Articles tagged with Osteoporosis
Professor Gerard Karsenty is awarded the first Herbert A. Fleisch ESCEO-IOF Medal for his pioneering work in understanding skeletal development and physiology. The medal recognizes his outstanding achievements in basic bone science, including identifying Runx2 as a master gene of osteoblast differentiation.
Scientists have identified NOTCH2 as the causative gene for Hajdu-Cheney syndrome, a rare disorder characterized by progressive bone loss and osteoporosis. The study provides vital insight into possible causes of osteoporosis and highlights the gene as a potential target for treating the condition.
Researchers found that tomatoes contain powerful antioxidants like lycopene, which has greater bioavailability after cooking and processing. Tomatoes also have anti-inflammatory functions and a lower risk of certain cancers, cardiovascular disease, osteoporosis and cognitive dysfunction.
A new study found that women taking bisphosphonates for five years or more may be at higher risk of certain kinds of fractures of their thigh bone, but the drugs still prevent hip fractures. The overall risk is low, and researchers recommend continuing use for high-risk patients
Recent studies on PCSK enzymes have shed light on novel functions in diseases such as cardiovascular disorders, osteoporosis, and cancer. The research has revealed that these enzymes may play a crucial role in regulating cholesterol levels and bone formation, offering potential new treatments for dyslipidemia and osteoporosis.
A commonly prescribed osteoporosis drug is associated with a slightly elevated risk of developing osteonecrosis of the jaw, but the risk remains extremely low. Patients taking oral bisphosphonates were nine times more likely to develop the condition than those who didn't.
Researchers found that people taking bisphosphonates lived longer than those without osteoporosis and even gained an extra five years of life. The study, published in the Journal of Clinical Endocrinology and Metabolism, suggests a possible link between bone health and toxic metal release.
A recent study found that people taking bisphosphonates for osteoporosis treatment live an extra five years compared to those not receiving the medication. This significant benefit is attributed to bisphosphonates' ability to reduce toxic metal release, which may contribute to improved health outcomes.
African American patients with hypertension who viewed stories about real patients experienced better blood pressure control compared to usual care. High-volume hospitals for congestive heart failure showed improved patient outcomes but higher costs, contradicting previous studies that only focused on cost-effectiveness.
Key findings show that patients fear fractures but do not always adhere to treatment, while doctors underestimate their patients' adherence and concerns. Community-based online support programs have a great potential to fill information gaps and improve patient-doctor dialogue.
The IOF and IFCC have identified research priorities and recommended specific bone turnover markers (s-PINP and s-CTX) as reference analytes for clinical and observational studies. Standardized protocols would greatly increase the clinical and research potential of BTMs, improving patient management and treatment adherence.
A new study confirms a rapid rise in hip fractures in Beijing, with significant increases in rates for older adults. The research reveals that the growing elderly population and increasing sedentary lifestyles are major contributors to this trend, posing a serious socio-economic challenge for healthcare systems.
A New Delhi study found that 76.7% of hip fracture patients were vitamin D deficient, with elevated PTH levels also common. The research suggests vitamin D levels may be a useful index for assessing hip fracture risk in elderly people.
The International Osteoporosis Foundation has presented its Young Investigators Awards to researchers from China, India, Japan, Sri Lanka, and Taiwan, highlighting the need for osteoporosis awareness in the region. The awards recognize outstanding research on hip fractures, falls, and vitamin D deficiency, promoting education, innovati...
Experts flag vitamin D deficiency as a major concern in the region, with severe deficiency across India and Pakistan. Interactive maps tracking vitamin D levels by region are being developed to identify problem areas and stimulate research studies.
The WHO Fracture Risk Assessment Tool (FRAX) has been released for Singapore, enabling health professionals to accurately assess the absolute risk of osteoporotic fractures. The online calculator, available in 27 country models, provides a 10-year probability of hip fracture and major osteoporotic fractures based on clinical risk factors.
A study presented at the Radiological Society of North America found that excessive internal abdominal fat may harm bone health in women. Research revealed that women with more visceral fat had increased bone marrow fat and decreased bone mineral density.
The Position Paper examines the evidence and concludes that atypical fractures in association with bisphosphonate use are rare. Available evidence shows that the well-known benefits of bisphosphonate treatment outweigh the relatively low risk of these rare, atypical fractures.
A recent study found that bone density remained stable for three years in patients who took a drug holiday from bisphosphonates, a popular class of osteoporosis drugs. The researchers recommend taking drug holidays after four to five years, but the study suggests that this duration may be longer, potentially up to three years.
