Articles tagged with Sterols
Researchers developed a sustainable solution to help tackle honeybee decline by creating an engineered food supplement. The new feed, designed to provide essential compounds found in plant pollen, significantly enhances colony reproduction.
A novel combination of cell biology and molecular computer simulations reveals that sterols' interactions with lipids shape membrane domains in yeast cells. This finding refines a 50-year-old textbook model, suggesting the complexity of sterol metabolism resulted from balancing lipid interactions for membrane organization.
Common prescription medications can disrupt sterol biosynthesis, potentially causing developmental disorders. The editorial highlights the need for mandatory sterol biosynthesis screening in clinical practice.
Researchers discovered that endoperoxides derived from ergosterol and 7-dehydrocholesterol induce the death of melanoma cells. This finding paves the way for expanding the use of photodynamic therapy in fighting skin cancer.
Researchers have discovered that commonly prescribed medications can disrupt sterol biosynthesis in developing brains, potentially affecting neural development and function. The study highlights the need for reevaluating medication safety during pregnancy and early childhood.
Researchers have identified a new pathway for ergosterol biosynthesis in Leishmania parasites, paving the way for more effective antiparasitic drugs. The discovery reveals that azole antifungals targeting a specific enzyme can be highly effective against leishmaniasis.
Researchers have discovered a new strategy to overcome docetaxel resistance in advanced prostate cancer patients, which may improve the efficacy of chemotherapy and prolong overall survival. The approach involves inhibiting cholesterol and lipid biosynthesis, reinducing sensitivity to the drug docetaxel.
A study published in PNAS reveals the structure of a protein linked to neurodegenerative disease Niemann-Pick type C, which accumulates cholesterol within cellular compartments. The research sheds light on the complex mechanism of cholesterol distribution and its role in maintaining optimal levels.
Researchers have discovered lipid fossils in ancient rocks, providing clues about the evolution of life. The findings suggest that a shift in animal feeding strategies occurred around 1.6 billion years ago, with some species abandoning phytosterol production as they obtained this nutrient from algae.
A new study found that social media platforms restrict user-generated content and advertising related to illegal muscle-building drugs but offer few restrictions on legal dietary supplements. This has raised concerns about the potential negative effects of these products on young people's health and behavior.
Researchers discovered that a Mediterranean marine worm can produce phytosterols de novo, and other animals have the genes to make these plant sterols. This finding reveals that many animal species may benefit from phytosterols' ability to improve blood cholesterol levels.
A study published in the American Heart Association found that six common dietary supplements did not lower LDL cholesterol levels when compared to a low-dose statin medication or placebo. The research suggests that these supplements are unlikely to offer meaningful impact on cholesterol levels, and a heart-healthy lifestyle is still t...
A team of scientists at Brookhaven National Laboratory has identified a key component of the assembly line responsible for oil droplet formation. The study suggests new ways to engineer plant tissues for increased oil accumulation, which could lead to sustainable oils for biofuels and other commodity products.
Researchers at Ca' Foscari University of Venice identified and dated traces of sterols in Lake Diamond and Kirkpatrick sediments, proving the presence of the Maori people. The study demonstrates a method for reconstructing human history by analyzing fecal sterols, which also shows the impact of the Maori population on the native forest.
Researchers at UT Southwestern Medical Center have determined the 3D atomic structure of a human sterol transporter that helps maintain cholesterol balance. This knowledge could lead to finding highly targeted therapies to treat or prevent diseases related to sterol imbalance.
A recent study published in the Journal of Clinical Lipidology found that corn oil significantly reduces cholesterol levels compared to extra virgin olive oil. The study showed a 10.9% reduction in LDL (bad) cholesterol and an 8.2% decrease in total cholesterol with corn oil.
Scientists have solved a decades-old medical mystery by understanding the mechanism of action of amphotericin, an antifungal drug that has been in use for over 50 years. The researchers found that most of the drug aggregates on the exterior of membranes, extracting sterols out of membranes like a sponge, leading to cell death.
A study found that consuming cholesterol-lowering foods, such as soy protein, nuts, and plant sterols, resulted in a greater decrease in LDL-C levels compared to a low-saturated-fat diet. The dietary portfolio approach showed significant percentage decreases in LDL-C levels with minimal clinic visits.
