Articles tagged with Arteries
A recent trial by Cleveland Clinic found that the drug RVX-208 failed to improve coronary health in patients with low HDL cholesterol, contradicting previous hopes for an 'HDL-raising' treatment. The study used intravascular ultrasonography to assess plaque buildup and found no significant difference between RVX-208 and placebo.
A Facebook intervention led to increased HIV testing among high-risk men, with a peer-led group showing significant results. The study found that more participants requested an HIV testing kit after 12 weeks compared to the control group.
A recent study published by the European Society of Cardiology found that quitting smoking reduces the risk of heart attacks and death to levels seen in never smokers. However, it does not reduce the presence or severity of coronary artery disease (CAD). The study examined over 13,000 patients from around the world and found that activ...
The PRAMI trial found that preventive PCI resulted in a two-thirds reduction of primary outcome events compared to culprit-only PCI. This new evidence suggests considering revising current guidelines for patients with multivessel disease and ST elevation myocardial infarction.
A study published in Neural Regeneration Research found that patients with a complete middle cerebral artery territory infarct showed significant improvement in motor function of their lower extremities after rehabilitation. However, no functional hand recovery was observed in these patients.
A small study found that patients who received minimally invasive stents had a 31% risk of needing another procedure within 24 months, compared to 54% for those who received bypass surgery. The researchers hope to confirm these findings with further study and develop guidelines for determining when a stent is likely to be best.
The study found that the number of individuals with PAD has increased by over 28% globally since 2000, driven by longer life expectancy and changing lifestyles. The researchers identified key risk factors for PAD, including smoking, diabetes, hypertension, and high cholesterol.
Beaumont Health System is part of a multicenter research study on the new AbsorbTM Bioresorbable Vascular Scaffold, which helps keep arteries open after angioplasty. The device dissolves naturally in the body, reducing the need for permanent stents.
Researchers at Columbia University Medical Center discovered a new genetic mutation, KCNK3, linked to pulmonary arterial hypertension (PAH), a rare fatal disease. The mutation affects potassium channels in the pulmonary artery and can be reversed with a phospholipase inhibitor.
Off-pump coronary artery bypass grafting (OPCAB) has failed to show significant improvements in short-term morbidity and mortality compared to traditional on-pump CABG surgery, according to a recent study published in Circulation. The technique may be abandoned unless surgeons can demonstrate comparable outcomes.
Researchers used near-infrared spectroscopy to detect lipid core plaque in narrowed arteries of 20 patients experiencing a STEMI. The study found that the characteristic makeup of arterial plaque blocking an artery and causing a heart attack can be identified in living patients.
A study of over 3,000 adults found that longer durations of obesity in young adulthood were associated with higher rates of coronary artery calcification, a predictor of coronary heart disease. The researchers also found that the presence and progression of subclinical atherosclerosis increased with duration of obesity.
Researchers at Gladstone Institutes have identified the molecular signals that direct blood vessel formation, revealing a precise order and timing of signals that spur artery formation. The study uncovers the role of Vegf and Dll4 in this process, shedding light on a so-called 'black box' of embryonic development.
Researchers found a 13-fold increase in wrist procedures for percutaneous coronary intervention (PCI) between 2004-07 and 2012. This shift may improve PCI safety, particularly in high-risk patients, by reducing bleeding complications.
A new study by Indiana University researchers found that highly active college-age individuals and middle-aged men and women do not exhibit arterial stiffening, a risk factor for cardiovascular disease. This suggests exercise may have beneficial effects on vascular health in young populations.
A new computational model analyzes the potential usefulness of drug-coated balloons, which may pose fewer risks than current treatments. The model explains how factors like balloon size and drug coating influence drug release and distribution.
Researchers have identified Dkk1 as a key player in the development of atherosclerosis, a condition that causes arteries to become stiff and narrow, leading to impaired blood flow. Targeting Dkk1 signaling may help limit arteriosclerotic disease, according to a new study.
A study of over 1,100 adults who had a stroke found that those living closest to major roads had lower kidney function and increased cardiovascular death rates. Exposure to air pollution from traffic was linked to reduced renal function and an increased risk of cardiovascular events.
A Cleveland Clinic study found that only 42% of deaths after angioplasty were caused by the procedure itself, highlighting the need for a more accurate reporting system. The researchers argue that alternative outcome reporting mechanisms should be considered to better reflect quality and performance.
Patients with increasing accumulations of coronary artery calcium were six times more likely to suffer a heart attack or die from heart disease. More frequent monitoring of patients with coronary artery calcium buildups could help determine the risk and give them time to make changes.
