Articles tagged with Osteoporosis
A new study found that patients who have suffered a Colles' fracture are at significantly increased risk of subsequent hip fractures. The risk is highest within the first month after the wrist fracture and increases with age. Both Colles' fracture and osteoporosis were significant independent factors that predicted hip fracture.
The Asia-Pacific region will see a dramatic rise in osteoporosis and related fractures by 2050, with more than half of hip fractures occurring in Asia. The report highlights the need for immediate action to reduce future costs and disability.
A new report by the International Osteoporosis Foundation warns that Hong Kong's rapidly ageing population will lead to a significant increase in hip fractures, resulting in severe disability and early deaths. The report recommends prioritizing osteoporosis treatment and prevention to mitigate this growing health problem.
A recent Loyola Medicine study compared the efficacy of denosumab and zoledronic acid in treating osteoporosis. Denosumab was found to have a significantly greater effect on increasing spine bone mineral density, while zoledronic acid caused more flulike symptoms.
Research with baboons found that genetic differences may regulate bone remodeling, a natural process where mature bone tissue is removed and replaced. This could explain why older women taking bisphosphonates are at risk of atypical fractures in their femurs, due to slower bone growth and accumulation of bone tissue.
More than 22 million postmenopausal women in the European Union are at risk of developing osteoporosis, which can lead to debilitating fractures, pain, and premature death. The disease is expected to increase by 23% from 2010 to 2025, with a total health burden estimated at 1,180,000 lost QALYs.
Loyola researchers found that zoledronic acid's kidney failure and calcium deficiency risks are extremely rare. The study of 237 patients showed a slight decline in calcium levels after the first infusion, but this effect is transient and only significant for those with normal vitamin D levels.
The Dartmouth Atlas report shows wide variation in prescription drug use among Medicare patients across US regions, with higher spending not related to proven treatment use. Effective therapies are underused in some areas, while potentially harmful medications are overprescribed.
Research identifies NADPH oxidase 4 (NOX4) as a promoter of bone resorption and osteoclastogenesis. Genetic disruption or inhibition of NOX4 has been shown to protect against bone loss in mouse models.
Fragility fractures in the EU are estimated to occur annually at 3.5 million, resulting in a healthcare cost of €37 billion, which is expected to rise to €45 billion in 2025. The report calls for prevention and treatment guidelines to address this growing concern.
A large meta-analysis of 23 studies involving over 4,000 healthy adults found no significant benefit from vitamin D supplements in preventing osteoporosis. The study's authors conclude that continuing widespread use of vitamin D for osteoporosis prevention in healthy adults without specific risk factors is inappropriate.
A recent study published in JAMA found that repeating bone mineral density (BMD) tests after four years offers limited value in assessing bone fracture risk in seniors aged 75 and older. The study suggests that updating clinical characteristics in the Fracture Risk Assessment Tool (FRAX) instead of repeating BMD tests may be a more eff...
A study in JAMA found that repeating bone mineral density (BMD) tests every 2 years provides little additional value for assessing fracture risk. The study, conducted on a cohort of older men and women with untreated osteoporosis, showed that BMD change provided little information beyond baseline BMD for clinical management.
A systematic review reveals that over one-third of the world's population may have low levels of vitamin D. Vitamin D values were higher in North America compared to Europe and the Middle-East. The review highlights the need for further research and public health measures to improve vitamin D status, particularly in high-risk groups su...
The report provides 13 key standards for effective coordinator-based FLS services, which have been shown to close the treatment gap and manage high-risk patients. Implementing these standards can help healthcare providers identify and treat patients at risk of secondary fractures, reducing future fracture risk and associated costs.
A study at the University of Eastern Finland found that abnormal bone properties in children with vertebral fractures and after solid organ transplantation can predict fracture risk. Bone histomorphometry revealed changes in bone composition that could explain increased fracture risk.
A new study found that patients who understand their potential risk for another fracture are more likely to take action. Knowing bone health and osteoporosis is pivotal in preventing future fractures.
Distal radius fractures, a common elderly fracture, require standardized measurement of clinical outcomes to inform evidence-based practice and research. ISFR-ISOF recommendations promote international consensus on core domains for assessment, including pain, function, and participation.
A study published in the Journal of Clinical Endocrinology & Metabolism found that probiotic Lactobacillus reuteri NCIMB 30242 increased circulating vitamin D levels by 25.5 percent in hypercholesterolemic adults over a nine-week intervention.
The National Osteoporosis Guideline Group (NOGG) Update 2013 provides updated guidance on the diagnosis and management of osteoporosis. The new recommendations cover glucocorticoid-induced osteoporosis, calcium and vitamin D therapy, and long-term bisphosphonate therapy.
