Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
High-performing primary care practices use similar strategies to manage change and improve diabetes care, including standardizing the care process, enhancing care teams, and engaging staff and clinicians. These practices also focus on proactive care, pre-visit planning, and improving patient relationships.
A new exercise-mimicking drug, SLU-PP-332, has shown promising results in obese mice, leading to weight loss and increased muscle activity without increasing physical activity. The drug works by boosting a natural metabolic pathway, making the body act like it is training for a marathon, resulting in faster metabolism of fat.
A new study reveals that most healthcare facilities in low- and middle-income countries are unprepared to deliver services for treating cardiovascular disease risk factors, including diabetes and hypertension. However, investing in HIV care may provide a solution by improving readiness.
The study found that type 1 diabetes incidence slightly increased overall, while type 2 diabetes significantly increased after the COVID-19 pandemic. Non-Hispanic Black and Hispanic youth were disproportionately affected.
Only 1% of US children who start obese in elementary school regain a healthy weight, while 25% eventually achieve it. Researchers analyzed childhood obesity trajectories, highlighting the slow pace of recovery.
A first-of-its-kind study by LSU Health New Orleans found that chronic diseases, such as hypertension and diabetes, explained nearly two-fifths of the racial disparity in COVID-associated hospitalizations. Non-Hispanic Black cancer patients had a higher prevalence of chronic diseases and were more than twice as likely to live in high-p...
Defective exosomes in diabetic patients drive inflammation and impair wound healing. Researchers identified alterations in exosome cargo and release that compromise wound healing in diabetes. New exosome-focused therapies may promote healing of chronic wounds.
A nationwide study from Karolinska Institutet in Sweden found that close relatives and partners of people with metabolic-associated fatty liver disease (MASLD) are at a higher risk of developing liver cancer and severe liver disease. This suggests that family members could benefit from the same lifestyle advice as patients with MASLD.
A groundbreaking study by UNIST researchers reveals that high levels of endotrophin in fat cells disrupt autophagy, leading to inflammation and insulin resistance. Inhibiting ATG7 protein function or neutralizing endotrophin shows promise as a potential treatment for obesity-related metabolic diseases.
Researchers found that Dectin-1 stimulation induced a unique immune signature in HIV-positive older adults, characterized by increased levels of IL-12, TNF-α, and IFN-α. This signature may contribute to the pro-inflammatory environment associated with HIV and aging.
Researchers developed a methodology to link gene activity with cellular behavior in human pancreas cells, revealing the dynamic behaviors of pancreatic cells and their role in diabetes. The study shows that certain genes, such as NEUROG3, are active for short periods during development and have implications for therapeutic applications.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
Researchers at University of Galway and MIT have developed an intelligent implantable device that can sense its environment, adapt to release drugs as required, and bypass scar tissue buildup. The device uses AI to tailor drug delivery to individual patients, reducing fibrotic encapsulation and ensuring consistent dosing.
A Tufts University study found that produce prescription programs associated with significant improvements in health outcomes, including halving food insecurity and lowering blood pressure. The programs provided free fruits and vegetables to low-income individuals with diet-related illnesses, resulting in clinically relevant outcomes.
Two studies demonstrate that artificial intelligence in colonoscopy can increase adenoma detection rates and reduce miss rates, but also lead to increased removal of non-neoplastic polyps. The findings suggest the need for additional research on more defined detection parameters before AI can be integrated into routine clinical care.
A KAUST researcher has created a highly sensitive glucose detector based on a thin-film transistor that can measure glucose levels in saliva with high accuracy. The device uses an enzyme to oxidize glucose present in the saliva, producing electrons that indicate the glucose concentration.
The study reveals that obesity-induced oxidative stress degrades CtBP2 protein, impairing pancreatic beta-cell function. This finding highlights the importance of targeting CtBP2 as a potential therapeutic strategy for obesity-related diseases.
The study found that racial and ethnic disparities in cardiometabolic diseases persisted despite social risk factors adjustments. Individuals with a more favorable social risk factor profile had lower rates of lifestyle risk factors and cardiometabolic diseases.
Researchers at ETH Zurich have developed a gene switch that uses sound waves to trigger insulin release in designer cells. The system works by embedding an ion channel protein from the bacterium E. coli into human cells, which opens in response to sound, causing insulin vesicles to fuse and release insulin.
The University of Tennessee Extension will address health disparities related to poor nutrition, physical activity, and obesity in seven rural Tennessee counties. The CDC's High Obesity Program funding aims to reduce chronic diseases by improving access to fresh foods and opportunities for physical activity.