The FRAX tool was clarified for its use in clinical practice through international discussions, enabling its wider implementation. The tool predicts a patient's 10-year fracture risk based on scientifically validated risk factors.
A team of researchers aims to develop a biological treatment for compression fractures, the most common type of bone fracture in osteoporosis patients. The goal is to promote healing and stimulate normal bone production.
A new report highlights the severe impact of spinal fractures, which can lead to stooped back, acute and chronic back pain, loss of height, and premature death. The IOF calls on health professionals to recognize signs of these fractures in their patients.
A study by the University of Michigan found that teriparatide, a drug marketed for osteoporosis, can also heal bone wounds in gum disease patients. The treatment showed a 29% improvement in bone-level measurements on x-rays, compared to a 3% improvement in the placebo group.
A new study found that Vitamin D deficiency is associated with a higher rate of abnormal bone density and osteoporosis in IBD patients. The study, which included 161 patients, revealed that nearly half of those with IBD under age 50 had reduced bone density.
A new study found that women aged 67 and older with normal bone mineral density scores may not need re-screening in 10 years. The researchers calculated estimated times for 10 percent of the women to transition to osteoporosis, finding that it would take about 16 years for this group to develop osteoporosis.
A new report highlights the severe impact of spinal fractures caused by osteoporosis, with millions at risk of further fractures and long-term disability. Experts call for early diagnosis and treatment to prevent devastating consequences.
Spinal osteoporotic fractures often go undiagnosed and untreated, leading to severe repercussions such as stooped back, acute pain, loss of height, and premature death. The IOF campaign aims to raise awareness and promote prevention, diagnosis, and early treatment.
The new guidelines, published in CMAJ, focus on identifying and managing fractures and assessing risk. Current data indicate that many fracture patients are not appropriately assessed or treated, highlighting the need for improved management of osteoporosis and fragility fractures.
A new Cochrane Systematic Review found that vitamin D supplements have no effect on bone density in healthy children. However, children with low levels of vitamin D may benefit from supplementation.
Researchers at Hebrew University discover a group of substances in the body controlling bone density, leading to development of a new osteoporosis drug. Oleoyl serine increases bone density in both healthy and osteoporotic mice, offering a promising approach to reversing bone loss.
A team of researchers has identified a key player in maintaining bone balance, finding that the protein Maf promotes bone formation and prevents osteoporosis. By understanding this age-related switch in cell type generation, new approaches to treat age-related osteoporosis may be developed.
A new report by the International Osteoporosis Foundation reveals poor post-fracture care in the region, with high mortality rates after hip fractures. The report predicts a significant increase in osteoporotic fractures due to aging populations and limited access to diagnostic tests and medication.
Spanish researchers have discovered a genetic link between the 677C>T variant and osteoporotic vertebral fractures in post-menopausal women. This finding highlights the importance of genetic analysis in identifying individuals at high risk for bone-related illnesses.
A novel nano-CT imaging technique enables researchers to visualize the nano-structure of bone samples with high precision. This allows for better understanding of structural changes related to osteoporosis and development of new therapeutic approaches.
A validated new model can predict postmenopausal osteoporosis incidence and prevalence in different national settings, providing a powerful tool for health policy decision making. The model was developed using Swedish data and showed a 5% margin of error compared to published data.
The study found that spine, hip, and upper leg fractures resulted in the greatest decrease in quality of life. Nearly 40% of women over 50 will experience a fracture, with chronic pain and reduced mobility being common consequences.
Children with celiac disease are at risk for poor bone health, but adding vitamins K and D to their diets can reduce this risk. Incorporating physical activity into daily routines also boosts bone strength and Vitamin D intake through outdoor exercise.
Researchers have discovered that bone cells' spindly extensions can sense mechanical stimulation, signaling the release of bone-growth factors. This breakthrough could lead to therapies for osteoporosis and bone loss associated with aging.
A comprehensive Argentinean epidemiological study found that one out of three women aged 50 or over suffers from osteoporosis, with a prevalence of vertebral fractures in 16% of women aged 50 or older. The study estimated annual costs of hip fractures and vertebral fractures to exceed $250 million USD per year.
Researchers at Loyola University Health System found long-lasting disruptions in hundreds of genes involved in bone formation in rats exposed to binge drinking. The study suggests that lifestyle-related damage done during young adulthood may have repercussions lasting decades.
The new guidelines update Osteoporosis Canada's recommendations on vitamin D intake for Canadians, citing the need for more research into optimal doses and safe upper limits. The recommended daily supplements range from 400-1000 IU for adults under 50, with higher doses required for those over 50.
