Articles tagged with Tissue Transplantation
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A Hopkins study reveals that T lymphocytes, part of the immune system, play a dual role in organ damage after transplantation. While they produce toxic chemicals that contribute to IRI, they also appear to protect transplanted kidneys from damage. The findings could lead to new strategies for preventing or rapidly treating IRI.
Researchers successfully transplanted embryonic pancreatic tissue from pigs into mice with reduced immune responses, enabling fully functional insulin production and normal blood sugar levels. The study's findings warrant further pre-clinical research on primate models to explore the potential for human transplantation.
Researchers developed engineered bladders using patients' own cells, showing improved functional parameters without bowel tissue complications. The procedure has the potential to treat bladder disease, but additional studies are needed for wider adoption.
Researchers at Rice University have developed a self-assembly method to grow dime-sized disks of cartilage with properties approaching native tissue. The technique uses only donor cells, eliminating rejection risks, and has been refined to produce virtually identical cartilage in terms of mechanical and biochemical makeup.
Full facial tissue transplantation is a successful approach in helping patients horribly disfigured by burns, accidents and other trauma. Traditional methods for facial reconstruction are reliable but may not match skin quality, texture and color, resulting in patchy appearances.
A Hopkins study successfully performed 21 out of 22 KPD transplants, showing the technique can offer transplants to many more patients who cannot receive a kidney from a loved one. The results could pave the way for a national matching registry and help hundreds of patients find compatible matches.
The University of Liverpool is leading a major €17 million European tissue engineering project, funded by the European Commission. The project aims to develop cost-effective methods for generating precise tissue types specific to individual patients.
A new study found that inhaling small amounts of carbon monoxide after transplant surgery can prevent the development of a lethal inflammatory reaction in mice. This could lead to a new treatment regimen for human patients, preventing complications such as obliterative bronchiolitis and improving their chances of survival.
A report describes four transplant recipients who contracted rabies from a common donor, demonstrating the risk of transmission through solid organ transplantation. The cases highlight the importance of considering rabies diagnosis in rapidly progressive neurological diseases.
Researchers found that transplanting pig pancreatic primordia into diabetic rats at precisely 28 days after fertilization cures their diabetes. Transplantation at this stage made the tissues invisible to the rat's immune system, leading to permanent cure without immune suppression.
A new study found that low concentrations of sodium nitrite prevent cell death in the hearts and livers of mice undergoing experimental heart attack and liver injury. The potent protective effect reduced dead tissue by 67% compared to control animals given nitrate.
Researchers found significant differences in mitral valve tissue between healthy and congestive heart failure patients, affecting the valve's strength and hydration levels. These changes may contribute to recurring surgical outcomes for patients with mitral regurgitation.
Researchers found that blocking CCL2 eliminates foreign body giant cells, protecting implants from damage. This discovery paves the way for a new class of therapeutic drugs to sustain implants and improve their functionality.
A patient with a 20-year history of heavy drinking underwent liver transplantation in 1999 and experienced progressive recovery of strength in both legs. The authors suggest that peripheral neuropathy in patients with alcoholic cirrhosis is reversible and should not be a contraindication to liver transplantation.
Researchers found that routine screening of blood samples to detect viral RNA in organ and tissue donors could reduce disease transmission among transplant recipients. The study suggests that nucleic acid testing (NAT) may be used to improve viral safety of grafts.
Researchers have successfully removed and preserved a woman's ovary, allowing for the potential restoration of her fertility after cancer treatment. The procedure shows promise in combating infertility caused by chemotherapy and radiotherapy, offering hope to women seeking to become pregnant again.
Scientists have grown functional kidneys in rats using embryonic tissue transplants, demonstrating their ability to filter blood and excrete waste. The research marks a critical step towards developing animal-to-human transplants to address chronic organ donation shortages.
Researchers discovered that choroid plexus cells can stimulate stem cell production and release neurotrophic factors after a stroke, reducing damage in animal models. The study suggests potential for new therapy to supplement the natural healing response of this tissue.
A study led by Michigan State University scientists found that lyophilization does not improve the safety of bones and tissues for transplantation, contradicting current clinical beliefs. The researchers tested five samples each of infected bone and tissue through lyophilization and found that the virus survived the process.
Virginia Tech researchers are creating biocompatible adhesives that can be activated with light to mend vascular tissue. The novel polymer has been shown to have promising properties for laser-assisted vascular repair, potentially speeding up the healing process and reducing complications.