Researchers at the University of New Hampshire found that pregnant women living in walkable areas engage in more physical activity and have fewer issues with pregnancy complications. The study also suggests that walking can have health benefits beyond exercise, such as social interactions and community engagement.
A study published in Liver Research found that glucokinase activators (GKAs) improved glucose tolerance and insulin sensitivity in mice with diet-induced obesity. However, GKAs also induced hepatic lipid accumulation, which activated the PERK-UPR signaling pathway.
A new study by Northwestern University found that non-Hispanic Black individuals have a significantly higher rate of pre-term births compared to non-Hispanic white individuals. Pre-pregnancy cardiovascular health and social determinants of health explain racial differences in preterm birth rates.
A University of Minnesota-led study found that long-term consumption of aspartame and saccharin is associated with increased volumes of visceral, intermuscular, and subcutaneous adipose tissue. The researchers recommend considering alternative approaches to artificial sweeteners due to potential health consequences.
Human cells have been found to synchronize their movements in unison, similar to grandfather clocks, allowing them to work more efficiently and combat diseases. This new understanding can pave the way for developing biochemical tools to prevent serious diseases like cancer and diabetes.
Researchers at CU Anschutz Medical Campus identify fructose as a central conduit to obesity and diseases. Fructose works differently than other nutrients by lowering active energy, stimulating food intake and leading to weight gain.
A new study published in MDPI suggests that pecans have anti-inflammatory properties and can increase energy expenditure, reducing the risk of obesity and diabetes. The research found that pecans modulate adipose tissue lipolysis and mitochondrial oxidative metabolism in liver and skeletal muscle.
A small pilot study found that drinking kombucha for four weeks reduced fasting blood glucose levels in people with type-II diabetes. The fermented tea drink was shown to lower average blood sugar levels by 48 milligrams per deciliter, with no significant difference between the group consuming kombucha and those consuming a placebo.
The conference will focus on optimizing patient care in the Latin America region, discussing strategies to improve heart health and address rising cardiovascular disease rates. Key topics include cardiac rehabilitation, heart failure management, and practical approaches for clinicians.
A new study from the University of Missouri found that poverty, low health literacy, cultural beliefs, lack of infrastructure, and political issues hinder diabetes self-management for Haitian migrants. The researchers suggest targeted interventions, such as community gardens and healthcare education through local priests.
Researchers at Mount Sinai discovered a new family of locally secreted molecules called 'mammokines' that play a crucial role in controlling mammary gland fat abundance. These findings have significant implications for breast health, lactation-related disorders, and metabolic syndromes.
A Northwestern University study found that only 60% of women with heart disease risk factors received counseling on optimizing their heart health during their six-week postpartum visit. The study highlights the need for improved access to care and increased awareness of maternal cardiovascular health monitoring.
A randomized controlled study found that participants who restricted their daily eating to between noon and 8 p.m. lost more weight and showed similar improvements in blood sugar levels compared to those on a calorie-restricted diet.
Researchers at the Complexity Science Hub found a significant link between malnutrition during pregnancy and an increased risk of type 2 diabetes. The study analyzed data from over 3.5 million people in Austria and found that men born during severe famine periods had a 78% higher incidence rate of new diabetes cases.
A recent study found that PCSK9 inhibitors may impair lung function in some patients, while statins have a protective effect on the brain, increasing hippocampus volume which may reduce dementia and depression risk. The study used genetic data from 340,000 UK Biobank participants.
Researchers at Cedars-Sinai have identified two disease-associated changes to the cornea in diabetes patients that delay wound healing. The study proposes three therapeutic pathways that reversed these changes and partially restored wound-healing function, offering new potential treatments for diabetes.
Researchers identify genes that directly influence what we eat and find foods that can boost brain health and protect the planet. New insights into genetic basis for food preferences could help improve personalized nutrition.
A comprehensive review of biochemical markers for bone fragility in diabetes identifies low bone turnover and alterations in bone quality as key factors. The study suggests that glycemic control, AGEs, and serum IGF-1 may have predictive value for fracture risk in patients with diabetes.
A new study suggests that reduced brain gray matter volume may mediate the association between glycemia and depression. Researchers observed a significant correlation between elevated glycosylated hemoglobin levels, reduced GMV, and depression in a large cohort of participants.
A nationwide produce prescription program for patients with diabetes and food insecurity could prevent 296,000 cases of cardiovascular disease and gain 260,000 quality-adjusted life years. The program is estimated to save $39.6 billion in healthcare spending and $4.8 billion in lost productivity costs.
