Articles tagged with Dna Replication
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A team of researchers has elucidated the mechanics of the endocycle, a novel cell cycle that plays a crucial role in plant and animal growth. By studying genetic transcription factors and enzymes driving endocycling, the team discovered a molecular oscillator that controls cell growth rates.
Researchers at NYU have developed a self-replication process using artificial DNA tile motifs, capable of producing complex structures with varying patterns and functions. The breakthrough could lead to the creation of new materials with unique properties.
Researchers at Hebrew University identified the molecular basis for DNA breakage, a key feature of cancer development. The study sheds light on how DNA replication stress leads to breaks, providing new insights into cancer development and potential therapeutic approaches.
Researchers developed a digital polymerase chain reaction (PCR) device that sets dramatic new performance standards in sensitivity and accuracy of sample screening. The device enables the direct counting of single molecules isolated in individual chambers.
Researchers at Hebrew University discovered that insufficient building blocks in cancer cells lead to DNA damage. External supply of DNA building blocks can reactivate normal DNA synthesis and reduce cancerous features.
Researchers at Scripps Research Institute and Lawrence Berkeley National Laboratory have discovered a key enzyme in DNA replication that may be exploited to develop an effective anti-cancer therapy. The enzyme FEN1 works in a way opposite to accepted dogma, providing a sophisticated machine for cutting DNA.
Researchers found that acetylation regulates DNA maintenance, favoring protection of genetic information. This discovery may lead to interventions enhancing the body's natural preservation of genetic info, potentially delaying aging-related diseases.
A novel study reveals that a protein complex (Smc5/6) helps release torsional stress during DNA replication, shedding light on heredity dynamics and potential new cancer treatments. The findings may lead to the development of drugs targeting Smc5/6, providing another tool for inhibiting tumour growth.
Research reveals that protein collisions during DNA replication can lead to errors and increase cancer risk. The study found that even head-on collisions between the 'fast train' of DNA replisome and the 'slow train' of RNA polymerase can cause damage.
A study found that Break-induced Replication, a method of DNA repair, is up to 2,800 times more likely to cause genetic mutations than normal cell repair. Researchers think four changes in replication machinery may contribute to its accuracy issues.
A recent study published in PLOS Biology reveals that Break-induced Replication (BIR) is up to 2,800 times more likely to cause genetic mutations than normal DNA synthesis. The researchers found that this method of DNA repair can lead to sudden bursts of mutagenesis, increasing the risk of cancerous cell development.
A novel protein called ORCA has been identified as crucial for the initiation of DNA replication and the organization of heterochromatin in mammalian cells. Its depletion leads to defects in cellular proliferation and cell cycle arrest, highlighting its critical role in controlling uncontrolled cell growth.
Researchers at Cornell University have discovered how protein Mec1 acts as a 'guardian of the genome' in yeast cells. The study shows that Mec1 monitors and repairs machinery responsible for replicating DNA, allowing it to restart and continue replicating.
McMaster University researchers have made a breakthrough in understanding the molecular mechanisms of hereditary colorectal cancers. They discovered how a specific protein, MutL, works within cells to repair DNA errors, paving the way for alternative cancer treatments and assessment tools.
Researchers observe DNA unfolding at high resolution for the first time, revealing two main mechanisms of separation. This breakthrough aims to design drugs that modulate gene activity and DNA replication.
Researchers discovered a new factor, DksA, that prevents conflict between DNA replication and transcription in E. coli. When present, DksA tags along with RNA polymerase and removes it from the track when DNA polymerase approaches, allowing for stable replication.
CSHL scientists have discovered how a protein called DDK triggers DNA replication by releasing a built-in brake on Mcm4. This finding may help shape the development of new cancer therapies.
By manipulating individual atoms in DNA, Professor Zhen Huang hopes to unlock new avenues for research into DNA replication and transcription. His study reveals that interactions between methyl and phosphate groups can reduce energy needed for DNA duplex separation, potentially leading to improved understanding of genetic processes.
Researchers at Rockefeller University discovered that telomeres resemble fragile sites in DNA, where replication can stall. A protein called TRF1 helps prevent this by removing unusual structures from telomeric DNA, allowing smooth progression of DNA replication.
Researchers at Burnham Institute have discovered that the protein kinase complex Cdc7/Dbf4 plays a crucial role in monitoring DNA damage control during replication and reinitiating replication after repair. This new understanding could lead to the development of new cancer therapies.
The Scripps Research Institute team has identified a protein called Nrm1 that plays a crucial role in regulating the cell cycle. When DNA replication stalls, Nrm1's repression of certain genes is blocked, allowing those genes to be expressed again, which enables the production of proteins needed to correct the problem.
Researchers discovered a relationship between long DNA sequences called palindromes and replication delays, which can lead to chromosomal breaks and cancer. Palindromes stall the replication machinery, causing DNA malfunction, and specific proteins may protect the genome from breaking at these sites.
Scientists at GIS found that DNA replication efficiency increases later in the S-phase, suggesting a novel approach for studying human biology and stem cell research. The discovery could lead to more efficient analyses and tests related to cellular replication.
DNA polymerase epsilon plays a primary role in replicating leading strand of DNA in bakers yeast, influencing genome stability and responses to environmental stress. The discovery advances understanding of DNA replication in higher organisms like humans.
