A new clinical trial from the University of Minnesota Medical School found that allopurinol did not slow kidney function in people with type 1 diabetes, despite reducing uric acid levels. The three-year study enrolled 530 participants and followed their glomerular filtration rate to assess kidney health.
A randomized clinical trial found that hydroxychloroquine had no effect on preventing COVID-19 in healthy individuals after exposure. The trial tested 821 participants and showed a slight increase in infection rates among those taking the medication.
A University of Minnesota Medical School researcher used functional MRI to demonstrate differences in visual motion perception among individuals with autism spectrum disorder. Brain responses show less neural suppression in the visual cortex, which may explain symptoms like sensory hypersensitivity.
Glioblastoma cells acquire radiation resistance by dumping exosomal microRNA miR-603, leading to increased protein production and insensitivity to radiation. This study reveals a new therapeutic strategy for overcoming cancer cell resistance.
The University of Minnesota Medical School has made a groundbreaking discovery to grow human-derived blood vessels in pigs, which have the potential to be used as a transplant solution for patients who need life-saving transplants.
University of Minnesota researchers have discovered that consuming olive oil in the Mediterranean diet may help improve lifespan and prevent aging-related diseases. The study suggests that combining olive oil with fasting, limiting caloric intake, and exercising can enhance its health benefits.
A new study suggests that targeting astrocyte calcium signaling could decrease amphetamine behavioral effects and potentially develop therapies for diseases with dysregulated dopamine. Astrocytes were previously considered 'support cells', but now shown to actively contribute to brain function.
Researchers have identified a decrease in heart transplant survival rates following the implementation of a new donor allocation system in the US. The study found that patients receiving hearts are sicker than in previous systems, leading to an increase in post-transplant mortality.
A new study by University of Minnesota researcher Ryan Langlois provides insights into the immune response to influenza. The research found that infected cells in the lungs can survive the clearance process and actually divide faster than uninfected cells.
University of Minnesota Medical School researchers have made a breakthrough in combating glioblastoma, the most common form of adult brain cancer. By combining ultrasound with engineered glass particles, they were able to create a 'Goldilocks' balance that awakens the body's immune response and boosts the effectiveness of immunotherapy.
Researchers at the University of Minnesota Medical School found that a little stress can actually improve the functioning of our internal biological clock. Stress leads to rhythmic phosphorylation of eIF2α, promoting production of ATF4 protein, which activates Per2 gene, ultimately making the clock tick faster.
Researchers have developed a new therapy using tri-specific natural killer engagers (TriKE) to activate the patient's immune cells to attack cancer. The Phase I clinical trial aims to treat Acute Myeloid Leukemia (AML), a common and aggressive form of leukemia.
Researchers found a chest compression frequency and depth combination associated with significantly improved outcomes in cardiac arrest cases outside the hospital. The optimal rate was 107 compressions per minute, and the ideal depth was 4.7 cm.
Anna Wojcicki, a University of Minnesota medical student, has been selected for the 2019 ASH Minority Medical Student Award Program to conduct translational research at Stanford University. She aims to develop new therapies for Acute Myeloid Leukemia by repurposing old drugs.
A team led by Michael Kyba identified an inhibitor that protects cells from toxic effects associated with facioscapulohumeral muscular dystrophy (FSHD) in cells and mice. The compound, iP300w, blocks the p300 enzyme needed by the DUX4 protein, preventing its toxic effects.
A University of Minnesota researcher has been awarded a $3.9 million NIH grant to develop novel vaccine strategies for cytomegalovirus (CMV), the most common infection causing birth defects and disabilities in US babies. The research aims to prevent congenital transmission of CMV by targeting pregnant women.
Researchers at U of M Medical School have discovered a new mechanism that could help treat obesity. The team found critical mutations in molecules implicated in obesity and diabetes, suggesting a possible therapeutic approach to human disease.
The University of Minnesota Medical School has been awarded a $945K grant to advance its cell-based therapy for Duchenne muscular dystrophy. Researchers aim to replace diseased muscle tissue with healthy muscle cells using human induced pluripotent stem cells.
Researchers developed a new method to detect specific types of mental effort using network-level brain activity. The study demonstrates that this approach can be used to improve patients' abilities to manage symptoms of mental illness.
A new study by University of Minnesota researchers demonstrates the ability to induce lasting immune tolerance in transplanted cells and organs without long-term use of anti-rejection drugs. This achievement opens up possibilities for a cure for type 1 diabetes.
Researchers at UMN Medical School found that estrogen deficiency leads to a 30-60% drop in muscle stem cells and severe difficulty reproducing new muscle after injury. Estrogen replacement therapy may help maintain muscle health, but risks cancer due to its effects on tissues.
Researchers at the University of Minnesota Medical School have identified a cellular mechanism that contributes to drug resistance in colon cancer. The study found that KRAS proteins can transfer between cancer cells via long, thin extensions called tunneling nanotubes, leading to more aggressive and invasive cancer behavior.
A new study has identified 40 crucial genes in Cryptococcus that impact human disease outcomes, offering a potential breakthrough in treatment. The findings could lead to personalized medicine approaches and reduced reliance on toxic antifungals.
A recent study published in JAMA Internal Medicine examines the impact of disease definition, comorbidity burden, and prognosis on hip fracture probability among late-life women. The research found that women with osteoporosis and comorbidities have a high probability of hip fractures despite competing mortality risk.
Researchers from the University of Minnesota Medical School discovered that large loops form between DNA sequences where a key protein Pax3 binds, and these loops are essential for the development of skeletal muscle. The study shows how 3D genome organization regulates cell differentiation in skeletal muscle formation.
