Articles tagged with Biomedical Engineering
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
Researchers developed a flexible microsystem to deliver light directly to internal cancer treatment sites, overcoming the limitation of traditional PDT. The system, powered wirelessly and containing tiny light-emitting components, shows promising results in laboratory tests, paving the way for more precise and effective cancer treatments.
Researchers developed Film-Rupture Actuated Capillary Enrichment (FACE) to collect airborne samples, achieving detection sensitivity 100 times higher than traditional systems. The device uses surface tension and a bioinspired physical mechanism, eliminating the need for pumps or batteries.
Researchers found that astrocyte shape and molecular characteristics vary across brain regions, influencing their distinct roles. The study reveals that the Nfix gene coordinates two parallel pathways involving GABA, which is essential for astrocyte-neuron communication, and its absence impairs memory consolidation.
Researchers developed a new high-resolution light-sheet imaging system that can document seizures in 3D in real-time, offering insights into seizure propagation and brain function. The study provides the first high-resolution 3D video of a seizure event from start to finish.
A research team at Case Western Reserve University is developing a non-invasive oral cancer test that can diagnose the disease in minutes. The test uses a simple oral swab and measures the ratio of two naturally occurring peptides, offering a promising alternative to current biopsy methods.
The study found that LVIS stent-assisted coiling provided effective aneurysm occlusion while producing measurable hemodynamic changes and maintaining procedural safety. Treatment reduced blood-flow activity within the aneurysm, with sustained improvements at 6 months.
Researchers have developed a new hydrogel made from peptides that can transport ions, generate electrical signals when squeezed, or interact with cells and biological molecules. The gel has tiny water channels and is electrically polarized due to its highly organized structure made from nanofibers.
Researchers used high-resolution ultrasound to measure a statistically significant reduction of 23.8% in measured scar depth after one treatment with DC microcurrent stimulation. The study found potential implications for tissue mobility and rehabilitation, but larger controlled studies are needed to confirm durability.
A BCM-led team will receive a $10 million award over five years to build FORECAST, an integrated system to study the emergence and expansion of deadly pathogens in human populations. The project aims to identify never-before-seen relationships between deadly pathogens and environmental drivers.
Researchers at USC have developed a genetic tool called the Mechano-Recorder to measure tumor cell softness. This insight can help target hard-to-reach cancer stem-like cells for destruction, potentially improving cancer treatment outcomes.
The UH Health initiative expands training, accelerates research and innovation, and improves access to care in Texas. It brings together medicine, nursing, pharmacy, optometry, psychology, social work, population health, and others under one interprofessional vision.
A team of researchers has developed a new way to study heart valve disorders by creating miniature, working models of the heart. The models, called assembloids, were grown from pluripotent adult stem cells and can be used to simulate various types of valve disorders, including mitral valve prolapse.
Researchers have developed a new stretchable catheter that can reveal features of arterial plaque not visible with conventional imaging. The device uses electrical measurements to identify metabolically active plaques, allowing doctors to spot potentially deadly buildup before it causes a heart attack.
Researchers from the University of Rochester's TraCe-bMPS have developed tissue chips that can predict dangerous immune reactions to cancer therapies. The technology, which uses human cells and sensors, has been accepted into the FDA's Innovative Science and Technology Approaches for New Drugs pilot program.
The collaboration aims to improve human tolerance to xenogeneic organs and reduce the risk of organ rejection. Researchers will explore immunomodulatory interventions to support patients with high unmet needs who face additional barriers to receiving timely liver transplants.
ASTRA-Net helps reconstruct overlooked peripheral airways, creating more complete maps for bronchoscopy procedures. The AI framework demonstrates strong performance in identifying fine peripheral airways and supports navigation to difficult-to-reach lung lesions.
Light-field microscopy (LFM) enables snapshot volumetric acquisition, allowing for faster synchronous three-dimensional information. Recent advances have made LFM practical for high-speed neuroimaging, particularly in calcium imaging and voltage imaging.
Researchers developed a new drug called CS18 that targets TopBP1, a biological switchboard controlling multiple cancer-driving pathways. CS18 reduces defenses helping cancer cells survive therapy and increases genes stopping uncontrolled growth.
A new wearable electric-field device has been shown to slow the growth and spread of aggressive breast cancer in preclinical models. The technology uses low-intensity electric fields that interact with cancer cells in a controlled way, reducing tumor growth and increasing immune responses.