Scientists discovered a genetic link between glycolysis and DNA replication in Bacillus subtilis, indicating that metabolic signals influence DNA synthesis and stability. This finding suggests a global regulatory function of central carbon metabolism in adjusting cellular functions to nutritional conditions.
Researchers at UNC School of Medicine have discovered a cellular mechanism that regulates DNA replication after exposure to UV radiation, potentially offering new protection against skin cancer. The study identified two proteins, Timeless and Tipin, which form a complex to slow down DNA replication in response to damage.
A new study reveals that viruses share common DNA replication mechanisms, with the SV40 T-ag protein facilitating DNA binding and assembly of complex proteins. This discovery sheds light on a complex process previously difficult to investigate in eukaryotes.
DNMT1 and G9a interact to positively influence each other's catalytic activities and maintain epigenetic marks. The interaction impairs histone H3K9 methylation when DNMT1 is knocked down.
Researchers have identified a common molecular machinery for initiating DNA replication in all three domains of life: Archaea, Bacteria, and Eukarya. This finding suggests that DNA replication is an ancient event that evolved millions of years ago.
Scientists have developed a new method to study Fanconi anemia proteins using Xenopus eggs, allowing them to study the proteins' function in DNA replication and repair. The research found that Fanconi proteins play a crucial role in preventing DNA breaks during replication, even if the DNA is damaged.
DinB DNA polymerase is specialized for proficiently replicating damaged G nucleotides, allowing cells to tolerate DNA damage and preventing cancer. The enzyme's unique ability is essential for survival, as mutations can render it inactive.
The researchers created an artificial mammalian replication origin that can specify a DNA replication origin and enable scientists to explore the mechanism of replication initiation. This discovery will provide a new direction for creating vectors for gene therapy that are less mutagenic than current integrating vectors.
Researchers at Mount Sinai School of Medicine identify a new way cells replicate through damaged DNA by using the protein Rev1 as a template. This discovery opens up a new area of study with potential innovative approaches to cancer prevention and treatment.
Two DNA polymerases, Pol III and Pol IV, coordinate their action to cross obstacles in the replication process. Pol III copies DNA while proofreading for errors, but can stall if it encounters a problem, allowing Pol IV to take over.
Researchers developed a method combining DNA sampling and mathematical modeling to measure methylation patterns during DNA replication. This technique allows examining how faithfully maintenance methylation is carried out across generations, which is crucial in understanding gene expression and its role in human disease.
Researchers at Scripps Research Institute create DNA with a third pairing, allowing for replication of unnatural bases. The development improves fidelity to near-perfect levels, paving the way for applications in biotechnology, medicine, data storage, and security.
Researchers discovered a molecule that brings DNA polymerase alpha to replication sites, and it stabilizes the complex. This finding suggests that targeting Mcm10 may prevent cancer cells from multiplying.
Researchers discovered a DNA repair enzyme that bypasses damaged spots in the DNA sequence to ensure cell survival. POL-Q's two-step process is the most efficient of any known DNA polymerase, making frequent errors in the process.
Huberman and Yompakdee found a stretch of DNA surrounding late-firing origins that contains repeats rich in the nucleic acid component guanine. These repeats, called Late Consensus Sequences (LCS), affect replication timing, with more copies causing regions to replicate late.
A DNA mutation called 8-oxoguanine can evade detection by DNA replication enzymes, allowing it to persist in the DNA strand and potentially lead to stable incorporation of a lethal mutation. This discovery sheds light on how oxidative lesions affect DNA replication and has implications for cancer risk.
Scientists have developed a 3D image of the UvsW enzyme, crucial for understanding replication-dependent replication in human cells. The findings reveal how this enzyme orchestrates the process by which viruses, plants and animals introduce new genes into DNA during replication.
Researchers have discovered that the DNA copying enzyme, DNA polymerase, retains a "short-term memory" of mismatches and halts itself past the point of the mismatch. The study found that mismatch structures differ dramatically from previous indirect biochemical studies, revealing why stalling occurs.
Researchers at UGA discovered a gene called CUL-4 that regulates DNA replication and prevents uncontrolled cell growth. The study used the tiny worm Caenorhabditis elegans as a model organism and found that CUL-4 promotes the degradation of a protein required for DNA replication initiation.
Researchers at Virginia Tech have designed a new class of molecules that can bind to and stop replication of DNA when triggered by light. The complex molecules, developed by Professor Karen Brewer's group, have demonstrated the ability to kill cells in the presence of light.
Scientists discovered that a protein called ATR protects fragile sites from breaking during DNA replication, controlling genome stability. Fragile site breaks are common in tumor cells and near genes associated with tumors, suggesting defects in the ATR pathway may contribute to cancer progression.
Researchers found that destroying two controller proteins restricts DNA replication to a single copy, maintaining genome integrity. Cells with mutant proteins produce excessive DNA, reflecting the importance of these proteins in controlling genome duplication.
Researchers used frog extracts to study DNA replication in Bloom's Syndrome, finding the protein essential for this process. This discovery may lead to new treatments for human cancer, as the protein is likely to have the same function in humans.
A University of Iowa research team has developed a way to isolate replicating DNA molecules for studying the replication process. This advance will allow investigators to better understand DNA replication and may lead to improved therapies for treating diseases such as cancer.