Articles tagged with Arteries
Researchers identified three genetic factors associated with peripheral artery disease, including variations on chromosome 13 that affect protein expression and blood vessel constriction. The study provides insight into the condition's causes and potential therapeutic targets.
Researchers found that just 10 minutes of walking after six hours of sitting can restore impaired vascular function and improve blood flow to the legs. This simple break can offset the harm caused by prolonged sitting and reduce the risk of cardiovascular complications.
A study by researchers from the University of Minnesota Medical School found that health care costs in one year were $18,000 higher in smokers with peripheral artery disease than non-smokers. Hospitalization rates among tobacco users with PAD were also significantly higher, at 49% within one year.
Researchers at Thomas Jefferson University found that arterial blood contains a higher number of circulating tumor cells (CTCs) than venous blood in uveal melanoma patients. This discovery raises concerns about the effectiveness of current detection techniques, which often rely on venous blood samples.
Researchers found that high uterine artery blood flow resistance in early pregnancy is associated with a 5-fold increased risk of preeclampsia, fetal growth restriction, and stillbirth. Increased cell death and reduced IGF2 expression may be causal factors of abnormal placental development.
Researchers have identified an age-related cause of arterial dysfunction, finding that older arteries have fewer sensory nerves and are less sensitive to a key neurotransmitter. This discovery could lead to future treatments for age-related vascular diseases such as stroke and cardiovascular disease.
Researchers found that coronary spasm at sites of atherosclerotic coronary artery narrowing significantly increases the risk of future heart attacks. Patients with these spasms are more likely to experience acute coronary syndrome, emphasizing the importance of monitoring and preventative therapy.
Research presented at ESC Congress found a strong association between cold weather and severe heart attacks in Winnipeg, Canada. A 6-year study showed that each 10°C drop in temperature increased the risk of ST-elevation myocardial infarction (STEMI) by 7%.
A study of over 55,000 CABG patients found diabetics had more postoperative complications and decreased long-term survival. The proportion of diabetic patients undergoing CABG increased 5-fold between 1970-2010, driven by higher costs and clinical risks.
A study by Rhode Island Hospital researchers found that few US hospitals comply with CDC recommendations for preventing infections associated with arterial catheters. The survey of 1,265 critical care clinicians revealed a significant deviation from clinical guidelines regarding the insertion of these catheters.
The Journal of Endovascular Therapy publishes the latest update to TASC II guidelines for managing peripheral arterial disease (PAD), emphasizing an endovascular-first approach and expanded lesion classification. The updated guidelines address treatment decisions for complex anatomies and critical limb ischemia.
Researchers found that coadministering statins with ezetimibe significantly reduced LDL cholesterol levels and plaque buildup in heart disease patients. The study showed a 40% lower cholesterol level and greater plaque regression compared to single-drug therapies.
Researchers found that aging actually offers significant protection against oxidative stress, as the endothelium adapts to regulate ROS and minimize cell death. This adaptation helps ensure arteries of older individuals can still function properly.
New imaging technique using radioactive sodium fluoride allows doctors to visualize unstable calcium deposits in arteries, enabling early diagnosis and development of new medicines. The technique non-invasively detects calcification in atherosclerosis, potentially revolutionizing treatment for patients at risk.
Researchers found that coronary artery calcification scans can accurately predict all-cause mortality up to 15 years in asymptomatic patients. The study's findings suggest that CAC scanning could help physicians identify patients at risk for early death and advise them to adopt healthier lifestyles.
The American Heart Association/American Stroke Association recommends the use of brain stent retrievers in certain patients undergoing acute ischemic strokes. The devices can restore blood flow and reduce stroke damage when treated promptly, making them a valuable option for carefully selected patients.
Researchers develop microrobots that can navigate in the bloodstream and clear blockages, offering a new treatment option for chronic total occlusion. The technology has the potential to be up to 90% successful and shorten recovery time.
Patients who viewed images of their calcified coronary arteries were more likely to stop smoking, lose weight and take statins. The study suggests that visualising health threats motivates patients to make changes, reducing plasma cholesterol levels and other risk factors.
A meta-analysis of 14 medium- to high-quality studies found that gentamicin-collagen sponges significantly reduced the incidence of sternal wound infections by 38% compared to controls. The use of sponges also reduced the risk of life-threatening inflammation of mid-chest tissues (mediastinitis).
Researchers have compared two novel ways of inhibiting atherosclerotic plaque-induced platelet activation, finding that one strategy is more effective at higher flow rates. The study suggests a new GPVI inhibitor may be used specifically to block thrombus formation at high-risk plaques.
