Articles tagged with Osteoporosis
A new study suggests that moderate drinking as part of a healthy lifestyle may benefit postmenopausal women's bone health by reducing the risk of osteoporosis. The researchers found an increase in blood markers of bone turnover after just two weeks of abstinence, but this effect reversed shortly after resumption of normal drinking habits.
Researchers found two key epigenetic regulating genes that govern cell-fate determination of human bone marrow stem cells. The discovery may allow stem cells to differentiate specifically into bone cells while inhibiting fat cell differentiation, paving the way for therapies in regenerative medicine and osteoporosis treatment.
New research finds that epilepsy patients taking antiepileptic drugs are up to four times more likely to suffer fractures and have osteoporosis compared to non-users. The study also showed a significant increase in falls among female patients taking the medication.
The International Osteoporosis Foundation provides guidance on screening strategies for osteoporosis in young adults, emphasizing the need for caution in diagnosis and treatment. The review highlights the importance of distinguishing between low bone mass and skeletal fragility in this age group.
The Endocrine Society has released new clinical practice guidelines for managing osteoporosis in men, highlighting the importance of bone density testing for those at risk. The guidelines estimate that one in five men aged 50 will experience an osteoporosis-related fracture in their lifetime, with mortality rates higher in men than women.
The International Osteoporosis Foundation reports a significant increase in osteoporosis-related fractures and diagnoses in Latin America, driven by the region's aging population. The projected rise in fragility fractures poses a substantial socio-economic burden on healthcare systems.
The International Osteoporosis Foundation predicts a significant rise in hip fractures in Brazil, projected to increase by 32% by 2050. This is largely attributed to the aging of the Brazilian population, with over 37% expected to be over 50 years old and 14% over 70 years old by then.
A recent study found that male patients with pulmonary disease have a very high risk of osteopenia/osteoporosis, which can be reduced by routine screening and early intervention. The study included 46 patients, most of whom were male, and showed that those with more severe lung disease are more likely to also have bone disease.
A study reevaluating the long-term effects of alendronate on bone fractures found that patients with low bone density at high risk of spine fractures can benefit from continuing therapy. However, for other types of fractures, there is limited data on continued treatment benefits.
The American Society for Bone and Mineral Research (ASBMR) emphasizes the need for further research to improve treatment guidelines for osteoporosis patients taking bisphosphonates. The organization suggests that more research is necessary to determine the optimal length of therapy, as current recommendations may not be suitable for al...
A large-scale study found that young men who engaged in load-bearing sports for four hours a week or more increased bone mass and gained larger bones compared to sedentary individuals. This is thought to offer protection against osteoporosis, which affects men and women alike, leading to porous and weak bones that fracture over time.
Researchers identified 56 genetic regions controlling bone density and found 14 variants increasing fracture risk in women. The study, involving 80,000 participants, reveals a significant link between genetic variations and osteoporosis.
Researchers at the University of Sheffield have identified three new ways to tackle bone diseases like osteoporosis. By understanding how individual cells respond to mechanical loading and stress, they've discovered that controlling ATP release during exercise could help build stronger bones.
Researchers have identified 32 previously unidentified genetic regions associated with osteoporosis and fracture, suggesting the combined contributions of dozens of genes. The study also highlights the complexity of the genetic architecture of disease and the need for larger studies to identify genes important in disease.
Hebrew SeniorLife researchers have identified 56 genetic variants associated with osteoporosis and bone mineral density. The study found that these variants can increase the risk of bone fractures, with women over 65 facing a higher risk. The findings may lead to personalized gene-based treatments for osteoporosis.
Common osteoporosis medications may increase the risk of scleritis and uveitis, two inflammatory eye diseases that can severely impact vision. First-time users of oral bisphosphonates are at a higher risk compared to non-users.
Long-term oral glucocorticoid therapy is associated with a significant risk of bone loss and fractures, particularly in older adults and those with higher doses. To mitigate this risk, patients should take preventive measures such as maintaining adequate calcium and protein intake, exercising regularly, and getting enough vitamin D.
The International Osteoporosis Foundation (IOF) and the European Calcified Tissue Society (ECTS) have published a guidance document outlining management strategies to prevent bone loss and related fractures in high-risk patients. The guidelines provide a framework for developing national assessment and treatment guidelines, emphasizing...
Research suggests that early growth in the womb and first few years of life is positively related to total hip bone size and mineral content. Stronger hips can protect against future hip fractures, leading to optimized early growth strategies to reduce osteoporotic fracture risk.
