Articles tagged with Diabetes
A new study provides preliminary evidence that an existing drug, α-difluoromethylornithine (DFMO), could be used to treat type 1 diabetes. The drug has already been FDA-approved for other indications and may offer a more convenient treatment option for patients.
A recent study presents exciting future possibilities for managing type 1 diabetes with the repurposed drug α-difluoromethylornithine (DFMO), which may reduce insulin dependency. The researchers have established preliminary safety of DFMO for individuals with type 1 diabetes, paving the way for innovative therapies.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
A new study published in JAMA Network Open found time-restricted eating to be safe and effective for people with Type 2 diabetes, helping them lose weight and control blood sugar levels. Participants who followed the time-restricted eating plan had an easier time sticking to it than those on a calorie-reduced diet.
Terminating metformin treatment was associated with higher risk of developing dementia in a large cohort of adults. The study of 41,000 participants found that early metformin cessation was linked to increased dementia incidence compared to continued use.
A study published in CANCER reveals that individuals with diabetes, especially those with diabetic complications, have a higher risk of dying early from colorectal cancer. Patients with complicated diabetes had an 85% higher odds of death from any cause and 41% higher odds of death from cancer.
Researchers at Ohio State University Wexner Medical Center are testing a novel diagnosis and treatment combination for painful diabetic neuropathy using spinal cord stimulation and small fiber nerve activity measurement. The approach has the potential to provide effective pain relief and potentially reverse neuropathy reversal.
Researchers from NUS have developed a novel magnetic gel that heals diabetic wounds by activating dormant skin cells and repairing damaged blood vessels. The treatment has shown promising results, healing wounds up to three times faster than conventional approaches.
A new study published in The American Journal of Clinical Nutrition found that consuming more red meat is associated with a higher risk of developing type 2 diabetes. Replacing red meat with plant-based protein sources like nuts and legumes may reduce this risk.
A new analysis of 50 years of data found that pregnant people who gained more than the recommended amount of weight had a higher risk of death from heart disease or diabetes in the decades following. Higher risk was found for all weight groups studied, but no increase in risk was uncovered among those who were obese.
Researchers develop 3D-printed device to encapsulate insulin-producing pancreatic cells and electronic sensors in the eye. The device enables cell-based therapy for Type 1 or Type 2 diabetes, eliminating the need for sutures and allowing real-time monitoring.
A new UK study finds that people with eating disorders are 2.11 times more likely to report physical multimorbidity. Anxiety, insomnia, and perceived stress are key influencers in this relationship.
A recent study found a compelling link between vitamin B12 deficiency and chronic inflammation, which can lead to various health problems. The research revealed an inverse relationship between vitamin B12 levels and inflammatory markers in humans and mice, suggesting that higher vitamin B12 levels may lower inflammatory markers.
A new study analyzing English primary care records found that hypertension, obesity, diabetes, and low HDL cholesterol confer a higher risk of dementia in South Asian and Black people compared to White individuals. The results suggest tailored dementia prevention efforts should be targeted towards minority ethnic groups.
Having obesity before and during early pregnancy is linked to adverse outcomes like high blood pressure, preeclampsia, and gestational diabetes. These complications account for a small percentage of increased cardiovascular disease risks in the years following pregnancy for people with obesity.
A new study found that pre-pregnancy obesity is a primary driver of future cardiovascular disease risk, rather than pregnancy complications. The research followed 4,216 individuals from early pregnancy to postpartum and found those with overweight or obese BMI had a higher risk of developing hypertensive disorders during pregnancy.
A recent study found that integrated clinics can improve health outcomes and reduce costs for patients with multiple chronic conditions. The INTE-Africa study showed that retention rates were close to 90% and viral suppression rates remained unchanged, highlighting the benefits of integrating HIV and non-communicable disease care.
A new study led by UCL researchers finds that integrated health care for chronic high-burden conditions like diabetes and hypertension is feasible and cost-effective. The study showed that integrated care was associated with high levels of retention in care, no adverse effect on viral suppression among people with HIV, and cost-saving ...
A study of 4,070 insured adults with diabetes found persistent disparities in poor glycemic control, even after adjusting for social, healthcare, and behavioral factors. The research highlights the need for further investigation into the barriers contributing to these disparities.
The study found that glucagon-like peptide-1 agonists are associated with a higher risk of pancreatitis, gastroparesis, and bowel obstruction compared to bupropion-naltrexone. Patients considering weight loss medication should be aware of these potential risks due to the drugs' wide use.
