Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
Researchers developed an inexpensive, water-powered electric bandage that accelerates wound healing in chronic wounds. The bandage produces an electric field that promotes healing and reduces inflammation, with animals treated with the bandage showing a 30% faster rate of wound closure.
A panel of experts has reached consensus on fasting terminology to enhance communication and cross-referencing in the field. The defined terms include 'fasting,' 'modified fasting,' and 'religious fasting,' among others, aiming to steer people away from unverified diets that can lead to unhealthy behaviors.
Maintaining stable hemoglobin A1c levels in individualized target ranges may lower Alzheimer disease and related dementias risk. Lower HbA1c time in range could identify patients at increased risk of these conditions.
A USC study found that prescription fills for semaglutide increased by over 400% between 2021 and 2023, with most prescriptions going to privately insured patients. The study suggests that this may worsen disparities in diabetes and obesity outcomes among Medicaid and Medicare recipients.
Researchers discovered ultrastructural abnormalities in obese patients with heart failure with preserved ejection fraction (HFpEF), which may be related to the impact of obesity on muscle structure. The study suggests that reducing obesity and using certain medications could help improve HFpEF outcomes.
A lack of adaptive equipment and trained staff in commercial gyms creates significant barriers to exercise for people with disabilities. The study highlights the need for more accessible options and awareness programs to encourage continued physical activity among this population.
A recent study found that almost 50% of older adults with diabetes experienced depression during the pandemic, with loneliness and chronic pain being major risk factors. The study also identified unexpected findings, including a higher risk of depression among those with higher income prior to the pandemic.
Researchers discovered a unique protective mechanism in pancreatic β-cells, relying on elevated levels of pro-survival proteins like cFLIP. This discovery challenges the dominant paradigm and offers new insights into diabetes research, potentially leading to novel strategies for preserving β-cell function.
Research highlights the need for further study on the impact of sustained heat exposure on hormone release and action. Heat exposure is associated with decreased fertility, increased risks of pregnancy complications and menopause symptoms, as well as worsened conditions like thyroid disorders and diabetes mellitus.
A new study found that adults with diabetes who meet the recommended physical activity guidelines may offset the increased mortality risk associated with excessive sitting time. The study analyzed data from over 12,000 adults with diabetes and found that those who were physically active had a lower risk of death compared to those who s...
Rates of hypertensive disorders of pregnancy increased from 6.1% to 8.5%, while related health conditions declined, according to a Canadian study. The growing population of high-risk obstetrical patients highlights the need for easily accessible specialized care.
A recent paper surveys advances in diabetes pathogenesis and treatment, highlighting the role of genes, environmental factors, and social determinants. The study suggests that understanding these dynamics is key to developing targeted interventions to reduce diabetes risk and manage its complications.
A new University of Michigan study found that over 82% of Americans aged 50-80 take one or more prescription medications, with 80% open to stopping certain drugs. However, researchers stress the importance of personalized guidance for deprescribing older adults, particularly those taking medication for cardiovascular disease or diabetes.
A nationwide study found a marked increase in new GLP-1RA prescriptions for obesity, particularly since 2020. Semaglutide was the most prescribed GLP-1RA, but prescriptions among those with obesity without type 2 diabetes spiked, worsening existing racial and ethnic disparities.
A significant increase in cannabis use among adults with diabetes has been found, with a 33.7% rise in prevalence between 2021 and 2022. Cannabis use may be driven by perceived therapeutic benefits and increased access to products after legalization.
A UC Riverside-led research team found that obesity causes chronic changes in the brain, leading to reduced connections between neurons and lower testosterone levels. The study suggests that the primary site of obesity's effects on reproductive function is the brain, rather than the testes or pituitary gland.
A follow-up study found that COVID-19 infection accelerated the progression from pre-symptomatic to clinical type 1 diabetes in youth, with no observed effect in adults. Further research is needed to determine whether vaccination and monitoring for COVID-19 symptoms can help prevent or delay this progression.
Researchers analyzed over 1.5 million patient records to find that metformin and SGLT-2 inhibitors lowered dementia and Alzheimer's disease risks compared to other antidiabetic drugs. The study suggests individualized treatment approaches considering patient-specific factors for optimal diabetes management.
