Researchers at Kyushu University developed a new mathematical model that simulates oxygen transport by red blood cells through tiny blood vessels and their delivery to surrounding tissues. The findings show that RBCs can naturally adjust the amount of oxygen released based on local requirements.
Cells on the intestinal surface are replaced every few days due to pulling forces that determine which cells are weakest and need to leave. Weakened cells are removed from the intestine due to disrupted tug-of-war behavior, leading to inflammation and disease.
Researchers explore the role of efferocytosis in reducing inflammation and containing injury spread after an ischemic stroke. Efferocytosis may offer a promising therapeutic strategy to promote neural regeneration and minimize brain damage.
Researchers have discovered a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis, allowing for the dramatic reduction of toxic effects of Alzheimer's-causing proteins. This breakthrough offers hope for new therapies to slow or prevent neurodegenerative diseases, promoting healthy aging.
Researchers have discovered that synchronization between the central circadian clock and peripheral clocks in muscle and skin is crucial for maintaining tissue function and preventing degenerative processes associated with aging. Time-restricted feeding can partially replace the central clock and enhance the autonomy of the muscle cloc...
Researchers discovered that the vitamin D/vitamin D receptor pathway protects enterocytes during aging, reducing ISC proliferation and centrosome amplification. This study provides insights into the molecular mechanisms underlying healthy aging in Drosophila.
Researchers found that impaired mitochondrial unfolded protein response causes accelerated telomere shortening in both oocytes and somatic cells of aging mice. This study highlights the link between loss of mitochondrial protein homeostasis, infertility, and somatic aging.
Researchers found that high levels of FSP1 are associated with relapse after cisplatin treatment in head and neck squamous cell carcinoma. Targeting FSP1 can attenuate tumor stemness and downregulate invasion and metastatic rates, suggesting a potential new approach for treating drug-tolerant persister cancer cells.
Researchers discovered that RvD2, a specialized proresolving lipid mediator, can alleviate established liver scarring or fibrosis. Treatment with RvD2 improved liver histopathology and increased bone marrow and blood monocytes.
Researchers unveil a groundbreaking MRI technology that non-invasively assesses brain iron homeostasis, shedding light on its role in normal brain function, aging, and disease. The technology offers sensitivity to changes in iron mobilization capacity and can differentiate between tumor tissue and healthy tissue.
A groundbreaking study by UNIST researchers reveals that high levels of endotrophin in fat cells disrupt autophagy, leading to inflammation and insulin resistance. Inhibiting ATG7 protein function or neutralizing endotrophin shows promise as a potential treatment for obesity-related metabolic diseases.
Researchers discovered that aging alters the pancreas's circadian rhythm by reorganizing its transcriptome. The study found that fibroblasts play a crucial role in regulating this reorganization, which affects the organ's resilience to aging-related pathologies.
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
A novel system to control protein aggregation in a model of Parkinson’s disease suggests that aggregation of alpha-synuclein plays a critical role in disrupting neuronal homeostasis and triggering neurodegeneration. Light treatment led to formation of Lewy body-like aggregates, neurodegeneration, and Parkinson-like motor deficits in mice.
A study found that intact astrocyte networks are essential for neural homeostasis, synaptic plasticity, and spatial cognitive abilities in adult mice. Disrupting these networks impairs spatial learning and memory due to altered neuronal excitability and compromised synaptic transmission.
Dysfunction in mitochondrial respiration leads to imbalanced extracellular matrix (ECM) and tissue organization in cartilage. Research discovered the respiratory chain plays a key role in maintaining ECM balance.
A team of scientists has investigated the impact of mechanical properties on epithelial tissues, finding that extracellular matrix stiffness dictates self-patterning and growth. The study's findings suggest a complex relationship between cell density and motility, with implications for aging and diagnostics of medical pathologies.
Researchers discovered a protective mechanism where dying cells activate the EGFR-ERK pathway in neighboring cells, preventing simultaneous cell death. This mechanism ensures tissue integrity and connectivity.
Researchers developed 'sci-Space,' a new approach to spatial transcriptomics, retaining single-cell resolution while resolving spatial context at larger scales. The technique was applied to developing mouse embryos, capturing spatial coordinates and whole transcriptomes of nearly 120,000 cells.
Researchers at Kanazawa University identified three genes Alk, Bclaf3 and Prkra that regulate the self-renewal and differentiation of gastric tissue stem cells. These genes suppress Wnt signaling, a pathway crucial for tissue homeostasis and recovery from damage.
Researchers have comprehensively described the human tissue virome atlas using next-generation sequencing technology. They detected 39 viral species in somatic tissues from 547 individuals and found associations between virus infection and human gene expression and disease onset.
Scientists discover a pro-survival mechanism in skin cancer cells, which may lead to new therapeutic targets. Researchers also develop a method to generate hyaline cartilage using adult skin cells.
Stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. Upon re-feeding, insulin-like peptide expression and stem cell numbers recover quickly.