Articles tagged with Cancer
Researchers propose targeting non-canonical HH/GLI signaling to improve response rate and durability of therapeutic effects exerted by SMO inhibition in melanoma. The findings suggest that combined targeting of hedgehog signaling and BRD4 could provide a novel therapeutic option against melanoma.
UCSB researchers develop platform to interpret cellular 'stress memory landscape', predicting future reaction to stressors. The study opens window into various cellular stress-related conditions, including aging, cancer and neurodegenerative diseases.
Scientists have teamed up to improve drug delivery by designing more effective lipid nanoparticles. Their latest study documents how high-throughput workflows can produce and characterize LNPs at record speed, with neatly ordered structures leading to better silencing of faulty genes in human neurons.
A new study by researchers at Dartmouth Cancer Center shows that a combination of estrogen and PARP inhibitors can effectively treat advanced ER+ breast cancer by damaging cancer cells and preventing DNA repair. The treatment strategy has been shown to be effective regardless of BRCA1 or BRCA2 genetic mutations.
A team of UVA Health experts warns that surgeon-scientists are struggling to obtain research funding, which could lead to a decline in innovations for patients. The researchers found that internal medicine trainees are six times more likely to secure R01 grants and career development awards.
Researchers at Tokyo Institute of Technology developed a novel boron agent that selectively accumulates in brain tumor cells, exhibits enhanced blood retention, and can be administered at low doses. The agent, PBC-IP, shows promising results in preclinical studies, highlighting its potential for radiotherapy in treating glioblastoma.
A new study by Rice University bioscientists reveals how plant cells collaborate to fuel growth, shedding light on corresponding mechanisms in human cells. The findings focus on the role of enzyme MIEL1 and its human counterpart PIRH2 in breaking down protein coatings on lipid droplets.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
Researchers at Nanyang Technological University discover ponatinib, an existing cancer drug, can block key steps in alternative lengthening of telomeres (ALT) mechanism. This could lead to new treatment options for ALT cancers, which currently lack targeted therapies.
A study found that high tumor monocyte content is linked to improved outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy. The degree of tumor mutational burden also predicts survival outcomes, suggesting a potential biomarker for selecting patients likely to benefit from immunochemotherapy.
Researchers at Paul Scherrer Institute have developed a beamline modification called momentum cooling to increase the transmission of proton beams, allowing for shorter treatment times. This breakthrough could enable faster treatments while maintaining accuracy and sparing healthy tissue, with potential benefits including reduced costs...
Researchers found that cigarette smoke and HPV interact to heighten the risk of head and neck cancer by increasing oxidative stress and DNA damage. The study's results pave the way for novel strategies in prevention and treatment.
Scientists have developed a method to engineer tubulins with precise post-translational modifications, revealing a new interplay between polyglutamylation and detyrosination. This breakthrough uncovers the tubulin code's connection to microtubule function and its regulation in cells.
Researchers at UC San Diego found a novel combination of KRAS and ERBB drug inhibitors outperformed treatments in human and mouse models of pancreatic cancer. The combination reduced drug resistance and increased survival rates.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
A randomized trial will be conducted to test whether sticking with the initial medication or switching to a different one increases quitting success. The study aims to provide guidance for clinicians on handling relapses and may explore the effectiveness of e-cigarettes as an alternative to traditional cigarettes.
A Michigan State University researcher has received a $3.2 million grant to develop tools for cancer survivors to manage symptoms and improve their well-being while taking oral anti-cancer medications. The project aims to provide scalable symptom monitoring and self-management strategies to reduce costs and emergency department visits.
A nationwide study of nearly two million women found that those with PCOS who have undergone menopause are more than twice as likely to be diagnosed with ovarian cancer. The risk was also significantly higher for a type of ovarian tumor known as serous borderline, which can lead to cancer later on.
Researchers have discovered that gene editing technologies may introduce unintended mutations and damage to DNA in early human embryos. The study found that most cells repair breaks in the DNA using non-homologous end joining, which can lead to additional genetic abnormalities.
