Articles tagged with Osteoporosis
A drug already FDA-approved for osteoporosis has been found to stimulate the production of cells controlling insulin balance in diabetic mice. This could lead to a potential new treatment for type 2 diabetes.
A comprehensive classification of rare genetic metabolic bone disorders has been developed, categorizing them into four major groups based on their metabolic pathway. This taxonomy provides valuable information for diagnosis, genetic testing, and the development of orphan drugs.
Use of bisphosphonates declined by 50% from 2008 to 2012 following media reports on rare fractures. The study published in Journal of Bone and Mineral Research reveals a dramatic drop in osteoporosis medication use.
A recent study found that one in four men over 50 will break a bone due to osteoporosis, surpassing prostate cancer incidence rates. The research suggests adding men to osteoporosis screening guidelines to address the high likelihood of vertebral fractures and low bone density.
A study found that osteoporosis screening rates increased among women at age 50, despite guidelines suggesting screening at age 65 unless risk factors are present. The presence of risk factors had a modest influence on screening decisions.
Up to 2 million American men suffer from osteoporosis, with worse health outcomes than women. Despite the severity of osteoporosis in men, fewer take preventive measures or undergo screening.
Patients with newly diagnosed and treated osteoporosis have an increased life expectancy of 15-26 years, depending on age and gender. Long-term management of osteoporosis is crucial to ensure optimal patient outcomes.
A study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that people with osteoporosis are at a 1.76-fold higher risk of developing sudden sensorineural hearing loss. Researchers analyzed medical records of over 10,600 individuals with osteoporosis and found that they were more likely to be diag...
A clinical trial found that zoledronic acid improved bone mineral density and reduced bone turnover in frail elderly women with osteoporosis. The treatment group showed significant increases in hip and spine bone mineral density at 12 and 24 months, while the placebo group showed decreases.
Osteoporosis-related fractures in China are expected to double by 2035, with costs rising to approximately US$25.58 billion by 2050. The study also found that women account for 73% of total costs, sustaining three times more fractures than men.
Sarcopenia, age-related muscle mass and strength loss, lacks a widely accepted clinical definition. A new review aims to develop refined criteria, addressing the need for a consensus definition.
A new study reveals UK hospital costs for hip fractures to be approximately £1.1 billion annually, highlighting the need for preventive measures. Fracture liaison services have been shown to reduce secondary fractures and improve quality of life.
A Canadian study found a significant treatment gap among high-risk patients with prior hip fractures or osteoporosis. The study suggests that those with prior hip fractures are least likely to receive osteoporosis therapy, emphasizing the need for better guidelines and knowledge transfer strategies.
A recent study published in Osteoporosis International found that painful knee osteoarthritis in women is associated with a higher risk of early death compared to unaffected women. The study, which followed middle-aged women for 24 years, also found no link between hand osteoarthritis and excess mortality risk.
A Swedish study shows that implementing Fracture Liaison Services can prevent a significant number of fractures, saving lives and reducing healthcare costs. The model predicts a reduction in fractures by 50% among patients identified with bone mineral testing, resulting in 19 quality-adjusted life years saved.
A phase 3 clinical trial found that abaloparatide reduces the rate of new spinal fractures by 86 percent and also significantly lowers the fracture rate at other parts of the body. The treatment also delays the time to the first nonvertebral fracture and increases bone mineral density.
A large study found that male smokers are more likely to develop osteoporosis and vertebral fractures compared to female smokers. Current guidelines do not recommend osteoporosis screening for men, but the researchers suggest that smokers of both genders should be screened for low bone density.
Recent articles in JBJS publications examine the relationship between bisphosphonates and atypical femoral fractures. Prodromal thigh pain, radiolucent lines on X-rays, and prolonged bisphosphonate use are indicators of an impending fracture. Conservative management with discontinuation and weight-bearing is recommended.
A new DNA vaccine targeting p62 has shown promising results in alleviating chronic inflammation and osteoporosis by exploiting the protein's role in autophagy. The vaccine, currently in phase I clinical trials, may offer a safe treatment for inflammatory bone loss.
New research from the University of Surrey found that potassium salts improve bone health by reducing bone resorption. The study showed a significant decrease in bone resorption and an increase in bone strength, potentially preventing osteoporosis.
A recent study published in Psychosomatic Medicine found that women with good life satisfaction had higher bone density and lower rates of osteoporosis compared to those with poor life satisfaction. Life satisfaction was positively associated with bone health, even after controlling for other risk factors.
