Articles tagged with Diabetes
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A study found that 670 nanometres of red light stimulated energy production within mitochondria, leading to increased glucose consumption and a 27.7% reduction in blood glucose levels. This non-invasive technique has the potential to impact diabetes control by reducing damaging fluctuations of blood glucose.
Researchers optimized polygenic risk scores using ancestrally diverse genomic data to improve accuracy across diverse populations. The recalibrated tests provided a more accurate assessment of disease risk for individuals with varied ancestral backgrounds.
Researchers from Pusan National University discovered a link between diabetes and periodontitis, showing pro-inflammatory cytokines rise in classical monocytes. The study highlights the systemic impact of these conditions on immune regulation and suggests a potential therapeutic target to reduce diabetes risk.
Researchers from Osaka University found that gargling with an antiseptic mouthwash can reduce periodontitis-related bacteria in patients with type 2 diabetes. This simple method may improve the lives of people with periodontitis-linked diseases such as diabetes, dementia, and cardiovascular disease.
A new study finds that Type 2 diabetes causes intervertebral discs to become stiffer and change shape earlier than normal. This leads to a compromised ability to withstand pressure, highlighting the need for preventative and therapeutic strategies.
A new study found that reducing out-of-pocket costs for patients with diabetes can lead to improved health outcomes, particularly among those living in lower-income areas. The study showed a 10.2% decrease in preventable diabetes complications among PDL members from lower-income areas compared to the control group.
A new DNA methylation-based method enables accurate assessment of pancreas cell composition, identifying specific cell types and providing insights into beta-cell dysfunction. The study offers direct clinical implications for understanding diabetes development and guiding tailored treatment strategies.
Research reveals that males born to obese mothers are more likely to be overweight at birth and develop metabolic complications in later life. The study suggests that male sex hormones play a crucial role in the development of the liver, which can lead to health issues if activated too strongly.
Researchers at Pennington Biomedical aim to investigate the effects of intermittent fasting and calorie counting on healthspan. Participants in the DiAL-Health study will be compensated up to $2,500 for their involvement.
Researchers have discovered that CAR T cells can be repurposed to target senescent cells, which accumulate with age and cause inflammation. This breakthrough offers a promising alternative to existing treatments, which often require repeated administration.
A study from the Korea University College of Medicine reveals that co-occurrence of diabetes and sarcopenia significantly elevates cardiovascular mortality, with nearly doubling the risk of both all-cause and cardiovascular deaths. Implementing preventive measures such as lifestyle changes, exercise, and balanced diet can mitigate this...
Researchers developed a new method to predict diabetes early using just two values from a blood sample. The SPINA Carb method is based on mathematical modeling and has been shown to be more reliable than other markers of glucose metabolism.
Researchers found that participants who achieved diabetes remission through weight loss had a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease. The study, led by Professor Edward Gregg, monitored over 5,000 patients for 12 years.
Despite pandemic disruptions, emergency visits, hospital admissions, and intensive care unit stays were lower for children. However, there were delays in new diagnoses of cancer and diabetes, and an increase in diabetic ketoacidosis among children with diabetes. Researchers urge education campaigns to improve future pandemic preparedness.
Researchers identified a significant decrease in insulin-producing beta cells with increasing age, correlating with pancreatic intraepithelial neoplasias. The study suggests that islet cell loss may be a key driver of senile diabetes, informing potential preventative treatments.
Researchers discovered that fruit bats have a genetic system controlling blood sugar levels, allowing them to consume up to twice their body weight in sugary fruit daily. The study's findings may lead to the development of better insulin- or sugar-sensing therapies for people with diabetes.
Researchers found that people with noncommunicable diseases experienced greater psychological distress, increased alcohol consumption, and disrupted medical care. Those with NCDs were more likely to report anxiety, depression, and difficulty accessing non-COVID medical care.
A recent genetic study has made a significant leap forward in understanding gestational diabetes by identifying nine novel genetic regions linked to the condition. The study, conducted on over 12,000 patients and 131,000 female controls, has nearly tripled the number of known genetic areas associated with gestational diabetes.
A diabetes drug called dulaglutide may significantly lower a woman's risk of substantial weight gain after giving up smoking. In contrast to men, women are five times as likely to experience substantial weight gain after stopping smoking, according to the study.
Scientists have identified a population of progenitor cells that strongly promote new blood vessel growth in ischemic limbs, showing promise as a treatment for preventing amputations. The discovery was made through single-cell transcriptomics and confirmed in mice with limb ischemia, where the treatment rescued limbs from amputation.