Researchers found reversal cells covering 80% of resorbed bone surfaces that gradually mature into osteoblasts during the reversal phase. Biopsies from postmenopausal patients with osteoporosis showed a high proportion of arrested cells, associated with bone loss.
A new osteoporosis treatment combination of denosumab and teriparatide was found to be more effective than individual therapies, increasing bone density in women with osteoporosis. The study showed significant improvements in BMD at the spine, hip, and femoral neck in women treated with the combination therapy.
A combination of two FDA-approved osteoporosis drugs, denosumab and teriparatide, was found to increase bone density more effectively than single-drug therapy in a small clinical trial. The treatment produced significant improvements in bone mineral density at multiple measured sites, including the lumbar spine and hip.
A study of 32,383 participants found that prolonged surgical delay after hip fracture significantly increases long-term mortality risk in older adults. The researchers suggested that early surgery may help mitigate this risk and improve patient outcomes.
A new report sets 13 achievable standards for best practice in implementing fracture liaison services worldwide to identify and treat patients at high risk of secondary fractures. The initiative aims to provide essential resources, establish mentoring programs, and promote global recognition for fracture liaison services.
A recent study from India reveals that patients with hip fractures experience high mortality and functional impairment rates, with 30.4% of patients passing away within a year of the fracture, and only 21.9% regaining normal motor function.
A Kaiser Permanente study found that nearly 30% of women with osteoporosis fail to pick up their bisphosphonate prescriptions within 60 days. The study identified patient and physician characteristics, such as age, emergency department utilization, and prescription medication use, that contribute to nonadherence.
Professor Diez-Perez has advanced understanding of osteoporosis through original scientific contributions, including epidemiology and clinical care. He is recognized for promoting medical innovation and improving patient outcomes.
Professor Socrates Papapoulos has made significant contributions to advancing osteoporosis research and advocacy worldwide. He is a renowned researcher at the Leiden University Medical Center and IOF Board member, with over 300 publications and several awards.
Professor Harry Genant has been recognized with the first IOF Olof Johnell Science Award for his influential work in noninvasive imaging methods, clinical advances, and best practice guidelines. He is a distinguished researcher, author, and educator, with extensive contributions to bone science and policy implementation.
The European Union faces a significant burden of osteoporosis, with 22 million women and 5.5 million men affected. The annual economic cost of new and prior fragility fractures is €37 billion, with costs expected to increase by 25% by 2025.
Dr. Mary Bouxsein has been recognized with the ESCEO-IOF Herbert Fleisch Medal for her outstanding contributions to understanding skeletal fragility through biomechanics. Her work focuses on predicting fracture risk using novel non-invasive imaging techniques.
A recent study found that simple educational strategies targeting doctors and patients after a fracture significantly improved osteoporosis testing rates, reducing fractures by two fewer per 1,000 patients. Mail-based notice interventions were effective and cost-efficient, with projected savings of $18,000 for every 1,000 patients.
A new EU scorecard highlights significant inequalities in osteoporosis care across European countries. Despite marked differences in fracture risk and services, approximately 57% of high-risk individuals remain untreated, with inadequate access to testing, treatment, and effective medications.
A recent study found that zoledronic acid, a common osteoporosis drug, not only slows bone loss but also increases levels of sclerostin, a biomarker that inhibits bone formation. This suggests that combination treatments may be needed to effectively treat osteoporosis and increase bone mass.
Professor Maria Luisa Brandi was awarded the prestigious ESCEO-IOF Servier Pierre D. Delmas Prize for her major scientific contributions to bone and mineral diseases. She is a renowned researcher with numerous patents and publications, recognized nationally and internationally.
Researchers found that smoking and depressive symptoms in adolescent girls negatively impact bone accrual and may be associated with lower bone mass or osteoporosis. The study suggests these factors have a negative impact on bone health, increasing the risk of fractures in postmenopausal years.
The new Guidance emphasizes the importance of early diagnosis and treatment for postmenopausal osteoporosis, citing high fracture rates and low treatment adherence. The report provides updated guidelines for assessing fracture risk, management algorithms, and nutritional recommendations to prevent fractures.
Scientists at Michigan State University found that a natural probiotic supplement can enhance bone density in male mice, but not female mice. The study suggests a possible new treatment for osteoporosis without the risks of traditional medications.
Researchers found that higher dairy intake, particularly from milk and yogurt, is associated with improved bone mineral density in the hip. However, cream consumption was linked to lower bone density. The study suggests choosing low-fat dairy products can increase nutrient intake and reduce saturated fat consumption.
