Articles tagged with Diabetes
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Researchers at the University of British Columbia have developed oral insulin drops that can be easily absorbed by the body, potentially replacing insulin injections. The drops contain a unique cell-penetrating peptide that helps insulin navigate through cells and reach the bloodstream quickly.
By 2050, at least 61% of US adults (184 million people) are projected to have some type of cardiovascular disease, with total costs tripling to $1.8 trillion. Population shifts, high blood pressure, and obesity will drive this increase.
A meta-analysis of 15 randomized studies found that patients taking GLP-1 medications experienced only mild differences in gastric emptying, delaying solid food by about 36 minutes. The findings suggest it may be safe to continue these medications before surgery without a high risk of aspiration.
A new study found that people exposed to higher levels of airplane noise were more likely to have a higher body mass index, an indicator for obesity that can lead to cardiometabolic diseases. The study highlights the role of environmental factors in shaping health outcomes.
Researchers found that GLP-1 receptor agonists and SGLT-2 inhibitors lower the risk of major cardiovascular events, such as heart attacks, and severe liver complications compared to other diabetes treatments. These medications also showed no significant increase in severe adverse events.
A new study found that almost two-thirds of prescribed tricyclic antidepressants were above the safe dosage threshold, with Black patients more likely to receive these high-dose medications. The research highlights the need for routine evaluation of drug efficacy in clinical care environments.
Researchers have developed a biomimetic artificial islet model using vascularized microcapsules to control blood sugar levels. The model integrates a microvascular network and uses microfluidic technology to achieve fine regulation of blood sugar levels, showing its effective potential as a treatment for diabetes.
A clinical trial found that SGLT2 inhibitor drugs improve cardiac outcomes and heart health by activating a defence mechanism that abolishes potential diuretic effects. The study suggests alternative mechanisms of action, such as metabolic changes that improve organ function.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
Dr. George Bray's paper tracks the development of obesity research over 100 years, from early explorations to modern medication interventions. The study highlights the chronic and relapsing nature of obesity as a disease process.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
A recent analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. Women with higher MetS scores are at a higher risk of poor-prognosis, estrogen receptor-positive, progesterone receptor-negative breast cancers.
A new study from Washington State University found that just a few days on a night shift schedule can disrupt protein rhythms related to blood glucose regulation and energy metabolism. This dysregulation may lead to chronic metabolic conditions such as diabetes and obesity.
In Brazil, deaths from diabetes and hypertension have increased significantly since 2020, even after excluding those linked to COVID-19. This persistent trend highlights the need for continued efforts to address these major public health concerns.
A recent meta-analysis found that one in four patients with insulin-dependent diabetes exhibit eating disorder symptoms, including binge eating and food restriction. Intentional insulin omission is a unique form of disordered eating where insulin doses are restricted or skipped due to fears of weight gain.
Researchers have discovered a repurposed cancer drug that can convert acinar cells into insulin-producing cells, which could provide a new avenue for treating diabetes. The treatment partially improved hyperglycemia and persisted without additional treatment in diabetic mice and non-human primates.
Researchers at MCG's Vascular Biology Center have identified a new treatment target for age-related macular degeneration (AMD), a leading cause of blindness. Targeting the adenosine receptor 2A (Adora2a) may block excessive blood vessel growth and fibrosis, potentially offering a more efficient treatment than current therapies.
The Hulen Place Clinic, serving 3,725 homeless individuals in Riverside County, has received a $500,000 funding boost from the San Manuel Band of Mission Indians. The clinic provides primary care, mental health services, and preventive care to low-income residents.
A new therapy has been identified that can penetrate the slime protecting drug-resistant bacteria, allowing it to be killed by the body's immune system or antibiotics. The antimicrobial peptide, derived from cow peptides, targets sugar connections in the slime structure, damaging its integrity and allowing entry.
Researchers found that cranberry extracts can stimulate beneficial bacteria in the gut, reducing inflammation and improving the prognosis of chronic diseases. The study suggests that cranberries may be a useful addition to a balanced diet in preventing or managing conditions like diabetes and cardiovascular disease.
A recent study published in BJSM found that increased cardio fitness level can reduce the risk of death from any cause and heart disease by 11-17% and 18%, respectively. Regular aerobic exercise programs can achieve this, leading to a reduced risk of early death and chronic conditions.
