Researchers found that Minneapolis youth who participated in restorative justice diversion were less likely to experience re-arrest than those processed through the traditional juvenile justice system. The study demonstrates the positive impact of this approach and highlights its potential to reduce racial disparities.
A University of Minnesota-led study shows that verapamil can increase pancreatic insulin secretion by 30% in children with newly-diagnosed type 1 diabetes. The treatment was well-tolerated and had a favorable safety profile, making it an appealing option for children and adults with the condition.
The University of Minnesota Medical School has received $1.4 million in funding to develop methods and risk management processes for clinical artificial intelligence and machine learning to optimize patient safety. The team will focus on understanding the performance of clinical AI at the individual patient level.
A team of researchers from the University of Minnesota Medical School identified approximately 100 genes associated with fat deposition in women. One gene, SNX10, was found to be strongly associated with cholesterol and triglycerides, which has implications for cardiovascular health.
Researchers found that pacing patients at faster heart rates improved quality of life, physical activity, and reduced atrial fibrillation. This new treatment approach shows promise in treating heart failure with a stiff heart muscle.
Researchers at the University of Minnesota Medical School conducted a large clinical trial comparing two commonly prescribed generic drugs, chlorthalidone and hydrochlorothiazide. The study found that both medications were equally effective in preventing cardiovascular disease and non-cancer death, contradicting current clinical guidel...
Researchers found that high-performing practices used proactive approaches to organize staff and manage patient interactions, leading to comprehensive addressing of patient care needs during in-person visits. The study suggests incorporating proactive patient care processes into primary care delivery to improve diabetes outcomes.
Researchers at the University of Minnesota Medical School found that patients often misunderstand medical phrases used by doctors, leading to confusion in health care plans. The study highlighted phrases like 'positive' lymph nodes and 'impressive' X-ray results being misinterpreted by patients.
Researchers found that Black patients were more likely to be recommended against surgical removal of their brain tumors, regardless of tumor size or socioeconomic status. The study provides a basis for future research on racial bias in clinical decision-making and its impact on patient outcomes.
Research reveals significant regional disparities in parental incarceration rates, with children of color and those living in impoverished households more likely to experience it. The study also highlights the need for tailored strategies to address health inequities in remote or under-resourced communities.
A study published in PLOS ONE found that adults with type 2 diabetes taking metformin had a 45% lower risk of needing a breathing machine or dying from COVID-19 compared to those not taking the medication. The research team analyzed data from a large database and suggested metformin may be an effective treatment option for reducing COV...
A study by University of Minnesota researchers found that personalized federated learning may offer an opportunity to develop both internal and externally validated algorithms. This technique enables multiple parties to train AI models collaboratively without exchanging or centralizing data sets, protecting sensitive medical informatio...
Research found persistent diversity gaps in the dermatology workforce pipeline, with females and UIM students underrepresented. Medical students from diverse backgrounds had increased odds of caring for underserved populations and practicing public health.
The University of Minnesota has received a 5-year, $2.5 million NIH grant to fund the Minn-KPMP project, a recruitment site for the Kidney Precision Medicine Project. The project aims to understand and treat chronic kidney disease and acute kidney injury using precision medicine.
Dr. Michele Statz has received a $50,000 National Science Foundation CIVIC planning grant to develop the Community Justice Worker model, training community health workers to provide formal legal advocacy in rural Alaska. The project aims to address unmet civil legal needs for low-income individuals and promote justice gaps in rural reg...
The University of Minnesota is leading a comprehensive global clinical study to reveal the functional effects of vagus nerve stimulation (VNS) across the human body. The $21M REVEAL project aims to assess autonomic, cardiovascular, metabolic, immune, and gastrointestinal function in response to VNS parameters.
Researchers identified unique mutations in the omicron spike protein adapted to the mouse receptor, suggesting possible animal origin. The findings also highlight the importance of epidemic surveillance of rodents to stop new COVID-19 variants.
Researchers found that specialty names and seniority titles are sources of misunderstanding among the general public. Physicians can reduce this confusion by describing their medical specialty and role in plain language.
A large clinical trial found that insulin glargine and liraglutide were superior to other diabetes drugs in controlling blood sugars. The study, published in the New England Journal of Medicine, compared four common medications used to treat type 2 diabetes when added to metformin.
Researchers have identified specific magnetic resonance imaging features that indicate cardiac sarcoidosis patients are at higher risk for adverse cardiac outcomes, including ventricular arrhythmias. These findings suggest that patients with certain cardiac MRI features may benefit from implantable cardioverter defibrillators.
Researchers found that Fecal Microbiota Transplant (FMT) using capsules has a cure rate of 86% at one month and 81% at two months for recurrent CDI, comparable to colonoscopic FMT. Patient selection is key to optimizing FMT success.
Researchers investigated the possible connection between maternal obesity and an increased risk of acute lymphoblastic leukemia in children. Changes in fetal epigenetics, insulin-like growth factor profiles, and immune cell populations have been proposed as potential explanations for this association.
Researchers found that discounted prices were 1.5 times higher for human medications than for pet medications, affecting over 60% of medications.
Medically underserved communities face significant barriers to endoscopy-related COVID-19 testing, potentially worsening health care disparities. Researchers recommend addressing these challenges by mailing test kits or offering rapid testing to mitigate delays in diagnosis and management of gastrointestinal illnesses.
Researchers at the University of Minnesota Medical School have received $19.3 million in NIH grants to map senescent cells and develop senolytic drugs. The project aims to create a 4D atlas of human senescent cells and advance knowledge on how to use senolytics to improve human health.