Research suggests that genetic variations in enzymes producing neuroactive steroids may be related to the risk of developing alcohol dependence. Studies have found linkages between AD and single nucleotide polymorphisms (SNPs) in genes encoding two key enzymes required for the generation of endogenous neuroactive steroids.
Researchers have discovered a compound that can obstruct the enzyme protecting a deadly parasite causing sleeping sickness, Chagas disease, and leishmaniasis. The findings provide new hope for developing effective treatments against these incurable diseases.
David W. Russell has received the 2010 Avanti Award in Lipids for his groundbreaking work on cholesterol metabolism and oxysterol function. His laboratory has elucidated the enzymatic pathways responsible for cholesterol breakdown and identified genes involved in related diseases.
A study found that plant sterols can accumulate in aortic valves, increasing the risk of stenosis. High levels of plant sterols were linked to higher blood concentrations, suggesting a potential health risk.
A University of Illinois study found that eating two CocoaVia dark chocolate bars daily lowered total cholesterol by 2% and LDL cholesterol by 5.3%. The drop in cholesterol numbers is attributed to plant sterols added to the bar and flavanols found in dark chocolate.
A new study suggests that daily consumption of CocoaVia dark chocolate bars containing cocoa flavanols and plant sterols significantly lowers total cholesterol by 2 percent and LDL cholesterol by 5.3 percent in individuals with elevated cholesterol. Regular consumption also reduces systolic blood pressure by 5 percent after 8 weeks.
A national survey of US high school girls found that those reporting anabolic steroid use had more health-harming behaviors, including smoking and taking diet pills. They were also more likely to experience mental health issues, such as depression and suicidal thoughts.
A reduced-calorie orange juice beverage fortified with plant sterols lowered 'bad' cholesterol and inflammation in healthy volunteers. The study found a significant decrease in C-reactive protein levels, suggesting a potential benefit for heart disease prevention.
A study published in The Journal of Nutrition found that eating two Right Direction Cookies daily lowered LDL cholesterol by ten percent and improved lipid subfraction profile. The cookies' combination of psyllium and plant sterols helps shift LDL particles toward a less atherogenic pattern, reducing cardiovascular risk.
Researchers found plant sterols significantly lowered LDL cholesterol and total cholesterol in patients taking statin drugs. The study suggests that adding plant sterols to the diet may provide an effective way to lower cardiovascular risk.
A new study found that combining plant sterols with exercise can significantly improve cholesterol levels in previously sedentary adults. The combination therapy favourably altered lipid profiles by decreasing total cholesterol and increasing high-density lipoprotein (HDL) cholesterol levels.
A new clinical trial has found that high skin sterol levels are associated with an increased risk of heart disease in patients with coronary artery disease. The study, published by IMI International Medical Innovations, used a prospective registry to examine the relationship between skin sterol and cardiovascular risk factors.
A 10-week study found that consuming plant sterol-fortified orange juice lowered total and LDL cholesterol levels by 7.2% and 12.4%, respectively. The researchers suggest this could be a healthy and appealing option for individuals with mildly elevated cholesterol.
A study of 177 patients found higher blood levels of sitosterol were associated with an increased risk of coronary events. Patients with high LDL cholesterol and elevated sitosterol levels were at nearly double the risk of a major coronary event.
Scientists use lab mice to identify genetic basis of cholesterol absorption, aiming to develop new treatments for heart disease. They pinpoint two chromosome regions as potential sites for genes regulating plant sterol levels, which reflect dietary cholesterol absorption.
A CSIRO trial found that plant sterol-enriched margarine can reduce LDL cholesterol by an average of 9.6%. The study showed that including the spread in the diet for three weeks resulted in a 10% reduction in cholesterol levels, which may lower the risk of heart disease.
Researchers found that brain steroid allopregnanolone mediates many of alcohol's effects, including anti-anxiety and anticonvulsant actions. The study suggests that blocking this compound may inhibit alcohol's sedative-hypnotic effects.
A new low-fat sterol ester spread can lower LDL cholesterol levels by 5-10% and may reduce the risk of heart attack and stroke. The study found that consuming 1-2 grams of the substance per day had similar cholesterol-lowering effects, making it a promising non-drug option for heart disease prevention.