Researchers have developed a pressure-alternating shoe insole that provides periods of rest to the soft tissues, thereby reducing the risk of diabetic foot ulcers. This innovative technology aims to mitigate the risk of complications from poor circulation and foot sores.
A new study found that telehealth can positively impact diabetes care by providing a home environment perspective. Researchers also identified the importance of clear patient guidelines and reviewing glucose trends during visits to make them efficient and effective.
Global disease burden rates dropped by 14.2% between 2010 and 2019, but the COVID-19 pandemic interrupted this trend, causing a 4.1% increase in disease burden in 2020 and a 7.2% increase in 2021.
A study published in the Canadian Journal of Diabetes found that approximately 1 in 5 older Canadian adults with diabetes developed functional limitations for the first time during the COVID-19 pandemic. Those with lower incomes faced a significantly higher risk of developing functional limitations compared to their peers.
A new study has identified a deficit in the placental expression of IGFBP1 and low circulating levels as associated with insulin resistance during pregnancy. The findings suggest that measuring IGFBP1 levels could help identify people at risk of developing gestational diabetes early in pregnancy.
A national cohort study of over 2 million Swedish women found that those experiencing five major adverse pregnancy outcomes had significantly higher mortality rates. The study highlights the importance of early preventive evaluation and long-term follow-up for detection and treatment of chronic disorders associated with premature morta...
Scientists at University of California San Diego discover how one TZD drug works and replicate its benefits in mice without side effects. Researchers identify specific microRNA responsible for beneficial metabolic effects, paving the way for potential new therapies for type 2 diabetes.
A study by Michigan Medicine found that about 1% of older adults using traditional Medicare have used asynchronous patient portal messaging to prompt a bill from their doctor or other healthcare provider. Most e-visits were with primary care providers, mainly for managing high blood pressure and diabetes.
A review of mitochondrial energy metabolism in diabetic cardiomyopathy reveals disrupted dynamics and oxidative stress as key triggers. Targeted therapies, such as antioxidants and ketogenic diets, show promise in combating this debilitating condition.
A new study suggests that most essential care for cardiovascular health happens in general primary care clinics, but many at high risk don't receive it. The study found that large percentages of people with major cardiovascular risk factors didn't see a primary care provider or cardiologist in the past year.
A new study suggests that anxiety and depression in younger women may accelerate the development of cardiovascular risk factors, putting them at nearly par with men of the same age. The researchers found that these mental health conditions were associated with a much higher relative risk among young women than seen in other groups.
A recent study found that eating fortified eggs had no adverse effect on blood cholesterol levels and may even have beneficial effects on cardiovascular health. Subgroup analyses revealed potential benefits among older adults and those with diabetes.
The study found that obesity rates have nearly tripled in adult men and doubled in women since 1990. The prevalence of malnutrition is now the most common form of malnutrition globally, affecting nearly 880 million adults and 160 million children. Obesity can lead to comorbidities like high blood pressure, heart disease, and diabetes.
A study of 280,783 adults in 55 LMICs found that only 20-30% take medications for hypertension and diabetes. The results highlight inadequate healthcare in these settings.
A recent study published in JAMA Network Open reveals that high prices for new diabetes medicines limit access worldwide. The research proposes that increased generic and biosimilar competition could significantly reduce prices, making treatments more affordable.
Researchers found a link between miscarriage and increased risks of developing gestational diabetes (44% higher) and pre-eclampsia (37% higher), but not with abortion. The study analyzed over 4 million pregnancies and suggests new ways to mitigate risks or prevent these conditions from progressing.
Researchers found that a high-fat diet suppresses the expression of a key protein in the gut, leading to inflammation and increased risk of Alzheimer's. Managing diabetes may be key to preventing or slowing down dementia symptoms.
Researchers have identified the unique nutritional profile of Canadian sea buckthorn berries, which are rich in polyphenols with potential health benefits for cardiovascular protection and anti-inflammatory properties. The study found that geographical factors influence the polyphenolic profile of the berries, making them a promising s...
A study published in Nature Metabolism reveals that the diabetes drug metformin and solid foods increase a hunger-reducing factor called Lac-Phe, while sugary drinks have minimal effect. This discovery could lead to new anti-obesity treatments and help explain why liquid calories drive obesity.
Researchers have developed a miniaturized optical sensor that can detect glucose levels in human blood plasma with comparable sensitivity to laboratory-based sensors. The device operates wirelessly using a coin battery and has demonstrated its viability in detecting glucose levels between 50-400mg/dL.
