Articles tagged with Biomedical Engineering
A $4 million NIH grant will help UC Davis researchers develop and test bioengineered grafts infused with ligands to treat neurogenic bladders in children. The grafts, designed to grow their own blood supply, have the potential to reduce complications after standard bladder augmentation surgery.
A new study published in Advanced Science shows that a programmable device can close complex wounds quickly, improving wound healing. The device uses customizable force to adapt to different wound shapes, promoting blood flow, nutrient delivery, and reduced scarring.
Researchers find that limiting methionine in the diet destabilizes DNA organization and leads to cancer cell death and increased animal survival. The study proposes a new connection between diet, gene regulation, and cancer growth, opening possibilities for treating aggressive brain tumors.
Scientists developed a bioelectronic material called SIRES that maintains conductivity despite stretching up to 300%. The device can be attached to internal organs and provide stable performance even during movement. A new platform for implantable sensors also sticks to wet tissues while delivering therapeutic interventions.
A study by Baylor College of Medicine researchers identifies a set of dysfunctional genes and specific cell types that are vulnerable early on to genetic changes in Rett syndrome. The research reveals that even healthy cells can be influenced by their environment, contributing to widespread brain dysfunction in the disease.
The review highlights advances in multi-scale bioelectrical interactions, analyzing challenges such as interface impedance and material-tissue compatibility. It emphasizes a shift towards application-driven design, integrating biological needs with material selection and device engineering.
A Texas A&M University biomedical engineering capstone team developed a pediatric jaw brace to help five-year-old David Hardy breathe at night. The device, called The JawDropper, successfully improved his breathing and was awarded a first-place prize among all biomedical teams.
Researchers create siRNA delivery system based on IVSA technology, which targets EGFR-positive tumors with high efficacy and low toxicity. The system enables precise targeting and overcomes drug resistance challenges.
Researchers propose reconsidering how histone deacetylase inhibitors work in cancer treatment, identifying genuine molecular targets as a key step to improve treatment. The study suggests that HDAC inhibitors may interfere with other proteins, suppressing cancer growth.
Researchers summarize recent developments in terahertz biophotonics, highlighting its potential for overcoming technical limitations in fields like skin cancer diagnosis, wound assessment, and drug discovery. The study provides a roadmap for future research to improve the field's practical applications.
A POSTECH research team developed a haptic device that can operate inside MRI scanners, enabling the measurement of brain activity during VR experiences. The study found that adding tactile feedback increased brain activation in areas responsible for motor control, attention, and cognitive processing.
A recent study published in Development reveals that the UTY gene on the human Y chromosome still contributes to transcriptional regulation during early development. Despite its low expression and reduced enzymatic activity, UTY co-occupies active regulatory elements with its X chromosome homolog UTX.
A new framework, VIBEMed, uses multi-agent collaboration to break complex clinical decisions into specialist roles and employs a three-level self-evolution mechanism to improve performance over time. This approach demonstrates superior performance in complex medical reasoning and treatment planning tasks.
The university's patented technology assists surgeons in detecting and visualizing significant arterial bleeding using augmented reality overlays, enabling precise control and quick action. This innovation aims to improve patient outcomes, save lives, and reduce hospital stays, infection rates, and treatment costs.
Scientists at Linköping University have developed artificial heart muscle cells using organic electronics, opening up new possibilities for prosthetics, heart implants, and sensors. The technology aims to harness the principles of effective electrical signaling in biological cardiac muscle cells.
The RBA hydrogels can stretch to more than three times their original length while remaining mechanically stable. They were used as strain sensors to detect subtle facial movements and distinguish between walking, jogging, and running in real time.
Researchers developed a novel fluorescent nanosensor to detect IPA, an emerging biomarker linked to gut health and disease. The sensor offers rapid detection within minutes, distinguishing IPA from closely related metabolites, enabling accurate measurement even in complex biological environments.
Researchers at MIT have created a pacemaker that uses ultrasound technology to stimulate the heart, offering a potential surgery-free alternative to traditional cardiac implants. The device is designed as a small sticker that sends ultrasound pulses through the chest to regulate heart contractions and correct arrhythmias.
