Articles tagged with Osteoporosis
A telephone-based counseling program using motivational interviewing showed modest improvements in medication adherence for certain subgroups, such as younger patients and those without previous fractures. However, the overall effect was no statistically significant improvement in adherence rates compared to a control group.
A nano-enabled intranasal formulation of teriparatide is being developed to treat osteoporosis, with the potential to provide easier administration and enhance efficacy. The project combines Critical Pharmaceuticals' nanotechnology expertise with the University of Nottingham's world-leading research capabilities.
The study validated the use of a microchip-based device to deliver teriparatide for osteoporosis treatment, with results comparable to standard injections. The implant showed biocompatibility and was well-tolerated by patients, providing proof-of-concept for long-term device viability.
Research found that discontinuing bisphosphonates after an atypical femur fracture significantly lowers the risk of a subsequent fracture. Bisphosphonates may suppress natural bone remodeling, leading to brittle bones and increased fracture risk.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that heart failure is associated with a 30% increase in major fractures. Researchers identified a high-risk population benefiting from increased screening and treatment for osteoporosis.
Researchers found early childhood growth influences adult bone density, with significant contributions from birth size and height growth. Childhood nutrition plays a crucial role in preventing adult bone disease like osteoporosis.
A new study found that women over 67 with normal bone mineral density scores do not need to be re-screened for osteoporosis for 15 years. This longer timeframe is based on the estimated time it takes for 10% of women in the highest bone density ranges to develop osteoporosis.
Researchers propose that manganese is essential for calcium absorption and its depletion may lead to osteoporosis. The study suggests a link between manganese deficiency and conditions like Alzheimer's and Parkinson's disease, highlighting the importance of maintaining bone health in relation to brain function.
A simple physician notification system improves postfracture care for osteoporotic patients, increasing bone mineral density tests by 13% and pharmacologic treatment initiation by 5%. Researchers suggest additional strategies may be more effective in combination.
A new audit report reveals a growing problem of osteoporosis in the Middle East and Africa, with predicted major increases in fractures and significant socioeconomic impact. Widespread vitamin D deficiency and low calcium intake contribute to the issue.
Six young investigators from the Middle East received prestigious grants for their top-ranking research abstracts presented at the IOF Regionals – 1st Middle-East & Africa Osteoporosis Meeting. The awards aim to encourage bone research among young researchers worldwide.
A study by Case Western Reserve University researchers suggests that the evolution of human vertebrae adapted for upright walking is the primary cause of backbone fractures, not osteoporosis. The team found that human vertebrae are larger and more porous than those in apes, but also thinner and less protected against cracks and breaks.
A three-step strategy for healthy bones and strong muscles is promoted by the International Osteoporosis Foundation, involving vitamin D intake, adequate calcium and protein in diet, and daily weight-bearing and muscle strengthening exercise. These components work together to optimize bone health and reduce falls and fractures in seniors.
Researchers at IRCM identified a new gene modulating bone mass and potentially leading to osteoporosis. This breakthrough may help identify individuals with a greater predisposition to the disease.
A recent study by Kaiser Permanente found that women aged 65-69 who break a hip are five times more likely to die within a year than those who don't. The study also discovered that for women aged 70-79, a hip fracture doubles the risk of dying, while for those aged 80 and older in excellent health, it nearly triples. These findings hig...
A Phase III trial demonstrated that the oral recombinant salmon calcitonin tablet OSTORA achieved superior efficacy to nasal calcitonin while showing equivalent safety. This offers a promising new treatment option for postmenopausal osteoporosis patients who have limited options due to side effects or poor tolerance.
Eight young investigators from Australia, China, India, and Japan received IOF Young Investigator Awards for their exceptional work on bone health. The award winners presented their research at the joint Asia-Pacific Osteoporosis and Bone Meeting & ANZBMS Annual Meeting.
Researchers develop salubrinal to treat weakened and broken bones by strengthening protein-producing machinery. Studies show accelerated healing in as little as a week, with potential for FDA approval.
The FRAX tool has been validated in 11 independent cohorts covering over 1 million patient years, providing empirical evidence to guide intervention. However, clinicians should be aware of the tool's limitations, including exclusion of certain risk factors and failure to account for variations in fracture rates within countries.
Vertebral fractures, often due to osteoporosis, can lead to severe consequences like spinal deformity and mortality. IOF recommends a systematic approach to manage vertebral compression fractures with minimally invasive techniques like vertebroplasty and balloon kyphoplasty.
People with multiple sclerosis are at risk of poor bone health in the early stages of the disease, with 51% experiencing osteoporosis or osteopenia. Low vitamin D levels can lead to reduced calcium absorption and bone mineralization.