OHSU scientists successfully transplanted ovarian tissue into monkeys, allowing the return of hormone cycles and egg production. The procedure may lead to new methods for preserving fertility in young cancer survivors.
A breakthrough in fertility preservation allows women to store their ovarian tissue before cancer treatment, which can be transplanted years later to restore reproductive function. The technique shows promise but also raises concerns about safety and effectiveness, prompting calls for further research.
A 7-month-old boy named Lukas received a groundbreaking artificial corneal transplant using the AlphaCor device, offering renewed hope for patients with high-risk traditional corneal transplants. The procedure's success marks a significant milestone in the development of this innovative technology.
Researchers found that exposing mice to Notch signal and donor material before transplantation stimulates an immune response, significantly increasing transplant acceptance. The approach targets T suppressor cells, promoting their expansion and reducing T helper cell activity.
Researchers successfully transplanted embryonic pancreatic tissue into rats with Type 1 diabetes, producing enough insulin to maintain normal blood-sugar levels. This breakthrough method has promising results and could potentially overcome the shortage of human organs for transplant.
Researchers are working on developing engineering tools to monitor breakups in tissues and organs, with the goal of improving storage methods for transplant tissues. The team aims to create systems that can safely store complex tissues and organs, which could lead to breakthroughs in disease treatment and expand organ availability.
Researchers at Duke University Medical Center have successfully treated seven out of 12 children with complete DiGeorge Syndrome using a thymus transplant procedure. The transplants enabled the children's bodies to form new immune systems, leading to improved survival rates and reduced infections.
Researchers have discovered that brain stem cells can be transplanted without being rejected by the immune system, thanks to their unique properties. This breakthrough could lead to new treatments for eye diseases such as blindness.
Researchers have successfully transplanted uteri into mice, paving the way for future womb transplants in humans. The study found that transplanted uteri can harbour pregnancies and rejection patterns are similar to other organs.
Researchers are exploring neural transplantation as a potential treatment for Parkinson's disease, despite initial disappointing results from clinical trials. Further studies aim to improve the effectiveness of transplants and address concerns about side effects such as dyskinesias.
Rice University researchers aim to develop new, noninvasive treatment options for damaged cartilage by using patient's own bone marrow cells to grow more cartilage. The goal is to create a biodegradable scaffold that promotes cartilage formation and avoids problems associated with current therapies like allografting.
Researchers found that a small region of tissue at the front edge of what in humans would be the upper lip controls development of the upper half of the face. Facial tissues remain responsive to their environment for about nine weeks, or through most of the first trimester.
A team of scientists from the University of Wisconsin-Madison has developed methods for recombining DNA segments in human embryonic stem cells using homologous recombination. This technique allows for manipulating any part of the human genome to study gene function and mimic human diseases.
Researchers report improved left-ventricular and overall heart function in a 72-year-old man after receiving undifferentiated stem cells. The grafted scar showed the presence of well-developed skeletal myotubes with preserved contractile structure, indicating long-term viability and functional potential.
Researchers have successfully transplanted immature mouse and rabbit testicular tissue, resulting in live births and mature sperm production. This breakthrough technique offers new hope for pre-pubertal boys and babies affected by cancer treatment, potentially restoring fertility through autotransplantation.
Researchers at Boston Children's Hospital used therapeutic cloning to create functional tissue in cows, including heart, muscle, and kidney tissue. The cloned cells showed no rejection response, a promising development for treating diseases with stem cells.
Researchers at Advanced Cell Technology successfully transplanted cloned tissues into animals without rejection. The study's findings suggest that nuclear transplantation could provide a limitless supply of immune-compatible cells and organs for regenerative therapies, tackling one of the major challenges in transplantation medicine.
The Johns Hopkins team has successfully transplanted kidneys from incompatible donors using a filtering technique, achieving a 93% success rate. The patients underwent plasmapheresis treatments and medication to prevent antibody re-emergence, allowing them to receive organs from donors of any blood type.
A new study found that patients receiving the drug Thymoglobulin had two and half times fewer episodes of acute kidney rejection than those receiving Simulect. The study's findings are significant as they show a potential benefit for up to half of kidney transplants from cadavers.
A new study led by Barbara Bregman found that delaying treatment for spinal cord injuries can lead to increased regrowth of nerve cell fibers. The addition of neurotrophins was key to this effect, with rats experiencing significant improvement in motor function.