The new guidelines recommend daily supplements of 400 to 1000 IU for adults under 50 without osteoporosis, increasing to 800-2000 IU for those over 50. Canadians can safely take daily vitamin D supplements up to 2000 IU without medical supervision.
A study of 825 postmenopausal women found that those with low calcium intake were more likely to develop both osteoporosis and hypertension. Researchers suggest that a low calcium diet may be a risk factor for these conditions.
A study found that patients taking bisphosphonates are often uninformed about the drug's possible side effects on oral health, including bisphosphonate-associated osteonecrosis of the jaw (BON). The researchers interviewed 73 participants and discovered that 82% were unsure if their physicians had informed them about potential adverse ...
The IOF-Servier Young Investigator Research Grant was awarded to two young researchers, Dr. Frank DeVries and Dr. Davide Ruffoni, for their innovative projects on osteoporosis. The grant aims to estimate the risk of fracture in patients with bariatric surgery and understand the mechanisms of implant integration in osteoporotic bone.
Researchers found a relationship between time spent in vigorous physical activity and strength of the femoral neck, independent of diet and lifestyle. The study suggests increasing physical activity in childhood can improve skeletal bone development and reduce the risk of osteoporosis later in life.
The ESCEO-IOF-ABBH Young Investigator Award recognizes the work of young researchers who have made significant contributions to osteoporosis research. The award is presented to researchers under the age of 40 who have submitted high-quality abstracts to the IOF WCO-ECCEO10 congress.
The International Osteoporosis Foundation recommends optimal vitamin D status through serum 25OHD levels and effective sun exposure. Vitamin D deficiency is associated with decreased muscle strength, increased risk of falls and osteoporotic fractures.
Research from the ICUROS study reveals that hospitalized vertebral fracture patients have a more substantial decrease in quality of life. This is attributed to co-morbidities and higher severity of fractures among hospitalized individuals.
The International Osteoporosis Foundation has announced the launch of new FRAX tools at the World Congress on Osteoporosis. The updated tools include a convenient iPhone application that allows for easy access to the fracture-risk calculator, and multilanguage tear sheets that can be completed in various languages.
John A. Kanis receives IOF Medal of Achievement for his long-standing and distinguished career advancing the field of osteoporosis research. He has published widely on disorders of skeletal metabolism, including osteoporosis, Paget's disease of bone, hyperparathyroidism, renal osteodystrophy and neoplasia.
The International Osteoporosis Foundation (IOF) has honored long-time associate Professor José Zanchetta with the prestigious Pierre Delmas Award. The award recognizes Dr. Zanchetta's commitment to advancing osteoporosis awareness and treatment in the Latin American region.
A new study found that long-term use of DMPA injections increases the risk of bone fractures in women under 50, with a 50% higher risk for users of progestin-only contraceptives. The results suggest that combined estrogen-containing oral contraceptives do not increase fracture risk
Young people with inflammatory bowel diseases are at increased risk of fracture due to low bone mass and poor bone architecture. This is attributed to factors such as poor nutrient absorption, glucocorticoid medication use, and altered trabecular bone tissue microarchitecture.
Four ESCEO-AMGEN Osteoporosis Fellowships valued at $50,000 each were awarded to outstanding researchers in osteoporosis, with projects focusing on vitamin D status, osteoporosis treatment preferences, and ephrin B2 system. The Fellowship Programme aims to advance clinical care and prevention through training physicians and PhDs.
The study analyzed over 11,000 elderly men in Sweden, US, and Hong Kong, finding that age significantly impacts the risk of falling, while ethnicity and environment play a role. The proportion of frequent fallers varied across countries, with highest rates in the US, followed by Sweden, and lowest in Hong Kong.
A new study suggests that higher dietary protein intake can lower the risk of hip fractures in elderly individuals. The research, conducted on 946 seniors from the Framingham Osteoporosis Study, found that those consuming more protein had a significantly lower incidence of hip fractures compared to those with lower protein intake.
Professor Pierre Jean Meunier received the prestigious Pierre Delmas Prize at the World Congress on Osteoporosis 2010 for his major scientific contributions to the study of bone and mineral diseases. The award honors his influential work in osteoporosis research, mentorship, and education.
A new study highlights the importance of osteoporosis screenings for fracture patients, who are at a high risk of future fractures. Women should ask their physicians questions about their bone health to educate themselves and receive timely treatment.
A team of international researchers has identified 20 genes associated with osteoporosis and bone weakness, including 13 genes never previously associated with the disease. The study, published in Nature Genetics, provides new insights into the genetic mechanisms that control bone strength.