The Biden-Harris Administration has launched a $50 million initiative to improve cancer outcomes in persistent poverty areas. The Persistent Poverty Initiative aims to build research capacity, foster cancer prevention research, and promote community-based programs to address the cumulative effects of poverty on cancer outcomes.
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
Researchers analyzed data on 34,789 endometrial cancer cases from Florida and the French Caribbean, finding that Caribbean Black women had the lowest rates for both subtypes. Non-endometrioid types were most common among US Black women, with rates increasing yearly for all groups.
A pioneering device captures single proteins stochastically, detecting them digitally at high concentrations. This breakthrough could lay the foundation for personalized disease prevention and treatment.
Children with parental cancer history face higher rates of unmet economic needs, including food security, housing affordability and transportation access. The study highlights the need for strategies to identify and support these vulnerable children.
Researchers developed a platform called Orion that bridges parallel worlds of microscopic analysis and multiplexed tissue imaging. The platform enables the integration of information from each source into a comprehensive view across the entire slide, predicting patient prognosis and tumor behavior.
Researchers have identified anti-malarial properties in cancer drugs, offering a potential solution to the growing crisis of drug-resistant malaria. The study found that certain protein kinase inhibitors exhibited strong anti-malarial effects, highlighting a new approach to accelerating drug discovery.
Rice University engineers developed a low-cost, point-of-care DNA test for HPV infections that can be used to screen for cervical cancer. The test, which requires just two pieces of equipment and delivers results in 45 minutes, has the potential to make cervical cancer screening more accessible in low- and middle-income countries.
Rensselaer Polytechnic Institute researcher Scott Forth is investigating the mechanical code underlying mitosis to combat cancer. His lab aims to determine how chromosomes are segregated during cell division, with potential insights into new diagnostics and treatments.
Researchers at City of Hope have developed a universal donor stem cell therapy that can treat degenerative brain diseases such as Canavan disease and Alzheimer's. The therapy, which uses an 'off-the-shelf' approach, has shown promising results in preclinical studies, reducing toxic accumulation of metabolites and improving motor function.
Researchers found that morphine interacts with toll-like receptor 4 to contribute to increased bone loss and pain. Blocking TLR4 prevents these effects, suggesting a new target for reducing opioid side effects.
Researchers developed tiny nano-sized pores that can detect specific proteins in complex biological fluids, such as blood. The breakthrough enables fast and accurate disease diagnosis, potentially leading to earlier interventions and improved treatment outcomes.
Researchers at UC San Diego have discovered that shattered DNA fragments are tethered together during cell division, allowing them to be reassembled in a different order. Destroying the tether may help prevent cancerous mutations and is now being explored as a therapeutic target.
A study by Martin-Luther-University Halle-Wittenberg found a link between high levels of IGF2BP2 and faster-growing bowel cancer tumours with chemotherapy resistance. The protein's role in cell growth and metabolism may lead to the development of new diagnostic procedures and therapeutic strategies.
Research suggests that the Bhopal gas disaster had long-term intergenerational effects on health and education. Men exposed in utero to toxic gas had a higher risk of disabilities and cancers, while those born later had reduced educational attainment. The sex ratio of births also changed among children born near the incident site.
Researchers discovered that components of heat-marred DNA can be absorbed during digestion and incorporated into the DNA of consumers, potentially triggering genetic mutations. This finding has important implications for dietary choices and public health, highlighting the need to reassess cooking methods.
A new study found that obesity is associated with an increased risk of certain cancers, with stronger links in female patients for gallbladder and endometrial cancer. The study also revealed differential effects between sexes on colorectal, esophageal, and liver cancer.
Researchers at MD Anderson Cancer Center develop new methodology to analyze earliest precursor stages of multiple myeloma, revealing substantial genomic and transcriptional heterogeneity. The study identifies potential therapeutic targets and biomarkers for high-risk patients.
Researchers at Mass General Cancer Center describe the evolution of proton therapy, its benefits to patients, and efforts to increase access worldwide. They highlight advancements in machine size reduction and treatment efficiency, paving the way for global democratisation.
Researchers discovered a group of intestinal T cells with α4β7 integrin receptors that can either suppress or enhance anti-PD-1 immunotherapy in cancer patients. Targeting these cells may improve treatment outcomes and reduce resistance to immune checkpoint blockade.
