Articles tagged with Cancer
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A team of researchers discovered that a mutation in the HMGB1 protein causes a rare disorder with severe malformations, suggesting a link between protein droplets and genetic disease. The study's findings could have implications for understanding congenital malformations, common diseases, and cancer.
Salk scientists discovered that when telomeres become very short, they communicate with mitochondria, triggering an inflammatory response. This process destroys cells that could become cancerous, preventing cancer formation. The findings highlight the importance of studying interactions between telomeres, mitochondria, and inflammation.
A new study found that long-term voluntary wheel running improved skeletal muscle and bone parameters in female mice, but the effects varied depending on body weight. High body weight was more beneficial for muscle and bone health with aging, especially when combined with exercise.
The American Society for Biochemistry and Molecular Biology is hosting its annual meeting, #DiscoverBMB, featuring award lectures by high-profile speakers. The event will take place March 25-28 in Seattle, with topics including quorum sensing and developmental mechanisms in African Trypanosomes and precision oncology.
Two studies published in Science Immunology reveal that TE-exon splicing junctions can differentiate tumors from healthy tissue, offering a potential solution to the field of immuno-oncology. The research identifies novel recurrent, cancer-specific targets and validates Mnemo's antigen discovery platform.
A recent study estimated that shifting from in-person visits to telemedicine for patients with cancer can result in substantial carbon emissions savings. By reducing the need for transportation, telemedicine can significantly decrease greenhouse gas emissions and contribute to a more sustainable healthcare system.
A new study suggests that higher consumption of ultra-processed foods may be linked to an increased risk of developing and dying from cancer. The study found that each 10% increase in ultra-processed food consumption was associated with a 2% increase in cancer incidence, as well as a 6% increase in mortality from cancer.
Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.
A study found a link between pain and indigestion medication purchases and ovarian cancer diagnoses, suggesting earlier symptom recognition. The research suggests that loyalty card data can be used to identify potential ovarian cancer cases.
Researchers developed a cancer-selective therapeutic agent that targets cancer cells' unique acidic pH microenvironment, inducing mitochondrial dysfunction and killing only cancer cells. The agent, Mito-SA, forms charge-shielded nano-assemblies that selectively disassemble in the tumoral environment.
A UK study found that people with type 2 diabetes have substantially higher cancer mortality rates than the general population. Breast cancer mortality in younger women with T2D is rising, highlighting the need for extended screening, better management of diabetes and its complications, and improved cancer treatments.
A new DNA biosensor developed by NIST, Brown University, and the French government-funded research institute CEA-Leti boasts accurate and inexpensive design. The modular device can measure biomarkers in a scalable and high-sensitivity manner.
Researchers at Tokyo University of Agriculture and Technology discovered a novel amyloid protein, α-S1 casein, which can cause disease in humans. The study found that overexpression and N-terminal truncation of α-S1-casein led to its formation as an amyloid protein.
Researchers at MUSC Hollings Cancer Center discovered the cellular origin of normal pancreatic fibroblasts and cancer-associated fibroblasts, which play a key role in tumor progression. The findings suggest that targeting cancer-associated fibroblasts holds exciting potential for therapeutic benefits.
Researchers identified geographic, racial and ethnic, socioeconomic, and clinical characteristics as key contributors to the elevated suicide risk among cancer patients. Timely symptom management and targeted psychosocial interventions are crucial for preventing suicide in individuals diagnosed with cancer.
A novel KRAS mutation promotes tumor evasion from innate immune surveillance by activating CD47, leading to decreased phagocytosis of cancer cells. Disruption of the KRAS-CD47 signaling axis with siRNA or inhibitors restores innate immune surveillance and enhances macrophage phagocytic capacity.
Researchers identified 14 pathogenic variants in genes related to mitosis and telomere integrity, suggesting alterations in these processes are key to sarcoma predisposition. The study provides new biological insight into sarcoma development and could inform better genetic risk profiles for the disease.
Researchers have created a genetic map to identify important genes causing sarcoma, a common childhood cancer. The study found that one in 14 individuals with sarcoma carries a clinically significant gene, offering hope for earlier diagnosis and treatment.
An international study led by the University of Trento revealed that social interactions play a key role in shaping the composition of our microbiomes. The researchers found that adults acquire microbes through close contact with family members, partners, and friends, while infants acquire them later on at birth.
A new prostate cancer therapy is being tested in clinical trials, targeting the treatment-resistant form of the disease. The therapy uses a drug called Abivertinib to block a specific protein that allows tumors to produce androgens, a goal of using more targeted treatments like TKIs.
