Articles tagged with Diabetes
Researchers have identified new potential therapeutic targets for diabetic kidney disease (DKD), a leading cause of kidney failure. The study reveals common and cell-type-specific changes caused by insulin-resistance, representing new targets for pharmacological or targeted gene therapy approaches.
A six-month clinical trial found that empathetic phone calls led to significant improvements in blood sugar control for low-income adults with diabetes. The patient-driven approach empowered individuals to receive support at a pace that suited their needs and schedules.
Researchers at Karolinska Institutet have identified two types of metabolic-associated fatty liver disease, a liver-specific type and a systemic type that affects other organs. The discovery could lead to improved diagnosis and treatment of this growing patient group, with potential benefits for cardiovascular health.
The addition of jabuticaba peel flour increased the bread's fiber content by over 50% and raised its antioxidant capacity by 1.35-3.53 times, leading to improved blood sugar control and insulin response. The study found that satiety increased after consuming the bread with jabuticaba peel flour, suggesting a lower glycemic index.
The novel compound HPH-15 outperforms metformin by activating AMPK at lower doses, improving glucose uptake and reducing fat accumulation in high-fat diet-induced obese mice. Additionally, it exhibits antifibrotic properties, potentially addressing liver fibrosis.
A research team developed a diabetes prediction system utilizing clinical and genetic data through deep learning AI algorithms. The system predicts the risk of developing type 2 diabetes within five years, enabling early preventive strategies.
A new study of over 4,000 postmenopausal women found that weaker handgrip strength is associated with a greater likelihood of having diabetes. Women who had been postmenopausal for more than 10 years showed an inverse relationship between handgrip strength and diabetes prevalence.
A new review reveals how sleep disturbances exacerbate dementia symptoms, impacting overall health and caregiver well-being. The study emphasizes the need for holistic approaches to address coexisting conditions like cardiovascular disease and diabetes.
Researchers found that certain cancer treatments, such as immune checkpoint inhibitors, can trigger damaging levels of inflammation in the heart and increase risk of heart disease. This is because these treatments interfere with immune regulation in the heart's largest blood vessels.
Researchers have developed a 3D artificial skin model with all three layers, simulating diseases and injuries more accurately. The model can replace animals in toxicological studies of medicines and cosmetics, enabling the development of new treatments without animal testing.
Dr Bøsch's work explores betalains' potential to impact blood pressure, diabetes, cardiovascular health, and gut microbiota. The award highlights the significance of her research in advancing functional food and feed applications with implications for human and animal health.
A U-shaped association between waist circumference and all-cause mortality was found in women, while a J-shaped trend was observed in men with type 2 diabetes. The study suggests that optimal waist circumference thresholds for minimizing mortality risk are 107 cm for women and 89 cm for men.
Proteins moving slowly through cells lead to widespread dysfunction, affecting gene expression, ribosome production, and more. Researchers propose restoring protein mobility as a therapeutic target for treating chronic diseases.
A systematic review of 18 randomized controlled trials found that drinking enough water can help with weight loss and prevent kidney stones. Drinking eight cups a day significantly decreased the likelihood of getting another kidney stone, while six cups a day helped adults lose weight.
The NYU-CUNY Prevention Research Center will improve diabetes management among low-income immigrant populations through culturally tailored education and support. The center aims to enhance capacity for community partners to adopt and implement evidence-based interventions effectively.
A study estimates that approximately one-third of eligible US adults without diabetes were excluded from clinical trials supporting GLP-1 and GLP-1/GIP medications. The FDA should consider updating labeling to advise caution on generalizing these medications' safety and effectiveness to excluded populations.
A new study from Northwestern Medicine reveals a significant increase in severe maternal morbidity and birth complications in Illinois between 2016 and 2023. The findings highlight the impact of chronic health conditions such as obesity, hypertension, and mental health disorders on pregnancy outcomes.
Christian Wolfrum will serve as NTU's chief academic officer, overseeing educational and research excellence, while strengthening talent development. He brings experience in translating research into real-world applications, having co-founded biotechnology firm Glycemicon AG.
Researchers at Monash University have discovered that LXA4 can halve inflammation and scar formation in diabetic hearts, offering a promising new treatment option. The study's findings suggest that LXA4-based therapies could be used to manage diabetic heart disease more effectively.
A new study reveals that infants exposed to gestational diabetes mellitus (GDM) in utero may not have as weighty of challenges as previously believed. GDM-exposed babies showed slower fat gain during their first year, suggesting a flexibility in early-life growth patterns.