A new intracellular checkpoint gene, CISH, has been found to suppress the ability of human T-cells to recognize and attack cancer cells. When CISH is disabled, T-cells more effectively recognize mutated proteins produced by tumors, making them more responsive to existing checkpoint therapies.
The study found that hospitals vary in their stocking practices and often rely on wholesale distributors or neighboring facilities to acquire non-stocked antimicrobials. Researchers recommend improving information sharing and collaboration among local hospitals to reduce barriers to timely treatment.
The study found that the number of babies born in Minnesota with CMV decreased from 1 in every 200 births to 1 in every 1,000 births between August 2020 and December 2021. This decline is attributed to strict hygienic precautions such as masking, hand-washing, and infection prevention behaviors.
A study from the University of Minnesota Medical School examines support programs for pregnant and postpartum individuals in six US state prisons. The research highlights the importance of collaboration between program facilitators and prison sites in determining program success.
The study found that metformin lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent. Metformin also showed a significant reduction in serious outcomes when prescribed early in the onset of symptoms.
A new study reveals that certain food proteins can cause white blood cells to become dysfunctional, leading to immune intolerance. Researchers found that the gut-associated-lymphoid tissue is a suppressive environment where lymphocytes undergo arrested development, preventing dangerous immune reactions to food.
A study published in Stem Cell Reports found that manipulating two signaling pathways, MAPK and PI3K-AKT, enhances the maturation of human-induced pluripotent stem cell-derived cardiomyocytes. This breakthrough discovery has significant implications for the development of cell therapy for heart disease.
Researchers found that visceral artery pseudoaneurysms in necrotizing pancreatitis are associated with significant morbidity and mortality. The study also highlighted the importance of early detection and treatment, as delayed diagnosis can lead to increased complications and mortality.
The article highlights six strategies for addressing climate-related health inequities, including adopting standards for sociopolitical constructs and centering marginalized community voices. Researchers emphasize the importance of dismantling structural racism, environmental justice efforts, and effective communication strategies.
Research found key components of the fellowship program, including flexible curricular structure and long-term health advocacy engagement, are associated with student growth. Community-centered models offer a compelling way to enable physician advocacy to center on community needs and foster innovative system change.
Researchers evaluated the real-time performance of an AI model to detect COVID-19 from chest X-rays and found that it did not outperform radiologist predictions. The study highlights the limitations of AI in diagnostic accuracy, particularly for certain groups such as women and minority populations.
A multidisciplinary study by the University of Minnesota found that girls and boys show similar rates of concerns for autism spectrum disorder when screened earlier. The research identified subtle differences in core symptoms but corrected for these biases to reveal a 'high concern' group with an equal sex ratio.
The University of Minnesota is studying how various levels of discrimination affect mental, physical, and social health. The study aims to develop interventions that promote health equity by addressing individual, neighborhood, institutional, and societal/policy levels of structural racism.
A new study from University of Minnesota Medical School suggests Fecal Microbiota Transplantation (FMT) is an optimal and cost-effective treatment option for the first recurrent Clostridioides difficile infection. The research model indicates it's effective and cost-effective when used in patients after a single episode of recurrent CDI.
The University of Minnesota has received a $66 million grant from the NIAID to establish a center for developing antiviral drugs for pandemic-level viruses, including SARS-CoV-2. The Midwest Antiviral Drug Discovery Center will bring together investigators from the University and sixteen other institutions nationwide.
Researchers from the University of Minnesota Medical School found a link between diet type and hydrogen sulfide production in the gut. An animal-based diet was shown to increase toxic gas production, while fiber-containing foods were beneficial to gut health.
A study led by the University of Minnesota Medical School found that exposure to helminths can stimulate the immune system and reduce predisposition for inflammatory bowel disease. The research revealed a unique glycosylation mechanism, O-GlcNAcylation, which activates epithelial cells to orchestrate an anti-helminth response.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about how GI bacteria communicate with each other during gene transfers. This new understanding may lead to innovative approaches in preventing hospital infections without increasing antibiotic resistance.
The University of Minnesota Medical School has been awarded two $3.25 million and $3.25 million NIH grants to study cardiovascular health among a diverse population of school-aged children. The research, led by Jerica Berge, will address social and structural determinants of health in primary care settings.
A team of scientists discovered that a disrupted circadian clock gene may contribute to the development of autism spectrum disorder. The study found that deleting the Bmal1 gene in mice led to autistic-like behaviors and cerebellar dysfunction, which were alleviated by mTORC1 inhibition.
A recent study published in Vaccine found that nearly 90% of healthcare workers accepted COVID-19 vaccines, particularly those serving immigrant communities. The researchers highlight the importance of education and interpersonal communication in influencing vaccine decisions.
Research from the University of Minnesota found that lower left atrial function was associated with higher risk of developing dementia. Atrial myopathy, characterized by abnormal left atrial function and size, was identified as an independent risk factor for dementia.
The study found that 43% of transgender and gender diverse students identified as nonbinary, with similar numbers identifying as pansexual (1.7%) as gay or lesbian (1.6%). Many LGBTQ+ youth reported depressive symptoms and experiences of identity-based bullying.
A study published in JAMA Network Open found that losartan treatment did not reduce lung injury in patients admitted with COVID-19, but may be needed for blood pressure support. Researchers emphasize the need for repurposing inexpensive medications to contain healthcare costs.
Research reveals significant socioeconomic disparities among US medical students, with high-income students overrepresented across racial and ethnic groups. Low-income students remain underrepresented, despite efforts to address this issue.