Researchers from Mount Sinai and City of Hope demonstrate a combination treatment that increases human insulin-producing beta cells by 700% in mice with diabetes. This breakthrough could lead to new treatments for the hundreds of millions of people with diabetes worldwide.
A USC Dornsife study finds that nearly one in four LA County residents experience food insecurity, while almost half with nutrition insecurity do not report food insecurity, highlighting the need for addressing both issues to improve access and address barriers to healthy diets.
A new study found that delaying diabetes diagnosis for at least four years through diet and exercise significantly lowers the risk of dying and experiencing cardiovascular events. Individuals who maintained prediabetic status for longer periods had better long-term health outcomes, with a reduced risk of death and complications.
A new study from the University of Toledo found that individuals with diabetes are nearly three times more likely to experience non-union complications following spinal fusion surgery. Researchers also found that diabetic patients have weaker bone growth and healing, leading to increased degeneration in adjacent segments of the spine.
The NTU team created a compact and flexible light-based sensing device, like a plaster, to provide highly accurate biomarker readings within minutes. The device detects glucose, lactate, and urea levels in sweat with ultra-high sensitivity and dynamic range.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
A Swedish researchers have created a questionnaire test that quickly identifies individuals at high risk of heart attack. The test has been shown to be as accurate as blood tests and blood pressure measurements, detecting 65% of those at the highest risk of cardiovascular disease.
Cutting processed meat intake by 30% reduces the risk of diabetes, cardiovascular disease, and colorectal cancer. The study found that this reduction would lead to over 350,000 fewer diabetes cases and tens of thousands fewer cardiovascular disease and colorectal cancer cases.
Researchers found that facial temperatures are associated with chronic illnesses like diabetes and high blood pressure. They discovered specific regions of the face where temperatures correlate with age and health, including the nose, eyes, and cheeks.
The Mount Sinai researchers have developed a comprehensive epidemiological dataset for youth diabetes and prediabetes research, derived from NHANES data collected from 1999 to 2018. The newly launched POND portal aims to facilitate an understanding of factors that may influence youth diabetes risk.
Researchers suggest programs delivering medically tailored meals to people with diet-sensitive conditions could lead to substantial savings in healthcare costs. The study found significant variation between US states but overall net cost savings in almost every state, with the largest projected savings in Connecticut and Pennsylvania.
A new study led by UCL researchers found that cardiovascular health is a significant risk factor for future dementia rates. The study analyzed data from 27 papers and found that rates of obesity and diabetes have increased over time, contributing to higher dementia risk.
A narrative review found a lack of evidence on the effective use of continuous glucose monitors (CGMs) in people not living with diabetes. The devices may have unintended adverse health effects, including anxiety about diet and blood sugar levels, potentially leading to eating disorders.
Women with obesity-related heart failure experienced greater weight loss and improved HF symptoms compared to men. Semaglutide improved HF-related symptoms, physical limitations, exercise function, reduced inflammation, and lower blood pressure across both sexes.
A randomized clinical trial found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of meal replacement diet improved glycemic outcomes and weight loss in the short term compared to metformin or empagliflozin. The study suggests a promising initial intervention for type 2 diabetes management.
A wearable health monitor developed by Washington State University researchers can accurately measure levels of important biochemicals in sweat during physical exercise. The device has the potential to track health conditions and diagnose common diseases, including diabetes, gout, kidney disease, and heart disease.
A recent study has identified three subgroups of gestational diabetes with different treatment needs, enabling personalized therapy and reducing complications for mothers and children. The analysis used cluster methods and machine learning to analyze data from 2682 women with gestational diabetes.
A study found that overexpressing a gene responsible for amino acid transport in the placenta can cause fetal growth to increase by 27%, while also providing insights into pregnancy complications like IUGR and obesity. The research has therapeutic implications, potentially informing treatments to prevent or treat these conditions.
