Articles tagged with Dentate Gyrus
A new study found that storytelling strategies with conceptual or perceptual details activate distinct brain networks, predicting how well participants recall core elements of the story. This suggests that people's preferred memory systems may vary across age groups, and tailored information could improve memory for older adults.
A recent study by Boston Children's Hospital researchers found that activity in the dentate gyrus helps keep us focused on our environment when our mind wanders. This neural activity also aids in forming memories.
Researchers found GV1001 decreases BACE and Aβ1-42 levels, reducing neurodegeneration and senescence in 3xTg-AD mice. It also increases survival, telomere length, and telomerase activity, contributing to improved lifespan.
The Texas Tech University Health Sciences Center has received a five-year, $1.87 million NIH grant to investigate the role of vitamin A depletion in Alzheimer's disease. The research aims to test the hypothesis that a lack of antioxidant all-trans retinoic acid (ATRA) promotes reactive oxygen species toxicity.
Researchers have identified a specific location in the hippocampus called the dentate gyrus where schizophrenia may originate. Studying rats with damaged SAP97, they found changes in activity in this region, directly linking alterations to the development of schizophrenia.
Researchers found damage to a brain part that regulates hyperactivity contributes to both memory issues and seizures in the most common form of epilepsy. This discovery may lead to earlier diagnosis and new treatments for epilepsy and related disorders.
Researchers at Tokyo University of Science discover that vicarious social defeat can cause psychological stress in mice, leading to depression and decreased neurogenesis. The study sheds light on the pathophysiology of depression and may lead to the development of novel antidepressants.
Researchers discovered a key molecular mechanism mediating GABAergic synaptic development and function, with somatostatin peptide found to regulate synaptic transmission between nerve cells.
Neurogenesis has been shown to have an additional role beyond learning and memory, with adult neural stem cells involved in regeneration. In a study published in JNeurosci, mice were exposed to a toxic substance that damaged the dentate gyrus, but recovered almost fully through neurogenesis.
The dentate gyrus uses a process called pattern separation to store distinct memories of similar events. Researchers found that parvalbumin-expressing interneurons play a key role in this process, using lateral inhibition to keep similar memories apart.
Researchers propose a new model identifying an unanticipated property of newly formed, immature neurons in the dentate gyrus. These cells enhance pattern discrimination by having fewer synaptic connections and high intrinsic excitability.
Scientists have discovered that newly generated brain cells, also known as adult neurogenesis, are required for memory formation and pattern separation. The study found that these cells exhibit unique activity patterns, which help distinguish between different environments.
Johns Hopkins University researchers identified the hippocampus region responsible for distinguishing between familiar and new memories. This finding validates theories about memory processing and may help explain memory impairments in diseases like Alzheimer's, potentially preserving people's memories as they age.
Researchers at Columbia University Irving Medical Center found that dietary flavanols can improve cognitive function and reverse age-related memory decline in healthy adults. The study showed noticeable improvements in the function of a specific brain region and significant performance on a memory test.
The study reveals that theta-gamma oscillations in the hippocampus are generated by excitatory and inhibitory synaptic signals, which provide rhythmic signals for temporal coding. The researchers also found that granule cell neurons send signals only at specific times during the cycle of oscillations.
A study by Columbia University researchers found that selectively activating the dentate gyrus in the hippocampus can reduce anxiety without affecting learning. This suggests that targeting this brain region could be used to treat certain anxiety disorders with minimal cognitive side effects.
A study by RIKEN-MIT Center found that specific neurons in the dentate gyrus serve distinct roles in memory formation based on whether they were produced from young or old neural stem cells. This discovery could lead to new drug targets for treating memory impairments associated with PTSD and aging.
Researchers found that substances in old mice's blood inhibit new nerve cell generation and impair cognitive function in young brains. Eotaxin, a protein attracting immune cells to areas where it has been secreted, was identified as a key factor contributing to aging-related changes.
Researchers discovered that newborn neurons in the hippocampus help separate individual events and form temporal relationships, improving spatial memory. This breakthrough sheds light on the purpose of neurogenesis and its role in adult brain function.
A computational model suggests that newborn brain cells add a unique time-related code to memories formed around the same time. This allows for recall of events from a certain period and connects independent events that occurred during the same hyperactive period, explaining why memories can be triggered by specific details.
A study by Columbia University Medical Center researchers found that rising blood glucose levels may contribute to normal cognitive decline in aging. Exercise has been suggested as a potential strategy to improve cognitive health by lowering glucose levels and improving brain function.
Research suggests that brain immaturity, specifically in the dentate gyrus region, may contribute to schizophrenia. This underdeveloped area affects working memory and mood regulation., The findings imply a potential biomarker for diagnosing and treating schizophrenia.
Researchers at the University of Bristol and MIT have discovered a key role for the dentate gyrus in rapid place recognition, which may help alleviate confusion among elderly individuals. The study's findings could also inform therapies for learning and behavioral disorders.
A new study found that traumatic brain injury reduces potassium-chloride co-transporter 2 (KCC2) levels in the dentate gyrus, leading to abnormal activity and seizures. The research also suggests that this imbalance may impair memory formation, particularly antegrade memory.
A study published in Molecular Psychiatry found that maternal separation causes the death of brain cells. However, researchers discovered that fluoxetine, a type of Prozac, can reverse these changes and promote cell growth in the dentate gyrus of rats.