A study of 184 grade I and II meningiomas found associations between specific tumor mutations and increased or decreased recurrence rates. Mutations in ATM and CREBBP were linked to accelerated recurrence, while POLE mutations showed protective effects, highlighting potential targets for intervention.
A new study found that the antibody-drug conjugate STRO-001 showed nanomolar cytotoxicity in 88% of cancer cell lines tested, with potent efficacy against proliferating B cells. The research supports ongoing clinical studies for patients with B-cell non-Hodgkin lymphoma.
Researchers discovered a molecular pathway critical to the initiation of pancreatic tumors, which can contribute to disease resistance and metastasis. Targeting this pathway could limit tumor progression, relapse, and spread by disrupting the interaction between cancer cells and their microenvironment.
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
A significant risk of suicide is observed among cancer surgery patients, especially those who are male, white, and divorced. These demographic factors are associated with the highest risk, highlighting the need for suicide screening in high-risk patient groups
Researchers discovered that 15-deoxy-prostamide-J2 induces ER stress-mediated apoptosis selectively in tumor cells, reducing melanoma growth. The molecule activates PERK, IP3R, and the mitochondrial permeability transition pore, leading to cell death.
A multidisciplinary team reviews genomic test results and recommends treatment options for patients with gastrointestinal cancer, identifying clinical trials suitable for most patients. The program has been successful in providing expert treatment guidance for over 500 patients and can be a model for other cancer centers.
A new study found that COVID-19 primarily affected patients with a moderate to critical course, often with comorbidities, whereas many had mild courses despite metastatic melanoma and systemic therapy, recommending continued treatment whenever possible.
A new cancer protein profile database has been created by KTH Royal Institute of Technology, mapping 1,463 proteins to 12 different cancer types. This database allows for the identification of individual cancer types using just a drop of blood, providing a promising new approach to cancer prediction and diagnosis.
A new study has identified a protein called LAP1 that makes melanoma cells more aggressive by changing their nucleus shape. The protein allows cancer cells to migrate and spread throughout the body, leading to poor outcomes in patients.
A randomized controlled trial found that community gardening increases fiber intake by 7% and physical activity levels, leading to lower stress and anxiety. The study also confirms the benefits of novice gardeners and highlights the social connections formed through community gardening.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
A recent Ludwig Cancer Research study reveals that the immune system's surveillance of cancer can induce metabolic adaptations in early-stage tumors, promoting their growth while evading lethal immune responses. The study identifies three key proteins orchestrating this effect: IFNγ, STAT3, and c-Myc.
Researchers identified two broad categories of MPNSTs based on their molecular makeup, one of which has a higher number of immune cells and tends to be more survivable. This discovery may lead to new treatment approaches for NF1 patients with MPNSTs, including immunotherapy and genetic testing.
Researchers at Salk Institute discover thousands of previously unknown microproteins in brown and white fat tissue, finding that one, Gm8773, increases feeding activity in mice. This discovery could lead to the development of a therapeutic to promote weight gain in certain disease situations.
A recent study found that the APOBEC3G enzyme can cause numerous mutations in bladder tumor cells, leading to increased malignancy and mortality. The research suggests that this enzyme could be a potential target for cancer treatment strategies.
Scientists at UC San Diego School of Medicine identified distinct patterns of cytokine and granzyme expression in tissue-resident memory T cells, highlighting their complex biology. These findings pave the way for a new branch of precision therapeutics targeting infection, cancer, and autoimmune diseases.
Researchers from Okayama University found that Actinidia arguta (Sarunashi) juice and its component isoquercetin inhibit lung cancer development in mice, accelerating DNA repair and suppressing Akt-mediated growth signaling. The study suggests Sarunashi juice as an attractive candidate for chemoprevention.
As we age, fat cells replace immune system tissue in lymph nodes, impairing their ability to fight infections and respond to vaccinations. This phenomenon, known as lymph node lipomatosis, is more common and prevalent with age, affecting the effectiveness of our immune system.
A global study has discovered a gene, SULT1A1, that may help reduce the risk of breast cancer, especially in women with BRCA1 gene mutations. The study, involving over 26,000 women, found that reducing levels of this protein can lower breast cancer risk and is being used to develop a new risk-reducing drug.
A systematic review and network meta-analysis found that acupressure has a greater effect on reducing sleep disturbance in patients with cancer. The study suggests that nurses should be trained in acupressure to help patients experiencing sleep problems. The analysis included 24 randomized controlled trials involving 2,002 patients.