A large public health survey in rural South Africa found that approximately half of people living with HIV, diabetes or hypertension have unmet health needs. The study's novel framework quantifies met and unmet health needs for individuals living with infectious and non-communicable diseases.
A new study published in Nature Communications found that global sugary drink consumption increased by at least 16% since 1990, with the highest intakes observed in Latin America and Sub-Saharan Africa. The study also reveals significant regional differences and correlations between sugary drink intake and socio-economic status.
A study published in Diabetes Care found that obesity, hypertension, and dyslipidemia alter cardiac energy production by interfering with metabolic substrate uptake. The research reveals early changes in apparently healthy middle-aged individuals, highlighting the importance of identifying mechanisms involved in heart disease onset.
A new clinical trial has found that administering metformin to pregnant women with gestational diabetes does not increase adverse neonatal outcomes or maternal health risks. The study provides hope for expectant mothers and healthcare providers seeking a safe alternative to traditional insulin-based treatments.
A randomized clinical trial found that early metformin treatment did not improve insulin initiation or fasting glucose levels in pregnant women with gestational diabetes. Further investigation into larger trials is warranted based on prespecified secondary outcome data.
University of Minnesota researchers identified top-performing primary care practices that deliver high-quality diabetes care through proactive patient outreach. These practices prioritize good communication and engagement with patients, fostering a strong doctor-patient relationship essential for overall health.
A 10-year study found that even low doses of radiation may contribute to an increased risk of diabetes among emergency workers at the Fukushima nuclear power plant. Researchers analyzed data from over 6,000 workers and found a significant association between low-dose radiation exposure and a higher risk of developing diabetes.
A study published in Blood Advances found that diabetes is associated with poorer survival rates in white patients with multiple myeloma, but not Black patients. Researchers believe higher insulin levels may accelerate cancer growth.
A new exercise-mimicking drug, SLU-PP-332, has shown promising results in obese mice, leading to weight loss and increased muscle activity without increasing physical activity. The drug works by boosting a natural metabolic pathway, making the body act like it is training for a marathon, resulting in faster metabolism of fat.
A study found that 80.3% of patients with metastatic breast cancer who received standard care treatment with alpelisib developed hyperglycemia, with 40.2% experiencing serious hyperglycemia. Lifestyle interventions and medication may help improve blood sugar levels and reduce the risk of needing to discontinue the drug.
High-performing primary care practices use similar strategies to manage change and improve diabetes care, including standardizing the care process, enhancing care teams, and engaging staff and clinicians. These practices also focus on proactive care, pre-visit planning, and improving patient relationships.
A new study reveals that most healthcare facilities in low- and middle-income countries are unprepared to deliver services for treating cardiovascular disease risk factors, including diabetes and hypertension. However, investing in HIV care may provide a solution by improving readiness.
The study found that type 1 diabetes incidence slightly increased overall, while type 2 diabetes significantly increased after the COVID-19 pandemic. Non-Hispanic Black and Hispanic youth were disproportionately affected.
Only 1% of US children who start obese in elementary school regain a healthy weight, while 25% eventually achieve it. Researchers analyzed childhood obesity trajectories, highlighting the slow pace of recovery.
A first-of-its-kind study by LSU Health New Orleans found that chronic diseases, such as hypertension and diabetes, explained nearly two-fifths of the racial disparity in COVID-associated hospitalizations. Non-Hispanic Black cancer patients had a higher prevalence of chronic diseases and were more than twice as likely to live in high-p...
A nationwide study from Karolinska Institutet in Sweden found that close relatives and partners of people with metabolic-associated fatty liver disease (MASLD) are at a higher risk of developing liver cancer and severe liver disease. This suggests that family members could benefit from the same lifestyle advice as patients with MASLD.
Defective exosomes in diabetic patients drive inflammation and impair wound healing. Researchers identified alterations in exosome cargo and release that compromise wound healing in diabetes. New exosome-focused therapies may promote healing of chronic wounds.
A groundbreaking study by UNIST researchers reveals that high levels of endotrophin in fat cells disrupt autophagy, leading to inflammation and insulin resistance. Inhibiting ATG7 protein function or neutralizing endotrophin shows promise as a potential treatment for obesity-related metabolic diseases.
Researchers developed a methodology to link gene activity with cellular behavior in human pancreas cells, revealing the dynamic behaviors of pancreatic cells and their role in diabetes. The study shows that certain genes, such as NEUROG3, are active for short periods during development and have implications for therapeutic applications.
