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Neurogenetics research sheds light on the causes of neurological disease

Recent advances in neurogenetics research have shed light on the genetic basis of human brain disorders, including Parkinson's and Alzheimer's diseases. Genetic discoveries have transformed clinical practice and provided new hope for patients and families affected by these devastating disorders.

Gene activity in the brain depends on genetic background

A new study found that gene activity patterns in the brain differ significantly among individuals with varying genetic backgrounds. The study, published in PNAS, mapped gene expression across 49 genes in seven genetically distinct mouse groups, revealing localized differences in gene activity.

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UT researcher links maternal genes to selfish behavior

UT researcher Francisco Úbeda and Andy Gardner found that genomic imprinting affects children's behavior, with paternal genes promoting altruism and maternal genes encouraging self-interest. This discovery has implications for understanding neurological disorders like autism and psychosis.

Secret funding fosters hope for new drugs for autism

A small drug company, Seaside Therapeutics, is developing potential treatments for Fragile X syndrome and autism with secret funding from an anonymous wealthy family. Two of its drugs show promise in clinical trials as treatments for these diseases.

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Hormonal birth control alters scent communication in primates

A Duke University study found that hormonal contraceptives alter the chemical cues used by ring-tailed lemurs to determine genetic fitness and relatedness. The study also showed that males are less interested in females treated with contraceptives, suggesting potential effects on human mate choice.

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Once bitten, twice shy -- a temperature switch triggers aversive memory

Scientists at the Max Planck Institute of Neurobiology have identified three dopamine-releasing nerve cells essential for associating odors with negative experiences. By manipulating these cells using a temperature switch, they demonstrated that even without an electric shock, fruit flies can learn to avoid specific odors.

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Mutations on 3 genes could predispose people to suicidal behaviour

A study has found that genetic mutations in three genes may predispose individuals to suicidal behavior. The research identified a model able to differentiate between people with and without a history of suicide attempts using an algorithm based on SNPs from these genes.

Researchers closer to untying autism's genetic knot

A new study has identified multiple rare genes involved in regulating central nervous system processes, shedding light on the genetic causes of autism spectrum disorders. The research may lead to innovative treatments and a better understanding of the disorder.

Biologists identify genes regulating sleeping and feeding

Scientists have identified two genes, Clock and cycle, that regulate the need to sleep and eat in fruit flies. The study found that these genes help flies regulate sleep when food is scarce, providing new insights into the neural mechanisms underlying this conflict.

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New autism susceptibility genes identified

Researchers have identified new autism susceptibility genes, including SHANK2 and SYNGAP1, which may lead to earlier diagnosis and better treatments. The study found that these genes are involved in synapse-related pathways and cellular proliferation, providing insights into possible common pathological mechanisms.

Researchers report new autism genes discovered

A team of researchers from the University of Illinois Chicago has identified new autism susceptibility genes, including SHANK2, SYNGAP1 and DLGAP2, through an international collaboration with Autism Speaks. These findings suggest that multiple rare variants or genetic changes may contribute to the development of autism.

Satellites, DNA and dolphins

Researchers used genetic data and oceanographic information from satellites to find two distinct populations of franciscanas in Argentina's coastal waters. The findings suggest that environmental factors, such as water temperature and turbidity, play a significant role in shaping population structure in marine animals.

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How nerve cells distinguish odors

Researchers at Heidelberg University Hospital discovered that inhibiting communication between nerve cells accelerates odor discrimination in mice. The study confirmed the function of lateral inhibition, which enables quick and reliable recognition of similar smells, using genetic manipulation and electrophysiological measurements.

ADHD linked to interaction of genetics and psychology

A study found that children with ADHD exhibit more symptoms when they experience high levels of self-blame during inter-parental conflict, which is associated with genetic variations related to serotonin activity. The study suggests a synergistic effect between genetic and environmental factors in the development of ADHD.

'A-maize-ing' discovery could lead to higher corn yields for food, feed and fuel

Scientists have made a significant discovery in corn breeding that could lead to higher crop yields, improved disease resistance and heartier plants able to withstand severe weather. By understanding the genetics of photoperiod response, researchers hope to be able to overcome the barrier to using tropical maize for temperate varieties.

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The sexual tug-of-war -- a genomic view

A study on fruit-flies published in PLOS Biology found that genes beneficial to males are detrimental to females, and vice versa. This genetic conflict maintains genetic variation within species by regulating sex-specific characteristics and strategies, such as resource acquisition for reproduction.