UK researchers have made significant progress in preserving fertility for women with cancer by grafting ovarian tissue from cancer patients into mice, demonstrating safety and feasibility. The study has raised hopes for women who require immediate treatment or lack a partner, offering an alternative to embryo freezing.
Researchers at UF'S Mcknight Brain Institute have found no ill effects in two U.S. patients who underwent a spinal cord transplantation procedure from 1997 to 2000. The tissue, obtained from aborted fetuses, seemed to partially fill cavities and prevent further deterioration of the patients' conditions.
Scientists have found that teenage girls with Turner's syndrome still possess follicles in their ovaries, which may enable them to produce eggs. This breakthrough discovery provides a glimmer of hope for these women who are usually infertile due to the syndrome. Further research is needed to confirm the findings and explore the possibi...
Researchers found that patients' immune systems counteract their normal response against donor organs, leading to graft acceptance. The discovery could help doctors monitor transplant patients more effectively and reduce dependence on immunosuppressants.
Researchers have successfully transplanted laboratory-grown neuronal cells into the brains of stroke patients, showing promise for recovering lost abilities. Six months after transplantation, six patients showed significant improvements in motor skills and metabolism, suggesting integration with existing tissue.
The National Institutes of Health (NIH) is launching a new clinical trial to test a promising transplant therapy for type 1 diabetes. The Edmonton protocol involves transplanting insulin-producing pancreas cells and aims to induce immune tolerance, allowing people with the condition to stop relying on insulin injections.
A study led by Johns Hopkins researchers found that patients with fulminant myocarditis can fully recover from the condition within two weeks without much damage to the heart or chance of relapse. Effective treatments include medications and mechanical pumps, which can increase blood flow and assist heart function.
A molecule family known as CSPGs is found to form a barrier that prevents nerve fiber connections from growing after spinal cord injury. Researchers at the University of Florida Brain Institute suggest that this could be a key factor contributing to the failure of adult mammals to regenerate their spinal cords.
The UofA research team is working to prevent rejection of transplanted islet cells, allowing diabetics to become insulin-free. Researchers are also developing procedures for transplanting islet cells before physical complications set in.
A new study of 27,050 kidney transplants found that patients with locally matched kidneys require less long-term care and incur lower costs. The average cost to Medicare was $60,436 for identical HLA markers, increasing by 34% as mismatches rose from one to six.
A new method uses silicon capsules with precise holes to implant healthy transplant cells, eliminating the need for immunosuppression and reducing organ transplantation.
A team of researchers at Washington University School of Medicine has been awarded a grant to develop new treatments for spinal cord injuries. They plan to use embryonic stem cells to replace damaged tissue and restore lost functions, with the long-term goal of enabling patients to regain bladder and bowel control and potentially walk ...
Researchers have successfully transplanted laboratory-grown neuronal cells into the brains of seven stroke patients, with some showing small improvements in motor skills and speech. The therapy, developed by scientists at the University of Pittsburgh Medical Center, aims to restore lost motor skills and has been deemed safe so far.
Duke University chemists have developed novel liquid polymers that can be solidified by laser light to seal transplanted insulin-producing cells inside a selectively permeable capsule. The microcapsules reduce excessive blood sugar levels in experimental diabetic rats for up to eight days.
Researchers at UNC-CH found that Pamidronate is highly effective in partially reversing bone loss caused by immuno-suppressant drugs after lung transplants. Patients treated with the drug experienced a 10% reversal of bone loss, and showed significant increases in femur and spine mineral densities.
Researchers developed an iNOS gene therapy that prevents chronic organ rejection and transplant arteriosclerosis in animal models. The study found that the gene therapy suppressed the disease process by triggering production of nitric oxide, which blocks blood flow in transplanted organs.
Researchers at UT Southwestern Medical Center have developed an oral vaccine that may prevent rejection of corneal transplants. The vaccine involves feeding processed corneal cells from donor corneas to recipients over time, training their immune system to accept donated corneas without the need for powerful immunosuppressive drugs.
Researchers at the University of Maryland Medical Center have developed a new approach to treating long-term diabetic patients by transplanting their pancreas alone. The study found that using two new anti-rejection drugs, Prograf and Cellcept, resulted in a one-year pancreas survival rate of 77 percent for patients.
Researchers at Penn State's Milton S. Hershey Medical Center are developing an electromechanical artificial heart to save thousands of lives. The device is expected to be widely available by 2005 and could implant over 50,000 patients per year.