Researchers have discovered zinc as a promising material for bioabsorbable stents, which can dissolve harmlessly after healing. Zinc's corrosion rate is exactly right, allowing it to degrade at a controlled pace.
Researchers discovered that VEGF-driven artery formation requires the binding of VEGFR2 and NRP1. Mice lacking a part of NRP1 molecule had poorly constructed arteries and failed to repair blood vessel blockages. This study opens new therapeutic opportunities for cardiovascular and anti-cancer therapies.
Metabolic disorders like excess abdominal fat, high blood pressure, and low HDL cholesterol are found in children as young as 6-8 years old. These conditions accumulate over time, leading to mild artery wall stiffness and reduced arterial dilation.
A new method to predict which patients with heart disease benefit more from surgery versus angioplasty has been developed by Stanford researchers. The study, published in Annals of Internal Medicine, found that individual characteristics such as gender, age, and diabetes history significantly impact the effectiveness of these procedures.
A minimally invasive treatment reduces blood flow to the prostate, shrinking it and providing a larger passageway for urine. The study shows promising results with significant symptom relief in 92% of patients after one month, with no major complications.
In a study presented at the Society of Interventional Radiology's Annual Scientific Meeting, researchers found that drug-coated stents can effectively treat critical limb ischemia by keeping clogged leg arteries open. The treatment resulted in a significant reduction in amputations and improved quality of life for patients.
Stenting of completely blocked mesenteric arteries can safely restore blood flow to the bowel and resolve patients' symptoms with few complications. This minimally invasive treatment is a game-changer for elderly patients and those with peripheral arterial disease, offering less risk and faster recovery time.
A study found that elevated PAPP-A levels were associated with a higher risk of cardiovascular events in people with cardiac chest pain due to heart disease. The presence of PAPP-A also predicted cardiovascular events, including heart attacks and strokes, even after controlling for other factors.
Researchers found that a clot-busting therapy can benefit some heart attack patients who cannot have immediate angioplasty, reducing all-cause mortality and cardiac rehospitalization. The STREAM trial included 1,915 patients from 15 countries and showed that drug therapy before transfer was at least as effective as angioplasty.
A study of ancient mummies from diverse cultures reveals that hardening of the arteries was a widespread problem globally, contradicting previous assumptions about its occurrence in ancient Egypt and diet-related factors. The research found that nearly half of the examined mummies showed signs of probable or definite atherosclerosis.
The NEXT trial found biolimus stent to be non-inferior to everolimus stent in target-lesion revascularization and stent thrombosis rates at one year. The study's long-term data will determine if the device's disappearing polymer offers superior benefits over other available stents.
The DKCRUSH-III trial shows that double kissing crush stenting reduces restenosis and improves long-term outcomes for patients with bifurcation lesions, a type of complex coronary lesion. The study found 6.8% in-stent restenosis rates with double kissing crush versus 12.6% with culotte stenting.
A new anti-inflammatory drug, inclacumab, has shown promising results in reducing heart muscle damage during angioplasty. The study involved 530 patients with myocardial infarction and found that a single dose of the drug reduced troponin I levels by 24%, offering great promise for its potential use in treating heart attack patients.
The study found that hybrid revascularization had a similar rate of major adverse events in the first year compared to percutaneous intervention. Hybrid revascularization combines coronary bypass surgery and stenting, offering a minimally invasive approach for treating multi-vessel coronary artery disease.
Research found that people exposed to secondhand tobacco smoke have a higher risk of developing early signs of heart disease, including coronary artery calcification. The study also shows that the level of exposure to secondhand smoke is directly linked to the severity of CAC.
Researchers found that blockages in coronary arteries, as measured by non-invasive CT scans, were significantly higher in patients who experienced a stroke. CAC levels above 400 Hounsfield units increased the risk of stroke three times in those under 65 and at low cardiovascular risk.
A study by 98-year-old researcher Fred Kummerow found that oxidized lipids contribute to heart disease by increasing calcium deposition on the arterial wall and interrupting blood flow. Oxidized cholesterol was also linked to an increased synthesis of a blood-clotting agent, thromboxane.
A study of 26,389 coronary patients found that 17% had a history of stroke or transient ischemic attack (TIA), associated with increased risk of heart attack and hemorrhagic stroke. Higher doses of anti-platelet or anti-coagulant therapy were linked to a high risk of bleeding complications.
Scientists have discovered a crucial role of ADAMTS7 enzyme in building up cells in coronary arteries, contributing to the development of coronary heart disease. The study found that a specific gene variant reduces risk by 50% and slows down plaque growth.