Research builds on genetic link to autism and schizophrenia

A genetic link between schizophrenia and autism is being studied by analyzing behavior in mice with a schizophrenia-linked mutation. Researchers hope to understand the effectiveness of antipsychotic drugs and potentially develop more targeted treatments.

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Use of multiple genetic markers not linked with better risk prediction of CVD

A study of over 19,000 women found that a genetic risk score based on multiple genetic markers was not associated with improved cardiovascular disease (CVD) risk prediction. Despite this, traditional factors such as family history and intermediate phenotypes like cholesterol levels remained significant predictors.

Great tits: birds with character

Researchers found a strong association between the DRD4 gene and novelty seeking behavior in great tits, but results varied across different populations. The study's findings mirror those of human research, suggesting that genetic factors may play a role in shaping personality traits.

How arthritis thrives

A Tel Aviv University expert reviews the links between autoimmune diseases, infections, genetics, and the environment. Environmental factors such as hairspray, lipstick, second-hand smoke, food chemicals, and UV exposure are found to trigger the onset of autoimmune diseases like rheumatoid arthritis and lupus.

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UC San Diego researchers synchronize blinking 'genetic clocks'

Researchers at UC San Diego successfully synchronized bacterial genetic clocks to blink in unison and alter their blinking rates in response to environmental conditions. The achievement is a crucial step towards creating genetic sensors that can monitor temperature, poisons, and other hazards.

Genome of parasitic wasps released

Scientists have decoded the genome of Nasonia, a parasitic wasp that eliminates agricultural pests by infesting fly pupae. The study reveals insights into the wasp's ability to prevent host death and its potential for genetic engineering to improve biological pest control.

Why do people 'play the longshot' and buy insurance? It's in our genes

A team of economists and molecular geneticists found that individuals with a high-activity variation of the MAOA gene prefer longshot lottery plays and purchase less insurance, suggesting an inborn bias in financial decision-making. This discovery complements recent findings on the neurobiological basis of economic risk-taking.

Apple iPad Pro 11-inch (M4)

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Canine compulsive disorder gene identified

Researchers have identified a genetic locus on chromosome 7 associated with canine compulsive disorder (CCD), a condition characterized by repetitive behaviors. The CDH2 gene region is linked to increased risk of CCD in Doberman breeds and may be involved in human OCD and autism spectrum disorders.

Canine compulsive disorder gene identified in dogs

A genetic locus on chromosome 7 has been linked to canine compulsive disorder, a condition characterized by repetitive behaviors. The neural cadherin-2 gene, CDH2, is involved in mediating synaptic activity and neuronal adhesion, suggesting a possible connection to human obsessive-compulsive disorder.

Up a little on the left ... now, over to the right ...

Researchers identified a family of proteins called Mrgprs that functions as itch receptors in a rare subset of nerve cells. The study found that MrgprA3 is the primary itch receptor for chloroquine, leading to potential new treatments for nonallergic itch.

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Startled flies may provide insight into ADHD

Researchers discovered two independent forms of arousal in fruit flies, with one mutation linked to increased startle response and decreased endogenous arousal. The findings suggest that environmentally stimulated arousal and sleep-wake transitions reflect distinct neural circuits, potentially shedding light on the neurobiology of ADHD.

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Developmental delay could stem from nicotinic receptor deletion

Researchers found a gene deletion in chromosome 15 associated with significant learning and behavioral problems, including developmental delay, mental retardation, and epilepsy. The study suggests that the nicotinic receptor plays a crucial role in these conditions.

Caught in the act: Butterfly mate preference shows how 1 species can become 2

Researchers found a population of tropical butterflies exhibiting diverging color patterns and reproductive preferences, suggesting the potential emergence of two distinct species. The study provides insights into the earliest stage of ecological speciation, where natural selection drives the divergence of populations into new species.

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Bad driving may have genetic basis, UCI study finds

A study by UC Irvine neuroscientists found that people with a particular gene variant performed more than 20 percent worse on a driving test than those without it. The variant limits the availability of brain-derived neurotrophic factor, which keeps memory strong.

Genes that drive you to drink (but don't make you an alcoholic)

A recent study published in BMC Biology identified genetic pathways associated with moderate alcohol consumption, but found no correlation between these genes and alcohol dependence. The research team found that drinking behavior was linked to pleasure and reward pathways in the brain, similar to satiety and appetite for food.