The Montefiore Einstein Cancer Center received a $2.9 million grant to train physicians and scientists to conduct clinical and translational oncology research, focusing on addressing health inequities in the Bronx. Scholars will engage in interdisciplinary research projects with community outreach and engagement.
A recent study found that germline genetic testing after cancer diagnosis is underutilized, with rates significantly lower among Asian, Black, and Hispanic patients compared to non-Hispanic whites. The study, published in JAMA, suggests disparities in access to genetic testing by race.
Researchers analyzed BORIS mutations and protein expression in breast cancer tissue samples, finding frequent mutations associated with breast carcinoma progression. The study suggests the BORIS gene as a potential biomarker for breast cancer.
Researchers updated their protein localization prediction model, MULocDeep, to provide more targeted predictions for biological discoveries. The tool helps researchers design more effective experiments and advance scientific discoveries related to drug development and treating diseases like epilepsy.
Researchers at Karolinska Institutet have identified how memory killer cells are formed and found a correlation between their presence in cancer tissue and improved survival rates in people with melanoma. The study suggests that harnessing the potential of these cells could lead to more effective immunotherapy.
The SISAQOL-IMI Consortium establishes an international consensus on patient-reported outcomes in cancer trials, aiming to improve the use of PROs. The new standards will enhance patient involvement and ensure the relevance of recommendations to the patient community.
Late-onset cognitive impairment emerged in adult childhood cancer survivors decades after diagnosis and treatment. Modifiable health behaviors and chronic health conditions significantly increase this risk.
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
The ATOM Coalition aims to improve cancer medicine availability and increase the capacity of lower-income countries to diagnose and manage cancer. The coalition prioritizes generic and biosimilar medicines for cancer treatments, targeting countries with high mortality rates.
A team of researchers from CSI Singapore has identified a transcription factor, TOX2, as a potential target for treating Natural Killer/T-cell Lymphoma (NKTL), an Epstein-Barr virus-associated cancer with poor treatment outcomes. The study found that TOX2 is overexpressed in NKTL patients and negatively associated with patient survival.
Researchers found that formalin fixation does not significantly alter the polarimetric properties of brain tissue, making it suitable for training machine-learning models. The study suggests that formalin-fixed brain tissue specimens can provide high-quality data for rapid and accurate diagnostic imaging in surgery.
Researchers developed a strategy targeting RNA recycling enzymes to prevent harm from cancer genes MYC, JUN and MIR155. This approach showed promise in slowing tumor growth in cancer patients.
Researchers tracked immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling. Early adulthood sees myeloid cells, while between 6-12 months old, there's a profound shift to T and B lymphocyte-dominance. The study reveals new insight into prostatic inflammaging and the window for interventions.
A literature review found that dietary nitrate from vegetables may prevent cardiovascular disease, while nitrate from meat and water may pose a cancer risk. Experts emphasize the need for clarification in current guidelines and more research to distinguish fact from fiction.
Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.
Researchers from China explore the mechanisms of action and clinical data of bispecific antibodies, which have shown promise in increasing cytotoxicity against cancerous cells and enhancing immune response towards tumor clearance. Several bsAbs are being evaluated in phase I-III clinical trials for lung cancer treatment.
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
A team of DGIST researchers led by Professor Kyungmoo Yea developed an antibody that effectively alleviates chemotherapy-induced cancer cachexia. The new treatment approach enhances patient response to continuous anti-cancer therapy, improving quality of life and restoring skeletal muscles and fat tissues.
The number of US cancer survivors with self-reported functional limitations has more than doubled since 2000, according to the study. Cancer survivors without functional limitations have seen relatively little growth over the same period.
Research finds military veterans exposed to low doses of chemical warfare agents have higher rates of mortality from genitourinary diseases and deaths attributable to alcohol. However, overall cancer incidence is not significantly associated with Porton Down attendance.
A study by Tufts University researchers reveals how DNA repair can fail near expanded repeats, leading to mutations and disease. The team found that certain proteins play a crucial role in stabilizing the DNA during repair.