Articles tagged with Pediatrics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study found that school-aged children can successfully use a nasal swab to obtain their own COVID-19 test specimen, providing data for recommendations on self-swabbing in schools and other settings. The study showed that children as young as 4 years old can follow instructions and collect their own samples with high accuracy.
A University of Massachusetts Amherst psychologist is using a $428,000 NIH grant to develop a home-based system that tracks preschoolers' tantrums and predicts mental illness risk. The system uses wearable devices and machine learning algorithms to identify high-risk children and provide critical information to parents.
Researchers found that mothers' higher depressive symptoms did not predict increases in children's behavior problems, including those with autism. The study suggests that maternal depression may have a complex impact on caregiving families.
Researchers identified five new hepatoblastoma tumor signatures that could help predict responses to chemotherapy treatments. The study used single-cell transcriptomic techniques to analyze tumors from infants and children, providing a window into normal development and cancer.
A study found that 47% of parents meeting criteria for post-traumatic stress disorder (PTSD) symptoms, compared to 12% of children with implantable cardioverter-defibrillators. The trauma triggered by a child's heart problems can affect the entire family.
A scalable prototype for newborn screening, including rapid Whole Genome Sequencing and virtual acute management guidance, has been developed to rapidly screen for several hundred genetic diseases. The system demonstrates feasibility in identifying genetic diseases with effective interventions.
A study of 137 children with early-onset psychosis found that over 70% had copy number variants, a common cause of neurodevelopmental disorders. The research suggests that chromosomal microarray testing can bring closure to families and improve treatment outcomes.
A recent study by Johns Hopkins Children's Center researchers found a significant rise in type 2 diabetes cases among children during the COVID-19 pandemic. The increase was largely attributed to reduced physical activity and weight gain due to lockdowns and virtual learning.
A study by Children's Hospital Colorado reveals a 77% surge in newly diagnosed youth-onset type 2 diabetes cases during the COVID-19 pandemic. The increasing prevalence of obesity and unhealthy habits since the pandemic's onset are thought to contribute to this rise.
Researchers at Karolinska Institutet have developed a potential curative treatment for neuroblastoma, using DHODH blockers in combination with chemotherapy to cure mice with the disease. The treatment has shown promising results and could improve survival rates for children with neuroblastoma.
Researchers have found that children with autism show significant differences in their pupillary light reflexes, which can be used as a potential screening biomarker. The study demonstrates the parameters of interest that matter for detecting autism and validates earlier findings using monocular technology.
A new study explores how active parent participation can improve neonatal health and reduce parental stress. The study found that cultural attitudes, collaboration between medical staff and parents, and availability of equipment are key factors in enabling parent-infant closeness.
A new study presents the first data-driven sex-specific model of pediatric cranial bone development, providing a quantitative normative reference for local cranial bone development during the first ten years of life. The model improves current understanding and clinical diagnoses of cranial development disorders.
A national follow-up study found that over a quarter of children and adolescents hospitalized with COVID-19 or multisystem inflammatory syndrome in children had persistent symptoms or activity impairment two to four months later. The study identified risk factors for prolonged recovery, including MIS-C and activity impairment.
A Rutgers study found that early-term births (37–38 weeks) have significantly higher symptoms of hyperactivity, ADHD, and cognitive problems or inattention compared to full-term births. Teachers' reports provided valuable input for the diagnosis of ADHD, highlighting the need for regular screenings.
A recent study published in Pediatrics found that neurologic complications are relatively common among children hospitalized with COVID-19, occurring in about 8% of cases. These complications can lead to life-altering conditions and increased hospital costs, highlighting the importance of vaccination and prevention strategies.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
A new study by researchers at UTHealth Houston found that children infected with COVID-19, but not hospitalized, can still develop long COVID symptoms up to three months past infection. The study also identified risk factors for long COVID in children, including unvaccination and obesity.
A new study published in Current Biology found that humans' ability to interpret babies' cries isn't innate but learned from experience. Parents of young babies are able to identify a baby's pain cries even if they have never heard this baby before, whereas inexperienced individuals are typically unable to do so.
A study by West Virginia University found that over 7% of junior high and high school students in rural Appalachia identified as gender-diverse, including nonbinary or transgender identities. This exceeds previous estimates and highlights the need for support services in these areas.