A large cohort study found that women experiencing moderate to severe hot flashes and night sweats have lower bone mineral density and higher rates of hip fracture. Women with these symptoms are more likely to have issues with bone health than their peers, highlighting the need for healthy lifestyle habits to prevent osteoporosis.
A study found that prescriptions for bisphosphonates remain low even among men at high risk of fractures on androgen deprivation therapy. The study suggests limited awareness among clinicians about optimal bone health management, particularly in men with prior osteoporosis or fragility fracture.
A large study found no association between rosuvastatin statin therapy and reduced fracture risk in participants with elevated inflammatory biomarkers. Despite potential biological pathways linking cardiovascular disease and osteoporosis, the results contradict previous studies suggesting a protective effect of statins on fractures.
A recent study forecasts the immense economic cost of osteoporotic fractures in China, expected to double by 2035 and reach $25.58 billion by 2050 due to an aging population.
The International Osteoporosis Foundation has awarded young investigators from four countries for their groundbreaking studies on bone health. Researchers have shed light on the impact of sedentary time, moderate-to-vigorous physical activity, and body weight change on bone strength in adolescent girls.
A new study has found that weight loss of 10 percent or more in seniors substantially increases the risk of hip fractures. The Singapore Chinese Health Study found that body weight changes were associated with a significant increase in hip fracture risk, whereas weight gain did not reduce risk significantly.
A new study from Beth Israel Deaconess Medical Center found that men with osteoporosis-related fractures are under-screened for bone density testing and treatment. The research highlights the importance of evaluating and treating older men for osteoporosis, as fracture rates among men are expected to increase dramatically by 2050.
A study found that older men are three times less likely than women to undergo osteoporosis screening and treatment after a broken wrist. This disparity increases the risk of future bone breaks and related complications in men, who already have twice the mortality rate of women following a hip fracture.
The International Osteoporosis Foundation has published a succinct slide deck highlighting 60 original scientific abstracts presented at the ASBMR meeting in September 2014. The slide kit provides clinically focused research on various aspects of bone health, including osteoporosis treatment and new strategies.
A new study found that US osteoporosis screening guidelines failed to identify the majority of younger post-menopausal women who experienced major fractures. The guidelines recommended testing and treatment for women aged 65+, but only predicted fractures in around 25% of those aged 50-64.
The International Osteoporosis Foundation reports that one-third of all hip fractures worldwide occur in men, with mortality rates as high as 37% in the first year following fracture. Millions of men are left vulnerable to early death and disability due to osteoporosis.
A new study reveals that preosteoclasts, a previously overlooked group of cells, play a crucial role in maintaining bone health. The discovery explains the success of an experimental osteoporosis drug and opens up new avenues for research into designing future studies.
Raloxifene increases bone toughness by altering the physical properties of the bone matrix, rather than just suppressing bone loss or altering cellular activity. This novel mechanism provides a new class of osteoporosis treatments that target bone's intrinsic strength.
A recent study published at Experimental Biology 2014 demonstrated the long-term efficacy of KoACT in reducing bone loss in post-menopausal women. The supplement, which combines a proprietary formulation of calcium and collagen, prevented whole body bone mineral density loss at twelve months compared to a control group.
A new microRNA has been identified as a potential therapeutic target for treating osteoporosis by blocking bone destruction. Researchers believe this discovery could lead to innovative treatments for conditions such as osteoporosis and other bone diseases.
A multinational study found that long-term denosumab treatment in postmenopausal women with osteoporosis leads to significant increases in bone density and sustained low rates of fractures. The treatment also shows a favorable benefit/risk profile, with no increase in overall risk of cancer, infection, or cardiovascular disease.
A phase II study shows romosozumab significantly increases bone mineral density and bone content in the spine and hip compared to teriparatide and placebo. Romosozumab stimulates bone formation and decreases resorption by inhibiting sclerostin, a promising new treatment for postmenopausal osteoporosis.
Researchers have discovered a new target, human plastin 3 (PLS3), that may be critical for the treatment of osteoporosis. Injection of PLS3 or related proteins in zebrafish where it has been suppressed can replace its loss and repair bone development anomalies.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that the World Health Organization's Fracture Risk Assessment Tool (FRAX) underestimates the true dangers for people who are younger than 65 or have been treated for a single broken bone. The study used the Canadian BMI-FRAX form of...