Researchers review microneedle materials, techniques and effects on wound healing in diabetic patients. They found that microneedles can enhance wound healing through various mechanisms.
Researchers at Flinders University have discovered a bedtime nasal spray that can reduce the severity of sleep apnea in people and lower their blood pressure. The study found that the spray, which blocks potassium channels, improved oxygen levels and reduced markers of OSA severity in 7 out of 10 participants.
A new study reveals that adults living in extreme poverty in LMICs have high rates of hypertension, diabetes, smoking, obesity, and dyslipidemia, yet are often untreated for these conditions. The findings challenge the common assumption that poverty protection against cardiovascular disease risk factors.
Researchers have successfully created a transgenic cow capable of producing human insulin in its milk. This breakthrough could lead to the mass production of insulin without the need for complex facilities or infrastructure. With further testing and FDA approval, this technology has the potential to revolutionize insulin production and...
A team of international scientists has developed an effective treatment for preventing infection in chronic wounds that does not involve antibiotics. The new method involves the plasma activation of hydrogel dressings, producing a unique mix of chemical oxidants that are effective in decontaminating and aiding healing.
A collaborative study found that patients with end-stage renal disease who undergo weight loss surgery can experience significant improvements in BMI, hypertension, and diabetes management. This enhancement of overall health and transplant viability offers hope for previously ineligible patients.
A meta-analysis by Associate Professor Diana Arabiat found that children born to mothers with pre-existing diabetes have lower mental and psychomotor development scores compared to those without previous exposure. This delay in psychomotor development can be related to numerous risk factors, including premature birth or intrauterine gr...
A novel approach estimates metabolic activity and infers blood glucose levels from near-infrared measurements in commercial smartphones and smartwatches. The phase delay between oxyhemoglobin and deoxyhemoglobin signals closely relates to oxygen consumption during cardiac cycles, serving as a gauge for metabolism.
A recent study found that many people with type 2 diabetes know little about their condition, highlighting the need to improve communication and disease knowledge. The study revealed significant gaps in knowledge, particularly regarding blood sugar monitoring and late-stage complications like ketoacidosis.
A study published in JAMA Surgery found that 56% of patients using GLP-1 RAs had significant gastric contents on ultrasound before elective procedures, despite adequate fasting. The study suggests that conventional fasting times may need to be reexamined for this patient subset.
Research has shown that dulaglutide, a diabetes drug, can reduce depressive-like behaviors in mice. The study identified four major pathways involved and linked markers of depression to lipid metabolism and tryptophan metabolism. This new perspective may facilitate the use of dulaglutide as a potential therapeutic strategy for depression.
A new study finds that generative AI can accelerate the design of healthcare software, particularly for complex medical problems like diabetes prevention. Researchers at NYU Langone Health used ChatGPT to develop a personalized automatic messaging system in over 40 hours, compared to 200 programmer hours with non-AI enabled efforts.
A study published in the International Journal of Gynecology & Obstetrics found that Medicaid expansion in Maryland led to improved newborn outcomes, including better Agar scores and reduced need for assisted ventilation. However, there were no significant differences in Cesarean section deliveries.
A large study found that people with class I obesity had double the risk of stillbirth at 39 weeks' gestation compared to those with normal BMI. The risk further increased with gestational age, with a more than fourfold risk at 40 weeks. Researchers hope that these findings will improve care for pregnant individuals with obesity.
Researchers found that obesity increases allosteric regulation during feeding and decreases it when fasting in mice livers. This disruption may lead to metabolic disorders like nonalcoholic fatty liver disease and Type 2 diabetes.
Researchers decode underlying mechanisms of DCM, hippocampal neurotoxicity, and dysbiosis mediated AD progression using mass spectrometry imaging. The studies found metabolic changes in DCM rat hearts and regulation of CYPs in the hippocampus, providing new perspectives on treatment strategies.
Recent advancements in automated insulin delivery systems have shown significant improvements in glucose control and time-in-range. The development of hybrid closed-loop systems has reduced hypoglycemia, particularly overnight, while also improving overall glucose control.
Healthcare providers must prioritize patient experience to improve diabetes care. This includes explaining treatment options and considering each patient's level of health literacy and cultural background.
A study found that 670 nanometres of red light stimulated energy production within mitochondria, leading to increased glucose consumption and a 27.7% reduction in blood glucose levels. This non-invasive technique has the potential to impact diabetes control by reducing damaging fluctuations of blood glucose.