Researchers determined that atrial fibrillation is independently associated with age-related and dementia changes. Longitudinal analysis showed increases in subclinical cerebral infarctions, sulcal size, ventricular size, and white matter hyperintensity volume in people with Afib.
Researchers found that chronic morphine treatment decreased survival in control mice, but not in sickle mice with sickle cell disease. Chronic opioid therapy also caused hyperalgesia, a condition of increased pain sensitivity, in sickle mice. The study suggests that opioids may still be effective for managing pain in SCD patients despi...
The 2019 American College of Cardiology/American Heart Association/Heart Rhythm Society Guidelines for the Management of Patients with Atrial Fibrillation provide updated management strategies for patients with AFib. The guidelines emphasize the use of new blood thinners and lifestyle modifications, such as weight loss and physical act...
A University of Minnesota Medical School research breakthrough highlights the potential of cell therapies for treating muscular dystrophy. The study identifies the molecular signature of muscle stem cells generated in vitro and their transformation upon transplantation into mice with muscular dystrophy.
Researchers create 3D in vitro model capable of isolating specific metastatic cells, providing platform for identifying potential therapies and screening anticancer drugs. The model also enables study of interactions between vasculature and drugs, yielding important answers.
Researchers at the University of Minnesota Medical School demonstrate spinal cord stimulation can immediately restore some voluntary movement and autonomic functions years after a paralyzing injury. The study expands inclusion guidelines for epidural stimulation, offering new hope for patients with traumatic spinal cord injury.
UMN researchers have created a more accurate prediction tool for atrial fibrillation-related stroke, considering abnormal P-wave indices and CHA2DS2-VASc variables. The P2-CHA2DS2-VASc score shows promise in classifying patients at higher risk of stroke.
Non-binary individuals experience significant health disparities, including higher rates of psychological stress and poverty, according to a new study. Researchers call for improved care and awareness of non-binary patients in healthcare settings.
A study by University of Minnesota Medical School researchers found that patients with abnormal blood glucose ranges have a higher rate of hospital readmission and death in the 30 days after discharge. Patients with 'borderline' high glucose levels who are not diagnosed with diabetes also experience worse outcomes.
Researchers at the University of Minnesota have made a significant breakthrough in understanding FSHD by determining the three-dimensional structure of the DUX4 protein. This protein is responsible for the disease, which affects approximately 1 million people globally and currently has no treatment. The study's findings provide valuabl...
Researchers emphasize the importance of collecting SOGI data to provide culturally sensitive care for LGBTQ+ patients, who face unique health disparities. Standardized data collection can impact nearly every aspect of clinical reasoning and management decisions.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about how liver cell communication affects disease progression. By studying the dialogue between hepatocytes and macrophages, they found that a specific ketone body metabolite helps protect against tissue fibrosis in non-alcoholic fatty liver...
Patients without insurance more likely to be transferred earlier, with higher mortality rates. The study highlights the need for improved health coverage and safety measures to reduce healthcare costs and harm.
Researchers used calcium imaging techniques to visualize spontaneous activity patterns in the mature visual cortex, finding precise organizational networks in the cerebral cortex much earlier than previously thought. These networks predict future brain function and are critical for processing complex sensory input.
Researchers at the University of Minnesota Medical School have discovered a subset of muscle stem cells that are located close to blood vessels and are likely to be the more potent stem cell population in maintaining muscle health. This groundbreaking study uses 3D technology to study the interaction between stem cells and blood vessel...
Researchers at the University of Minnesota Medical School have discovered a natural product called Fisetin that reduces the level of damaged cells in the body, causing aging. This compound has been shown to improve health and extend lifespan even when treatment is initiated late in life.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about the influenza virus, finding that its replication rate differs significantly between various cell types. The study reveals that certain cells are protected from severe infection, while others remain vulnerable to viral damage.
Researchers at UMN Medical School found that senolytic drugs can reverse physical dysfunction caused by aging cells, extending lifespan in animal models. A high-fat diet or being old enhances this dysfunction.
Researchers used a Pavlovian model to investigate the role of dopamine neurons in assigning value to environmental cues. They found that dopamine neurons can imbue cues with motivational value, driving actions and approach towards specific locations.
A study published in JAMA Dermatology found that adults who use sunless tanning products continue to engage in risky tanning behaviors, such as indoor tanning and sunburn. The researchers suggest that these products may inadvertently reinforce desires for tanned skin, making them ineffective in reducing skin cancer rates.
A new study found that young adults who had a parent incarcerated during childhood are more likely to skip needed healthcare, smoke cigarettes, engage in risky sexual behaviors, and abuse alcohol and prescription drugs. Young Black adults were disproportionately affected, with a higher prevalence of parental incarceration.
A University of Minnesota Medical School study found that 73% of patients gained a new diagnosis after transfer, while 47% lost one. Data sharing mechanisms associated with lower mortality and reduced information loss among transferred patients.
Researchers discovered that mice, rats, and humans all exhibit the sunk cost fallacy, preferring to continue with a choice despite clear evidence of a better alternative. The study used economic games to test species' willingness to wait for rewards, finding that all three groups became more reluctant to quit as time passed.
Researchers found that the P2RX7 protein influences the body's long-term immune system and helps generate memory cells protecting against certain viruses and reinfection. Certain drugs used to control neuropathic chronic pain can cause these immune memory cells to decay, leaving individuals vulnerable to infections.
Researchers at the University of Minnesota Medical School have developed an algorithm to better identify seriously ill hospitalized patients, empowering them to make informed decisions about their medical care. The data-driven approach aims to reduce unnecessary invasive procedures and improve end-of-life planning.