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that obstructive sleep apnea raises the risk of osteoporosis, especially among women and older individuals. The study used data from Taiwan's National Health Insurance program to track 1,377 people with obstructive sleep apnea and comp...
Dr. Jonathan D. Adachi has been awarded the IOF Olof Johnell Science Award for his internationally recognized contributions to osteoporosis research, including epidemiological studies and clinical trials. He is also a prominent advocate for osteoporosis prevention and treatment.
Researchers found no association between calcium and increased risk of coronary heart disease in postmenopausal women. The meta-analysis of randomized controlled trials suggests that calcium supplementation with or without vitamin D may be safe for cardiovascular health.
A study of 749 postmenopausal women found that ankle fractures were associated with lower areal BMD and altered bone microstructure, similar to forearm fractures. These findings suggest that ankle fractures should be considered osteoporotic fractures in fracture risk assessment.
A UCLA-led study found that higher education levels are associated with lower rates of bone fractures among non-white women. The study followed over 2,000 pre-menopausal women for nine years and found that those with at least some postgraduate education had an 87% lower non-traumatic fracture rate than those with less education.
Dr. Vladyslav Povoroznyuk, President of the Ukrainian Osteoporosis Association, received the first CNS Medal from IOF. He has contributed to spreading key prevention messages and implemented local campaigns promoting bone health.
The Too Fit to Fracture Initiative presented exercise recommendations for individuals with osteoporosis and spine fractures. The panel recommends a multicomponent exercise program with resistance and balance training, and daily balance training and endurance training are recommended for all individuals with osteoporosis.
Professor René Rizzoli has made significant contributions to understanding osteoporosis, a disease that affects millions worldwide. Through his work with the International Osteoporosis Foundation (IOF), he has helped promote medical innovation and improved care for patients.
A Norwegian study found that higher screen time was associated with lower bone mineral density in boys, while girls who spent more time on computers had higher BMD than their peers. The findings suggest that sedentary lifestyles during adolescence can impact bone health and increase the risk of osteoporosis.
A Swedish study found that long-term low levels of vitamin D intake are associated with higher 10-year fracture risk in elderly women. The study showed that vitamin D insufficiency sustained over 5 years contributed to increased 10-year fracture incidence, especially in those with consistently low vitamin D levels.
A study of 176 pre-pubertal boys found that high levels of protein intake combined with rigorous physical activity led to increased bone mineral content and density. This synergy between high protein intake and exercise was shown to positively impact bone structure and strength, even from pre-puberty through mid-late adolescence.
Researchers found an osteoporosis screening campaign using FRAX as a pre-screening tool to be cost-effective if there is optimum follow-up and adherence to medication. The study used microsimulation modeling to estimate the incremental cost-effectiveness ratio of the strategy versus no intervention.
The International Osteoporosis Foundation (IOF) awarded the IOF President's Award to six osteoporosis experts from Asia-Pacific, Eastern Europe, Latin America, Middle East, Western Europe, and North America. The winners were recognized for their outstanding contributions to education and awareness of osteoporosis worldwide.
Jean-Marc Kaufman receives prestigious award for his groundbreaking work on osteoporosis and ageing in men. He has advanced our understanding of sex steroids' regulation and action in health and disease.
Professor Cyrus Cooper has made significant contributions to the study of bone and mineral diseases, including pioneering clinical studies on peak bone mass and vitamin D insufficiency. His work has provided valuable insights into the risk factors for osteoporosis and hip fracture in late adulthood.
The IOF-Servier Young Investigator Research Grant aims to develop and validate a sarcopenia-specific quality-of-life (QoL) tool. The grant will be used to assess the impact of sarcopenia on QoL in two prospective cohorts. Sarcopenia affects seniors, causing loss of muscle mass and strength.
Citrate, a natural cell by-product, is mixed with water to create a fluid trapped between bone crystals, allowing flexibility and absorbing pressure. Without citrate, crystals fuse together, becoming brittle and prone to shattering.
A study by Nadia Obi found that older women with higher BMI or those who received trastuzumab had an increased risk for hypertension, while low-weight patients were more likely to develop osteoporosis. Regular exercise and monitoring are recommended to prevent these conditions.
Researchers found that the current US Preventive Services Task Force strategy identifies only 34% of women in this age group with osteoporosis. This could lead to missed opportunities for fracture risk reduction among high-risk women.
Scientists at Washington University School of Medicine have discovered a potent stimulator of new bone growth, which could lead to new treatments for osteoporosis. The study found that the WNT7B protein enhances bone formation through the mTOR pathway.