Researchers found that patient outcomes improve when fracture clinics have a dedicated person to screen for and treat osteoporosis. The study also shows that testing and treatment within the program leads to better outcomes, rather than referring patients elsewhere.
Researchers at Rensselaer Polytechnic Institute developed a new process for analyzing bone tissue, providing insights into the fight against osteoporosis and aiding forensic studies. The technique uses laser-capture microscopy to determine protein signatures in nanoscale bone samples.
The International Osteoporosis Foundation calls for improved strategies to close the treatment gap and reduce the future burden of fractures. A new report estimates that increasing treatment uptake could avoid 13% of projected fractures by 2025, resulting in 95,000 fewer fractures annually.
A large treatment gap in Europe has been identified, leaving millions of older adults at unnecessary risk of fragility fractures. The report found that only a minority of high-risk patients are receiving treatment, despite advances in risk assessment and effective medication being widely available.
A new report reveals that osteoporotic fractures have a significant impact on European society, resulting in an estimated 2.5 million new fractures annually and €30.7 billion in health costs. The report estimates that the economic burden of fractures will increase to €38.5 billion by 2025.
Researchers at Ames Laboratory discovered citrate plays a crucial role in the nanostructure of bones, providing stiffness and preventing crack propagation. Higher citrate concentrations result in thinner apatite nanocrystals, which are more resistant to brittleness.
A lower dose of zoledronic acid has been found to increase bone density and decrease bone resorption, potentially reducing the risk of osteoporotic fractures. The study suggests that a one-fifth or one-half of the recommended dose may be sufficient for this effect.
Researchers found that women with low bone density are seven times more likely to benefit from bisphosphonate drugs when their vitamin D levels are above the recommended threshold. Maintaining adequate vitamin D levels is crucial for optimizing osteoporosis treatment, particularly in postmenopausal women.
Research shows bariatric surgery significantly increases fracture risk, with patients experiencing a 2.3-fold higher chance of bone fractures compared to the general population. Patients who underwent gastric bypass surgery had an increased risk of fractures at nearly all skeletal sites, including feet and hands.
A new IOF position paper advocates for coordinator-based systems to optimize outcome in fragility fracture patients, improving diagnosis and treatment of osteoporosis. This approach has been shown to reduce the risk of fractures and save money in healthcare systems.
A study of 1,030 patients with celiac disease found they were 4.5 times more likely to develop osteoporosis compared to healthy individuals. The bone mineral density loss was significantly pronounced in the lumbar spine but not the femoral neck.
Balicatib, a new osteoporosis treatment, causes skin hardening syndromes in patients. Researchers at Boston University School of Medicine found that the drug inhibits CathepsinK, leading to collagen and elastin degradation.
A Canadian study found that 12% of heart failure patients had moderate to severe vertebral compression fractures, a sign of osteoporosis. Only 15% of these patients were being treated for osteoporosis, despite having a higher risk for fractures.
A University of Illinois study suggests that increasing dietary calcium and vitamin D or taking supplements can significantly increase bone mineral density and reduce hip fracture risk. The researchers recommend a 'portfolio diet' with adequate protein, less sodium, and more magnesium and potassium for optimal bone health.
A recent study by American Academy of Orthopaedic Surgeons highlights the lack of knowledge about osteoporosis among certain patient groups, increasing their risk of fractures. Patients with fragility fractures, male individuals, and those who are unemployed or have limited English proficiency tend to know less about osteoporosis.
A review paper by IOF examines global hip fracture incidence trends, finding changes in age-specific rates in different regions. The study highlights the need for further research to understand the socio-economic burden of fragility fractures worldwide.
A study found that green tea and tai chi can enhance bone strength and reduce inflammation in postmenopausal women. The combination of moderate green tea consumption and tai chi practice showed significant benefits in bone markers, muscle strength, and quality of life.
Obese postmenopausal women are almost as likely to fracture as non-obese women, with specific sites like the upper arm, ankle, and lower leg being more prone to fractures in obese individuals. Poor mobility and a history of early menopause also play significant roles.
Researchers found that including falls history with clinical risk factors and bone mineral density values significantly enhances the accuracy of fracture prediction models. The study showed a 6% improvement in accuracy for men, with positive predictive values of 21.5% and 29.8% for women.
A recent study published in Osteoporosis International found substantial initial quality of life loss following osteoporotic fractures, particularly for hip and vertebral fractures. The study, part of the ICUROS international patient-based study, identified significant variations in quality of life loss between countries.
