Articles tagged with In Vitro Assays
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
AcCELLerate has partnered with ATCC to provide customized Master, Working, and assay-ready instaCELL banks for research clients. Researchers will gain access to high-quality, authenticated cell lines with increased assay reproducibility.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
Researchers developed a new system, MEMPHIS, that models mRNA vaccine responses in a dish, providing insight into vaccine activity in vulnerable populations. The study found muted innate immune responses in people over age 60, indicating an impaired ability to support Th1 immunity.
Researchers develop physiologically relevant model to investigate breast cancer bone metastasis, holding promise for predicting risk and developing new treatments.
Researchers developed a compact 'gene scissor' tool, TnpB, which shows a 4.4-fold increase in efficiency of modifying DNA, making it more effective as a gene editing tool. The tool can be used to treat patients with familial hypercholesterolemia, reducing cholesterol levels by nearly 80%.
A high-throughput analysis of 26 medically important snakes in sub-Saharan Africa reveals the benefits of an integrated approach to understanding their venom composition and function. The study provides a solid foundation for further research on snake biology and antivenom development.
A new serological test, PepSeq, allows scientists to quickly test antibody binding against hundreds of thousands of protein targets, helping prepare for and respond to pandemics. The technology identifies specific antibodies that provide protection against infection, holding promise for developing effective vaccines and treatments.
An international research team developed an animal-free testing battery to detect developmental neurotoxicity, using human cells instead of animals. The results show that the testing battery is technically feasible and already has a measurement sensitivity comparable to animal experiments.
A recent study published in Applied In Vitro Toxicology found that tobacco-free nicotine pouches exhibit reduced levels of toxicants and biological activity compared to combustible cigarette smoke. The products, manufactured by Imperial Brands, showed substantially reduced genotoxicity and cytotoxicity in three toxicological assays.
A new study found that Omicron's immune-evading capabilities are significant, but some vaccinated and previously infected individuals have 'stronger' protection. However, the protection from Omicron may be compromised over time.
Researchers from FAU and MIT develop a microfluidic assay to study the mechanical performance of red blood cells under hypoxic conditions. The study reveals that cyclic hypoxia can lead to mechanical degradation of the red blood cell membrane, contributing to aging.
A new assay using HEPATOPAC model identifies drugs with high DILI risk, showing high sensitivity and specificity. BioIVT's advanced in vitro liver model provides a promising solution for preclinical DILI risk assessment.
New research by British American Tobacco indicates that modern oral nicotine products (MOPs) are less biologically active than traditional cigarettes and snus, with some products failing to elicit a biological response. The study suggests MOPs may be a reduced-risk option for users who switch completely from smoking.
Researchers found that PFASs, such as PFOS and PFNA, have high binding affinities to Baikal seal PPARα, suggesting a role in toxicity. In vitro and in silico approaches revealed interspecies differences in the binding of PFASs to PPARα.
The novel vaping product produced greatly reduced mutagenicity and cytotoxicity compared to cigarette smoke. Further studies are required to substantiate its potential as a reduced-risk product.
Researchers discovered a link between BSEP inhibition and FXR activation, explaining the weak concordance between BSEP inhibition potency and cholestatic DILI incidence. The C-DILI assay has been shown to have high in vitro-in vivo correlation among compounds known to have a risk of DILI.
Research highlights the effects of nanoparticles on platelet activation and plasmatic coagulation, a complex process essential for human life. Studies demonstrate that nanoparticles can alter hemostasis in various diseases, such as cancer and diabetes, emphasizing the need for thorough testing and regulation.
The symposium aims to improve science-informed hazard prediction and risk assessment for pesticides and other agrochemicals. New approaches, including high-throughput methods, are being developed to reduce the use of animal testing and increase transparency in risk assessments.
Bioengineering professor Dimitrios Morikis and research scientist Monte Radeke are searching for chemical compounds targeting the complement system to treat age-related macular degeneration. They will use computational screening, experimental testing, and human retinal cell-based models to identify potential treatments.
A recent study by researchers from Lawrence Berkeley National Laboratory found that thirdhand smoke causes significant genetic damage in human cells. Chronic exposure is worse than acute exposure, with higher concentrations of chemical compounds causing more DNA damage over time.