Proactive screening of diabetic patients with coronary heart disease does not improve long-term survival rates or lower future cardiac events, according to a new study. The study found that focusing on proven interventions like medication management and lifestyle changes can help patients with diabetes lead healthier lives.
Researchers from Universidad Miguel Hernandez de Elche found that bisphenol analogs BPF and BPS, marketed as safer alternatives to BPA, accumulate in biological membranes and disrupt endocrine function. The study suggests these compounds pose health risks similar to those of BPA.
Researchers at the University of Nottingham have discovered that GLP-1 receptor agonists may be effective in reducing alcohol consumption. The study suggests that this type of diabetes medication could potentially treat excessive alcohol use and lead to a reduction in alcohol-related deaths.
Researchers from UAB have developed a gene therapy that reverses metabolic dysfunction-associated steatohepatitis (MASH) in mice, and most obese and type 2 diabetic patients could benefit from this treatment. The therapy, based on the fibroblast growth factor 21 protein, mediates long-term reversal of liver fibrosis and MASH.
A study found that monochromatic infrared light combined with physical therapy significantly reduced pain and improved sleep quality in patients with peripheral diabetic neuropathy. The treatment was effective in reducing symptoms and improving functionality for patients with intense pain.
Researchers found semaglutide and liraglutide substantially decrease AUD hospitalization risk compared to approved medications. Clinical trials are needed to confirm these findings and explore their efficacy in treating AUD.
A new study maps the gut microbiome of over 1,300 children under five years old in Ethiopia, revealing a clear link between gut bacteria composition and the duration of diarrhea. The researchers identify beneficial bacteria that produce short-chain fatty acids, which are lacking in children with chronic diarrhea.
The Ochsner Accountable Care Network achieved its eighth consecutive year of top-ranking results in clinical performance and healthcare savings. The network saved Medicare $30.9 million for over 58,000 beneficiaries in 2023, improving health outcomes while reducing costs.
The editorial highlights how digital tools improve patient outcomes through better monitoring, individualized care, and seamless communication between patients and healthcare providers. Digital health innovations also address key challenges such as data privacy and accessibility.
Exosomes play a critical role in diabetic cardiomyopathy progression by carrying detrimental molecules such as pro-inflammatory factors and miR-21, but also show cardioprotective effects like miR-133a. Exosome-based therapies hold promise for targeting damaged cardiac tissues directly and reversing pathological remodeling.
The American Heart Association has awarded $75,000 to local entrepreneurs to develop innovative solutions addressing health inequities in their communities. The EmPOWERED to Serve Business Accelerator program supports social entrepreneurs and organizations focused on improving health outcomes.
Scientists from Kaunas University of Technology and Lithuanian University of Health Sciences developed a non-invasive ultrasonic foot stimulation device to improve blood circulation in the lower limbs. The device uses low-frequency ultrasound to stimulate blood flow and regulate thrombogenesis, immune response, and inflammatory processes.
Researchers from Brazil's Center for Research on Redox Processes in Biomedicine found that high blood sugar can cause thrombosis by altering endothelial function and promoting platelet adhesion. They identified a specific molecular mechanism involving protein disulfide isomerase A1 as a key regulator of this process.
A new Australian study found that night shift workers who eat meals or snacks during their shift have significantly worse glucose tolerance compared to those who fast. Insulin sensitivity is also disrupted among all participants, regardless of their eating habits.
Researchers developed porous dermal fillers that accelerate tissue healing and regeneration for diabetic wounds. The novel approach combining electrospinning and electrospraying technologies creates biocompatible microspheres that promote cell migration, granulation tissue formation, and neovascularization.
A study of over 13 million hours of data found that exposure to bright nights and dark days is associated with an increased risk of death. Those exposed to high levels of light at night had a 21–34% increased risk, while those exposed to high levels of daylight had a 17–34% reduction in their risk of death.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
A study conducted by Hiddo L. Heerspink at the University Medical Center Groningen found that Ozempic reduced protein in urine by 52% and decreased kidney inflammation by 30%, as well as lowering blood pressure and reducing a key measure of heart failure
A recent study found that the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) as anti-obesity medications more than doubled from 2022 to 2023, while rates of metabolic bariatric surgery dropped by one quarter. This shift in treatment options has implications for access to comprehensive multidisciplinary care for obesity.
Researchers discovered that tuberculosis alters liver metabolism and can push patients towards metabolic disease like diabetes. The study suggests undiagnosed TB could be a significant contributor to metabolic health issues.
