Articles tagged with Skin
Researchers have successfully sequenced the complete genome of Malassezia globosa, a naturally occurring fungus responsible for dandruff and other skin conditions. The genetic make-up of M. globosa has expanded treatment targets from a few observational characteristics to over 4,000 molecular targets.
The NHS spends £16 million a year on specialized bath products for eczema, despite lack of evidence showing their effectiveness. Healthcare professionals often recommend them to patients, but experts disagree on their value.
Researchers at Massachusetts General Hospital found a strong association between exposure to gadolinium-containing contrast agents and the development of nephrogenic systemic fibrosis (NSF) in kidney failure patients. The study also showed that individuals with NSF had a significantly increased risk of dying within two years.
A new study published in Arthritis & Rheumatism found that patients with kidney failure who develop nephrogenic systemic fibrosis (NSF) have a significantly higher risk of dying. Gadolinium exposure is identified as a significant risk factor for developing NSF.
Researchers found that an enzyme called transglutaminase-2 (TG2) may be involved in the development of nephrogenic systemic fibrosis (NSF), a rare tightening and swelling of the skin and organs. The study suggests a potential strategy for preventing or treating NSF using drugs that inhibit TG-2 activation.
A new topical lotion has shown high degree of safety and tolerability in treating toenail fungus. The treatment avoids systemic absorption, reducing risks of cardiac and liver toxicity associated with current oral medications.
Research finds that Staphylococcus aureus bacteria can contaminate hospital surfaces and patient hands through stool samples, increasing the risk of infections. The study also reveals a significant link between intestinal colonization and S. aureus skin presence in hospitalized patients.
Researchers have discovered that sulforaphane can prevent severe blistering and skin breakage associated with the rare genetic disease EBS. The study, funded by various organizations, found marked improvement in treated mice, suggesting a potential therapeutic for this condition.
A survey of 369 Florida high school students found that white Hispanic teens were more likely to use tanning beds and less likely to protect themselves from the sun, compared to their white non-Hispanic peers. White Hispanics have a lower rate of skin cancer but are often diagnosed at a later stage, suggesting differences in knowledge ...
Research found that administering cannabinoids like THC reduces allergic reactions in mice with contact dermatitis. The study suggests a protective role for the endocannabinoid system in skin allergy and potential therapeutic applications.
Researchers found distinct compartments of fat in the face that age at varying rates, challenging previous theories on aging. This breakthrough offers new ways to rejuvenate the face and may hold clues to other diseases such as obesity, diabetes, and cancer.
Researchers found that over-production of two inflammatory proteins causes excessive levels of a third protein, leading to rosacea symptoms. Elevated stratum corneum tryptic enzymes (SCTE) and cathelicidin also contribute to the disease.
Scientists at University of Bonn discover endocannabinoids regulate inflammation processes. Extracts from hemp plant also show anti-inflammatory effects, potentially leading to new treatments.
New guidelines provide a rational treatment approach for managing skin reactions caused by Epidermal Growth Factor Receptor Inhibitors (EGFRIs), which are used to treat various types of cancer. The recommended treatment involves using moisturizers, protecting against sunlight, and targeted medications to manage the severity of the rash.
Researchers assessed the effectiveness of topical retinol lotion in reducing wrinkles and improving skin aging severity. The study found significant reduction in wrinkle formation and increased collagen production, leading to improved appearance and skin resilience.
A study by University of Cincinnati researcher David Hom found that treating skin wounds with a concentrated topical gel of the patient's own blood platelets resulted in faster healing. The gel showed a statistically significant increased wound closure compared to antibiotic ointment, with some sites closing up to two days earlier.
Researchers tested retinol-containing lotions on elderly patients, finding significant reductions in wrinkles, roughness, and overall aging severity. The study also showed increased collagen production, making the skin more resistant to injury and ulcer formation.
A comprehensive review suggests that wearing protective clothing is a more effective way to prevent skin cancer and sun damage than relying on sunscreen. The review highlights the characteristics of clothing that can provide optimal protection, including tightly woven fabrics like denim and wool.
Researchers have found that mice lacking organic cation transporter 1 (OCT1) exhibit reduced metformin effects on AMPK phosphorylation and glucose control. Additionally, seven mutations in OCT1 were identified in humans, which reduce metformin uptake, indicating the importance of OCT1 in mediating metformin's therapeutic effects.
Researchers found a significant link between smoking and skin damage in non-facial areas, such as the inside of the upper arm. Smoking was associated with an increased degree of skin aging, with smokers showing more severe fine wrinkling than nonsmokers.