A new portable blood testing device connects via Bluetooth and uses AI to analyze blood samples, providing real-time health insights. This technology allows for regular monitoring of patients undergoing chemotherapy or taking medications with potential side effects.
Researchers developed realistic skin-like test models to reproduce a range of skin tones and simulate blood flow, helping device developers identify biases in light-based medical technologies. The models showed improved optical signals detection across different pigmentation levels.
A team at Pusan National University created a stretchable organic electrochemical transistor that can be easily reprogrammed to perform different functions. The device combines logic, memory, and a visible color readout without complex circuitry.
Researchers developed an AI model capable of generating accurate, high-resolution pressure maps using just a few anatomical landmarks, enabling lower-cost foot health monitoring in rural and remote regions. The study demonstrates the potential for AI to overcome challenges associated with traditional plantar pressure monitoring systems.
A new study found that children preparing for stem cell transplantation already have subtle respiratory abnormalities, including increased small-airway resistance and greater lung stiffness. These abnormalities are likely related to their underlying disease or previous therapies rather than the transplant itself.
Researchers at Institute of Science Tokyo developed strategies to overcome xenophagocytosis, which eliminates living donor cells in interspecies organ generation. By blocking this response, they significantly improved donor cell survival and generated rat pancreas in mice.
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Recent progress in lanthanide carriers is mapped to improve biomedical imaging and diagnosis, combining optical, X-ray, and magnetic resonance imaging techniques. These carriers enable high-resolution imaging with tunability for different applications, reducing tissue damage and enhancing image clarity.
Researchers propose a four-stage pathway to evaluate AI for intracranial aneurysm detection, including lesion-level testing, reader performance evaluation, and surveillance after deployment. The framework aims to assess the tool's net clinical benefit in specific care settings.
Researchers at the University of Queensland have developed ultra-wideband radar sensors to measure muscle forces in a non-invasive way. This technology has the potential to improve rehabilitation, injury prevention, and recovery for people with motor neuron disease or aging. The goal is to eventually use real-time sensor data to assist...
Researchers have developed a way to quickly create customizable synthetic blood vessel grafts in just minutes using additive manufacturing. The new technique, called Focused Rotary Jet Spinning, allows for precise control over diameter and wall thickness, making it ideal for acute trauma situations and complex pediatric heart surgeries.
Researchers at the University of Manchester have developed a new family of antifungal agents that are more potent and less toxic than existing treatments. The compounds, which were discovered through genome mining, showed increased antifungal activity and improved solubility compared to existing drugs.
Scientists at the University of Osaka have created a new technique to build blood supply systems for artificial tissues. They successfully fabricated tubular hydrogel structures with controlled lumen sizes and complex geometries, paving the way for creating vascular models that can investigate the development of fully synthetic tissues.
Dr. Yi Li receives CPRIT funding to develop treatments for solitary fibrous tumor, a rare cancer driven by gene fusions. Researchers are working on novel therapies, including immunotherapy and antisense oligonucleotides, to reduce cancer-causing signal activity.
A new study from Reichman University found that a short three-week digital training program improved motor function and brain activity in Parkinson's patients. The program, called DopApp, strengthened connectivity between brain regions responsible for movement and induced localized changes in neural circuits.
A Chinese research team has proposed a novel approach to separate dimethyl carbonate from methanol using a tailor-made ionic liquid and heat pump-assisted distillation. The method significantly reduces energy consumption and costs compared to traditional methods, making it an attractive solution for the chemical industry.
Emerging non-endocytic delivery strategies enable direct cytosolic delivery of proteins, nucleic acids, and gene-editing tools, providing new opportunities for biomedical therapies. The review discusses their application prospects in gene therapy, macromolecular drug delivery, and cellular engineering.
Researchers at HKUST develop a biocompatible chemical reaction to create targeted anticancer prodrugs, enabling precise drug activation in cancer cells. The breakthrough uses the EBB group and gold catalysts, offering a promising strategy for reducing collateral toxicity.
Researchers at Binghamton University are developing an ear probe that utilizes the unique way spiders 'hear' through their webs to detect inner-ear problems. The probe uses patented sensing technology inspired by spider silk, which can respond to sound with perfect fidelity from 1 Hz up to 50 kHz.
The US Naval Research Lab is developing continuous biomanufacturing technologies to produce critical materials more efficiently and sustainably. The approach uses surface-bound microbial cells to generate valuable compounds over extended periods, reducing energy requirements and equipment size.