An epigenetic study of over 18,000 people in Scotland identified associations between certain DNA modifications and increased risks of breast cancer, type II diabetes, and chronic obstructive pulmonary disease (COPD). The findings provide new insights into the underlying mechanisms of these diseases.
A recent study published in Scientific Reports has uncovered the crucial role of glutaminase 2 in maintaining glucose homeostasis in pancreatic β-cells, particularly under conditions of hyperglycemia. The research team found that impaired GLS2 activity drives the onset of diabetes mellitus by disrupting insulin and glucagon regulation.
A new study from the University of Missouri-Columbia found that supportive communities and education about breastfeeding health benefits can boost breastfeeding rates, particularly in rural areas where it is less common. The study also showed that reduced stigma surrounding breastfeeding occurred with increased community exposure.
The study highlights the increasing global burden of childhood diabetes, with rising deaths and disability-adjusted life-years. Improved understanding of diabetes epidemiology in children is crucial for prevention and control efforts.
Researchers have developed a biodegradable fluorescent nanoprobe to detect diabetic retinopathy (DR) at its early molecular stage. The nanoprobe binds to VEGFR-2, expressed in the retinal microvessels, allowing for early diagnosis and intervention.
Dr. Jun Zou's research aims to explain how diabetes causes heart disease and develop approaches to prevent it. He investigates the role of gut microbiota in cardiac dysfunction, with potential therapeutic strategies for maintaining a healthy intestinal-microbiota relationship.
A new study found that higher doses of oral semaglutide improved regulation of blood sugar levels and weight loss compared to lower doses. Participants who received the 25mg and 50mg doses lost an average of 17.5 pounds, nearly twice as much weight loss as those who took the lowest dose.
The global prevalence of diabetes is expected to more than double from 6.1% to 12.8% by 2050, with every country experiencing an increase. The study found that high body mass index and dietary risks are primary contributors to type 2 diabetes.
A randomized phase II study found that adding metformin to androgen deprivation therapy did not reduce the risk of metabolic syndrome or improve PSA response in patients with advanced prostate cancer. Metformin showed some antitumor effects through mTOR inhibition, but these were not significant.
A retrospective cohort study found a significant increase in gestational diabetes cases during the COVID-19 pandemic compared to pre-pandemic periods. The study attributed this rise to changes in population demographics and lifestyle factors related to the pandemic.
In 2021, 9.6 million Americans had diabetic retinopathy and 1.84 million had vision-threatening forms. The number of people living with diabetes-related eye disease has grown since the last prevalence estimate in 2004.
Children and teenagers with diabetes frequently employ inaccurate CGM alarm settings, which may lead to reduced usefulness of these devices. Research highlights the importance of following recommended alarm best practices to ensure patients receive real-time glycemic data while minimizing alarm fatigue.
A recent study published in Diabetologia has uncovered a crucial gene called RELA that plays a vital role in maintaining normal blood-sugar levels. The researchers found that when the RELA gene is removed, it leads to impaired insulin secretion and pre-diabetic conditions.
A new study from Keck Medicine of USC reveals significant racial disparities in the diagnosis and treatment of peripheral artery disease (PAD) among Black and white patients. Black patients are nearly 50% less likely to receive vascular interventions, leading to a higher risk of stroke, heart attack, or amputation.
Researchers propose a new method to diagnose tubular abnormalities in diabetic kidney disease by combining sodium concentration measurement with urinary albumin. The study uses 23Na MRI, which images metabolic changes in sodium, revealing impaired countercurrent multiplication system in diabetic mice kidneys.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
A University of Massachusetts Amherst researcher has updated the Pregnancy Physical Activity Questionnaire (PPAQ), a widely used tool for measuring prenatal physical activity. The new PPAQ is considered reliable and valid, providing estimates of physical activity and sedentary behavior in pregnant women.
Scientists have developed an ultra-high-resolution optical coherence tomography device to detect Diabetic Peripheral Neuropathy (DPN) in the cornea. The non-contact rapid imaging technology allows for early detection of small nerve fibres affected by DPN, enabling timely treatment and prevention of disability.
Researchers analyzed data from 120 clinical trials and found no evidence that treatment efficacies differ depending on the number of comorbidities. The study suggests that modest levels of comorbidities do not affect treatment outcomes, providing valuable insights for clinicians to make informed recommendations.
Researchers have unlocked insights into how brown fat tissue can be harnessed to combat obesity and remove glucose from the blood. The study used a cryogenic electron microscope to view mitochondrial uncoupling protein 1 in atomic detail, revealing potential new ways to promote weight loss.