Articles tagged with Genetic Analysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Genetic analysis reveals African village dogs have directly descended from indigenous dogs, with higher genetic diversity than modern breeds. This challenges the claim that dogs were first domesticated in East Asia.
A team of scientists, including those from the University of Toronto, identified two genes for cataloging the world's plants. DNA barcoding allows rapid classification using a short genetic marker in an organism's DNA.
A study analyzing rare genetic disorders suggests that maternal and paternal genes continue to interact well into childhood, potentially influencing the pace of growth and sexual maturity. This ongoing interplay may be responsible for humanity's unusual extended childhood and unique life history patterns.
Researchers found that three genes affect dopamine function in the brain, predicting approach and avoidance behaviors, as well as exploratory decision-making. These findings may help shape future treatments for conditions like Parkinson's disease.
A Stanford bioethicist and colleagues argue that the lack of federal regulation in genetic ancestry testing poses significant ethical concerns, including potential misuse and a lack of informed consent. The authors call for stronger oversight and industry standards to protect vulnerable groups.
Researchers have identified a crucial role of the Foxp2 gene in human language development using a mouse model. The study found that alterations in this gene are closely linked to speech and language ability, and that it plays a significant role in various organ systems.
A new algorithm developed by Carnegie Mellon University has revealed how genetic networks in fruit flies evolve during their life cycle. The Tesla algorithm uses machine learning techniques to analyze the rewiring of these networks over time, providing insights into how they respond to stimuli and become dysfunctional.
A meta-analysis of 14 studies failed to find an association between a genetic marker, stressful life events, and the risk of major depression. The study did find a significant association between the number of stressful life events and depression.
A new analysis of data from 14 studies found a strong association between stressful life events and depression risk. However, the presumed high-risk version of the serotonin transporter gene did not show an increased risk for major depression alone or in interaction with stressful life events.
A genetic analysis found that high levels of lipoprotein(a) are associated with an increased risk of heart attack, even after adjusting for other factors. The study suggests that reducing lipoprotein(a) levels may help lower the risk of heart attack.
Researchers at the University of Illinois developed a new solid-state nanopore sensor made from aluminum oxide, exhibiting superior mechanical properties and noise performance. The sensor can detect single molecules with signal-to-noise comparable to other technologies, opening doors for personalized medicine and advanced diagnostics.
Researchers at the University of Wisconsin-Madison have discovered that certain squids can perceive light through a light-emitting organ beyond their eyes. This finding may lead to new insights into controlling and perceiving light. The study suggests that the squid's light organ, which is also involved in camouflage, uses the same pro...
Researchers at the University of Pittsburgh Cancer Institute have identified eight genes that can predict a patient's response to melanoma treatment. The study, presented at the ASCO annual meeting, used Neural Network Analysis to survey over 25,000 genes and regulators in tumor tissues from 21 patients with metastatic melanoma.
Indonesian zebu cattle have a unique origin with banteng (Bos javanicus) as part of their ancestry, adapted to tropical climates. The study shows that many famous 'racing bulls' from Madura descended from banteng cows.
Researchers found that 62% of patients with chronic uSpA had Chlamydia infection, significantly higher than controls. This suggests Chlamydia may play a role in causing this type of arthritis.
A study published in the American Journal of Human Genetics found a significant evidence for a gene on chromosome 9q21 that may contribute to pelvic floor disorders. The researchers analyzed DNA from 70 women from 32 families with at least two cases of pelvic floor disorders and found significant evidence for a genetic predisposition.
A research team led by Dr Keith Shearwin and Dr Ian Dodd from the University of Adelaide has been awarded a US$900,000 grant to investigate DNA looping. The study aims to understand how correct DNA loops are formed to control gene expression in cells.
DNA analysis reveals two distinct species of worm that resemble each other in appearance, leading to a reevaluation of the Earth's biodiversity. The discovery could have significant consequences for laboratory testing and our understanding of environmental toxins.
Researchers at the University of Liverpool have developed a new method to identify genes that help protect the body from age-related changes. The study analyzed over five million gene measurements across multiple tissue types in animals and humans, highlighting key biological mechanisms that allow the body to adapt to aging.
Researchers have found that human heart cells develop into adulthood around age 6, with the percentage of new cells decreasing significantly with age. This discovery may lead to new pharmacological strategies to stimulate heart cell regeneration and complement cell transplantation.
Researchers analyzed three decades of yeast studies to find exponential growth in scientific understanding and productivity trends. They discovered that scientists tend to focus on familiar genes and study important genes before less influential ones.