A novel biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin shows promising efficacy in treating periodontitis. The material has adhesive properties, allowing for targeted release of therapeutic compounds, and has been shown to promote regeneration of periodontal tissues.
A new monitoring system, NeuroSense, tracks cerebrospinal fluid at the bedside for faster intervention in intensive care units. The system detects biomarkers of infection and flow rate, enabling early warning of complications and better treatment decisions.
Researchers have developed custom 4D-printed implants that expand slowly and steadily, reducing the need for repeated injections and surgeries. The devices were tested in rabbits and showed promising results, including improved skin adaptation, reduced complications, and increased precision in reconstructive surgery.
A University of Michigan research team is exploring the development of knee exoskeletons to reduce joint contact forces and relieve osteoarthritis pain. Preliminary testing suggests that these orthotic brace-based exos and drone-style motors could provide significant relief.
Current evidence suggests P2Y2 signaling is associated with multiple cancer-related processes, including cell proliferation, migration, and EMT. The receptor has also been linked to intracellular signaling pathways such as EGFR, PI3K–AKT, and MAPK.
A University of Utah team developed a smartwatch prototype that tracks blood pressure and flow using electrical properties of blood flow for continuous, cuff-free readings. The technology harnesses physics and machine learning to provide accurate and interpretable results.
Researchers found that traumatic occlusion combined with periodontitis leads to significant bone loss due to upregulated inflammatory pathways. The study suggests that excessive bite force does not directly cause damage but exacerbates existing dysregulation, making clinical applications of occlusal adjustment in treatment more relevant.
Researchers developed a nanofiber drug delivery system that uses electrospun fiber membranes to deliver multiple drugs in concert, demonstrating improved efficacy against glioblastoma. The system enables localized long-term delivery of drugs directly at the tumor site after surgery.
Researchers at Institute of Science Tokyo genetically engineer cyanobacteria to produce sulfated polysaccharides, a sustainable route for manufacturing biomaterials. The study demonstrates the feasibility of engineering complex biosynthetic pathways in photosynthetic organisms.
Researchers from Zhejiang University present a comprehensive overview of stem cell-based strategies for treating traumatic brain injury. The study explores the therapeutic effects of stem cells, exosomes, and biomaterial scaffolds in promoting brain repair and functional recovery.
Researchers discovered acteoside alleviates hepatic ischemia-reperfusion injury through two mechanisms: inhibiting IRF1 nuclear translocation and promoting CMPK2 degradation. Acteoside reduces liver injury, serum ALT/AST, inflammatory infiltration, oxidative stress, and mtDNA release.
Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.
Researchers found that different types of tea create kombuchas with distinct chemical profiles, flavors, and aromas. Green and oolong teas produced kombuchas with high antioxidant activity, while black and pu-erh teas resulted in earthier flavors.
Researchers at Cincinnati Children's Hospital Medical Center have developed a new method to produce large, functional human gut organoids with nerve cells, growing them twice as fast as previous methods. These organoids can now be used for patching damage or restoring diminished functions of the small intestine, stomach, or colon.
Researchers identify conceptual weaknesses in established methods, suggesting targeted nerve and muscle activations for non-invasive electrostimulation. The study advocates for reconsidering high-frequency pulse usage to exhaust full potential for restoring motor function after paralysis.
YTHDF2 plays critical roles in regulating HSC fate, immune cell development, and tumor-immune interactions. It also modulates the tumor microenvironment to promote tumor progression.
Researchers synthesized preclinical and clinical evidence of mRNA cancer vaccines across various cancers, including melanoma, non-small cell lung cancer, and acute myeloid leukemia. Key findings include improved recurrence-free survival in patients treated with mRNA-4157 plus pembrolizumab for melanoma.
Aging across the female reproductive tract is characterized by declining estrogen, cellular senescence, and chronic inflammation. Multi-omics datasets provide a powerful framework to measure biological age and reveal tissue-specific vulnerabilities.
