Articles tagged with Genome Dynamics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The study created a critical framework for understanding the architecture of the genome and its association with gene function in cells. The 4DN Consortium integrated data from over a dozen techniques to compile an extensive catalogue of looping interactions between genes and regulatory elements.
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that inflexible DNA within nucleosomes regulates the positioning of INO80, a chromatin remodeling complex. This unique mechanism allows INO80 to position itself on the surface of nucleosomes at the right location.
Researchers have unveiled the molecular mechanisms underlying L1's retrotransposition and integration into genomic DNA. The study reveals that ORF2p interacts primarily with the DNA backbone through electrostatic forces, enabling site-specific cleavage during retrotransposition.
A study published in Science Advances has discovered that the RAD21L protein plays a crucial role in regulating DNA structure and gene expression in sperm precursor cells. The absence of this protein leads to defects in chromosome pairing, genetic recombination, and spermatogenesis, resulting in male infertility.
Researchers at Stowers Institute for Medical Research have identified the precise location where human chromosomes break and recombine to form Robertsonian chromosomes. The study reveals that repetitive DNA sequences play a central role in genome organization and evolution, explaining how these rearrangements form and remain stable.
Researchers have identified hundreds of RNA regulatory switches in living cells that can be used to develop new treatments for diseases. The discovery, published in Nature Biotechnology, uses a novel method to map the complex structures of RNA molecules and uncover functional switches with high accuracy.
Researchers developed a new computational tool using generative AI to identify key gene combinations underlying complex illnesses. The method amplifies limited gene expression data, enabling researchers to resolve patterns of gene activity that cause complex traits.
Researchers found evidence that introners, a type of selfish gene, are responsible for spreading genetic complexity across species. The study revealed eight instances of horizontal gene transfer between unrelated species, suggesting that introners may hitchhike on giant viruses to transfer between species.
Researchers have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis, a crucial step in cell division. The study found that LEM-3 is essential for resolving persistent DNA bridges and maintaining chromosomal stability.
Researchers at Northwestern University discovered that DNA's behavior changes in a crowded environment, affecting the amount of stress required for strand separation. The study used microscopic magnetic tweezers to investigate interactions between DNA and various molecules.
Researchers discovered that independent evolution of chromosome copies in oribatid mites enables genetic diversity through mechanisms like the Meselson effect and horizontal gene transfer. This approach allows for rapid adaptation to environmental changes and supports long-term survival.
Hybrids between two manakin species in Panama have remained relatively stable over the past 30 years, with minimal changes in genomic markers. The phenotypic transition zone also shows stability, with only one trait having shifted location, suggesting a potential selection for green bellies.
A Kyoto University research group developed RENGE, a computational model to estimate gene regulatory networks in multicellular organisms. The method measures time-series gene expression and uses the proprietary model to infer regulatory dynamics.
A computational model of the more than 26 million atoms in a DNA-packed viral capsid has expanded our understanding of virus structure and DNA dynamics. The study found that the DNA formed switchback loops as it was pushed into the capsid, similar to how DNA is organized in eukaryotic cells.
A 46% increase in gonorrhoea cases in Denmark has been reported, particularly among younger women and men who have sex with women. Genomic analysis reveals distinct clones driving the increase, which may be more susceptible to treatment and have higher transmissibility.
A large international study has identified 27 genetic variants that increase the risk of ADHD, more than twice as many as previous studies. The study found that these variants affect genes involved in brain development and dopamine regulation.
Researchers at KAUST have discovered the molecular mechanisms of DNA repair by studying the interaction between two enzymes, Lig1 and PCNA. Lig1 seals nicks in DNA by attaching to a ring-shaped protein called PCNA, which dislodges another enzyme FEN1 to prepare for sealing.
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
A recent study found that most structural variants in cacao genomes are deleterious, impairing gene function and adapting plants to stressors. However, some variants facilitate adaptation by influencing gene expression, particularly those associated with pathogen resistance genes.
Researchers at Universitat Autonoma de Barcelona discover dynamic changes in genome organisation affect male germ cell development and fertility. Chromosomal rearrangements alter chromosome folding, impacting meiotic recombination and genetic diversity.
A new framework uses math to understand how genetic information and cell interactions give rise to tissue function, potentially aiding in understanding diseases like cancer. Researchers aim to apply this approach to real-world genome and cell biology experiments to inform future work on cancer and cell reprogramming.
The University of California, Riverside has received a five-year, $2.4 million grant from the Howard Hughes Medical Institute to support STEM education and increase retention rates among underrepresented groups. The grant will provide lower division science students with early research immersion and career exploration opportunities.