Articles tagged with Osteoporosis
Raloxifene increases bone toughness by altering the physical properties of the bone matrix, rather than just suppressing bone loss or altering cellular activity. This novel mechanism provides a new class of osteoporosis treatments that target bone's intrinsic strength.
A recent study published at Experimental Biology 2014 demonstrated the long-term efficacy of KoACT in reducing bone loss in post-menopausal women. The supplement, which combines a proprietary formulation of calcium and collagen, prevented whole body bone mineral density loss at twelve months compared to a control group.
A new microRNA has been identified as a potential therapeutic target for treating osteoporosis by blocking bone destruction. Researchers believe this discovery could lead to innovative treatments for conditions such as osteoporosis and other bone diseases.
A multinational study found that long-term denosumab treatment in postmenopausal women with osteoporosis leads to significant increases in bone density and sustained low rates of fractures. The treatment also shows a favorable benefit/risk profile, with no increase in overall risk of cancer, infection, or cardiovascular disease.
A phase II study shows romosozumab significantly increases bone mineral density and bone content in the spine and hip compared to teriparatide and placebo. Romosozumab stimulates bone formation and decreases resorption by inhibiting sclerostin, a promising new treatment for postmenopausal osteoporosis.
Researchers have discovered a new target, human plastin 3 (PLS3), that may be critical for the treatment of osteoporosis. Injection of PLS3 or related proteins in zebrafish where it has been suppressed can replace its loss and repair bone development anomalies.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that the World Health Organization's Fracture Risk Assessment Tool (FRAX) underestimates the true dangers for people who are younger than 65 or have been treated for a single broken bone. The study used the Canadian BMI-FRAX form of...
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that obstructive sleep apnea raises the risk of osteoporosis, especially among women and older individuals. The study used data from Taiwan's National Health Insurance program to track 1,377 people with obstructive sleep apnea and comp...
Dr. Jonathan D. Adachi has been awarded the IOF Olof Johnell Science Award for his internationally recognized contributions to osteoporosis research, including epidemiological studies and clinical trials. He is also a prominent advocate for osteoporosis prevention and treatment.
Researchers found no association between calcium and increased risk of coronary heart disease in postmenopausal women. The meta-analysis of randomized controlled trials suggests that calcium supplementation with or without vitamin D may be safe for cardiovascular health.
A study of 749 postmenopausal women found that ankle fractures were associated with lower areal BMD and altered bone microstructure, similar to forearm fractures. These findings suggest that ankle fractures should be considered osteoporotic fractures in fracture risk assessment.
Dr. Vladyslav Povoroznyuk, President of the Ukrainian Osteoporosis Association, received the first CNS Medal from IOF. He has contributed to spreading key prevention messages and implemented local campaigns promoting bone health.
The Too Fit to Fracture Initiative presented exercise recommendations for individuals with osteoporosis and spine fractures. The panel recommends a multicomponent exercise program with resistance and balance training, and daily balance training and endurance training are recommended for all individuals with osteoporosis.
Professor René Rizzoli has made significant contributions to understanding osteoporosis, a disease that affects millions worldwide. Through his work with the International Osteoporosis Foundation (IOF), he has helped promote medical innovation and improved care for patients.
A Norwegian study found that higher screen time was associated with lower bone mineral density in boys, while girls who spent more time on computers had higher BMD than their peers. The findings suggest that sedentary lifestyles during adolescence can impact bone health and increase the risk of osteoporosis.
A Swedish study found that long-term low levels of vitamin D intake are associated with higher 10-year fracture risk in elderly women. The study showed that vitamin D insufficiency sustained over 5 years contributed to increased 10-year fracture incidence, especially in those with consistently low vitamin D levels.
A UCLA-led study found that higher education levels are associated with lower rates of bone fractures among non-white women. The study followed over 2,000 pre-menopausal women for nine years and found that those with at least some postgraduate education had an 87% lower non-traumatic fracture rate than those with less education.
Researchers found an osteoporosis screening campaign using FRAX as a pre-screening tool to be cost-effective if there is optimum follow-up and adherence to medication. The study used microsimulation modeling to estimate the incremental cost-effectiveness ratio of the strategy versus no intervention.
The International Osteoporosis Foundation (IOF) awarded the IOF President's Award to six osteoporosis experts from Asia-Pacific, Eastern Europe, Latin America, Middle East, Western Europe, and North America. The winners were recognized for their outstanding contributions to education and awareness of osteoporosis worldwide.
Jean-Marc Kaufman receives prestigious award for his groundbreaking work on osteoporosis and ageing in men. He has advanced our understanding of sex steroids' regulation and action in health and disease.