A nationwide study is investigating the effects of COVID-19 on patients in the US, with a focus on understanding and preventing lingering symptoms. The four-year study, RECOVER Initiative, will enroll up to 20,000 participants and explore factors that put individuals at risk for long-COVID.
The NCI-backed Molecular Targets Platform streamlines and catalyzes drug development by integrating pediatric cancer targets and pathways. This platform empowers researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.
A study found eight classes of health conditions common among pediatric obese patients, including respiratory and sleep disorders. The researchers used a pattern mining algorithm on electronic health records of 49,694 patients to identify clinically similar subtypes.
A new study published in Clinical & Experimental Allergy reveals a 4-fold increase in allergy clinics for children in the UK, but most are small and vary in services offered. The research highlights the need for standardized care through national networks and simulation training to ensure safe service provision.
A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.
Research found that breastfed premature infants have improved gut barrier function and nutrient absorption due to the presence of Bifidobacterium breve. This strain strengthens the intestinal wall, protecting against disease. The discovery could lead to promising clinical interventions to increase survival rates of vulnerable preemies.
A new vaccine formulation has protected newborn mice against respiratory syncytial virus (RSV) and evoked strong responses in human immune cells. The vaccine uses an adjuvant combination that stimulates type 1 T-helper responses, which are hard to stimulate in newborns but are needed for a strong defense against viral pathogens.
Researchers found that ancestral SARS-CoV-2 replicates less efficiently in pediatric nasal epithelial cells, with a heightened antiviral response. This protection is not observed with the Omicron variant, highlighting the need for further study on emerging variants.
Researchers at Columbia University Irving Medical Center developed a novel algorithm that identified nearly 20,000 adverse drug events (ADEs) signals across seven pediatric development stages. The study utilizes predictive modeling on real-world data to overcome limited data within individual stages.
Researchers at VCU Massey Cancer Center have discovered a new target for treating high-risk neuroblastoma, a deadly pediatric cancer. A novel compound called SHP099 has shown promising results in shrinking tumors and killing cancer cells.
A new study by University of California - San Francisco-led researchers found that tweens who spend more time on screens have a higher likelihood of developing disruptive behavior disorders. Social media was most likely to be linked to conduct disorder, while other forms of screen use were associated with oppositional defiant disorder....
A recent study published in the European Respiratory Journal found that children who grow up near green spaces have better lung function. The research suggests that increasing exposure to vegetation close to home can improve lung health, especially when combined with other factors such as physical activity and reduced air pollution.
A multicenter study found that preterm children with bronchopulmonary dysplasia who attend daycare are more likely to visit the emergency department, use systemic steroids, and experience chronic respiratory symptoms. The risk of these complications is highest in infants under 1 year old and may persist until 36 months of age.
A new study estimates that exposure to PFAS chemicals may result in $5.5-63 billion in lifetime health costs due to conditions like low birth weight, childhood obesity, kidney cancer, and hypothyroidism. The study supports the EPA's decision to lower safe allowable levels of these substances.
Researchers at WVU are conducting a four-year study to investigate long COVID's impact on pediatric patients, exploring questions like prevalence, symptoms, and treatment options. The study will enroll children from infancy to 25 years old and analyze biomarkers for long COVID susceptibility.
Researchers found associations between census-tract measures of social determinants, such as educational attainment and violent crime, with pediatric asthma morbidity rates. These findings suggest opportunities for community-based interventions to reduce pediatric asthma morbidity.
Researchers found that mothers who didn't transmit HCMV to their infants had higher levels of antibody-dependent cellular phagocytosis, suggesting a non-neutralizing immunity mechanism. This finding has implications for the development of effective HCMV vaccines.
A new study from Dartmouth Cancer Center re-examines claims of high pediatric cancer rates in New Hampshire, revealing the Northeast region has a statistically significantly higher incidence of cancer compared to all other U.S. regions. Within the Northeastern states, no single state is an outlier, with significant variations in incide...
Researchers found that children with autism process brain waves differently when focused on body movements versus colors, highlighting a key challenge in communication.
A new blocking antibody therapy targeting placental growth factor (PlGF) has shown promise in treating advanced, treatment-refractory pediatric brain cancer. The therapy, called TB-403, was well-tolerated and induced stable disease in some patients.
A recent study published in the Journal of the American Heart Association found that Black children who have stroke after heart transplant are more than three times as likely to die compared to their white counterparts. The researchers analyzed data from 8,224 children who received cardiac transplants between 1994 and 2019.