Researchers found that Dectin-1 stimulation induced a unique immune signature in HIV-positive older adults, characterized by increased levels of IL-12, TNF-α, and IFN-α. This signature may contribute to the pro-inflammatory environment associated with HIV and aging.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers at University of Galway and MIT have developed an intelligent implantable device that can sense its environment, adapt to release drugs as required, and bypass scar tissue buildup. The device uses AI to tailor drug delivery to individual patients, reducing fibrotic encapsulation and ensuring consistent dosing.
A Tufts University study found that produce prescription programs associated with significant improvements in health outcomes, including halving food insecurity and lowering blood pressure. The programs provided free fruits and vegetables to low-income individuals with diet-related illnesses, resulting in clinically relevant outcomes.
Two studies demonstrate that artificial intelligence in colonoscopy can increase adenoma detection rates and reduce miss rates, but also lead to increased removal of non-neoplastic polyps. The findings suggest the need for additional research on more defined detection parameters before AI can be integrated into routine clinical care.
A KAUST researcher has created a highly sensitive glucose detector based on a thin-film transistor that can measure glucose levels in saliva with high accuracy. The device uses an enzyme to oxidize glucose present in the saliva, producing electrons that indicate the glucose concentration.
The study reveals that obesity-induced oxidative stress degrades CtBP2 protein, impairing pancreatic beta-cell function. This finding highlights the importance of targeting CtBP2 as a potential therapeutic strategy for obesity-related diseases.
The study found that racial and ethnic disparities in cardiometabolic diseases persisted despite social risk factors adjustments. Individuals with a more favorable social risk factor profile had lower rates of lifestyle risk factors and cardiometabolic diseases.
Researchers at ETH Zurich have developed a gene switch that uses sound waves to trigger insulin release in designer cells. The system works by embedding an ion channel protein from the bacterium E. coli into human cells, which opens in response to sound, causing insulin vesicles to fuse and release insulin.
The University of Tennessee Extension will address health disparities related to poor nutrition, physical activity, and obesity in seven rural Tennessee counties. The CDC's High Obesity Program funding aims to reduce chronic diseases by improving access to fresh foods and opportunities for physical activity.
Researchers at the University of New Hampshire found that pregnant women living in walkable areas engage in more physical activity and have fewer issues with pregnancy complications. The study also suggests that walking can have health benefits beyond exercise, such as social interactions and community engagement.
A study published in Liver Research found that glucokinase activators (GKAs) improved glucose tolerance and insulin sensitivity in mice with diet-induced obesity. However, GKAs also induced hepatic lipid accumulation, which activated the PERK-UPR signaling pathway.
A new study by Northwestern University found that non-Hispanic Black individuals have a significantly higher rate of pre-term births compared to non-Hispanic white individuals. Pre-pregnancy cardiovascular health and social determinants of health explain racial differences in preterm birth rates.
A University of Minnesota-led study found that long-term consumption of aspartame and saccharin is associated with increased volumes of visceral, intermuscular, and subcutaneous adipose tissue. The researchers recommend considering alternative approaches to artificial sweeteners due to potential health consequences.
Human cells have been found to synchronize their movements in unison, similar to grandfather clocks, allowing them to work more efficiently and combat diseases. This new understanding can pave the way for developing biochemical tools to prevent serious diseases like cancer and diabetes.
Researchers at CU Anschutz Medical Campus identify fructose as a central conduit to obesity and diseases. Fructose works differently than other nutrients by lowering active energy, stimulating food intake and leading to weight gain.
A new study published in MDPI suggests that pecans have anti-inflammatory properties and can increase energy expenditure, reducing the risk of obesity and diabetes. The research found that pecans modulate adipose tissue lipolysis and mitochondrial oxidative metabolism in liver and skeletal muscle.
A small pilot study found that drinking kombucha for four weeks reduced fasting blood glucose levels in people with type-II diabetes. The fermented tea drink was shown to lower average blood sugar levels by 48 milligrams per deciliter, with no significant difference between the group consuming kombucha and those consuming a placebo.
The conference will focus on optimizing patient care in the Latin America region, discussing strategies to improve heart health and address rising cardiovascular disease rates. Key topics include cardiac rehabilitation, heart failure management, and practical approaches for clinicians.
A new study from the University of Missouri found that poverty, low health literacy, cultural beliefs, lack of infrastructure, and political issues hinder diabetes self-management for Haitian migrants. The researchers suggest targeted interventions, such as community gardens and healthcare education through local priests.
Researchers at Mount Sinai discovered a new family of locally secreted molecules called 'mammokines' that play a crucial role in controlling mammary gland fat abundance. These findings have significant implications for breast health, lactation-related disorders, and metabolic syndromes.