Flori Corpodean, a postdoctoral researcher at Pennington Biomedical, has been selected as the sole recipient of the 2024 Resident Research Award. She is exploring how the brain and intestinal tract communicate through her research on altered nutrient delivery.
A study found childhood cancer survivors have twice the risk of developing prediabetes as the general public, increasing their risk of life-threatening diseases. Lifestyle interventions may help reduce this risk and improve their life expectancy.
Using metformin plus insulin to treat preexisting type 2 or gestational diabetes diagnosed early in pregnancy did not show a reduction in composite neonatal adverse outcomes. The study suggests that the effect of reducing large-for-gestational-age infant risk after adding metformin to insulin warrants further investigation.
Researchers developed a method to measure microvascular changes in the skin using AI and optoacoustic imaging technology, enabling non-invasive assessment of diabetes severity. The study identified 32 significant changes in blood vessels, which can be used to monitor disease progression.
Scientists at Case Western Reserve University identified a novel enzyme, SCAN, which attaches nitric oxide to proteins, including the receptor for insulin action. Blocking this enzyme protects from diabetes, suggesting it may be a cause of the disease.
A study from Monash University reveals the levels of NOX4 protein change as fatty liver disease progresses, offering hope for prevention and treatment. Removing NOX4 in obese mice leads to NASH and liver damage, while artificially raising its levels protects against it.
A new study provides practical guidance for implementing governance for sharing EHR data for chronic disease surveillance, which could reduce delays and provide more accurate metrics. The approach has already shown success in the Multi-State EHR-Based Network for Disease Surveillance.
Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
The Joint Action on Cardiovascular Diseases and Diabetes (JACARDI) aims to reduce the burden of cardiovascular diseases and diabetes in EU member states through 143 pilot projects. The project will test and offer solutions throughout the patient journey, focusing on prevention, early detection, treatment, care, and self-management.
In a significant breakthrough, research revealed that macrophages 'eat' pancreatic beta cells to regulate insulin levels after pregnancy. This process helps maintain normal blood glucose levels.
Researchers at Tohoku University successfully regenerated pancreatic beta-cells in mice by stimulating autonomic vagal nerves connected to the pancreas. This innovative approach improved insulin function and increased beta-cell numbers, ameliorating diabetes symptoms.
A new study by Staffordshire University warns people with type-1 diabetes to use fitness video games with caution, as they may change perceptions of fatigue levels. The researchers recommend updating measurement tools for virtual game platforms to ensure safe and accurate exercise tracking.
Researchers at Gladstone Institutes have identified cells and molecules that go awry in the developing hearts of fetuses in women with diabetes, leading to higher levels of retinoic acid activity. The study could eventually lead to interventions to lower heart malformations risk in babies born to women with diabetes.
Researchers at Salk Institute uncover a mechanism for repairing damaged nerves during peripheral neuropathy, with protein Mitf playing a key role. The findings have the potential to inspire novel therapeutics that bolster repair function and heal peripheral neuropathy.
Researchers at Wayne State University aim to extend the lifespan of infusion pumps and injection ports to minimize tissue damage and maintain site integrity. The project seeks to reduce inflammation and fibrosis caused by insulin phenolic preservatives, leading to improved diabetes management practices.
Researchers at the University of Tsukuba discovered a novel pathway where pancreatic beta-cells undergo dedifferentiation and differentiate into acinar-like cells, contributing to insulin secretory capacity reduction. The study also identified Anxa10 as a key gene upregulated in pancreatic beta-cells during diabetes onset.
A study by the Keck School of Medicine of USC found that liver cancer risk increases with each successive generation of Mexican Americans, particularly among men. The research analyzed data from over 30,000 participants and found third-generation Mexicans to be 66% more likely to develop liver cancer than first-generation individuals.
A study of over 20,000 middle-aged US adults found lower income status linked to increased hypertension risk. Higher-income adults faced rising rates of diabetes and obesity. Targeted public health initiatives are needed to address growing cardiovascular mortality among middle-aged adults.
A genetic study found that grizzly bears' energy production follows a daily pattern even during hibernation, with a blunted amplitude and shifted peak. This suggests that the circadian rhythm helps bears conserve energy while still maintaining some metabolic function.
Researchers Reshmi Parameswaran and Carlos Subauste at Case Western Reserve University have received funding for their work on finding new treatments for B-cell cancer and diabetic retinopathy, a leading cause of blindness. They aim to develop more effective cell therapies and inhibitors to treat these diseases.