A new study published in Radiology found that non-calcified arterial plaque is associated with diabetes, high systolic blood pressure, and elevated 'bad' cholesterol levels. CT angiography can quantify plaque burden and assess progression or regression of coronary artery disease in low-to-moderate risk individuals.
Researchers have developed a drug-releasing electronic stent that provides diagnostic feedback by measuring blood flow, which slows when an artery starts narrowing. The device can also heat up on command to speed up drug delivery, and it can dissolve once it's no longer needed, reducing the risk of blood clot formation.
Researchers found that almost 83% of participants regained mobility after six months with home exercise and support, compared to 36.4%. Home-based walking programs can help prevent mobility loss in patients with clogged leg arteries.
A new study suggests that exercise training to strengthen hip flexor muscles can increase walking distance and reduce calf pain in patients with clogged leg arteries. Researchers found that PAD patients use their ankle flexors more during walking due to weakness in hip muscles.
A recent study compared cardiac surgery residents to attending physicians performing coronary artery bypass grafting and found similar patient outcomes and graft patency. Residents acted as primary surgeon in majority of surgeries, but with proper supervision, they achieved comparable results to attendings.
A study published in The Journal of General Physiology reveals the distinct roles of calcium channels in controlling arterial tone and blood flow to the brain. Researchers found that blocking L-type and T-type channels has opposite effects on blood flow, with one promoting vasodilation and the other constricting arteries.
Researchers found that atrial fibrillation, the most prevalent heart rhythm disorder, is associated only with non-ST segment elevation myocardial infarction (NSTEMI) type of heart attack, increasing risk by 63 percent overall and higher rates in women. Atrial fibrillation has long been known to be a risk factor for stroke.
New research found that over one-third of patients without established heart disease who underwent Agatston-scored CT scans were reclassified as being at very low risk for cardiovascular disease. This shift in classification could spare these patients from unnecessary statin therapy, according to the study.
Research finds that thinner slice thicknesses of 0.5-1 mm can accurately measure coronary artery calcium with isotropic data acquisition at the same radiation dose. This method reduces inaccuracies caused by partial volume averaging errors found in standard 3 mm slices.
3D simulations analyze local flow fields and identify correlation between left coronary angulation and wall shear stress changes. CFD complements cardiac CT imaging by defining internal biomechanics, including stresses and strain within the coronary artery system.
A commonly prescribed antidepressant caused up to six-fold increase in coronary artery atherosclerosis in non-human primates. Researchers found that female monkeys treated with the medication developed three times more atherosclerosis than those given a placebo.
A study found that dialysis patients with high parathyroid hormone levels and subsequent bone loss are at risk for worsening coronary artery calcification. Monitoring these factors could help prevent cardiovascular problems and early death in dialysis patients.
A study found that peanut consumption with a high-fat meal improved post-meal triglyceride response and preserved endothelial function in overweight males. Peanuts were shown to be atheroprotective as part of a high-fat meal, potentially reducing the risk of coronary disease.
A new study published in JAMA finds that using a stent to widen narrowed brain arteries does not provide better outcomes than medication alone. The trial enrolled 112 patients and found increased stroke or TIA risk with stent use, as well as higher mortality rates.
A new study published in the New England Journal of Medicine found that routine thrombectomy during angioplasty for heart attacks does not provide a benefit and may increase the risk of stroke. The study included over 10,000 patients and randomly assigned half to receive angioplasty alone or with manual thrombectomy.
Patients over 80 with acute coronary syndromes who received invasive procedures had a 47% reduction in heart attacks, urgent revascularization, stroke, and death compared to conservative treatment. The study suggests that older patients may be denied necessary treatments due to their age.
A study published by the American College of Cardiology found that patients undergoing coronary angiogram with radial access had a significantly lower risk of major bleeding and death compared to those with femoral access. The study suggests that the arm should be the preferred approach for most catheter-based heart procedures.
Patients with multivessel coronary artery disease receive better outcomes with coronary artery bypass grafting (CABG) than angioplasty and stent implantation, according to a study. This is in line with past studies that have shown CABG leads to better outcomes for patients with multiple narrowed arteries.
A study found that complete revascularization after emergency angioplasty for STEMI reduced unplanned angioplasty or bypass surgery by 12%. Rates of death and repeat heart attacks were comparable between groups. The approach may help patients avoid future cardiac events.
A study of over 18,000 patients found that newer drug-coated stents have similar long-term rates of death as traditional bypass surgery. However, the stent group had slightly more heart attacks in the long term.