The grant will support research on the relationships between body composition, muscle and bone strength. Dr Edwards' project aims to clarify uncertainties with regard to these relationships and assess their impact on fracture risk.
Professor Cyrus Cooper was awarded the IOF Medal of Achievement for advancing knowledge of osteoporosis through original and outstanding scientific contributions. He has led research programs on epidemiology, bone mineral accrual, and preventive strategies against hip fracture.
Dr. Claus Christiansen received the ESCEO-IOF Medal for his groundbreaking work on calcium metabolism in postmenopausal women. He has published extensively over 900 articles and book chapters, and has been a leading figure in osteoporosis research for over three decades.
René Rizzoli receives the award for his major scientific contributions to osteoporosis research and advocacy. He is recognized for both his clinical achievements and long-term impact as an educator and advocate in the field.
A new study has found a significant variation in hip fracture risk across the globe, with countries experiencing a 10-fold difference in incidence rates. The study's findings indicate that higher risk countries for both men and women are located in North Western and Central Europe.
Researchers at the Academy of Finland have developed a new, laser-based ultrasound technique to accurately assess osteoporosis. This method uses photo-acoustic methods to produce an ultrasound pulse that propagates along the bone, providing a more accurate measurement than current X-ray methods.
Osteoporosis experts advocate for shorter intervals between DXA scans for high-risk women, patients with low bone mineral density, and those receiving osteoporosis medication. This approach can prevent debilitating fractures and reduce healthcare costs.
The clinical guide highlights the benefits of selective estrogen receptor modulators (SERMs) in reducing fracture risk for postmenopausal women. SERMs, such as bazedoxifene and lasofoxifene, offer a new therapeutic option with potential anti-fracture effects.
A telephone-based counseling program using motivational interviewing showed modest improvements in medication adherence for certain subgroups, such as younger patients and those without previous fractures. However, the overall effect was no statistically significant improvement in adherence rates compared to a control group.
A nano-enabled intranasal formulation of teriparatide is being developed to treat osteoporosis, with the potential to provide easier administration and enhance efficacy. The project combines Critical Pharmaceuticals' nanotechnology expertise with the University of Nottingham's world-leading research capabilities.
The study validated the use of a microchip-based device to deliver teriparatide for osteoporosis treatment, with results comparable to standard injections. The implant showed biocompatibility and was well-tolerated by patients, providing proof-of-concept for long-term device viability.
Research found that discontinuing bisphosphonates after an atypical femur fracture significantly lowers the risk of a subsequent fracture. Bisphosphonates may suppress natural bone remodeling, leading to brittle bones and increased fracture risk.
Researchers found early childhood growth influences adult bone density, with significant contributions from birth size and height growth. Childhood nutrition plays a crucial role in preventing adult bone disease like osteoporosis.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that heart failure is associated with a 30% increase in major fractures. Researchers identified a high-risk population benefiting from increased screening and treatment for osteoporosis.
A new study found that women over 67 with normal bone mineral density scores do not need to be re-screened for osteoporosis for 15 years. This longer timeframe is based on the estimated time it takes for 10% of women in the highest bone density ranges to develop osteoporosis.
Researchers propose that manganese is essential for calcium absorption and its depletion may lead to osteoporosis. The study suggests a link between manganese deficiency and conditions like Alzheimer's and Parkinson's disease, highlighting the importance of maintaining bone health in relation to brain function.
A simple physician notification system improves postfracture care for osteoporotic patients, increasing bone mineral density tests by 13% and pharmacologic treatment initiation by 5%. Researchers suggest additional strategies may be more effective in combination.
A new audit report reveals a growing problem of osteoporosis in the Middle East and Africa, with predicted major increases in fractures and significant socioeconomic impact. Widespread vitamin D deficiency and low calcium intake contribute to the issue.
Six young investigators from the Middle East received prestigious grants for their top-ranking research abstracts presented at the IOF Regionals – 1st Middle-East & Africa Osteoporosis Meeting. The awards aim to encourage bone research among young researchers worldwide.
A study by Case Western Reserve University researchers suggests that the evolution of human vertebrae adapted for upright walking is the primary cause of backbone fractures, not osteoporosis. The team found that human vertebrae are larger and more porous than those in apes, but also thinner and less protected against cracks and breaks.
A three-step strategy for healthy bones and strong muscles is promoted by the International Osteoporosis Foundation, involving vitamin D intake, adequate calcium and protein in diet, and daily weight-bearing and muscle strengthening exercise. These components work together to optimize bone health and reduce falls and fractures in seniors.
