Articles tagged with Cancer
Researchers developed a drug that triggers the destruction of damaged mitochondria, restored motor function in aging mice with ALS-like symptoms. The results show promising promise for treating neurodegenerative diseases like Parkinson's and Alzheimer's disease.
Researchers at the University of Freiburg have developed modified CAR-T cells that prevent exhaustion and significantly enhance therapy effectiveness in a preclinical animal model. The new approach uses the delta chain signaling subunit instead of the zeta chain, which triggers a more balanced immune response.
An international team of researchers analyzed 1.7 million cells from 225 samples across 11 different cancer types, identifying regions in the DNA that are differentially activated or inactivated in a cancer-specific manner. These epigenetic changes create a signature for each tumour and correspond to hallmarks of cancer.
A recent study found that formaldehyde, a common environmental hazard, can change the epigenetics of cells. The toxic substance alters the regulation of genes and is linked to an increased risk of developing cancer, as well as other diseases such as hepatic degeneration and asthma.
Researchers at Mainz University Medical Center aim to improve patients' quality of life by applying smart data technology to physical activity. The DECIDE project aims to provide individualized control of patients' daily physical activity, while the RELEVIUM project focuses on alleviating pain and weight loss in pancreatic cancer patie...
Researchers found that urine biomarkers can be more accurate than serum biomarkers for detecting specific diseases. The study highlights the potential of combining urinary and serum biomarkers for holistic disease diagnosis and management. However, challenges remain in standardizing urinary biomarker assays and expanding their applicat...
A new study by NUS provides insights into how BRCA2 mutations impact breast tissue cells, leading to early breast cancer development. The research found that healthy mammary glands are not predisposed to form lesions, but HR- luminal cells with BRCA2 mutations exhibit enhanced organoid formation and survival under replication stress.
Researchers at Duke University developed an innovative antibody approach to target and kill tumor-promoting molecules found in cancer cells. The study revealed notable reductions in tumor growth and minimal side effects, making it a promising new treatment option for various types of cancer.
The Center for Innovation and Translation of POC Technologies for Equitable Cancer Care will prioritize development of POC tests for oral, cervical and gastrointestinal cancers. CITEC's goal is to identify needed technologies, accelerate their development, evaluate their performance in diverse settings.
A study by researchers at the University of Illinois found a significant relationship between soy expansion and childhood leukemia deaths in Brazil. Pesticide use in the region has been linked to increased cancer mortality, with an estimated 123 children under 10 dying from ALL associated with pesticide exposure between 2008 and 2019.
A new therapeutic option has been found for patients with a treatment-resistant tumor mutation called KRAS G12C. The sotorasib and panitumumab combination demonstrated superior progression-free survival rates compared to standard of care.
Researchers have discovered a novel biomarker that enables the evaluation of near-infrared photoimmunotherapy (NIR-PIT) treatment success. The biomarker uses microbubbles to track tumor vessels and measure the effectiveness of NIR-PIT, which combines antibodies and near-infrared light to destroy cancer cells.
Researchers aim to validate noninvasive screening test using exosomal microRNAs for early detection of pancreatic ductal adenocarcinoma. The goal is to reduce unnecessary surgeries and improve health equity by including diverse populations in the study.
Researchers developed a blood test to detect cancer earlier in individuals with Li-Fraumeni syndrome, an inherited condition with a high risk of developing cancer. The study provides a proof-of-principle framework for detecting specific cancers earlier, paving the way for further clinical trials and improved patient care.
A study of 5,435 adolescents and young adults with cancer found that those receiving specialty palliative care experienced a decrease in pain severity. However, the intervention did not affect other symptoms, highlighting the need for new interventions targeting other symptoms during treatment.
A new study published in The American Journal of Clinical Nutrition found that consuming more red meat is associated with a higher risk of developing type 2 diabetes. Replacing red meat with plant-based protein sources like nuts and legumes may reduce this risk.
A new method for studying cancer cells' behavior on soft and stiff tissue environments has been developed, revealing crucial survival cues for cell growth. The study challenges the long-held assumption that cells prefer stiffer surfaces, opening up new possibilities for research in cancer biology and tissue engineering.
Jinglei Ping, a UMass Amherst engineering professor, has received a $1.9 million grant to investigate a new method of regulating exosome traffic using electronic signals. This approach aims to control cell communication in cancer and heart disease research.
The Ludwig Leadership Fellows Program aims to address the loss of young talent from academic science by offering independent research funding, laboratory space, and mentorship. The program provides up to five years of support, including $350,000 per year for research expenses and salary.