A study of preterm infants found that those who received more maternal milk in early life had better academic achievement, higher IQs, and reduced ADHD symptoms. Higher intake of maternal milk was also associated with improved reading and math scores.
A large-scale study analyzing 29 studies and 139,624 participants found that people who viewed tobacco content on social media are more likely to report using tobacco. The study also identified susceptible individuals who may be influenced by pro-tobacco content.
Researchers propose a theory on how SARS-CoV-2 infects the body, leading to hyperactivation of the immune system and post-COVID syndromes. The hypothesis suggests that molecular motifs on the spike protein interact with immune cells, causing an overreaction and mistakenly attacking organs.
A study published in the Journal of Applied Research on Children found that both gun-owning and non-gun-owning parents are receptive to discussions about gun locks and firearm safety measures with their child's pediatrician. The study, led by researchers at the University of Pennsylvania School of Medicine, shows promise for reducing f...
A comprehensive study found that prenatal exposure to endocrine-disrupting chemicals is associated with non-alcoholic fatty liver disease in children. The researchers measured 45 chemicals in pregnant women and found elevated levels of biomarkers indicating risk for liver disease in children who were more highly exposed.
A multicenter study found that radiologists can accurately diagnose rickets and classic metaphyseal lesions (CMLs) with high interobserver agreement and diagnostic performance. The study highlighted the importance of considering age factors in diagnosis, as CMLs mostly occur in children younger than 6 months.
A multicenter study found that traditional Chinese medicine Yupingfeng was as effective as allopathic drugs in treating recurrent respiratory tract infections in children. The study showed a substantially greater reduction in RRTI events and similar safety profiles across all three groups.
A new study found that hospitals can reduce excessive opioid prescribing by implementing an evidence-based default setting for opioid prescriptions written in electronic health records. The study showed that patients who received a standard prescription size with a lower default dose of opioids had similar pain control, but took home f...
A three-year study found that telehealth consultations with a pediatric infectious disease specialist reduced antibiotic usage in 8 Texas nurseries serving rural and medically underserved areas by 32%. The consultations helped healthcare providers make more informed decisions about when to use antibiotics, ensuring the proper balance b...
A recent study from Penn State's Center for Childhood Obesity Research found that second-born children in families where mothers received responsive parenting training slept an average of 40 minutes longer per night. The training also promoted healthier feeding practices and lower body mass indices (BMIs) in infants.
A Rutgers study found that parental depression affects about one in five US families and can have severe consequences on children's health. The research suggests that increased screening for parental depression across a wider age range has the potential to identify families in need of resources.
Researchers found multiple gene variants contributing to pediatric NAFLD risk and disease severity, including novel SNPs associated with liver fibrosis. These genetic associations may guide future therapeutics for pediatric NAFLD, a chronic childhood disease linked to increased cardiovascular risk and mortality.
A study found that young adolescents who were targets of cyberbullying were more likely to report suicidal thoughts and attempts, distinct from traditional offline bullying. Cyberbullying was associated with an independent risk factor for youth suicidality, highlighting the need for online screening and interventions.
Researchers will evaluate COVID-19 vaccination safety in 1,800 pregnant participants and monitor immune response. The study aims to provide information on vaccine efficacy for mothers and babies.
A study found that over 60% of parents of children with kidney disease or hypertension are unsure or unwilling to vaccinate their child against COVID-19. Effective vaccines exist to protect children from COVID-19, and the findings highlight the need for clear communication to address parental concerns.
The American Academy of Pediatrics has updated its safe-sleep guidelines, recommending babies sleep on their backs on flat, level surfaces to reduce SIDS risk. The guidelines also emphasize the importance of breastfeeding, pacifier use, and avoiding drugs and alcohol exposure.
A new study published in CMAJ found that youth hockey players with more years of bodychecking experience had a significantly higher risk of concussion than those with less experience. The researchers collected data on 941 players aged 15-17 and found that concussion was the most common injury, making up over one-third of all injuries.
A new study found that Black and Hispanic children are more likely to develop asthma, even in well-resourced neighborhoods. Neighborhood characteristics at birth and race/ethnicity-based inequities may play a role in the development of childhood wheezing and asthma.
Researchers found significant decrease in national Kawasaki disease cases in 2020, coinciding with school closures and masking mandates. KD cases rebounded after lifting of masks and return of in-person schooling, hinting at respiratory portal of entry as trigger.