Researchers have developed a new treatment for diabetic retinopathy that addresses the root cause of the disease, preventing progression and potential blindness. The anti-ceramide immunotherapy has been shown to be effective in animal and cell culture models, offering a safer alternative to current treatments.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
Nutrition 2024 will explore the role of diet in exercise performance, brain health, and disease prevention. Researchers will share emerging findings on the relationships between specific foods and chronic diseases.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
A cohort study found lower moderate to vigorous physical activity levels linked to increased cardiovascular disease or mortality in normoglycemic Hispanic and non-Hispanic adults. Adults with prediabetes may gain from reducing sedentary behavior and improving lifestyle factors beyond exercise alone
Researchers at the University of British Columbia have developed oral insulin drops that can be easily absorbed by the body, potentially replacing insulin injections. The drops contain a unique cell-penetrating peptide that helps insulin navigate through cells and reach the bloodstream quickly.
By 2050, at least 61% of US adults (184 million people) are projected to have some type of cardiovascular disease, with total costs tripling to $1.8 trillion. Population shifts, high blood pressure, and obesity will drive this increase.
A meta-analysis of 15 randomized studies found that patients taking GLP-1 medications experienced only mild differences in gastric emptying, delaying solid food by about 36 minutes. The findings suggest it may be safe to continue these medications before surgery without a high risk of aspiration.
A new study found that people exposed to higher levels of airplane noise were more likely to have a higher body mass index, an indicator for obesity that can lead to cardiometabolic diseases. The study highlights the role of environmental factors in shaping health outcomes.
Researchers found that GLP-1 receptor agonists and SGLT-2 inhibitors lower the risk of major cardiovascular events, such as heart attacks, and severe liver complications compared to other diabetes treatments. These medications also showed no significant increase in severe adverse events.
A new study found that almost two-thirds of prescribed tricyclic antidepressants were above the safe dosage threshold, with Black patients more likely to receive these high-dose medications. The research highlights the need for routine evaluation of drug efficacy in clinical care environments.
Researchers have developed a biomimetic artificial islet model using vascularized microcapsules to control blood sugar levels. The model integrates a microvascular network and uses microfluidic technology to achieve fine regulation of blood sugar levels, showing its effective potential as a treatment for diabetes.
A clinical trial found that SGLT2 inhibitor drugs improve cardiac outcomes and heart health by activating a defence mechanism that abolishes potential diuretic effects. The study suggests alternative mechanisms of action, such as metabolic changes that improve organ function.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
Dr. George Bray's paper tracks the development of obesity research over 100 years, from early explorations to modern medication interventions. The study highlights the chronic and relapsing nature of obesity as a disease process.
The Endocrine Society will unveil new research on male birth control and anti-obesity medications during ENDO 2024 news conferences. The society's Vitamin D Clinical Practice Guideline is also being shared publicly for the first time, featuring discussions on its recommendations.
A recent analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. Women with higher MetS scores are at a higher risk of poor-prognosis, estrogen receptor-positive, progesterone receptor-negative breast cancers.
In Brazil, deaths from diabetes and hypertension have increased significantly since 2020, even after excluding those linked to COVID-19. This persistent trend highlights the need for continued efforts to address these major public health concerns.
A new study from Washington State University found that just a few days on a night shift schedule can disrupt protein rhythms related to blood glucose regulation and energy metabolism. This dysregulation may lead to chronic metabolic conditions such as diabetes and obesity.
A recent meta-analysis found that one in four patients with insulin-dependent diabetes exhibit eating disorder symptoms, including binge eating and food restriction. Intentional insulin omission is a unique form of disordered eating where insulin doses are restricted or skipped due to fears of weight gain.
Researchers have discovered a repurposed cancer drug that can convert acinar cells into insulin-producing cells, which could provide a new avenue for treating diabetes. The treatment partially improved hyperglycemia and persisted without additional treatment in diabetic mice and non-human primates.
Researchers at MCG's Vascular Biology Center have identified a new treatment target for age-related macular degeneration (AMD), a leading cause of blindness. Targeting the adenosine receptor 2A (Adora2a) may block excessive blood vessel growth and fibrosis, potentially offering a more efficient treatment than current therapies.
The Hulen Place Clinic, serving 3,725 homeless individuals in Riverside County, has received a $500,000 funding boost from the San Manuel Band of Mission Indians. The clinic provides primary care, mental health services, and preventive care to low-income residents.
A new therapy has been identified that can penetrate the slime protecting drug-resistant bacteria, allowing it to be killed by the body's immune system or antibiotics. The antimicrobial peptide, derived from cow peptides, targets sugar connections in the slime structure, damaging its integrity and allowing entry.