A new probiotic-guided chimeric antigen receptor (CAR)-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find and destroy tumor cells in situ. The approach expands the scope of CAR-T cell therapy to include solid tumors, which are poorly infiltrated by T cells.
Researchers at Columbia University have engineered tumor-colonizing bacteria to produce synthetic targets that direct CAR-T cells to destroy cancer cells. The probiotic-guided CAR-T cell platform has shown safety and effectiveness in multiple models of human and mouse cancers.
Female cancer survivors perceive high fertility risks despite actual rates being lower, highlighting need for counseling on infertility risk throughout survivorship. Counseling may reduce misalignment between perceptions and actual risk, decreasing fertility-related distress and informing family planning decisions.
A multilevel primary care intervention, including electronic health record reminders and patient outreach, improved timely follow-up of overdue abnormal cancer screening test results for breast, cervical, colorectal, and lung cancer. The intervention was found to be effective in reducing missed screenings.
Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.
A new cancer drug candidate has been found to restore the effectiveness of the immune system in fighting tumors, including melanoma, bladder cancer, leukemia, and colon cancer. The drug works by lowering a toxic compound called MTA, which impairs normal functioning of immune cells and blocks immunotherapies.
Researchers propose a novel method for early cancer diagnosis using standardized mechanical property measurements, potentially detecting cancer earlier than current optical techniques. The method involves analyzing the elasticity coefficient of cells using atomic force microscopes or simpler indenters.
A new study reveals that changing nutrient use can reprogram immune cells, potentially treating cancer and infections. By blocking choline metabolism, researchers found a 'tremendous reprogramming of the immune profile' in mice, suggesting this knowledge could lead to novel therapies.
Case Western Reserve University and University Hospitals researchers will focus on understanding the molecular and genetic factors that trigger Barrett's esophagus development and progression to esophageal cancer. The goal is to translate discoveries into effective prevention and treatments for patients, reducing cancer mortalities.
Researchers developed three new two-photon probes that can visualize organelles in cells, enabling better understanding of cellular functions and tissue imaging. The probes are designed to detect pH levels, viscosity, and ionic species, providing more specific insights into cell viability and treatment responses.
Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.
Researchers have developed a new approach to treating invasive bladder cancer, combining chemotherapy and immunotherapy, which may preserve quality of life. In a phase 2 clinical trial, approximately 43% of patients achieved complete response without surgical removal of the bladder.
Researchers have discovered that brain tumors manipulate immune cells called neutrophils to promote tumor growth and suppress anti-cancer responses. The study identifies key mechanisms by which the tumor microenvironment converts neutrophils into immunosuppressive agents, providing new avenues for treating gliomas and brain metastases.
The American Society for Radiation Oncology announced the winners of its new combination therapy challenge, which aims to improve prostate cancer treatments using relugolix in combination with radiation therapy. The three winning research proposals will receive funding over four to five years.
A Rice University-led team of researchers has been awarded $45 million to develop a new sense-and-respond implant technology that could improve immunotherapy outcomes for patients with difficult-to-treat cancers. The technology, called THOR, aims to provide real-time data from the tumor environment to guide more effective therapies.
Scientists from IRB Barcelona have revealed how chromosomal instability activates a signalling pathway known as JAK/STAT, promoting caspase activity and DNA injury. This damage allows cells to escape from the primary tumour, thereby leading to metastasis.
Researchers identified potential therapeutic targets for Alzheimer's disease and other conditions using a new approach combining AI-driven target identification with protein phase separation analysis. The study provides insights into the role of protein phase separation in human disease and its potential as a therapeutic target.
Researchers at Mayo Clinic discovered that senescent macrophages in the lung promote tumor growth by blocking the immune system's response to abnormal cell growth. Eliminating these senescent cells delays tumor formation, suggesting a potential therapeutic target for cancer treatment.
Researchers discovered that fine-tuning mitochondrial energy production reduces melanoma tumor growth and enhances immune response in mice. The study reveals that manipulating mitochondrial electron transport increases expression of immune genes and makes tumor cells more visible to killer T cells.
Researchers found that combining adoptive T cell therapy with a personalized cancer vaccine improved control of the disease in 12 out of 17 patients with late-stage ovarian cancer. The treatment was also safe and relatively well-tolerated, with median overall survival time exceeding six months for most patients.
Researchers found that beta-blockers can revive exhausted killer T cells, making them better cancer fighters. The study discovered a link between the sympathetic stress response and immune system response to cancer.