A study of 176 pre-pubertal boys found that high levels of protein intake combined with rigorous physical activity led to increased bone mineral content and density. This synergy between high protein intake and exercise was shown to positively impact bone structure and strength, even from pre-puberty through mid-late adolescence.
The IOF-Servier Young Investigator Research Grant aims to develop and validate a sarcopenia-specific quality-of-life (QoL) tool. The grant will be used to assess the impact of sarcopenia on QoL in two prospective cohorts. Sarcopenia affects seniors, causing loss of muscle mass and strength.
Professor Cyrus Cooper has made significant contributions to the study of bone and mineral diseases, including pioneering clinical studies on peak bone mass and vitamin D insufficiency. His work has provided valuable insights into the risk factors for osteoporosis and hip fracture in late adulthood.
Citrate, a natural cell by-product, is mixed with water to create a fluid trapped between bone crystals, allowing flexibility and absorbing pressure. Without citrate, crystals fuse together, becoming brittle and prone to shattering.
A study by Nadia Obi found that older women with higher BMI or those who received trastuzumab had an increased risk for hypertension, while low-weight patients were more likely to develop osteoporosis. Regular exercise and monitoring are recommended to prevent these conditions.
Researchers found that the current US Preventive Services Task Force strategy identifies only 34% of women in this age group with osteoporosis. This could lead to missed opportunities for fracture risk reduction among high-risk women.
Scientists at Washington University School of Medicine have discovered a potent stimulator of new bone growth, which could lead to new treatments for osteoporosis. The study found that the WNT7B protein enhances bone formation through the mTOR pathway.
A Penn State College of Medicine researcher developed an automated system that identifies high-risk osteoporosis patients and encourages follow-up treatment to prevent future fractures. The system resulted in a 60% follow-up rate among those who received letters, compared to 14% of those who did not receive letters.
The study found that FRAX was widely used in North America and Europe, but its uptake varied greatly across countries. Countries with high FRAX use per capita included the USA, UK, Canada, and Switzerland, while many African and South East Asian countries had low or no usage.
A new study from Loyola University Health System found that patients should resume treatment immediately after a fracture, decline in bone strength, or early rise in signs of increased fracture risk. Elderly patients and those with very low bone strength require closer follow-up during drug holidays.
A Hong Kong-based study found that 75% of second hip fractures occurred within 4 years of the initial fracture, with female patients experiencing a higher incidence. The study also revealed lower survival rates after a second hip fracture, with median survival times of 3 years and 8 months compared to 4 years and 10 months after the fi...
Five young investigators from China, Chinese Taipei, Hong Kong, Malaysia, and Pakistan received the IOF Young Investigator Awards for outstanding bone health research. The awards recognize the top-scoring abstracts presented at the 4th Asia-Pacific Osteoporosis Meeting.
A cross-sectional study by Tokyo University found exercising in middle age is a protective factor against sarcopenia and effective in maintaining muscle strength and physical performance. The prevalence of sarcopenia was higher with increasing age, but exercise habits in middle age were significantly associated with lower risk.
A new study found that patients who have suffered a Colles' fracture are at significantly increased risk of subsequent hip fractures. The risk is highest within the first month after the wrist fracture and increases with age. Both Colles' fracture and osteoporosis were significant independent factors that predicted hip fracture.
The Asia-Pacific region will see a dramatic rise in osteoporosis and related fractures by 2050, with more than half of hip fractures occurring in Asia. The report highlights the need for immediate action to reduce future costs and disability.
A new report by the International Osteoporosis Foundation warns that Hong Kong's rapidly ageing population will lead to a significant increase in hip fractures, resulting in severe disability and early deaths. The report recommends prioritizing osteoporosis treatment and prevention to mitigate this growing health problem.
A recent Loyola Medicine study compared the efficacy of denosumab and zoledronic acid in treating osteoporosis. Denosumab was found to have a significantly greater effect on increasing spine bone mineral density, while zoledronic acid caused more flulike symptoms.
Research with baboons found that genetic differences may regulate bone remodeling, a natural process where mature bone tissue is removed and replaced. This could explain why older women taking bisphosphonates are at risk of atypical fractures in their femurs, due to slower bone growth and accumulation of bone tissue.
More than 22 million postmenopausal women in the European Union are at risk of developing osteoporosis, which can lead to debilitating fractures, pain, and premature death. The disease is expected to increase by 23% from 2010 to 2025, with a total health burden estimated at 1,180,000 lost QALYs.
Loyola researchers found that zoledronic acid's kidney failure and calcium deficiency risks are extremely rare. The study of 237 patients showed a slight decline in calcium levels after the first infusion, but this effect is transient and only significant for those with normal vitamin D levels.