A large randomized controlled trial found no significant improvements in cardiovascular death, non-fatal heart attack, stroke, or subsequent surgery in patients who received remote ischemic preconditioning before coronary artery bypass grafting. However, the study did reveal a 15% reduction in heart injury within 72 hours after surgery.
Studies link energy drink consumption to increased resting blood pressure, while smoking is associated with a higher risk of fractured stents in limb arteries. Social habits also play a role in recovery from early-onset heart attacks in low-income urban communities.
Research finds that excess sitting is associated with coronary artery calcification, an early indicator of heart problems. Reducing sedentary time by just one hour per day could have a significant positive impact on future cardiovascular health.
A new treatment option for benign prostatic hyperplasia (BPH) has been shown to improve patient symptoms regardless of prostate size. Prostate artery embolization (PAE) is a minimally invasive procedure that blocks blood flow to the enlarged gland, resulting in reduced risk of bleeding and urinary complications.
A recent meta-analysis of 36 studies found that moderate coffee consumption is associated with a decreased risk of heart disease. Participants who consumed 3-5 cups of coffee per day had the lowest risk of clogged arteries and heart attacks.
Scientists have found that the MMP12 enzyme travels to the center of cells, contradicting previous assumptions. This discovery may lead to the development of treatments to turn off this enzyme and others like it when they cause damage.
A Cornell University study reports for the first time how arteries form in the embryonic gut and guide the development of the lymphatic system, providing a new avenue to explore treatments for cancer metastasis and gut-specific lymphatic diseases. The research links a master-regulator gene, Pitx2, to artery and lymphatic formation.
A new study found that diabetic patients with even mild coronary artery disease are at a comparable risk of heart attacks and major adverse events to those with severe obstructive disease. Researchers used cardiac computed tomography angiography data from 14,000 patients to evaluate long-term prognostic value in diabetic patients.
Researchers have discovered a gene variant, PHACTR1, that reduces the risk of cervical artery dissection and other related conditions. This finding could lead to new treatment strategies for stroke prevention in young adults.
Researchers used big data analysis to identify crizotinib, a cancer drug, as a possible candidate for a new stent coating. The medication helped prevent stent disease and protected the endothelium without affecting blood vessel lining in mice.
A study of 68,765 STEMI patients found that 53% had non-IRA disease, significantly associated with increased 30-day mortality. The presence of non-IRA disease was consistent with findings from the KAMIR registry but not the Duke database.
A recent study by Duke University researchers found that over half of STEMI heart attack patients had one or both of their other arteries obstructed, leading to worse outcomes. The study suggests that opening all blocked arteries may become a standard procedure.
A study of 4,524 patients found that intravascular VCDs were more effective than manual compression in achieving hemostasis, with fewer device failures and shorter time to hemostasis. The results suggest that VCDs may be a safer alternative for closing artery access sites following coronary angiography.
A new study found that taking short walking breaks during prolonged sitting can significantly improve endothelial function and reduce cardiovascular risks. The research involved 11 healthy men who sat for three hours with or without regular breaks, showing that breaks can prevent decline in arterial function.
A University of Kentucky research team has made a surprising discovery about oxidized LDL's role in cholesterol transport. The findings indicate that mildly oxidized LDL may actually prevent increases in cholesterol accumulation in arterial walls, potentially leading to new treatments for heart disease.
A new generation of coronary artery stent combining a biodegradable component with an ultrathin scaffold showed promising results compared to the current gold standard. The trial demonstrated non-inferiority of the experimental stent, but superiority in patients presenting heart attack.
A new study found that early administration of ticagrelor, an anti-clot medication, in the ambulance may prevent stent thrombosis in heart attack patients. The ATLANTIC study showed a significant reduction in stent thrombosis at 24 and 30 hours in the ambulance treatment arm compared to the in-hospital treatment arm.
A new study found that complete revascularisation of all significantly blocked arteries leads to better outcomes in heart attack patients compared to only unblocking the culprit artery. Patients who underwent complete revascularisation had a lower risk of major adverse cardiac events, including death, recurrent MI, and heart failure.
Researchers found that complete ablation of main and accessory renal arteries led to greater blood pressure reductions with renal denervation. The procedure was successful in 67% of patients, but incomplete ablation did not significantly impact results. Further investigations are needed to confirm these findings.
Renal artery stenting may benefit patients with kidney artery blockages who were excluded from clinical trials. Expert panel recommendations suggest patients with cardiac disturbance or severe high blood pressure are good candidates for the procedure, while others may not be suitable due to mild or moderate blockages.