Researchers at IRCM identified a new gene modulating bone mass and potentially leading to osteoporosis. This breakthrough may help identify individuals with a greater predisposition to the disease.
A recent study by Kaiser Permanente found that women aged 65-69 who break a hip are five times more likely to die within a year than those who don't. The study also discovered that for women aged 70-79, a hip fracture doubles the risk of dying, while for those aged 80 and older in excellent health, it nearly triples. These findings hig...
A Phase III trial demonstrated that the oral recombinant salmon calcitonin tablet OSTORA achieved superior efficacy to nasal calcitonin while showing equivalent safety. This offers a promising new treatment option for postmenopausal osteoporosis patients who have limited options due to side effects or poor tolerance.
Eight young investigators from Australia, China, India, and Japan received IOF Young Investigator Awards for their exceptional work on bone health. The award winners presented their research at the joint Asia-Pacific Osteoporosis and Bone Meeting & ANZBMS Annual Meeting.
Researchers develop salubrinal to treat weakened and broken bones by strengthening protein-producing machinery. Studies show accelerated healing in as little as a week, with potential for FDA approval.
The FRAX tool has been validated in 11 independent cohorts covering over 1 million patient years, providing empirical evidence to guide intervention. However, clinicians should be aware of the tool's limitations, including exclusion of certain risk factors and failure to account for variations in fracture rates within countries.
Vertebral fractures, often due to osteoporosis, can lead to severe consequences like spinal deformity and mortality. IOF recommends a systematic approach to manage vertebral compression fractures with minimally invasive techniques like vertebroplasty and balloon kyphoplasty.
People with multiple sclerosis are at risk of poor bone health in the early stages of the disease, with 51% experiencing osteoporosis or osteopenia. Low vitamin D levels can lead to reduced calcium absorption and bone mineralization.
Researchers found that patient outcomes improve when fracture clinics have a dedicated person to screen for and treat osteoporosis. The study also shows that testing and treatment within the program leads to better outcomes, rather than referring patients elsewhere.
Researchers at Rensselaer Polytechnic Institute developed a new process for analyzing bone tissue, providing insights into the fight against osteoporosis and aiding forensic studies. The technique uses laser-capture microscopy to determine protein signatures in nanoscale bone samples.
The International Osteoporosis Foundation calls for improved strategies to close the treatment gap and reduce the future burden of fractures. A new report estimates that increasing treatment uptake could avoid 13% of projected fractures by 2025, resulting in 95,000 fewer fractures annually.
A large treatment gap in Europe has been identified, leaving millions of older adults at unnecessary risk of fragility fractures. The report found that only a minority of high-risk patients are receiving treatment, despite advances in risk assessment and effective medication being widely available.
A new report reveals that osteoporotic fractures have a significant impact on European society, resulting in an estimated 2.5 million new fractures annually and €30.7 billion in health costs. The report estimates that the economic burden of fractures will increase to €38.5 billion by 2025.
Researchers at Ames Laboratory discovered citrate plays a crucial role in the nanostructure of bones, providing stiffness and preventing crack propagation. Higher citrate concentrations result in thinner apatite nanocrystals, which are more resistant to brittleness.
Researchers found that women with low bone density are seven times more likely to benefit from bisphosphonate drugs when their vitamin D levels are above the recommended threshold. Maintaining adequate vitamin D levels is crucial for optimizing osteoporosis treatment, particularly in postmenopausal women.
A lower dose of zoledronic acid has been found to increase bone density and decrease bone resorption, potentially reducing the risk of osteoporotic fractures. The study suggests that a one-fifth or one-half of the recommended dose may be sufficient for this effect.
Research shows bariatric surgery significantly increases fracture risk, with patients experiencing a 2.3-fold higher chance of bone fractures compared to the general population. Patients who underwent gastric bypass surgery had an increased risk of fractures at nearly all skeletal sites, including feet and hands.
A new IOF position paper advocates for coordinator-based systems to optimize outcome in fragility fracture patients, improving diagnosis and treatment of osteoporosis. This approach has been shown to reduce the risk of fractures and save money in healthcare systems.
A study of 1,030 patients with celiac disease found they were 4.5 times more likely to develop osteoporosis compared to healthy individuals. The bone mineral density loss was significantly pronounced in the lumbar spine but not the femoral neck.
Balicatib, a new osteoporosis treatment, causes skin hardening syndromes in patients. Researchers at Boston University School of Medicine found that the drug inhibits CathepsinK, leading to collagen and elastin degradation.