Five young investigators from the Asia-Pacific region were awarded prestigious grants for their top-ranking abstracts. The IOF Young Investigator Award valued at USD 1,000 and invited them to present their work in oral presentations during a special plenary session.
Researchers found that Vietnamese women who received nutrition education counselling showed significant increases in calcium intake and stable bone mass. In contrast, the control group experienced decreased bone mass. The study suggests community-based education programmes can improve bone health in postmenopausal women.
A new study reveals how tiny holes in bones can weaken them, but also shows that strengthening osteocalcin could lead to stronger bones. Researchers suggest that increasing vitamin K intake through foods like spinach and broccoli may help prevent bone fractures.
Researchers found that teenage girls who smoke accumulate less bone during a critical growth period and carry a higher risk of developing osteoporosis later in life. The study suggests that strategies to help prevent osteoporosis should focus on preventing smoking, particularly among adolescent girls.
A genetic variation in the vitamin D receptor has been linked to a decreased risk of developing osteoporosis, according to a meta-analysis of 26 studies. The study suggests that individuals with this variation may have a significantly lower risk of bone mineral density loss.
A new study from Karolinska Institutet in Sweden suggests that digital X-ray radiogrammetry (DXR) used on standard hand radiographs can help identify patients at higher risk of hip fracture. DXR is a technique comparable to more costly methods and may be used preventively to identify people at risk for osteoporosis.
A new health-economic model shows that increasing dairy food consumption can prevent osteoporotic fractures and reduce healthcare costs. The study found that France, Sweden, and the Netherlands could potentially save millions of euros in healthcare costs by boosting dietary calcium intake.
A study by University of Alberta researchers found that providing educational information to physicians and patients improved osteoporosis treatment rates. The intervention led to a significant increase in follow-up testing and treatment, especially among men who are often overlooked as having the condition.
A new approach for assessing fracture risk combines bone density measures with body size and bone size, predicting risk accurately regardless of race or ethnicity. The study found that this composite bone strength index performed just as well as traditional methods in a group of nearly 2,000 women.
A new report by IOF calls for the implementation of coordinator-based post-fracture care to prevent secondary fractures. The report highlights a significant care gap in diagnosing osteoporosis and assessing falls risk among fracture patients.
A new report by the International Osteoporosis Foundation highlights the alarming rate of unaddressed osteoporosis and related falls in clinics and hospitals worldwide. The 'Capture the Fracture' campaign urges concerted global efforts to implement proven models of care, aiming to break the cycle of secondary fractures.
Researchers at Mount Sinai School of Medicine have shown that large doses of vitamin C can stimulate bone formation and prevent bone loss in animal models. The study suggests that vitamin C may be a promising therapeutic agent for treating osteoporosis, particularly in developing nations where treatment options are limited.
The International Osteoporosis Foundation (IOF) presented annual Young Investigator Awards to top five ranking abstracts at its regional meeting. The award recipients received USD 1,000 and were invited to present their work during a special plenary session.
Researchers have developed a new computerized technique to diagnose osteoporosis using X-rays, which estimates bone porosity and improves accuracy over visual examination. The system has shown high accuracy rates of less than 2% in detecting osteoporosis in elderly Asian patients.
The International Osteoporosis Foundation has published new guidelines to help doctors assess treatment efficacy in patients who experience a fracture while on medication for osteoporosis. The guidelines outline a checklist of pragmatic criteria that can be used to define treatment failure and take appropriate action.
A new study suggests that a dual-action polyclonal antibody may offer more effective protection against osteoporosis by slowing bone destruction and building bone. This novel approach has the potential to be safer than existing treatments.
A new study published in the Journal of Clinical Endocrinology and Metabolism found that even minor physical activity can benefit bone health in premenopausal women by reducing sclerostin and enhancing IGF-1 levels. The study involved 1,235 premenopausal women who were followed for eight weeks, with those engaging in more than two hour...
Researchers have identified two related oncogenes, FAM83A and B, which enable breast cancer cells to survive treatment with EGFR TKIs. Expression of these genes in human tumors is correlated with decreased overall survival.
Researchers found that cigarette smoke produces large amounts of two proteins that stimulate the production of osteoclasts, cells responsible for breaking down old bone. This process weakens bones and increases the risk of fractures and disability among older people.
A task force report calls for routine osteoporosis testing and medication treatment for all adults over 50 who experience a fracture, with the goal of reducing hip fractures by 20% by 2020. Fracture liaison services have been shown to significantly improve follow-up assessment and treatment, reducing repeat occurrences.