The Dartmouth Atlas report shows wide variation in prescription drug use among Medicare patients across US regions, with higher spending not related to proven treatment use. Effective therapies are underused in some areas, while potentially harmful medications are overprescribed.
Research identifies NADPH oxidase 4 (NOX4) as a promoter of bone resorption and osteoclastogenesis. Genetic disruption or inhibition of NOX4 has been shown to protect against bone loss in mouse models.
Fragility fractures in the EU are estimated to occur annually at 3.5 million, resulting in a healthcare cost of €37 billion, which is expected to rise to €45 billion in 2025. The report calls for prevention and treatment guidelines to address this growing concern.
A large meta-analysis of 23 studies involving over 4,000 healthy adults found no significant benefit from vitamin D supplements in preventing osteoporosis. The study's authors conclude that continuing widespread use of vitamin D for osteoporosis prevention in healthy adults without specific risk factors is inappropriate.
A study in JAMA found that repeating bone mineral density (BMD) tests every 2 years provides little additional value for assessing fracture risk. The study, conducted on a cohort of older men and women with untreated osteoporosis, showed that BMD change provided little information beyond baseline BMD for clinical management.
A recent study published in JAMA found that repeating bone mineral density (BMD) tests after four years offers limited value in assessing bone fracture risk in seniors aged 75 and older. The study suggests that updating clinical characteristics in the Fracture Risk Assessment Tool (FRAX) instead of repeating BMD tests may be a more eff...
A systematic review reveals that over one-third of the world's population may have low levels of vitamin D. Vitamin D values were higher in North America compared to Europe and the Middle-East. The review highlights the need for further research and public health measures to improve vitamin D status, particularly in high-risk groups su...
The report provides 13 key standards for effective coordinator-based FLS services, which have been shown to close the treatment gap and manage high-risk patients. Implementing these standards can help healthcare providers identify and treat patients at risk of secondary fractures, reducing future fracture risk and associated costs.
A study at the University of Eastern Finland found that abnormal bone properties in children with vertebral fractures and after solid organ transplantation can predict fracture risk. Bone histomorphometry revealed changes in bone composition that could explain increased fracture risk.
A new study found that patients who understand their potential risk for another fracture are more likely to take action. Knowing bone health and osteoporosis is pivotal in preventing future fractures.
Distal radius fractures, a common elderly fracture, require standardized measurement of clinical outcomes to inform evidence-based practice and research. ISFR-ISOF recommendations promote international consensus on core domains for assessment, including pain, function, and participation.
The National Osteoporosis Guideline Group (NOGG) Update 2013 provides updated guidance on the diagnosis and management of osteoporosis. The new recommendations cover glucocorticoid-induced osteoporosis, calcium and vitamin D therapy, and long-term bisphosphonate therapy.
A study published in the Journal of Clinical Endocrinology & Metabolism found that probiotic Lactobacillus reuteri NCIMB 30242 increased circulating vitamin D levels by 25.5 percent in hypercholesterolemic adults over a nine-week intervention.
Researchers found reversal cells covering 80% of resorbed bone surfaces that gradually mature into osteoblasts during the reversal phase. Biopsies from postmenopausal patients with osteoporosis showed a high proportion of arrested cells, associated with bone loss.
A combination of two FDA-approved osteoporosis drugs, denosumab and teriparatide, was found to increase bone density more effectively than single-drug therapy in a small clinical trial. The treatment produced significant improvements in bone mineral density at multiple measured sites, including the lumbar spine and hip.
A new osteoporosis treatment combination of denosumab and teriparatide was found to be more effective than individual therapies, increasing bone density in women with osteoporosis. The study showed significant improvements in BMD at the spine, hip, and femoral neck in women treated with the combination therapy.
A new report sets 13 achievable standards for best practice in implementing fracture liaison services worldwide to identify and treat patients at high risk of secondary fractures. The initiative aims to provide essential resources, establish mentoring programs, and promote global recognition for fracture liaison services.
A recent study from India reveals that patients with hip fractures experience high mortality and functional impairment rates, with 30.4% of patients passing away within a year of the fracture, and only 21.9% regaining normal motor function.
A study of 32,383 participants found that prolonged surgical delay after hip fracture significantly increases long-term mortality risk in older adults. The researchers suggested that early surgery may help mitigate this risk and improve patient outcomes.
Professor Diez-Perez has advanced understanding of osteoporosis through original scientific contributions, including epidemiology and clinical care. He is recognized for promoting medical innovation and improving patient outcomes.