Two University of Alberta researchers have discovered eight genes directly related to disc degeneration, providing valuable insights into its biological mechanisms. The study's findings may lead to effective interventions for individuals prone to spine problems, such as those with obesity or genetic susceptibility.
A new synthetic gene circuit allows for precise dosing of gene expression in yeast cells, enabling accurate analysis of a gene's role in normal and abnormal cellular function. The circuit utilizes negative feedback loops to achieve a linear dose-response relationship.
Researchers analyzed wheat gene expression to understand its adaptability across climates and developed new strains for higher yields. The study found over 1 in 10 genes may be affected by a phenomenon contributing to the wheat's hearty nature.
Researchers have created an algorithm that analyzes gene expression and protein production to identify genes and pathways that can affect cell survival. The new method, ResponseNet, has led to new insights into the connection between alpha-synuclein toxicity and basic cell processes.
Researchers at University of Washington developed prototype malaria test printed on disposable Mylar card that can work months later without refrigeration. The test uses microfluidics and dry reagents stabilized with sugar to retain activity after 60 days.
Scientists have developed a method to test sperm quality before IVF treatment, increasing conception chances. The new process uses Raman spectroscopy to identify DNA damage in sperm, providing a non-destructive 'quality score'.
A new study suggests that combining HPV DNA testing with cytology and repeat HPV testing can increase cervical cancer screening detection rates without a substantial increase in false-positive tests. This approach resulted in a 30% higher detection rate compared to cytology alone, while doubling the number of required tests.
Researchers are using DNA testing to determine the origins of medieval manuscripts, resolving issues with handwriting and dialect-based dating methods. By analyzing genetic data from parchment skins, scientists can identify similarities between manuscripts and pinpoint their time and place of origin.
The study identified six new genes associated with obesity, including TMEM18, KCTD15, and GNPDA2, which show a neural effect. These genes are active in brain cells and have been validated in multiple studies.
A genome-wide study has identified a new subtype of childhood acute lymphoblastic leukemia associated with a poor treatment outcome. The study found that patients with this subtype have a high relapse rate and poor disease-free survival, highlighting the need for further research and treatment options.
Researchers have made significant progress in defining the genetic signature of Alzheimer's disease, a complex neurodegenerative disorder. The study identified a new SNP on chromosome 12q13 and confirmed the known apolipoprotein E association, revealing that 50% of the genetic risk effect remains unexplained.
Joseph H. Nadeau, Ph.D., was elected as an American Association for the Advancement of Science (AAAS) Fellow for his contributions to mouse genetics and mouse genome informatics and analysis. The award recognizes his sustained and significant efforts to advance science in these areas.
A new study published in Epidemiology found that smoking during the first trimester of pregnancy increases the risk of cleft lip in newborns. The study suggests that 19% of cases may be due to maternal smoking, with a two-fold increased risk from heavy smoking and 1.6 fold risk from passive smoking.
Researchers found evidence of a mother, father, and two sons aged 8-9 and 4-5 years buried face-to-face with arms interlinked. The graves also showed signs of violent raids and injuries, indicating a tragic event in prehistoric Central Europe.
Researchers analyzed 13,223 school children aged 13-14 from four locations to investigate asthma prevalence. The study found that asthma symptoms were lowest in mainland China, highest in Canada-born individuals, and varied among Hong Kong residents.
A recent study has identified four novel genes associated with Alzheimer's disease, including a gene on chromosome 14 that may influence age of onset. The research also found connections to other diseases, such as spinocerebellar ataxia and innate immune system disorders.
The McGovern Institute's MINT program awards up to $100,000 in seed funding for innovative collaborative projects in neuroscience research. Recent awards focus on developing alternative electrode materials, manipulating intracellular signaling pathways with light, and improving computational analysis of brain imaging data.
A new genetic association study found associations between six mouse genes and specific human anxiety disorders, including social phobia, generalized anxiety disorder, and panic disorder. The study suggests that these genes may play a role in predisposing individuals to developing an anxiety disorder.
A study by Tomislav Domazet-Lošo and Diethard Tautz reveals that most disease-associated genes originated before the first cells emerged, with only recently evolved genes showing no link to human diseases. This discovery sheds light on the evolutionary origins of genetic diseases affecting humans and other living organisms.
Researchers at Arizona State University have developed a method to produce complex DNA nanostructures inside living cells, using the cell's copy machine to replicate millions of copies. This breakthrough could enable the scaling up of DNA nanotechnology and open up new possibilities for synthetic biology applications.