H2AK119Ub is a versatile histone mark that organizes the genome into functional domains, orchestrates gene silencing, and maintains cell identities during development. Disruption of its signaling network is recognized as a driver of human diseases, particularly cancer.
A new study by the University of Southampton has found that reusable catheters are just as safe for patients as single-use ones and do not increase the risk of urinary tract infections. The study followed hundreds of patients for a year and discovered that those who tested reusable catheters used 35 per cent fewer antibiotics.
Paligenosis is a three-stage process involving autophagy, stemness gene induction, and proliferation. It ensures efficient regeneration in tissues like the stomach and pancreas, but its dysregulated activation can drive metaplasia and cancer. The review discusses biomarker prospects for distinguishing adaptive repair from malignant drift.
Researchers at Duke University developed a new approach to deliver GLP-1 medications orally that maintains efficacy without requiring fasting. The technique uses an elastin-like polypeptide-based delivery system that protects the peptide from stomach acid and releases it in the intestines, bypassing the stomach's destructive acids.
Researchers in Brazil's Cerrado biome found that reducing stream sampling from 11 to 6 transects maintained reliable classification of streams as least-disturbed, moderately disturbed, or severely disturbed. The study suggests a streamlined approach can reduce field time and processing costs while preserving ecological indicators.
The review outlines a comprehensive understanding of the chemokine and receptor network in the tumor microenvironment, introducing a novel 3D targeting framework to guide precision combination immunotherapies. The proposed
Recent advancements in animal models, organoid models, and bioengineered organoids have provided new tools for studying primary sclerosing cholangitis. These models replicate the effects of bile retention and inflammation, enabling studies of disease mechanisms, drug screening, and preclinical evaluation.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
Lanthanide nanoprobes have improved signal-to-noise ratio, enabling ultrasensitive detection of cancer biomarkers and visual identification of cancer cells. The nanoparticles maintain stable luminescence across a wide pH range and in simulated human body fluids, ensuring reliable performance.
A Spanish clinical trial demonstrates the potential of mesenchymal stem cells to reduce inflammation in Recessive Dystrophic Epidermolysis Bullosa (RDEB) patients, also known as 'butterfly skin'. The treatment showed improved symptoms like pruritus, sleep disturbances, and fatigue after receiving infusions.
The journal MedScience aims to integrate cutting-edge insights across medical sciences, focusing on emerging fields like cell therapy, AI-driven drug discovery, and precision medicine. This new platform serves as a dynamic hub for international academic exchange and translation of scientific breakthroughs into clinical practice.
The study found that visual occlusion triggers brain compensation characterized by enhanced functional connectivity between the right precentral and middle frontal gyri. Walking activates multiple sensorimotor pathways to support basic locomotion, and visual occlusion further strengthens this connection as a compensatory mechanism.
High-altitude exposure disrupts the gut ecosystem, leading to dysbiosis, impaired barrier function, and increased intestinal permeability. The gut microbiome influences host energy metabolism, immune responses, and acclimatization capacity, and alterations are linked to diseases such as metabolic disorders and colorectal cancer.
Researchers found that smoking substantially stiffens human lung parenchyma, making breathing progressively difficult. The study provides detailed mechanical data for human lungs, which may improve ventilator design and surgical planning tools.
Researchers at Mizzou's Molecular Imaging and Theranostics Center developed an automated approach to producing the prostate cancer treatment. The new method produces CTT1403 in just 38 minutes, compared to six hours with traditional methods, using a commercially available automated synthesis system.
Researchers discovered that disrupted PTH1R signaling drives abnormal cementum growth and tooth-bone fusion in adult mice, leading to severe dental complications. The study identified the loss of PTH1R signaling as a critical molecular safeguard against excessive cementum formation.
A new study by Technische Universität Berlin reveals that teaching Large Language Models to mimic human intuition and reasoning improves their ability to provide accurate medical care-seeking advice. The 'human reasoning blueprint' approach increased overall accuracy across all models, with significant gains in self-care advice.
Recent advances in medications, devices, and care pathways are redefining heart failure (HF) treatment. Emerging therapies beyond traditional EF silos have demonstrated broad efficacy across LVEF categories.