Dr. Helena Johansson and Dr. Maria-Belen Zanchetta receive $50,000 USD Fellowship to support their osteoporosis research at Sahlgrenska Academy and Instituto de Investigaciones Metabólicas, respectively. The award aims to promote research excellence in the bone field.
The ESCEO Young Investigators Awards were presented to Dr. Nick Harvey and Dr. Michaël Hiligsmann for their outstanding contributions to bone and mineral research. Their awards, valued at €2,500, recognize excellence in bone mineral research and are supported by a grant from MSD.
A new study reveals that hip fractures and vertebral fractures are major contributors to the economic cost, with Germany bearing the highest costs. The study estimates that prevention through early risk assessment is key to reducing these costs.
John A. Kanis, a leading expert in bone and mineral diseases, has made significant scientific contributions to the study of osteoporosis. He is currently President of the International Osteoporosis Foundation and WHO Advisor on Osteoporosis.
The Philippine Foundation was awarded a grant to establish an innovative bone health awareness program, promoting healthy nutrition and lifestyle habits to prevent osteoporosis. The program aims to raise awareness and make a real difference in communities, with a focus on education and community engagement.
The IOF-AMGEN/GSK Health Professionals Awareness Grants aim to improve knowledge of osteoporosis among clinicians and allied health professionals. The three grants support innovative projects by IOF member societies that focus on improving knowledge and diagnosis of osteoporosis.
The Association 'Women without Osteoporosis' of Bulgaria has received the 2011 IOF Linda Edwards Memorial Award for its outstanding campaigns to increase awareness, prevention, and treatment of osteoporosis. The award recognizes the organization's efforts to improve care for patients and its dedication to raising osteoporosis awareness.
Professor Gerard Karsenty is awarded the first Herbert A. Fleisch ESCEO-IOF Medal for his pioneering work in understanding skeletal development and physiology. The medal recognizes his outstanding achievements in basic bone science, including identifying Runx2 as a master gene of osteoblast differentiation.
Scientists have identified NOTCH2 as the causative gene for Hajdu-Cheney syndrome, a rare disorder characterized by progressive bone loss and osteoporosis. The study provides vital insight into possible causes of osteoporosis and highlights the gene as a potential target for treating the condition.
Researchers found that tomatoes contain powerful antioxidants like lycopene, which has greater bioavailability after cooking and processing. Tomatoes also have anti-inflammatory functions and a lower risk of certain cancers, cardiovascular disease, osteoporosis and cognitive dysfunction.
A new study found that women taking bisphosphonates for five years or more may be at higher risk of certain kinds of fractures of their thigh bone, but the drugs still prevent hip fractures. The overall risk is low, and researchers recommend continuing use for high-risk patients
Recent studies on PCSK enzymes have shed light on novel functions in diseases such as cardiovascular disorders, osteoporosis, and cancer. The research has revealed that these enzymes may play a crucial role in regulating cholesterol levels and bone formation, offering potential new treatments for dyslipidemia and osteoporosis.
A commonly prescribed osteoporosis drug is associated with a slightly elevated risk of developing osteonecrosis of the jaw, but the risk remains extremely low. Patients taking oral bisphosphonates were nine times more likely to develop the condition than those who didn't.
Researchers found that people taking bisphosphonates lived longer than those without osteoporosis and even gained an extra five years of life. The study, published in the Journal of Clinical Endocrinology and Metabolism, suggests a possible link between bone health and toxic metal release.
A recent study found that people taking bisphosphonates for osteoporosis treatment live an extra five years compared to those not receiving the medication. This significant benefit is attributed to bisphosphonates' ability to reduce toxic metal release, which may contribute to improved health outcomes.
African American patients with hypertension who viewed stories about real patients experienced better blood pressure control compared to usual care. High-volume hospitals for congestive heart failure showed improved patient outcomes but higher costs, contradicting previous studies that only focused on cost-effectiveness.
Key findings show that patients fear fractures but do not always adhere to treatment, while doctors underestimate their patients' adherence and concerns. Community-based online support programs have a great potential to fill information gaps and improve patient-doctor dialogue.
The IOF and IFCC have identified research priorities and recommended specific bone turnover markers (s-PINP and s-CTX) as reference analytes for clinical and observational studies. Standardized protocols would greatly increase the clinical and research potential of BTMs, improving patient management and treatment adherence.
A new study confirms a rapid rise in hip fractures in Beijing, with significant increases in rates for older adults. The research reveals that the growing elderly population and increasing sedentary lifestyles are major contributors to this trend, posing a serious socio-economic challenge for healthcare systems.