Researchers found a correlation between smoking and increased fine wrinkling in photo-protected skin, particularly among participants over 65. The study used a novel grading scale to assess the severity of skin aging, which was not previously available for photo-protected areas.
Researchers found that multiple low-energy plasma treatments reduced wrinkles by 37% and improved facial appearance by 68%. The treatments had a minor healing process, making them an attractive option for patients seeking minimally invasive resurfacing procedures.
Research by UCSD School of Medicine reveals that Vitamin D3 plays a crucial role in controlling the body's innate immune response and protecting against infections. Fluctuations in vitamin D3 levels affect the healing process of skin wounds, with lower concentrations linked to increased susceptibility to infection.
Studies by LA BioMed researchers found that close contacts of patients with CA-MRSA infection may be at higher risk of acquiring an infection. The findings suggest that CA-MRSA strains are more transmissible than traditional S. aureus strains, emphasizing the need for cautious treatment and contact isolation.
A study found that learning skin self-examination with a partner enhances the perceived importance and performance of this critical cancer prevention behavior. Participants who learned together showed stronger intentions to examine their skin regularly, especially in hard-to-see areas like the scalp and back.
Researchers at the University of Cincinnati have created genetically modified skin cells that produce higher levels of human beta defensin 4 (HBD4), which killed more bacteria than normal skin cells. These cells may help combat infections in burn patients and reduce dependence on topical antibiotics.
Repetitive motion speeds nanoparticle uptake through the skin, according to a study by researchers at Rice University. The team found that flexing the skin increases nanoparticle penetration and depth, with more buckyballs taken up after 24 hours.
Researchers demonstrate that trichostatin A can counteract muscular dystrophy in mice by promoting muscle regeneration and upregulating follistatin, a key protein involved in muscle development. Further studies are needed to determine the effectiveness of the drug in larger animals before it can be tested in humans.
Researchers have developed a new sunscreen ingredient that repairs sunburned skin and prevents skin cancer. The ingredient releases an active chelator that mops up free iron released when the skin burns, reducing inflammation and pain.
Researchers at UNC Health Care have found a way to treat pemphigus vulgaris without shutting off the immune system. They used a known compound to turn off signals that trigger skin damage, preventing blistering and other signs of the disease.
A recent study reveals that children with chronic skin diseases like eczema and psoriasis experience impaired quality of life comparable to those with kidney disease. This is largely due to social stigma, teasing, and bullying, which can lead to emotional distress and poor self-esteem.
A randomized, double-blind trial found PUVA therapy to be more effective than NB-UVB in treating moderate-to-severe plaque psoriasis. Patients treated with PUVA achieved skin clearance in a significantly shorter number of treatments and had a higher rate of sustained clearance.
Researchers have defined normal melanocyte numbers in sun-exposed skin, distinguishing sun damage from early melanoma. This finding allows for less tissue removal and trauma to the skin.
Research finds high incidence of skin diseases among Hispanic migrant farmworkers, including acne and foot fungus. The study highlights the need for better health education and access to services for these workers.
Primary care physicians can improve their ability to detect malignant skin lesions using simplified dermoscopy techniques, resulting in a 25% increase in sensitivity. The use of dermoscopy reduces the number of false negatives and improves patient outcomes.
Researchers found that genetic makeup can predict fat distribution patterns and obesity risk, identifying key genes involved in controlling development. The study suggests that different forms of obesity may be a developmental problem starting early in life.
A new study reveals that people with eczema may benefit from smallpox vaccination due to their immune system's overproduction of inflammation-promoting molecules. The research suggests that developing drugs or creams to mimic the action of LL-37 or neutralizing IL-4 and IL-13 could be effective in boosting the immune response.
A recent study found that women are more likely to develop infections after coronary artery bypass graft (CABG) surgery, leading to a higher risk of death. The researchers discovered that urinary, digestive, respiratory and skin and subcutaneous tissue infections were more common in women than men.
Beta-glucan, a soluble fiber found in oat kernels, has been shown to penetrate the skin naturally, promoting wound healing and reducing scarring. The compound works through the inter-cellular lipid matrix to enter lower levels of the skin, making it a potential alternative to Botox for non-invasive treatments.
Researchers at the Research Institute of Molecular Pathology in Vienna have developed an animal model for psoriasis, revealing that epidermal alterations can initiate skin lesions and arthritis. The discovery challenges long-held beliefs about autoimmune diseases and provides a powerful tool for future studies.