The Inflation Reduction Act offers significant benefits for public health through its tax credits and financial incentives. The law aims to reduce the adverse health effects of climate change by targeting greenhouse gases, conventional air pollutants, and carcinogenic chemical contaminants. By providing a more politically feasible appr...
Researchers analyzed COX-2 levels and segmental chromosome aberrations in pediatric neuroblastoma tumor samples. Positive correlations between pre-CT Ch 7q gain and COX-2 expression were found, as well as negative correlations between Ch 7q gain and Ch 11q deletion.
The study reveals that SETD1A overexpression is associated with poorer disease-free survival in pancreatic cancer patients. Artificially cultured cells showed increased cell growth and migration when SETD1A levels were overexpressed, while knocking down SETD1A expression led to decreased RUVBL1 gene expression.
Researchers developed a laser-based approach to perform microbiopsies, enabling fast, painless tissue sampling with minimal damage. The novel technique uses laser ablation to extract tiny tissue volumes, which can be analyzed using virtual H&E imaging and other techniques in minutes, not hours.
A new UC Davis study reveals that close to half of the cancer deaths in California over two years (2017-2019) were associated with tobacco use, totaling 93,764 Californians. Tobacco control efforts have contributed to a decline in cancer mortality in California, but quitting is essential for patients with cancer.
A new study finds that inadequate pollination leads to a 3-5% loss of fruit, vegetable, and nut production, resulting in 427,000 excess deaths annually from lost healthy food consumption. The health burden is greater in middle- and higher-income countries with high rates of non-communicable diseases.
Salk scientists have developed a new therapeutic compound called FexD, which reverses gut inflammation in mouse models of inflammatory bowel disease. By activating the master regulator protein FXR, FexD reduces inflammation and restores balance to the digestive system.
Researchers found that simultaneously targeting two signalling switches can severely inhibit tumour angiogenesis, cancer growth and metastasis in multiple models of cancer. This approach has the potential to restrict a cancer's ability to escape therapy by rapidly destroying the VEGF receptor when both receptors are targeted.
A recent study by City of Hope found that only 30% of patients with advanced neuroendocrine tumors prioritize living longer as their top goal. Instead, 70% focus on addressing pain, fatigue, and losing function. The research highlights the need for better communication between care providers and patients to develop personalized treatme...
Researchers at UCSF and IBM Research create a predictive model that encodes commands for cells to kill cancer cells. By combining words that guide engineered immune cells, they can predict which elements should be included in a cell to carry out precise behaviors. This advance allows scientists to rapidly design new cellular therapies.
A study published in the Journal of Dentistry found that patients with unexplained brain abscesses were three times more likely to have oral bacteria present. The researchers also discovered significantly higher counts of Streptococcus anginosus, a bacterium linked to dental abscesses and infections in internal organs.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
Researchers have identified three new subtypes of glioblastoma, a type of brain cancer, based on the presence of specific non-cancer cells. These subtypes may help identify targeted therapies, such as immunotherapies, for improved patient outcomes.
Research highlights importance of long-term screening and healthy lifestyle behaviors in reducing cardiovascular disease risk among young cancer survivors. Factors such as sociodemographic status, income, education, smoking status, and physical activity levels are associated with increased or decreased CVD risk.
Researchers from Trinity College Dublin analyzed ancient DNA from two men with multiple osteochondromas, a rare genetic disease, and identified new mutations in the EXT1 gene. This study is the first to discover a new disease mutation in ancient genomic data.
A study using spatial single-cell transcriptomics reveals the spatial organization of cancer cells in patient tissues across ages and locations. The research highlights age- and location-dependent differences in tumor biology, suggesting that kids and adults with diffuse midline gliomas may need different treatments.
A recent study led by the University of Nevada, Reno and the Pan American Health Organization suggests that the adoption of front-of-pack nutrition labeling can help reduce poor-nutrition related non-communicable diseases in the region. Improved FOPNL systems have been associated with improved diet quality and reduced risk of NCDs.
Researchers identify POLQ's vital role in responding to DNA replication stress and its potential as a cancer target. Inhibiting POLQ may limit mutation diversity and cancer evolution, offering new hope for cancer treatment.
Researchers from Kaunas University of Technology and Lithuanian University of Health Sciences developed an AI-based system to evaluate the 'substitute voice' of laryngectomy patients, allowing for faster detection of pathologies. The Acoustic Substitution Voice Index (ASVI) uses acoustic parameters and artificial intelligence methods t...