A team at DGIST discovered a method to enhance magnetic nanoparticle penetration into cancer cells, improving therapeutic effects. Rotational magnetic fields aid in chain disassembly and propulsion of magnetic nanoparticles, increasing cellular absorption and treatment efficacy.
Veratramine from Veratrum japonicum significantly inhibits prostate cancer cell proliferation and survivability. The research team also found that veratramine increases ATM/ATR protein expression and suppresses Akt protein, leading to decreased tumor size and toxicity in immunodeficient mice.
Researchers found that inhibiting isocitrate dehydrogenase in T cells leads to transformation into memory cells with enhanced anti-tumor activity. This discovery could improve CAR-T and other adoptive cell therapies by overcoming exhaustion.
Researchers found higher 5-year survival rates among Kaiser Permanente patients compared to National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) estimates. Improved screening rates, cancer treatment pathways, and coordinated care may have contributed to these higher survival rates.
Researchers developed a technology to rapidly screen genetic edits in immune cells, identifying a new combination that improves their effectiveness against cancers. By combining multiple genes into long DNA stretches and testing thousands of combinations, scientists discovered that different CARs can be optimized by different factors.
CityU and AFCR have signed a MoU to promote cutting-edge cancer-related innovative inventions and commercialization. The partnership aims to foster the development of biomedicine and related innovation, with world-leading scholars from Harvard Medical School attending the inaugural 'Innovation Series in Biomedicine' forum.
The City of Hope will lead the way in integrating complementary therapies into cancer care, supporting holistic treatment for patients. The Cherng Family Center's research and clinical programs aim to advance evidence-based standards for integrative oncology, creating an international destination for its transformational work.
A first-of-its-kind study by LSU Health New Orleans found that chronic diseases, such as hypertension and diabetes, explained nearly two-fifths of the racial disparity in COVID-associated hospitalizations. Non-Hispanic Black cancer patients had a higher prevalence of chronic diseases and were more than twice as likely to live in high-p...
Researchers found that a combination of AXL and EGFR inhibitors can suppress tumor growth and prevent relapse in patients with certain cancers. The study clarifies the novel regulatory mechanism by which AXL stimulates YAP via the EGFR-LATS1/2 axis.
A recent special issue investigates the molecular mechanisms behind cancer's malignant phenotype, exploring topics such as metabolic reprogramming and tumor heterogeneity. The findings aim to contribute to the development of mechanism-based approaches for cancer treatment.
A systematic review found that antidepressants are equally effective and safe for patients with both depression and physical health issues as those without. The study suggests that treating these patients with antidepressants can improve quality of life and reduce the course of physical disease.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
This review summarizes six common RNA modifications, including m6A, m5C, m1A, m7G, Ψ, and A-to-I editing, which play crucial roles in various human diseases. The authors discuss the mechanisms of these modifications and their targeting by small molecule inhibitors.
A new study from the University of Michigan found significant language-based disparities in patients' access to cancer care. English-speaking callers were able to get information on next steps 94% of the time, while Spanish-speakers and Mandarin-speakers were only connected at 38% and 28% respectively.
Research published in BMJ Oncology reveals a global increase of 79% in new cancer cases among those under 50 between 1990 and 2019. Breast cancer accounted for the highest number of early onset cases, while cancers of the windpipe and prostate rose the fastest.
Researchers developed a targeted microRNA therapy that slowed cancer tumor growth in a 21-day study. The therapy, which combines a delivery system with modified microRNA-34a, suppressed the activity of genes driving cancer and resistance to other therapies.
A study of 11.7 million adults in Ontario, Canada, reveals that COVID-19 infection is associated with significantly higher mortality rates among cancer patients who do not receive prioritized critical care treatment.
A novel liquid biopsy technology developed by UCSC Assistant Professor Daniel Kim's lab leverages RNA 'dark matter' to enhance cancer diagnosis. The test detects both protein-coding and repetitive noncoding RNAs in the blood, showing improved sensitivity for early-stage cancer detection.
A new study finds that cost-cutting policy changes, mobile apps, and psychological strategies can increase medication adherence by nearly 1.5 times among breast cancer survivors. The study also highlights the importance of managing side effects through physical therapy, exercise, and behavioral counseling.
A recent study by Osaka Metropolitan University researchers has discovered the anti-cancer effects of Kencur extract and its main active ingredient, ethyl p-methoxycinnamate (EMC). The findings indicate that EMC suppresses cancer cell growth at both cellular and animal levels.