A genetic association with SERPING1 has been found to be strongly linked to age-related macular degeneration, a leading cause of visual impairment and blindness. The study's findings have significant implications for the development of novel treatments for this devastating disease.
A comprehensive assessment of the world's 5,487 wild mammal species reveals that one in four is threatened with extinction. The study, led by the IUCN, utilizes the Field Museum's extensive collection to track population trends and habitat destruction.
The US Preventive Services Task Force (USPSTF) recommends high-intensity behavioral counseling for all sexually active individuals at increased risk for STIs. The new stool DNA test is twice as effective at detecting colon cancer and polyps than previous tests, showing promise for improved screening effectiveness.
Molecular diagnostic products are based on cutting-edge research in genomics and proteomics, enabling early detection of cancer and optimizing drug therapy. Companies like Roche, Myriad Genetics, and Genomic Health are well-positioned for future growth with their genetic tests and companion diagnostics.
A genetic risk score was developed from three identified genes associated with increased uric acid levels and a 40-fold increased risk for developing gout. The study analyzed over 20,000 participants and found that more than 3 million US adults have gout due to factors such as obesity, diet, and certain medications.
A study found that a specific gene variation linked to a protein hormone secreted by fat cells is associated with a lower risk of colorectal cancer. The discovery suggests that the adiponectin axis may play an important role in modifying colorectal cancer risk.
A computer model analysis suggests that different cervical cancer prevention approaches offer varying trade-offs between minimizing cancer risk and false-positive test results. Combined cytologic and HPV testing leads to more referrals for colposcopy than other strategies, with a three-fold difference in referrals for the least and mos...
A new analysis links a variant in the vitamin D receptor gene, BsmI, to an increased risk of developing melanoma. Research suggests that vitamin D has protective effects against cancer due to its regulation of cell growth and death.
A new rapid screening test for HPV has shown a 90% success rate in detecting precancerous cells in women in Shanxi province, eastern China. The careHPV test is designed to be simple, affordable and easy to use, making it an effective primary screening method for cervical-cancer prevention in rural and low-resource settings.
A new rapid screening test for HPV has shown a 90% success rate in detecting precancerous cervical disease in rural China. The careHPV test is designed to be simple, affordable, and easy to perform with minimal training, offering hope for cervical cancer prevention in low-resource settings.
Researchers developed a novel approach to analyze cellular waste, discovering previously hidden relationships between genes and small molecules that can turn them off. The study found four new microRNAs in Arabidopsis thaliana, boosting the total to 183.
The University of Virginia lab has created a hand-held device that can conduct DNA tests from a pin-prick-size droplet of blood in under an hour, reducing wait times and costs. This technology has far-reaching implications for personalized medicine, crime scene investigation, and agricultural biotechnology.
A study of 704 Amish adults found that those with low physical activity levels had a stronger association between FTO gene variants and increased BMI. Physical activity levels above average were shown to offset the genetic predisposition to obesity, suggesting personalized lifestyle recommendations may be effective in preventing weight...
A study analyzing 300 newspaper articles reveals five main 'gene frames' used by media, from deterministic to evolutionary and playful metaphors. The findings aim to provide a tool for scientists and journalists to better communicate genetics to the public.
Researchers have discovered that the diversity of parasitic wasps is even higher than initially suspected, with 313 provisional species identified through a combination of ecological and genetic data. The new analysis sheds light on a group of insects that are already known for their staggering diversity, with estimates suggesting that...
Researchers have traced the origin of Tahitian vanilla to tropical forests of Guatemala, where it began as a pre-Columbian Maya cultivar. The team used genetic analysis to confirm that Tahitian vanilla is a hybrid offspring between two native species in Central America.
Researchers from Harvard Medical School and Brandeis University used a full-genome RNAi screen to identify genes essential for brain development in neurons. The study revealed unexpected roles for genes involved in signaling, protein trafficking, and cytoskeletal proteins.
Researchers have made significant progress in understanding the complex metabolic networks involved in tomato fruit development. By analyzing over 1200 quantitative metabolic loci (QMLs), scientists identified associations between metabolites and genes that regulate fruit metabolism. This knowledge can be used to alter metabolic pathwa...
Researchers have discovered a genetic variation in the plasminogen gene that affects susceptibility to invasive Aspergillus fumigatus infections. Genetic testing may help identify high-risk individuals and inform pre- and post-transplant care.