The EAT2 study, led by Dr. Ursula White, investigates the lasting health effects of short-term weight gain and loss on fat tissue and overall health. Participants will undergo a dietary intervention program followed by an eight-week weight loss treatment.
A new study found that people with opioid or alcohol use disorder who take Ozempic or similar medications have a lower rate of opioid overdose and alcohol intoxication. The medication, which treats diabetes and weight-related conditions, may also alter the brain's reward-response pathways associated with substance use.
Researchers at Brown University have found a way to extend the lifespan of flies by suppressing a hormone that regulates insulin secretion. The study suggests that certain medications used to treat human obesity and diabetes may also impact aging, making it a promising area of research for future studies.
Researchers at Indiana University are developing next-generation ophthalmoscopes to spot early warning signs of diseases like Alzheimer's, diabetes, and heart disease with a simple eye scan. The technology uses machine learning and AI to reduce diagnosis time from days to minutes.
A study from the University of Surrey found that people with a preference for sweets are at a higher risk of developing depression, diabetes, and suffering a stroke. The researchers used artificial intelligence to group 180,000 volunteers into three profiles: health-conscious, omnivore, and sweet tooth.
A high-fat diet can promote overweight and increase diabetes risk, but fat alone does not change the brain's hypothalamus. Other macronutrients like sugar may have more profound effects on AgRP neurons.
Researchers have developed a new treatment for deep diabetic foot ulcers, using intact fish skin grafts to promote healing. The study found that this innovative approach showed promising results in improving wound closure and reducing infection rates.
A new study published in JAMA Network Open found that racial and ethnic minorities are more likely to have claims for free preventive care denied by insurance plans, leading to unexpected bills or lack of access. Healthcare providers also charge disadvantaged groups a higher amount for preventive services.
A recent study published in Liver Cancer found that patients with diabetes mellitus and comorbid obesity are at a higher risk of liver cancer recurrence after resection. The risk is significantly higher for those with comorbid obesity, increasing by approximately 3.8 times over five years postoperatively.
A Carnegie Mellon University-led team is developing a bioelectronic implant called ROGUE that can produce a year's supply of treatment for chronic diseases like Type 2 diabetes and obesity. The device will offer continuous, adjustable therapy deployment via a minimally invasive procedure.
Researchers developed glucose-responsive micelles that encapsulate and protect glucagon, releasing it when blood sugar levels drop below a certain threshold. The micelles prevented hypoglycemia in mouse trials, achieving normal blood sugar levels within 40 minutes.
A randomized controlled trial found that time-restricted eating (TRE) led to greater improvements in glucose control, weight loss, and fat reduction compared to standard nutrition counseling in adults with metabolic syndrome. TRE resulted in a lower risk of muscle mass loss during weight loss.
The study found that progress in reducing excess mortality among Black individuals was stalled by an increase in mortality from external causes. Cardiovascular diseases, diabetes, and certain cancers still pose significant health risks to the US Black population.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.
A new hand-held scanner can generate highly detailed 3D images in seconds, paving the way for earlier disease diagnosis. The technology uses laser-generated ultrasound waves to visualize subtle changes in blood vessels, helping inform patient care and diagnose conditions like cancer and cardiovascular disease.
A study suggests that semaglutide may have therapeutic value in preventing opioid overdoses by reducing the associated risk. The results require further validation, but the findings indicate a potential benefit for patients with comorbid type 2 diabetes and opioid use disorder.
Researchers found that low extracellular sodium concentrations decrease specific mRNA expression and nitric oxide production in microglia, potentially contributing to hyponatremia-induced neuronal dysfunctions. Microglial activation can lead to inflammation and regulate neurotransmission.
A recent study published in Diabetes, Obesity and Metabolism reveals that intensive diabetes treatment can positively impact periodontal inflammation. The research found improvements in glycoalbumin levels and Periodontal Inflamed Surface Area, indicating reduced blood glucose levels and periodontal disease.
A new study by University of Illinois Chicago researchers found that high levels of toxic metals in urine predicted faster increases in blood sugar. Individuals with highest arsenic exposure qualified as prediabetic 23 months earlier and diabetic 65 months earlier than those with lowest exposure.
Research found that babies born to pregnant women consuming high-fat, high-energy diets are more likely to develop heart problems and diabetes as adults due to fetal damage. Consuming a high-fat diet during pregnancy also increases the likelihood of insulin resistance in adulthood.