deaths from cardiovascular disease and cancers are main reasons for the widening gap among less-educated Americans.
Researchers used reverberation mapping to determine the mass of NGC 4395's black hole, finding it to be about 10,000 times the mass of our sun. This is the smallest black hole found via this technique and provides new insights into dwarf galaxies and their nuclear black holes.