A new USC study identifies two metabolites that may predict which young Latino people are most likely to develop prediabetes. The research found that allylphenol sulfate and caprylic acid were the most predictive of prediabetes when combined with other risk factors.
Researchers analyzed FDA and patent records to find that manufacturers extended market exclusivity by filing additional patents after FDA approval and obtaining patents on delivery devices. This resulted in a median of 16 years of protection, surpassing other top-selling small-molecule drugs.
A nationwide UK diabetes prevention program has been shown to improve glycemic control and reduce the risk of Type 2 diabetes in adults. The program, which refers high-risk individuals to lifestyle counseling, has strong evidence supporting its effectiveness.
A 20% reduction in major adverse cardiovascular events has been observed for patients with obesity but no history of diabetes taking semaglutide. This study marks a significant milestone, demonstrating the cardiovascular benefits of semaglutide beyond its weight loss effects.
A recent study found that chronic insufficient sleep can increase insulin resistance in healthy women, with more pronounced effects on postmenopausal women. Insulin resistance can lead to a higher risk of developing type 2 diabetes.
The COVID-19 pandemic and drug overdose epidemic significantly contributed to the widening gender gap in US life expectancy. Chronic metabolic disease and mental illness are also thought to play a role in the growing disparity.
A recent clinical trial found that semaglutide significantly reduced cardiovascular events in adults with overweight or obesity who do not have diabetes. The medication was shown to lower the risk of death from cardiovascular causes, nonfatal heart attacks, and strokes by 20% compared to placebo.
A new study finds that people with antibodies to common foods like dairy and peanuts are at a higher risk of cardiovascular-related death. The research suggests that these subtle immune responses may lead to inflammation and contribute to heart disease over time.
Researchers from Helmholtz Munich discovered that GIP decreases body weight by interacting with specific inhibitory neurons in the brain, offering a revolutionary approach to patients worldwide. The study reveals the underlying molecular mechanisms of GIPR:GLP-1R co-agonists and their potential as next-generation anti-obesity drugs.
The American Gastroenterological Association suggests a balanced approach when treating patients on GLP-1 RAs undergoing endoscopic procedures. AGA recommends proceeding with the procedure as planned for patients who followed standard pre-procedure fasting instructions and do not have symptoms suggesting retained gastric contents.
A recent study presents exciting future possibilities for managing type 1 diabetes with the repurposed drug α-difluoromethylornithine (DFMO), which may reduce insulin dependency. The researchers have established preliminary safety of DFMO for individuals with type 1 diabetes, paving the way for innovative therapies.
A new study provides preliminary evidence that an existing drug, α-difluoromethylornithine (DFMO), could be used to treat type 1 diabetes. The drug has already been FDA-approved for other indications and may offer a more convenient treatment option for patients.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
A new study published in JAMA Network Open found time-restricted eating to be safe and effective for people with Type 2 diabetes, helping them lose weight and control blood sugar levels. Participants who followed the time-restricted eating plan had an easier time sticking to it than those on a calorie-reduced diet.
Terminating metformin treatment was associated with higher risk of developing dementia in a large cohort of adults. The study of 41,000 participants found that early metformin cessation was linked to increased dementia incidence compared to continued use.
A study published in CANCER reveals that individuals with diabetes, especially those with diabetic complications, have a higher risk of dying early from colorectal cancer. Patients with complicated diabetes had an 85% higher odds of death from any cause and 41% higher odds of death from cancer.
Researchers at Ohio State University Wexner Medical Center are testing a novel diagnosis and treatment combination for painful diabetic neuropathy using spinal cord stimulation and small fiber nerve activity measurement. The approach has the potential to provide effective pain relief and potentially reverse neuropathy reversal.
Researchers from NUS have developed a novel magnetic gel that heals diabetic wounds by activating dormant skin cells and repairing damaged blood vessels. The treatment has shown promising results, healing wounds up to three times faster than conventional approaches.
A new study published in The American Journal of Clinical Nutrition found that consuming more red meat is associated with a higher risk of developing type 2 diabetes. Replacing red meat with plant-based protein sources like nuts and legumes may reduce this risk.
A new analysis of 50 years of data found that pregnant people who gained more than the recommended amount of weight had a higher risk of death from heart disease or diabetes in the decades following. Higher risk was found for all weight groups studied, but no increase in risk was uncovered among those who were obese.