Scientists at UVA have developed a new method to target glioblastoma, the most common and deadly brain cancer, by delivering microRNAs through the brain's natural barrier. The approach shows promise in slowing tumor growth and extending survival in animal models.
Researchers at Science Tokyo develop a Ramsey-based magnetometer that overcomes thermal limitations, enabling close-proximity detection of weak biomagnetic signals. The sensor achieves high sensitivity and safe operation near biological tissue.
Researchers have developed a novel method to control miniature rotations using water flow at a surface, allowing for the creation of targeted ultrafine structures such as twisted fibers for wires and sutures. This approach enables the assembly of complex structures without mechanical contact or chemical propulsion systems.
JMIR Publications is sponsoring the upcoming BioMedEng26 conference to promote biomedical engineering innovation. The journal JMIR Biomedical Engineering will be highlighted during the event, with Dr. Javad Sarvestan discussing its focus on cutting-edge engineering applications and peer-review process.
A UMass Amherst-led team is developing a new approach to prevent bladder cancer recurrence by exfoliating the bladder lining. The technology uses irreversible electroporation to target premalignant cells, offering a potential alternative to surgical removal or aggressive treatments.
A new model, PSIDMViT, combines anatomy, physics, and machine learning to predict accurate dose distributions for CyberKnife radiation therapy. The study shows improved agreement with Monte Carlo reference doses and reduced computation time, suggesting a promising strategy for improving radiotherapy dose prediction.
Researchers identified simple changes to surgical tools that can significantly affect how pressure is distributed across the esophageal wall during neck surgery. Wider retractor blades reduced stress beneath the center of the blade by up to 82%, but also shifted higher stress toward the edges.
Researchers have identified a widespread source of error in a popular genome study method and created a machine-learning tool to correct it. PATTY uses machine learning to reduce artifacts while preserving real signals in noisy data, giving researchers a clearer view of gene activity control.
The study reveals that different forms and levels of partner proteins involved in the disease lead to distinct molecular interactions and biological outcomes in different tissues. The findings suggest that directing therapies to specific protein forms may improve treatment options for neurological diseases.
A research team developed a walking-support robot that uses large-area tactile contact at the torso to track movement intent and share load. The system continuously adapts as the coupled human-robot dynamics evolve, allowing intention alignment and balance support to emerge from the same physical channel.
A new study published in Chinese Neurosurgical Journal found that real-time MRI and brain function monitoring during neurosurgery can improve the removal of tumors affecting the corpus callosum more effectively and safely. This multimodal approach gave patients about 30 extra months after treatment before the tumor grew back or worsene...
University of Oregon researchers engineer molecules and control regenerative cue release to improve healing outcomes for complex injuries. A staggered sequence approach shows better blood vessel regeneration, and the method is being applied to bone healing, muscle repair, and spinal cord regeneration.
Researchers found subtle patterns in brain activity while children listened to speech linked to verbal communication abilities in autistic youths. Altered brain signals suggested the brain may process speech less efficiently, with noisier signals associated with lower scores on everyday verbal communication.
Researchers at Baylor College of Medicine identified a vulnerability in triple-negative breast cancers with LIG1 loss and used it to develop a new therapy for chemotherapy-resistant TNBC tumors. A combination of olaparib and ceralasertib showed significant effectiveness in reducing tumor growth in animal models.
A study by Pompeu Fabra University, ONT, and Vall d'Hebron Hospital reveals that public investment in liver transplants not only improves patient survival but also generates a positive social and economic return. The study estimates that liver transplant patients contribute over 100 million euros to the Spanish economy annually.
A novel biological pathway has been uncovered that can lead to seizures when disrupted, providing a new approach for improved diagnosis. The study identifies an association between defective genes and increased glutamatergic transmission, which can increase the risk of seizures.
Researchers at MIT have created a precise way to engineer artificial blood vessels by mechanically stretching and pulling a "blood vessel on a chip". The new method, reported in the Proceedings of the National Academy of Sciences, enables controlled sprouting of new vessels and programming of their growth patterns.
A new award will help advance the proof-of-concept work toward commercialization of an at-home HIV test that detects cases not caught by lab tests. The device, called Click Chemistry Amplified Nanopore (CAN) sensing, has shown promising results in early studies.
Researchers developed DeepHHF, an AI model that identifies patients at high risk of heart failure up to five years in advance. The model analyzes standard ECG recordings and detects subtle abnormalities that are often imperceptible to the human eye.