Multiple short exposures to wet work can cause more dermatitis than single long exposures, emphasizing the need for preventive measures. Reducing frequent and intense exposure of hands to water, detergents, and soaps is crucial in preventing hand eczema.
A study by Michigan Medicine found that adults use over-the-counter hydrocortisone creams in limited and appropriate ways, with a 73% compliance rate. In children, hydrocortisone cream was used primarily for insect bites, rashes, eczema, and itchy skin, with 72% of use following recommended guidelines.
A study published in the Journal of Cosmetic Dermatology found that cosmetic-grade mineral oil is not comedogenic, contradicting previous assumptions. As a result, consumers should look for skin care products labeled as non-comedogenic rather than 'mineral oil-free'.
Researchers found that injecting a wart with a skin test antigen from mumps, Candida, or Trichophyton can clear the wart and other distant warts. Patients who responded to treatment were more likely to have an immune response to HPV, suggesting intralesional immunotherapy induces HPV-directed immunity.
A study by the Mayo Clinic found that arm lift surgery is generally safe, with a complication rate of relatively low numbers. The most common complications were fluid collections under the skin, poor scarring, skin infection, and nerve injuries. These complications can include numbness in the forearms or pain in the hand and forearm.
Research by Vikesland and his associates suggests that consumer products containing triclosan can produce chloroform when mixed with chlorinated water, which can be absorbed through skin or inhaled. The production of chloroform has implications for human health and the environment due to its potential to accumulate in body tissues.
Scientists at NIST and Johns Hopkins University have developed a new optical method that can image subsurface structures under skin using polarized light. The method minimizes unwanted light scattering and may eventually be used to produce more detailed images of deeper layers of skin for diagnosing various types of skin cancers.
A simple intervention using UV filter photos increased sun protection during incidental exposure, with 37% of participants reporting sunless tanner use. The study also found that the intervention led to more friends and family being informed about UV damage and sun protection.
A study found that preterm babies who received sunflower seed oil had a significantly lower risk of infection compared to those who did not receive the treatment. The effect was most pronounced when treatment was started within 24 hours of birth, with a 56% reduction in bloodstream infections.
S. epidermidis produces poly-gamma-glutamate (PGA) to protect itself from innate host defenses during infection. The findings suggest PGA as a promising target for drug development to combat related illnesses.
DermaVir induces HIV-specific immune reconstitution, eliminating need for daily injections. The vaccine has shown significant antiviral activity and minimal side effects compared to current treatments.
Researchers found that a protein called STAT3 is crucial for the development of psoriasis and can be reversed with a specific treatment. The study's findings offer a potential new target for medications to relieve symptoms of psoriasis.
Researchers at the University of Michigan have discovered a compound that suppresses cell growth in psoriasis models, offering new hope for treating this life-long genetic condition. The compound, benzodiazepine-423, is selectively applied topically and shows great potential for controlling disease progression.
Researchers found that laser resurfacing can improve the look of sun-damaged skin and reduce acne scars with nonablative laser treatment. Increasing volume of botulinum exotoxin A at lower concentrations affects a larger area, making it suitable for treating larger areas like the forehead.
Brett Wong's research identifies histamine receptors as contributing to increased blood flow during heat stress, which can help improve survival rates among elderly and those with conditions like diabetes and heart disease.
Burn victims may soon experience restored faces with a single operation, reducing pain and recovery time. Surgeons utilize innovative techniques to create thick skin flaps with unique blood supplies, eliminating huge scars and promoting emotional healing.
Barbed sutures enable minimally invasive facial rejuvenation with limited downtime, while ultrasonic body contouring provides liposuction-like results without pain or recovery time. Wrinkle fillers like Restylane and Sculptra are expected to skyrocket in demand due to their effectiveness.
Researchers found that muscle mechanoreceptor stimulation, independent of central command, significantly increased forearm sweat rate during passive cycling recovery. In contrast, chest sweat rate was only increased at the mid-recovery period. The study suggests that muscle mechanoreceptors are equally important in producing sweat as h...
A new product developed for soft tissue augmentation showed high efficacy and patient satisfaction rates of 74%, 80%, and 88% respectively. Moderate pain occurred in 59% of patients, but resolved within two weeks. Long-term safety profile remains unknown.
Researchers at Saint Louis University are testing a new, attenuated vaccine against smallpox, which could be administered to individuals with compromised immune systems. The study aims to explore the safety and efficacy of this investigational drug in a broader population.