A recent NIH-funded study found that using advanced imaging shortly after an acute ischemic stroke did not identify a subgroup of patients who could benefit from clot removal procedures. The study, MR RESCUE, tested an invasive clot removal strategy in patients with large clots blocking major brain arteries.
A randomized controlled trial involving 656 patients found that intra-arterial device-based approach plus standard drug therapy did not improve functional independence after 90 days. Intra-arterial therapy was more effective at removing clots and re-establishing blood flow, but it did not lead to improved disability.
Patients with peripheral artery disease who received ramipril for 24 weeks experienced significant improvements in pain-free walking time and maximum walking time, as well as enhanced physical health and quality of life. Ramipril also showed promise in improving patient-perceived ability to perform daily activities.
Researchers have identified an early predictor for glaucoma, a condition that affects nearly three million people in the US and 60 million worldwide. The study found that certain changes in blood vessels in the retina can be an early warning sign of increased risk for glaucoma.
A new study found that heart calcium scans can identify people with Type 2 diabetes at high risk for developing potentially fatal cardiovascular disease, as well as those at low risk. The test can help doctors provide more effective treatments and improve outcomes by diagnosing a precise risk level.
Researchers at the University of Missouri have developed a new method to detect artery inflammation in pigs using targeted micro-bubbles. The technique, which has shown promising results, may help identify patients at risk for strokes and monitor the effectiveness of treatments.
A new study published in Radiology found that cerebral angioplasty and stent placement can be an effective treatment for stroke patients, with a significant improvement in outcomes compared to no additional therapy. The procedure was shown to improve symptoms and quality of life for approximately 43.5% of patients.
Researchers have found that bilirubin can limit arterial lesions by blocking vascular smooth muscle cell growth, potentially preventing heart attacks and other cardiovascular symptoms.
Scientists at Albert Einstein College of Medicine have discovered that coronary arteries form from cells in the ventricles, which can potentially be used to regenerate healthy vessels. This breakthrough could lead to more effective cardiac care and treatments for heart disease.
Researchers at Imperial College London confirm the life-saving role of specialist heart attack centres through a new study. The findings show that primary angioplasty reduces death rates from heart attacks by 22% when bias is accounted for, highlighting the importance of making these centres widely available.
A recent study published in The New England Journal of Medicine found that cardiac bypass surgery is superior to percutaneous coronary intervention (PCI) for adults with diabetes and multi-vessel coronary heart disease. After five years, the CABG group had fewer adverse events and better survival rates than the PCI group.
A study by the Heart and Stroke Foundation found that consuming just one high-fat breakfast sandwich can decrease blood vessel function by 15-20% in healthy university students. This temporary effect highlights the potential for a single high-fat meal to have long-term consequences on heart health.
A recent study published in the University of Montreal found that consuming junk food meals damages artery health, whereas Mediterranean meals rich in good fats can even improve endothelial function. Participants with higher blood triglyceride levels showed greater benefits from healthy meals.
The radial approach has been shown to significantly reduce the incidence of major bleeding and access site complications compared to the femoral approach. In STEMI patients undergoing primary PCI within 12 hours, radial access was associated with a lower rate of major adverse cardiovascular events.
A new MRI technique has shown promise in identifying early-stage coronary disease, which can be treated with lifestyle changes and medications. The study used time-resolved multi-frame acquisition to measure coronary artery wall thickness with a high success rate and precise measurements.
A new study found that consuming one apple a day for four weeks lowered blood levels of oxidized LDL by 40 percent. The polyphenols in apples played a significant role in this effect.
MicroRNA-145-based gene therapy reduces plaque size and increases stability in mice, providing new insights into atherosclerosis treatment. The approach also makes the fibrous cap area more resilient to rupture, a key event in heart attacks.
Patients with stable coronary artery disease who have at least one narrowed blood vessel benefit from early stent placement, reducing hospitalization and urgent revascularization needs. The study used fractional flow reserve to identify eligible patients, which significantly reduces the risk of adverse events.
Improved treatment and management of acute myocardial infarction have led to significant reductions in 30-day mortality, from 12.9% to 3.9%, and in-hospital complications. The analysis suggests that the declines are due to both increased use of recommended interventions and earlier use of medications.
Analysis of four French registries from 1995 to 2010 shows significant improvements in management and outcomes for acute myocardial infarction (AMI) patients, resulting in a notable decrease in 30-day mortality rates. This improvement is attributed to increased use of coronary angiography/PCI and early adoption of recommended medications.
A study examined the long-term safety of two different types of drug-eluting stents, finding no significant difference in stent thrombosis rates over three years. However, differences emerged when dual antiplatelet therapy was used low, suggesting its importance for patients with these stents.